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168 results on '"Lichy, Jack"'

1. Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease

Author

Hung, Adriana M., Assimon, Victoria A., Chen, Hua-Chang, Yu, Zhihong, Vlasschaert, Caitlyn, Triozzi, Jefferson L., Chan, Helen, Wheless, Lee, Wilson, Otis, Shah, Shailja C., Mack, Taralynn, Thompson, Trevor, Matheny, Michael E., Chandrasekar, Saranya, Mozaffari, Sahar V., Chung, Cecilia P., Tsao, Philip, Susztak, Katalin, Siew, Edward D., Estrada, Karol, Gaziano, J. Michael, Graham, Robert R., Tao, Ran, Hoek, Maarten, Robinson-Cohen, Cassianne, Green, Eric M., Bick, Alexander G., Muralidhar, Sumitra, Moser, Jennifer, Deen, Jennifer E., Tsao, Philip S., Gaziano, J. Michael, Hauser, Elizabeth, Kilbourne, Amy, Luoh, Shiuh-Wen, Matheny, Michael, Oslin, Dave, Churby, Lori, Whitbourne, Stacey B., Brewer, Jessica V., Shayan, Shahpoor (Alex), Selva, Luis E., Pyarajan, Saiju, Cho, Kelly, DuVall, Scott L., Brophy, Mary T., Stephens, Brady, Connor, Todd, Argyres, Dean P., Assimes, Tim, Hung, Adriana, Kranzler, Henry, Aguayo, Samuel, Ahuja, Sunil, Alexander, Kathrina, Androulakis, Xiao M., Balasubramanian, Prakash, Ballas, Zuhair, Beckham, Jean, Bhushan, Sujata, Boyko, Edward, Cohen, David, Dellitalia, Louis, Faulk, L. Christine, Fayad, Joseph, Fujii, Daryl, Gappy, Saib, Gesek, Frank, Greco, Jennifer, Godschalk, Michael, Gress, Todd W., Gupta, Samir, Gutierrez, Salvador, Harley, John, Hammer, Kimberly, Hamner, Mark, Hurley, Robin, Iruvanti, Pran, Jacono, Frank, Jhala, Darshana, Kinlay, Scott, Klein, Jon, Landry, Michael, Liang, Peter, Liangpunsakul, Suthat, Lichy, Jack, Mahan, C. Scott, Marrache, Ronnie, Mastorides, Stephen, Mates, Elisabeth, Mattocks, Kristin, Meyer, Paul, Moorman, Jonathan, Morgan, Timothy, Murdoch, Maureen, Norton, James, Okusaga, Olaoluwa, Oursler, Kris Ann, Palacio, Ana, Poon, Samuel, Potter, Emily, Rauchman, Michael, Servatius, Richard, Sharma, Satish, Smith, River, Sriram, Peruvemba, Strollo, Patrick, Jr., Tandon, Neeraj, Tsao, Philip, Villareal, Gerardo, Wallbom, Agnes, Walsh, Jessica, Wells, John, Whittle, Jeffrey, Whooley, Mary, Williams, Allison E., Wilson, Peter, Xu, Junzhe, and Yeh, Shing Shing

Published
2023
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2. Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies

Author

Fang, Huaying, Hui, Qin, Lynch, Julie, Honerlaw, Jacqueline, Assimes, Themistocles L, Huang, Jie, Vujkovic, Marijana, Damrauer, Scott M, Pyarajan, Saiju, Gaziano, J Michael, DuVall, Scott L, O’Donnell, Christopher J, Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter WF, Tsao, Philip S, Sun, Yan, Tang, Hua, Ramoni, Rachel, Breeling, Jim, Huang, Grant, Muralidhar, Sumitra, Moser, Jennifer, Whitbourne, Stacey B, Brewer, Jessica V, Concato, John, Warren, Stuart, Argyres, Dean P, Stephens, Brady, Brophy, Mary T, Humphries, Donald E, Do, Nhan, Shayan, Shahpoor, Nguyen, Xuan-Mai T, Hauser, Elizabeth, Sun, Yan V, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Harley, John, Whittle, Jeffrey, Beckham, Jean, Wells, John, Gutierrez, Salvador, Gibson, Gretchen, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Haddock, Kathlyn Sue, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Buford, Malcolm, Mastorides, Stephen, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Swann, Alan, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Washburn, Ronald, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Callaghan, John, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Gutierrez, Amparo, Schifman, Ronald, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Oehlert, Mary, Wallbom, Agnes, Fernando, Ronald, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Anderson, Gwenevere, Sonel, Elif, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Fayad, Joseph, Hung, Adriana, and Lichy, Jack

