Search

Your search keyword '"Lickert, Heiko"' showing total 805 results
Start Over Author "Lickert, Heiko"
805 results on '"Lickert, Heiko"'

2. Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Author

Grandl, Gerald, Collden, Gustav, Feng, Jin, Bhattacharya, Sreya, Klingelhuber, Felix, Schomann, Leopold, Bilekova, Sara, Ansarullah, Xu, Weiwei, Far, Fataneh Fathi, Tost, Monica, Gruber, Tim, Bastidas-Ponce, Aimée, Zhang, Qian, Novikoff, Aaron, Liskiewicz, Arkadiusz, Liskiewicz, Daniela, Garcia-Caceres, Cristina, Feuchtinger, Annette, Tschöp, Matthias H., Krahmer, Natalie, Lickert, Heiko, and Müller, Timo D.

Published
2024
Full Text
View/download PDF

3. Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Author

Liskiewicz, Arkadiusz, Khalil, Ahmed, Liskiewicz, Daniela, Novikoff, Aaron, Grandl, Gerald, Maity-Kumar, Gandhari, Gutgesell, Robert M., Bakhti, Mostafa, Bastidas-Ponce, Aimée, Czarnecki, Oliver, Makris, Konstantinos, Lickert, Heiko, Feuchtinger, Annette, Tost, Monica, Coupland, Callum, Ständer, Lisa, Akindehin, Seun, Prakash, Sneha, Abrar, Faiyaz, Castelino, Russell L., He, Yantao, Knerr, Patrick J., Yang, Bin, Hogendorf, Wouter F. J., Zhang, Shiqi, Hofmann, Susanna M., Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., Douros, Jonathan D., and Müller, Timo D.

Published
2023
Full Text
View/download PDF

7. Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Author

Akindehin, Seun, Liskiewicz, Arkadiusz, Liskiewicz, Daniela, Bernecker, Miriam, Garcia-Caceres, Cristina, Drucker, Daniel J., Finan, Brian, Grandl, Gerald, Gutgesell, Robert, Hofmann, Susanna M., Khalil, Ahmed, Liu, Xue, Cota, Perla, Bakhti, Mostafa, Czarnecki, Oliver, Bastidas-Ponce, Aimée, Lickert, Heiko, Kang, Lingru, Maity, Gandhari, Novikoff, Aaron, Parlee, Sebastian, Pathak, Ekta, Schriever, Sonja C., Sterr, Michael, Ussar, Siegfried, Zhang, Qian, DiMarchi, Richard, Tschöp, Matthias H., Pfluger, Paul T., Douros, Jonathan D., and Müller, Timo D.

Published
2024
Full Text
View/download PDF

11. Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

Author

Griess, Kerstin, Rieck, Michael, Müller, Nadine, Karsai, Gergely, Hartwig, Sonja, Pelligra, Angela, Hardt, Robert, Schlegel, Caroline, Kuboth, Jennifer, Uhlemeyer, Celina, Trenkamp, Sandra, Jeruschke, Kay, Weiss, Jürgen, Peifer-Weiss, Leon, Xu, Weiwei, Cames, Sandra, Yi, Xiaoyan, Cnop, Miriam, Beller, Mathias, Stark, Holger, Kondadi, Arun Kumar, Reichert, Andreas S., Markgraf, Daniel, Wammers, Marianne, Häussinger, Dieter, Kuss, Oliver, Lehr, Stefan, Eizirik, Decio, Lickert, Heiko, Lammert, Eckhard, Roden, Michael, Winter, Dominic, Al-Hasani, Hadi, Höglinger, Doris, Hornemann, Thorsten, Brüning, Jens C., and Belgardt, Bengt-Frederik