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, Generic health relevance, Algorithms, Ethnicity, Genome-Wide Association Study, Humans, Machine Learning, Racial Groups, Support Vector Machine, VA Million Veteran Program, biobank, ethnicity-specific trait loci, genetic ancestry, multi-ethnic cohort, self-reported race/ethnicity, stratified analysis, trans-ethnic GWAS, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic factors influencing complex traits related to health and disease among minority populations. At the same time, the genetic diversity in these cohorts presents new challenges for analysis and interpretation. We consider the utility of race and/or ethnicity categories in genome-wide association studies (GWASs) of multi-ethnic cohorts. We demonstrate that race/ethnicity information enhances the ability to understand population-specific genetic architecture. To address the practical issue that self-identified racial/ethnic information may be incomplete, we propose a machine learning algorithm that produces a surrogate variable, termed HARE. We use height as a model trait to demonstrate the utility of HARE and ethnicity-specific GWASs.

Published
2019

3. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)

Author

Song, Rebecca J, Nguyen, Xuan-Mai T, Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C, Gagnon, David R, Cho, Kelly, O'Donnell, Christopher J, Concato, John, Gaziano, J Michael, Djoussé, Luc, Program, VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Robey, Brooks, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, Gibson, Gretchen, and Heinz

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Substance Misuse, Brain Disorders, Heart Disease - Coronary Heart Disease, Alcoholism, Alcohol Use and Health, Heart Disease, Cardiovascular, Clinical Research, Atherosclerosis, Stroke, Oral and gastrointestinal, Good Health and Well Being, Aged, Alcohol Drinking, Alcoholic Beverages, Alcoholism, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Protective Factors, Risk Factors, Self Report, United States, Veterans, VA Million Veteran Program, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.

Published
2018

4. DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program

Author

Djoussé, Luc, Ho, Yuk‐Lam, Nguyen, Xuan‐Mai T, Gagnon, David R, Wilson, Peter WF, Cho, Kelly, Gaziano, J Michael, Program, the VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado‐Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, and Gibson, Gretchen

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Hypertension, Atherosclerosis, Clinical Research, Cardiovascular, Prevention, Good Health and Well Being, Aged, Coronary Artery Disease, Diet, Healthy, Dietary Approaches To Stop Hypertension, Female, Humans, Incidence, Male, Middle Aged, Patient Compliance, Prognosis, Prospective Studies, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Time Factors, United States, Veterans Health, VA Million Veteran Program, coronary artery disease, epidemiology, nutrition, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend,

Published
2018

6. Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort

Author

Gaziano, J. Michael, Ramoni, Rachel, Breeling, Jim, Chang, Kyong-Mi, Huang, Grant, Muralidhar, Sumitra, O’Donnell, Christopher J., Tsao, Philip S., Moser, Jennifer, Whitbourne, Stacey B., Brewer, Jessica V., Concato, John, Warren, Stuart, D, Pharm, Argyres, Dean P., Stephens, Brady, Brophy, Mary T., Humphries, Donald E., Do, Nhan, Shayan, Shahpoor, Nguyen, Xuan-Mai T., Pyarajan, Saiju, Cho, Kelly, Hauser, Elizabeth, Sun, Yan, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Harley, John, Whittle, Jeffrey, Beckham, Jean, Wells, John, Gutierrez, Salvador, Gibson, Gretchen, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Haddock, Kathlyn Sue, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Buford, Malcolm, Mastorides, Stephen, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Swann, Alan, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Washburn, Ronald, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Callaghan, John, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Gutierrez, Amparo, Schifman, Ronald, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Oehlert, Mary, Wallbom, Agnes, Fernando, Ronald, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Anderson, Gwenevere, Tsao, Philip, Sonel, Elif, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Fayad, Joseph, Hung, Adriana, Lichy, Jack, Hurley, Robin, Robey, Brooks, Striker, Robert, Harrington, Kelly M., Song, Rebecca J., Hannagan, Keri, Quaden, Rachel, Gagnon, David R., Deen, Jennifer E., O’Leary, Timothy J., and Gaziano, John Michael

Published
2019
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7. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)

Author

Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E., Sriram, Peruvemba, Tsao, Philip S., Boyko, Edward J., Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J., McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C., Hamner, Mark B., Florez, Hermes J., Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R., Davis, Lori, Hurley, Robin A., Meyer, Laurence, Ahuja, Sunil K., Konicki, Eric P., Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D., Callaghan, John T., Aguayo, Samuel M., Gupta, Samir, Washburn, Ronald G., Oehlert, Mary E., Hung, Adriana M., Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B., Childress, Richard D., Godschalk, Michael F., Shuldiner, Alan R., Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R., Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M., Harley, John B., Mattocks, Kristin, Robey, Brooks, Striker, Robert T., Rauchman, Michael, Wells, John, Ballas, Zuhair K., Woods, Susan S., Yeh, Shing Shing, Ratcliffe, Nora R., Klein, Jon B., Golden, Adam G., Ginzburg, Harold M., Sharma, Satish, Oursler, Kris Ann K., Whooley, Mary A., Gibson, Gretchen, Heinz, Song, Rebecca J., Nguyen, Xuan-Mai T., Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C., Gagnon, David R., Cho, Kelly, O'Donnell, Christopher J., Concato, John, Gaziano, J. Michael, and Djoussé, Luc

Published
2018
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9. Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture

Author

Katz, Alexander E., primary, Yang, Min-Lee, additional, Levin, Michael G., additional, Tcheandjieu, Catherine, additional, Mathis, Michael, additional, Hunker, Kristina, additional, Blackburn, Susan, additional, Eliason, Jonathan L., additional, Coleman, Dawn M., additional, Fendrikova-Mahlay, Natalia, additional, Gornik, Heather L., additional, Karmakar, Monita, additional, Hill, Hannah, additional, Xu, Chang, additional, Zawistowski, Matthew, additional, Brummett, Chad M., additional, Zoellner, Sebastian, additional, Zhou, Xiang, additional, O’Donnell, Christopher J., additional, Douglas, Julie A., additional, Assimes, Themistocles L., additional, Tsao, Phillip S., additional, Li, Jun Z., additional, Damrauer, Scott M., additional, Stanley, James C., additional, Ganesh, Santhi K., additional, Gaziano, J. Michael, additional, Muralidhar, Sumitra, additional, Ramoni, Rachel, additional, Beckham, Jean, additional, Chang, Kyong-Mi, additional, Tsao, Philip S., additional, Breeling, James, additional, Huang, Grant, additional, Casas, Juan P., additional, Moser, Jennifer, additional, Whitbourne, Stacey B., additional, Brewer, Jessica V., additional, Aslan, Mihaela, additional, Connor, Todd, additional, Argyres, Dean P., additional, Stephens, Brady, additional, Brophy, Mary T., additional, Humphries, Donald E., additional, Selva, Luis E., additional, Do, Nhan, additional, Shayan, Shahpoor (Alex), additional, Cho, Kelly, additional, Churby, Lori, additional, Pyarajan, Saiju, additional, DuVall, Scott L., additional, Hauser, Elizabeth, additional, Sun, Yan, additional, Zhao, Hongyu, additional, Wilson, Peter, additional, McArdle, Rachel, additional, Dellitalia, Louis, additional, Mattocks, Kristin, additional, Harley, John, additional, Whittle, Jeffrey, additional, Jacono, Frank, additional, Wells, John, additional, Gutierrez, Salvador, additional, Gibson, Gretchen, additional, Hammer, Kimberly, additional, Kaminsky, Laurence, additional, Villareal, Gerardo, additional, Kinlay, Scott, additional, Xu, Junzhe, additional, Hamner, Mark, additional, Mathew, Roy, additional, Bhushan, Sujata, additional, Iruvanti, Pran, additional, Godschalk, Michael, additional, Ballas, Zuhair, additional, Ivins, Douglas, additional, Mastorides, Stephen, additional, Moorman, Jonathan, additional, Gappy, Saib, additional, Klein, Jon, additional, Ratcliffe, Nora, additional, Florez, Hermes, additional, Okusaga, Olaoluwa, additional, Murdoch, Maureen, additional, Sriram, Peruvemba, additional, Yeh, Shing Shing, additional, Tandon, Neeraj, additional, Jhala, Darshana, additional, Aguayo, Samuel, additional, Cohen, David, additional, Sharma, Satish, additional, Liangpunsakul, Suthat, additional, Oursler, Kris Ann, additional, Whooley, Mary, additional, Ahuja, Sunil, additional, Constans, Joseph, additional, Meyer, Paul, additional, Greco, Jennifer, additional, Rauchman, Michael, additional, Servatius, Richard, additional, Gaddy, Melinda, additional, Wallbom, Agnes, additional, Morgan, Timothy, additional, Stapley, Todd, additional, Sherman, Scott, additional, Ross, George, additional, Tsao, Philip, additional, Strollo, Patrick, additional, Boyko, Edward, additional, Meyer, Laurence, additional, Gupta, Samir, additional, Huq, Mostaqul, additional, Fayad, Joseph, additional, Hung, Adriana, additional, Lichy, Jack, additional, Hurley, Robin, additional, Robey, Brooks, additional, and Striker, Robert, additional