Published
2023
Full Text
View/download PDF

12. Distinct molecular profiles of skull bone marrow in health and neurological disorders

Author

Kolabas, Zeynep Ilgin, Kuemmerle, Louis B., Perneczky, Robert, Förstera, Benjamin, Ulukaya, Selin, Ali, Mayar, Kapoor, Saketh, Bartos, Laura M., Büttner, Maren, Caliskan, Ozum Sehnaz, Rong, Zhouyi, Mai, Hongcheng, Höher, Luciano, Jeridi, Denise, Molbay, Muge, Khalin, Igor, Deligiannis, Ioannis K., Negwer, Moritz, Roberts, Kenny, Simats, Alba, Carofiglio, Olga, Todorov, Mihail I., Horvath, Izabela, Ozturk, Furkan, Hummel, Selina, Biechele, Gloria, Zatcepin, Artem, Unterrainer, Marcus, Gnörich, Johannes, Roodselaar, Jay, Shrouder, Joshua, Khosravani, Pardis, Tast, Benjamin, Richter, Lisa, Díaz-Marugán, Laura, Kaltenecker, Doris, Lux, Laurin, Chen, Ying, Zhao, Shan, Rauchmann, Boris-Stephan, Sterr, Michael, Kunze, Ines, Stanic, Karen, Kan, Vanessa W.Y., Besson-Girard, Simon, Katzdobler, Sabrina, Palleis, Carla, Schädler, Julia, Paetzold, Johannes C., Liebscher, Sabine, Hauser, Anja E., Gokce, Ozgun, Lickert, Heiko, Steinke, Hanno, Benakis, Corinne, Braun, Christian, Martinez-Jimenez, Celia P., Buerger, Katharina, Albert, Nathalie L., Höglinger, Günter, Levin, Johannes, Haass, Christian, Kopczak, Anna, Dichgans, Martin, Havla, Joachim, Kümpfel, Tania, Kerschensteiner, Martin, Schifferer, Martina, Simons, Mikael, Liesz, Arthur, Krahmer, Natalie, Bayraktar, Omer A., Franzmeier, Nicolai, Plesnila, Nikolaus, Erener, Suheda, Puelles, Victor G., Delbridge, Claire, Bhatia, Harsharan Singh, Hellal, Farida, Elsner, Markus, Bechmann, Ingo, Ondruschka, Benjamin, Brendel, Matthias, Theis, Fabian J., and Erturk, Ali

Published
2023
Full Text
View/download PDF

16. Functional Analysis of INK4 Locus in Endocrine Development and Function

Author

Lickert, Heiko (Prof. Dr.), Lickert, Heiko (Prof. Dr.);Floss, Thomas (Prof. Dr.), Shahryari, Alireza, Lickert, Heiko (Prof. Dr.), Lickert, Heiko (Prof. Dr.);Floss, Thomas (Prof. Dr.), and Shahryari, Alireza

Abstract

Here, we deciphered a molecular mechanism that how GWAS-INK4 risk region is linked to type 2 diabetes. We deleted the 8 kb risk region in human stem cells and then differentiated towards beta-cells. The KO cells revealed less proliferation rate and less functionality, impaired insulin secretion. In parallel, we designed a strategy that could improve gene editing efficiency for CRISPR/Cas9 genome engineering in human stem cells via small RNAs., Haben wir einen molekularen Mechanismus entschlüsselt, der zeigt, wie die GWAS-INK4-Risikoregion mit Typ-2-Diabetes zusammenhängt. Wir haben die 8-kb-Risikoregion in menschlichen Stammzellen gelöscht und dann in Richtung Beta-Zellen differenziert. Die KO-Zellen zeigten eine geringere Proliferationsrate und eine geringere Funktionalität, eine beeinträchtigte Insulinsekretion. Parallel dazu entwarfen wir eine Strategie, die die Effizienz der Genbearbeitung für das CRISPR/Cas9-Genom-Engineering in menschlichen Stammzellen über kleine RNAs verbessern könnte.