Published
2022
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10. Glaucoma Genetic Risk Scores in the Million Veteran Program

Author

Waksmunski, Andrea R., primary, Kinzy, Tyler G., additional, Cruz, Lauren A., additional, Nealon, Cari L., additional, Halladay, Christopher W., additional, Simpson, Piana, additional, Canania, Rachael L., additional, Anthony, Scott A., additional, Roncone, David P., additional, Sawicki Rogers, Lea, additional, Leber, Jenna N., additional, Dougherty, Jacquelyn M., additional, Greenberg, Paul B., additional, Sullivan, Jack M., additional, Wu, Wen-Chih, additional, Iyengar, Sudha K., additional, Crawford, Dana C., additional, Peachey, Neal S., additional, Cooke Bailey, Jessica N., additional, Gaziano, J. Michael, additional, Ramoni, Rachel, additional, Breeling, Jim, additional, Chang, Kyong-Mi, additional, Huang, Grant, additional, Muralidhar, Sumitra, additional, O’Donnell, Christopher J., additional, Tsao, Philip S., additional, Moser, Jennifer, additional, Whitbourne, Stacey B., additional, Brewer, Jessica V., additional, Concato, John, additional, Warren, Stuart, additional, Argyres, Dean P., additional, Stephens, Brady, additional, Brophy, Mary T., additional, Humphries, Donald E., additional, Do, Nhan, additional, Shayan, Shahpoor, additional, Nguyen, Xuan-Mai T., additional, Pyarajan, Saiju, additional, Cho, Kelly, additional, Hauser, Elizabeth, additional, Sun, Yan, additional, Zhao, Hongyu, additional, Wilson, Peter, additional, McArdle, Rachel, additional, Dellitalia, Louis, additional, Harley, John, additional, Whittle, Jeffrey, additional, Beckham, Jean, additional, Wells, John, additional, Gutierrez, Salvador, additional, Gibson, Gretchen, additional, Kaminsky, Laurence, additional, Villareal, Gerardo, additional, Kinlay, Scott, additional, Xu, Junzhe, additional, Hamner, Mark, additional, Haddock, Kathlyn Sue, additional, Bhushan, Sujata, additional, Iruvanti, Pran, additional, Godschalk, Michael, additional, Ballas, Zuhair, additional, Buford, Malcolm, additional, Mastorides, Stephen, additional, Klein, Jon, additional, Ratcliffe, Nora, additional, Florez, Hermes, additional, Swann, Alan, additional, Murdoch, Maureen, additional, Sriram, Peruvemba, additional, Yeh, Shing Shing, additional, Washburn, Ronald, additional, Jhala, Darshana, additional, Aguayo, Samuel, additional, Cohen, David, additional, Sharma, Satish, additional, Callaghan, John, additional, Oursler, Kris Ann, additional, Whooley, Mary, additional, Ahuja, Sunil, additional, Gutierrez, Amparo, additional, Schifman, Ronald, additional, Greco, Jennifer, additional, Rauchman, Michael, additional, Servatius, Richard, additional, Oehlert, Mary, additional, Wallbom, Agnes, additional, Fernando, Ronald, additional, Morgan, Timothy, additional, Stapley, Todd, additional, Sherman, Scott, additional, Anderson, Gwenevere, additional, Tsao, Philip, additional, Sonel, Elif, additional, Boyko, Edward, additional, Meyer, Laurence, additional, Gupta, Samir, additional, Fayad, Joseph, additional, Hung, Adriana, additional, Lichy, Jack, additional, Hurley, Robin, additional, Robey, Brooks, additional, and Striker, Robert, additional

Published
2022
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21. Novel mutation in cutaneous oncocytoma identified by next‐generation sequencing.

Author

Smith, Shane D. B., Ma, Charles, Lichy, Jack, Chen, Wen, and Nava, Victor E.

Subjects
NUCLEOTIDE sequencing, LINCRNA
Abstract

NGS identified a somatic mutation of EGFR and long noncoding RNA EGFR antisense RNA 1 (lnc EGFR-AS1). We document a case report of cutaneous oncocytoma with a novel mutation of uncertain significance affecting EGFR and EGFR-AS1. CO is currently classified in Weedon's Skin Pathology as an adnexal tumor, although the cell of origin is unknown.[1] It is unclear whether this neoplasm occurs due to a specific mutation, copy number alteration, or another pathogenesis. [Extracted from the article]

Published
2023
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25. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program

Author

Klarin, Derek, primary, Verma, Shefali Setia, additional, Judy, Renae, additional, Dikilitas, Ozan, additional, Wolford, Brooke N., additional, Paranjpe, Ishan, additional, Levin, Michael G., additional, Pan, Cuiping, additional, Tcheandjieu, Catherine, additional, Spin, Joshua M., additional, Lynch, Julie, additional, Assimes, Themistocles L., additional, Åldstedt Nyrønning, Linn, additional, Mattsson, Erney, additional, Edwards, Todd L., additional, Denny, Josh, additional, Larson, Eric, additional, Lee, Ming Ta Michael, additional, Carrell, David, additional, Zhang, Yanfei, additional, Jarvik, Gail P., additional, Gharavi, Ali G., additional, Harley, John, additional, Mentch, Frank, additional, Pacheco, Jennifer A., additional, Hakonarson, Hakon, additional, Skogholt, Anne Heidi, additional, Thomas, Laurent, additional, Gabrielsen, Maiken Elvestad, additional, Hveem, Kristian, additional, Nielsen, Jonas Bille, additional, Zhou, Wei, additional, Fritsche, Lars, additional, Huang, Jie, additional, Natarajan, Pradeep, additional, Sun, Yan V., additional, DuVall, Scott L., additional, Rader, Daniel J., additional, Cho, Kelly, additional, Chang, Kyong-Mi, additional, Wilson, Peter W.F., additional, O’Donnell, Christopher J., additional, Kathiresan, Sekar, additional, Scali, Salvatore T., additional, Berceli, Scott A., additional, Willer, Cristen, additional, Jones, Gregory T., additional, Bown, Matthew J., additional, Nadkarni, Girish, additional, Kullo, Iftikhar J., additional, Ritchie, Marylyn, additional, Damrauer, Scott M., additional, Tsao, Philip S., additional, Gaziano, J. Michael, additional, Ramoni, Rachel, additional, Beckham, Jean, additional, Breeling, Jim, additional, Huang, Grant, additional, Muralidhar, Sumitra, additional, Casas Romero, J.P., additional, Moser, Jennifer, additional, Whitbourne, Stacey B., additional, Brewer, Jessica V., additional, Concato, John, additional, Warren, Stuart, additional, Argyres, Dean P., additional, Stephens, Brady, additional, Brophy, Mary T., additional, Humphries, Donald E., additional, Do, Nhan, additional, Shayan, Shahpoor, additional, Nguyen, Xuan-Mai T., additional, Pyarajan, Saiju, additional, Hauser, Elizabeth, additional, Sun, Yan, additional, Zhao, Hongyu, additional, Wilson, Peter, additional, McArdle, Rachel, additional, Dellitalia, Louis, additional, Zablocki, Clement J., additional, Whittle, Jeffrey, additional, Wells, John, additional, Gutierrez, Salvador, additional, Gibson, Gretchen, additional, Kaminsky, Laurence, additional, Villareal, Gerardo, additional, Kinlay, Scott, additional, Xu, Junzhe, additional, Hamner, Mark, additional, Haddock, Kathlyn Sue, additional, Bhushan, Sujata, additional, Iruvanti, Pran, additional, Godschalk, Michael, additional, Ballas, Zuhair, additional, Buford, Malcolm, additional, Mastorides, Stephen, additional, Klein, Jon, additional, Ratcliffe, Nora, additional, Florez, Hermes, additional, Swann, Alan, additional, Murdoch, Maureen, additional, Sriram, Peruvemba, additional, Yeh, Shing