Published
2024

19. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Author

Quarta, Carmelo, Stemmer, Kerstin, Novikoff, Aaron, Yang, Bin, Klingelhuber, Felix, Harger, Alex, Bakhti, Mostafa, Bastidas-Ponce, Aimee, Baugé, Eric, Campbell, Jonathan E., Capozzi, Megan, Clemmensen, Christoffer, Collden, Gustav, Cota, Perla, Douros, Jon, Drucker, Daniel J., DuBois, Barent, Feuchtinger, Annette, Garcia-Caceres, Cristina, Grandl, Gerald, Hennuyer, Nathalie, Herzig, Stephan, Hofmann, Susanna M., Knerr, Patrick J., Kulaj, Konxhe, Lalloyer, Fanny, Lickert, Heiko, Liskiewicz, Arek, Liskiewicz, Daniela, Maity, Gandhari, Perez-Tilve, Diego, Prakash, Sneha, Sanchez-Garrido, Miguel A., Zhang, Qian, Staels, Bart, Krahmer, Natalie, DiMarchi, Richard D., Tschöp, Matthias H., Finan, Brian, and Müller, Timo D.

Published
2022
Full Text
View/download PDF

21. Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

Author

Schmidt, Sebastian, Luecken, Malte D., Trümbach, Dietrich, Hembach, Sina, Niedermeier, Kristina M., Wenck, Nicole, Pflügler, Klaus, Stautner, Constantin, Böttcher, Anika, Lickert, Heiko, Ramirez-Suastegui, Ciro, Ahmad, Ruhel, Ziller, Michael J., Fitzgerald, Julia C., Ruf, Viktoria, van de Berg, Wilma D. J., Jonker, Allert J., Gasser, Thomas, Winner, Beate, Winkler, Jürgen, Vogt Weisenhorn, Daniela M., Giesert, Florian, Theis, Fabian J., and Wurst, Wolfgang

Published
2022
Full Text
View/download PDF

26. Animal models of obesity and diabetes mellitus

Author

Kleinert, Maximilian, Clemmensen, Christoffer, Hofmann, Susanna M, Moore, Mary C, Renner, Simone, Woods, Stephen C, Huypens, Peter, Beckers, Johannes, de Angelis, Martin Hrabe, Schürmann, Annette, Bakhti, Mostafa, Klingenspor, Martin, Heiman, Mark, Cherrington, Alan D, Ristow, Michael, Lickert, Heiko, Wolf, Eckhard, Havel, Peter J, Müller, Timo D, and Tschöp, Matthias H

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Biotechnology, Nutrition, Obesity, Neurodegenerative, Diabetes, Metabolic and endocrine, Animals, Body Mass Index, Diabetes Mellitus, Type 2, Disease Models, Animal, Dogs, Fishes, Haplorhini, Humans, Mice, Rats, Risk Assessment, Sensitivity and Specificity, Swine, Endocrinology & Metabolism, Clinical sciences
Abstract

More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.

Published
2018

27. Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues

Author

De Castro, Sandra CP, Hirst, Caroline S, Savery, Dawn, Rolo, Ana, Lickert, Heiko, Andersen, Bogi, Copp, Andrew J, and Greene, Nicholas DE

Subjects
Biomedical and Clinical Sciences, Neurosciences, Congenital Structural Anomalies, Spina Bifida, Genetics, Pediatric, Rare Diseases, 1.1 Normal biological development and functioning, Aetiology, Underpinning research, 2.1 Biological and endogenous factors, Neurological, Animals, DNA-Binding Proteins, Embryonic Development, Gene Expression Regulation, Developmental, Genes, Reporter, Germ Layers, Mice, Mice, Knockout, Mice, Transgenic, Neural Plate, Neural Tube, Neural Tube Defects, Neurulation, Organ Specificity, RNA, Messenger, Spinal Dysraphism, Transcription Factors, Neural tube defects, grainyhead, spina bifida, curly tail, mouse embryo, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Failure of neural tube closure leads to neural tube defects (NTDs), common congenital abnormalities in humans. Among the genes whose loss of function causes NTDs in mice, Grainyhead-like3 (Grhl3) is essential for spinal neural tube closure, with null mutants exhibiting fully penetrant spina bifida. During spinal neurulation Grhl3 is initially expressed in the surface (non-neural) ectoderm, subsequently in the neuroepithelial component of the neural folds and at the node-streak border, and finally in the hindgut endoderm. Here, we show that endoderm-specific knockout of Grhl3 causes late-arising spinal NTDs, preceded by increased ventral curvature of the caudal region which was shown previously to suppress closure of the spinal neural folds. This finding supports the hypothesis that diminished Grhl3 expression in the hindgut is the cause of spinal NTDs in the curly tail, carrying a hypomorphic Grhl3 allele. Complete loss of Grhl3 function produces a more severe phenotype in which closure fails earlier in neurulation, before the stage of onset of expression in the hindgut of wild-type embryos. This implicates additional tissues and NTD mechanisms in Grhl3 null embryos. Conditional knockout of Grhl3 in the neural plate and node-streak border has minimal effect on closure, suggesting that abnormal function of surface ectoderm, where Grhl3 transcripts are first detected, is primarily responsible for early failure of spinal neurulation in Grhl3 null embryos.