Shing, additional, Washburn, Ronald, additional, Jhala, Darshana, additional, Aguayo, Samuel, additional, Cohen, David, additional, Sharma, Satish, additional, Callaghan, John, additional, Oursler, Kris Ann, additional, Whooley, Mary, additional, Ahuja, Sunil, additional, Gutierrez, Amparo, additional, Schifman, Ronald, additional, Greco, Jennifer, additional, Rauchman, Michael, additional, Servatius, Richard, additional, Oehlert, Mary, additional, Wallbom, Agnes, additional, Fernando, Ronald, additional, Morgan, Timothy, additional, Stapley, Todd, additional, Sherman, Scott, additional, Anderson, Gwenevere, additional, Tsao, Philip, additional, Sonel, Elif, additional, Boyko, Edward, additional, Meyer, Laurence, additional, Gupta, Samir, additional, Fayad, Joseph, additional, Hung, Adriana, additional, Lichy, Jack, additional, Hurley, Robin, additional, Robey, Brooks, additional, and Striker, Robert, additional

Published
2020
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30. Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort

Author

Harrington, Kelly M., primary, Nguyen, Xuan-Mai T., additional, Song, Rebecca J., additional, Hannagan, Keri, additional, Quaden, Rachel, additional, Gagnon, David R., additional, Cho, Kelly, additional, Deen, Jennifer E., additional, Muralidhar, Sumitra, additional, O’Leary, Timothy J., additional, Gaziano, John Michael, additional, Whitbourne, Stacey B., additional, Gaziano, J. Michael, additional, Ramoni, Rachel, additional, Breeling, Jim, additional, Chang, Kyong-Mi, additional, Huang, Grant, additional, O’Donnell, Christopher J., additional, Tsao, Philip S., additional, Moser, Jennifer, additional, Brewer, Jessica V., additional, Concato, John, additional, Warren, Stuart, additional, D, Pharm, additional, Argyres, Dean P., additional, Stephens, Brady, additional, Brophy, Mary T., additional, Humphries, Donald E., additional, Do, Nhan, additional, Shayan, Shahpoor, additional, Pyarajan, Saiju, additional, Hauser, Elizabeth, additional, Sun, Yan, additional, Zhao, Hongyu, additional, Wilson, Peter, additional, McArdle, Rachel, additional, Dellitalia, Louis, additional, Harley, John, additional, Whittle, Jeffrey, additional, Beckham, Jean, additional, Wells, John, additional, Gutierrez, Salvador, additional, Gibson, Gretchen, additional, Kaminsky, Laurence, additional, Villareal, Gerardo, additional, Kinlay, Scott, additional, Xu, Junzhe, additional, Hamner, Mark, additional, Haddock, Kathlyn Sue, additional, Bhushan, Sujata, additional, Iruvanti, Pran, additional, Godschalk, Michael, additional, Ballas, Zuhair, additional, Buford, Malcolm, additional, Mastorides, Stephen, additional, Klein, Jon, additional, Ratcliffe, Nora, additional, Florez, Hermes, additional, Swann, Alan, additional, Murdoch, Maureen, additional, Sriram, Peruvemba, additional, Yeh, Shing Shing, additional, Washburn, Ronald, additional, Jhala, Darshana, additional, Aguayo, Samuel, additional, Cohen, David, additional, Sharma, Satish, additional, Callaghan, John, additional, Oursler, Kris Ann, additional, Whooley, Mary, additional, Ahuja, Sunil, additional, Gutierrez, Amparo, additional, Schifman, Ronald, additional, Greco, Jennifer, additional, Rauchman, Michael, additional, Servatius, Richard, additional, Oehlert, Mary, additional, Wallbom, Agnes, additional, Fernando, Ronald, additional, Morgan, Timothy, additional, Stapley, Todd, additional, Sherman, Scott, additional, Anderson, Gwenevere, additional, Tsao, Philip, additional, Sonel, Elif, additional, Boyko, Edward, additional, Meyer, Laurence, additional, Gupta, Samir, additional, Fayad, Joseph, additional, Hung, Adriana, additional, Lichy, Jack, additional, Hurley, Robin, additional, Robey, Brooks, additional, and Striker, Robert, additional

Published
2019
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38. Activation-induced cytidine deaminase expression in diffuse large B-cell lymphoma with a paracortical growth pattern: a lymphoma of possible interfollicular large B-cell origin

Author

Aguilera, Nadine S., Auerbach, Aaron, Barekman, Carol L., Lichy, Jack, and Abbondanzo, Susan L.

Subjects
Immunohistochemistry -- Usage, Immunoglobulins -- Health aspects -- Research, Lymphomas -- Diagnosis -- Research, Health
Abstract

Context.--Activation-induced cytidine deaminase, necessary for immunoglobulin somatic hypermutation and class switch recombination, is usually expressed within the follicular dendritic network but is also expressed in a population of interfollicular large B cells outside the germinal center. Objective.--To report 7 cases of diffuse large B-cell lymphoma with a distinct paracortical distribution. Expression of activation-induced cytidine deaminase, previously described in interfollicular large B cells, was evaluated. Design.--A panel of immunohistochemical markers, including double staining for activation-induced cytidine deaminase and CD20, was used to illustrate the cases. Molecular studies were performed by polymerase chain reaction in the paraffin-embedded tissue for t(14;18) chromosomal translocation and immunoglobulin heavy chain and T-cell receptor rearrangements. Results.--Patients included 3 males and 4 females ranging in age from 11 to 59 years (mean, 39 years). All specimens were lymph nodes (4 from the groin, 2 from the neck, and 1 from the axilla). Malignant lymphocytes were positive for CD20 and negative for CD5 and CD10. Staining for CD30, CD43, and BCL-2 was variable. The malignant cells showed at least focal staining with activation-induced cytidine deaminase. All cases were found to be monoclonal by immunoglobulin heavy-chain gene rearrangement or showed light-chain restriction. None of the tested cases showed t(14;18). Conclusions.--Diffuse large B-cell lymphoma with a paracortical distribution is unusual and may be a distinct morphologic variant. More study is necessary to determine the stage of B-cell development and the cell of origin of these tumors. However, activation-induced cytidine deaminase expression suggests they may arise from a putative interfollicular large B cell. (Arch Pathol Lab Med. 2010;134:449^56), Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of neoplasms, with the mean age of patients at diagnosis in the sixth or seventh decade of life. (1) Many recent [...]

Published
2010

47. Inducible siRNA Vectors for Probing Signaling Pathways in Breast Cancer Cells

Author

AMERICAN REGISTRY OF PATHOLOGY WASHINGTON DC, Lichy, Jack H., AMERICAN REGISTRY OF PATHOLOGY WASHINGTON DC, and Lichy, Jack H.

Abstract

The purpose of this project was to investigate the utility of inducible siRNA vectors for analyzing signal transduction pathways in breast cancer cell lines.

Published
2004

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