Published
2018

29. Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem Cells

Author

Kelle, Dolunay, primary, Ugur, Enes, additional, Rusha, Ejona, additional, Shaposhnikov, Dmitry, additional, Livigni, Alessandra, additional, Horschitz, Sandra, additional, Davoudi, Mahnaz, additional, Blutke, Andreas, additional, Bushe, Judith, additional, Sterr, Michael, additional, Arkhipova, Ksenia, additional, Tak, Benjamin, additional, de Vries, Ruben, additional, Hochane, Mazène, additional, Spruijt, Britte, additional, Haji Ali, Aicha, additional, Lickert, Heiko, additional, Feuchtinger, Annette, additional, Koch, Philipp, additional, Mann, Matthias, additional, Leonhardt, Heinrich, additional, Wilson, Valerie, additional, and Drukker, Micha, additional

Published
2024
Full Text
View/download PDF

32. Mitosis Detection in Intestinal Crypt Images with Hough Forest and Conditional Random Fields

Author

Bortsova, Gerda, Sterr, Michael, Wang, Lichao, Milletari, Fausto, Navab, Nassir, Böttcher, Anika, Lickert, Heiko, Theis, Fabian, and Peng, Tingying

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Intestinal enteroendocrine cells secrete hormones that are vital for the regulation of glucose metabolism but their differentiation from intestinal stem cells is not fully understood. Asymmetric stem cell divisions have been linked to intestinal stem cell homeostasis and secretory fate commitment. We monitored cell divisions using 4D live cell imaging of cultured intestinal crypts to characterize division modes by means of measurable features such as orientation or shape. A statistical analysis of these measurements requires annotation of mitosis events, which is currently a tedious and time-consuming task that has to be performed manually. To assist data processing, we developed a learning based method to automatically detect mitosis events. The method contains a dual-phase framework for joint detection of dividing cells (mothers) and their progeny (daughters). In the first phase we detect mother and daughters independently using Hough Forest whilst in the second phase we associate mother and daughters by modelling their joint probability as Conditional Random Field (CRF). The method has been evaluated on 32 movies and has achieved an AUC of 72%, which can be used in conjunction with manual correction and dramatically speed up the processing pipeline., Comment: Accepted at the 7th International Conference on Machine Learning in Medical Imaging

Published
2016

34. Gene Therapy

Author

Shahryari, Alireza, primary, Nazari, Zahra, additional, Jazi, Marie Saghaeian, additional, Hashemi-Shahraki, Fatemeh, additional, Wißmiller, Katharina, additional, Xu, Weiwei, additional, Burtscher, Ingo, additional, and Lickert, Heiko, additional

Published
2022
Full Text
View/download PDF

35. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Author

Zhang, Qian, Delessa, Challa Tenagne, Augustin, Robert, Bakhti, Mostafa, Colldén, Gustav, Drucker, Daniel J., Feuchtinger, Annette, Caceres, Cristina Garcia, Grandl, Gerald, Harger, Alexandra, Herzig, Stephan, Hofmann, Susanna, Holleman, Cassie Lynn, Jastroch, Martin, Keipert, Susanne, Kleinert, Maximilian, Knerr, Patrick J., Kulaj, Konxhe, Legutko, Beata, Lickert, Heiko, Liu, Xue, Luippold, Gerd, Lutter, Dominik, Malogajski, Emilija, Medina, Marta Tarquis, Mowery, Stephanie A., Blutke, Andreas, Perez-Tilve, Diego, Salinno, Ciro, Sehrer, Laura, DiMarchi, Richard D., Tschöp, Matthias H., Stemmer, Kerstin, Finan, Brian, Wolfrum, Christian, and Müller, Timo D.

Published
2021
Full Text
View/download PDF

39. Author Correction: Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates

Author

Böttcher, Anika, Büttner, Maren, Tritschler, Sophie, Sterr, Michael, Aliluev, Alexandra, Oppenländer, Lena, Burtscher, Ingo, Sass, Steffen, Irmler, Martin, Beckers, Johannes, Ziegenhain, Christoph, Enard, Wolfgang, Schamberger, Andrea C., Verhamme, Fien M., Eickelberg, Oliver, Theis, Fabian J., and Lickert, Heiko

Published
2021
Full Text
View/download PDF

41. Inceptor counteracts insulin signalling in β-cells to control glycaemia

Author

Ansarullah, Jain, Chirag, Far, Fataneh Fathi, Homberg, Sarah, Wißmiller, Katharina, von Hahn, Felizitas Gräfin, Raducanu, Aurelia, Schirge, Silvia, Sterr, Michael, Bilekova, Sara, Siehler, Johanna, Wiener, Julius, Oppenländer, Lena, Morshedi, Amir, Bastidas-Ponce, Aimée, Collden, Gustav, Irmler, Martin, Beckers, Johannes, Feuchtinger, Annette, Grzybek, Michal, Ahlbrecht, Christin, Feederle, Regina, Plettenburg, Oliver, Müller, Timo D., Meier, Matthias, Tschöp, Matthias H., Coskun, Ünal, and Lickert, Heiko

Published
2021
Full Text
View/download PDF

42. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

Author

Müller, Janis A., Groß, Rüdiger, Conzelmann, Carina, Krüger, Jana, Merle, Uta, Steinhart, Johannes, Weil, Tatjana, Koepke, Lennart, Bozzo, Caterina Prelli, Read, Clarissa, Fois, Giorgio, Eiseler, Tim, Gehrmann, Julia, van Vuuren, Joanne, Wessbecher, Isabel M., Frick, Manfred, Costa, Ivan G., Breunig, Markus, Grüner, Beate, Peters, Lynn, Schuster, Michael, Liebau, Stefan, Seufferlein, Thomas, Stenger, Steffen, Stenzinger, Albrecht, MacDonald, Patrick E., Kirchhoff, Frank, Sparrer, Konstantin M. J., Walther, Paul, Lickert, Heiko, Barth, Thomas F. E., Wagner, Martin, Münch, Jan, Heller, Sandra, and Kleger, Alexander

Published
2021
Full Text
View/download PDF

46. PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Author

Nasteska, Daniela, Fine, Nicholas H. F., Ashford, Fiona B., Cuozzo, Federica, Viloria, Katrina, Smith, Gabrielle, Dahir, Aisha, Dawson, Peter W. J., Lai, Yu-Chiang, Bastidas-Ponce, Aimée, Bakhti, Mostafa, Rutter, Guy A., Fiancette, Remi, Nano, Rita, Piemonti, Lorenzo, Lickert, Heiko, Zhou, Qiao, Akerman, Ildem, and Hodson, David J.

Published
2021
Full Text
View/download PDF

47. Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Author

Suwandhi, Lisa, Altun, Irem, Karlina, Ruth, Miok, Viktorian, Wiedemann, Tobias, Fischer, David, Walzthoeni, Thomas, Lindner, Christina, Böttcher, Anika, Heinzmann, Silke S., Israel, Andreas, Khalil, Ahmed Elagamy Mohamed Mahmoud, Braun, Alexander, Pramme-Steinwachs, Ines, Burtscher, Ingo, Schmitt-Kopplin, Philippe, Heinig, Matthias, Elsner, Martin, Lickert, Heiko, Theis, Fabian J., and Ussar, Siegfried

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results