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Researchers from Nanjing Medical University conducted a study on Oral Lichen Planus (OLP) to explore the role of T cell glycolytic enzymes in mediating Th1/Th2 imbalance. The study involved 120 OLP patients and 120 control volunteers, finding higher expressions of specific enzymes and cytokines in OLP patients. The research concluded that T cell glycolytic enzymes and Th1/Th2 imbalance are associated with the basic pathological changes in OLP patients. [Extracted from the article]

Researchers at Shanxi Medical University School and Hospital of Stomatology have conducted a study on oral lichen planus, a chronic inflammatory disorder affecting the oral cavity. The research focused on the role of matrix metalloproteinase-12 (MMP12) in compromising the epithelial barrier integrity in oral lichen planus by degrading fibronectin. The study found that increased MMP12 levels in macrophages from diseased tissues lead to fibronectin degradation in keratinocytes, resulting in oral epithelial barrier disruption. The findings suggest that MMP12 plays a significant role in mediating oral epithelial barrier integrity in oral lichen planus. [Extracted from the article]

A recent study conducted at Pontifical Catholic University in Porto Alegre, Brazil, explored the association between oral lichen planus (OLP) and sleep quality. The research, which included four observational case-control studies with a total of 1125 participants, found that OLP patients had higher sleep disturbance scores compared to control groups. However, the evidence for this association is limited due to the small number of studies and their heterogeneity. This study was supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ). [Extracted from the article]

Researchers at the University of Pennsylvania recently conducted a study on Lichen Planus, a chronic inflammatory skin disease affecting 1%-2% of Americans. The study found that specific cytokines, including CXCL9, CXCL10, and CCL19, play a role in recruiting T lymphocytes to the skin in Lichen Planus. This research sheds light on the molecular pathogenesis of the disease and identifies CCL19 as a potential therapeutic target for treatment. The findings were published in JCI Insight and provide valuable insights into the understanding and potential treatment of Lichen Planus. [Extracted from the article]

A recent study conducted at Uva Wellassa University focused on the diagnostic potential of salivary biomarkers in detecting early-stage oral squamous cell carcinoma (OSCC). The research examined the salivary concentrations of specific biomarkers, such as OAZ1, SAT, S100P, IL-1b, and IL-8, to identify pre-cancerous and cancerous states within the oral cavity. The study, which included a cohort of patients with OSCC, oral submucous fibrosis (OSF), oral lichen planus (OLP), and healthy controls, demonstrated that when these five biomarkers are used together, they provide a high predictive probability for detecting OSCC. This novel clinical technique has the potential to be an efficient tool for early cancer detection and may have broader applications in health monitoring. [Extracted from the article]

Researchers at Habib Thameur Hospital in Tunis, Tunisia, conducted a study on lichen planus pigmentosus (LPP), an acquired pigmentary disorder that primarily affects dark-skinned populations. The study aimed to describe the dermoscopic features of LPP and their correlation with histopathological findings. The research found various dermoscopic patterns in LPP lesions, such as dots, globules, and blue-white veil, which could help in characterizing the dermatosis. The study concluded that certain dermoscopic features, like blotches and blue-white veil with rosettes, could be specific indicators of LPP, providing valuable insights into the disease progression. [Extracted from the article]

A recent report from the Dermatology Unit in Bologna, Italy, highlights the unique presentation of nail psoriasis and nail lichen planus in individuals with skin of color. The study focused on 30 patients with skin of color, describing the clinical manifestations of these conditions and emphasizing the importance of timely and effective care. The research underscores the need for dermatologists to be aware of the distinct characteristics of nail diseases in diverse populations to ensure accurate diagnosis and treatment. [Extracted from the article]

A recent study conducted at the Atal Bihari Vajpayee Institute of Medical Sciences focused on the efficacy and safety of low-dose methotrexate in treating generalized and recalcitrant lichen planus (LP) patients. The research found that methotrexate demonstrated high efficacy and a good safety profile in extensive cutaneous LP, potentially serving as a safer alternative to steroids for the condition. The study analyzed the clinical and therapeutic details of 42 LP patients treated with low-dose methotrexate, with most patients achieving complete resolution within a mean duration of 14.76 weeks and experiencing minor side effects. [Extracted from the article]

The article discusses a systematic review of treatment strategies for erosive genital lichen planus (EGLP), a severe form of lichen planus that causes painful erosions in the genital area. The review emphasizes the importance of patient-centered care and highlights various treatment options such as topical corticosteroids, systemic medications, and surgical interventions. While current therapies are available, some cases of EGLP are refractory to treatment, leading to chronic symptoms and reduced quality of life. The research suggests that a tailored, multidimensional approach is necessary for managing EGLP, with a focus on developing new therapies to improve outcomes and enhance patient care. [Extracted from the article]

Researchers at Bogomolets National Medical University have reported new data on oral lichen planus, a condition with potential risks of malignancy. The study aimed to identify a genetic predisposition to oral lichen planus by analyzing blood groups in patients. The research found correlations between specific blood groups and the development of erosive and hyperkeratotic forms of lichen planus, suggesting a potential link between genetic factors and the disease. [Extracted from the article]

Researchers at the Medical University of Plovdiv conducted a study on oral lichen planus (OLP), a mucocutaneous disease that causes lesions in the mouth. They found that photobiomodulation therapy with a diode laser significantly reduced pain levels and clinical scores of OLP lesions. The therapy also led to a decrease in pro-inflammatory cytokine levels and histological improvements in 60% of patients. This research highlights the effectiveness of photobiomodulation therapy in treating OLP at clinical, molecular, and histomorphological levels. [Extracted from the article]

A report from University College London (UCL) investigates the impact of oral lichen planus (OLP) on the prognosis of oral epithelial dysplasia (OED). The study found that patients with OLP had a twofold increased risk of developing new primary OED events compared to those without OLP. However, there was no significant difference in progression to malignancy or mortality between the two groups. Further research is needed to understand the effects of OLP on progression to oral squamous cell carcinoma (OSCC) and mortality. [Extracted from the article]

Researchers from Shanghai Jiao Tong University conducted a study on oral lichen planus (OLP) patients to analyze the bacterial communities in their oral mucosa and saliva. The study found differences in the composition, genera associated with OLP severity, and co-occurrence patterns of bacterial communities between OLP patients and healthy controls. The research, supported by the National Natural Science Foundation of China, concluded that the microbial diversity was similar between OLP patients and healthy controls, but the topological properties of the microbial networks differed. This peer-reviewed study provides valuable insights into the oral health of OLP patients. [Extracted from the article]

A recent study conducted by researchers at Queen Mary University of London focused on erosive lichen planus (ELP) and its impact on different ethnicities. The study found that ELP takes longer to diagnose, requires prolonged tertiary care, and is more resistant to treatment compared to milder forms of lichen planus. Patients with ELP have increased medical and oral health needs, are at greater risk of scarring, and may require systemic immunosuppression. The research highlights the importance of educating primary caregivers on ELP's presentation and understanding the mechanisms driving the disease for improved diagnostics and treatment. [Extracted from the article]

A recent study conducted at Islamic Azad University focused on the role of circRNAs in oral cancer, specifically investigating circ-0008798 and circ-0035967 as potential biomarkers in oral lichen planus and oral squamous cell carcinoma. The research found significant upregulation of the MAP2K1 gene in oral cancer tissues, while circ-0008798 and circ-0035967 were down-regulated. The study suggests that these circRNAs could serve as promising biomarkers for the development and progression of oral cancer. For more information, readers can refer to the article "CIRC-0008798 and CIRC-0035967 as novel biomarkers in oral lichen planus and oral squamous cell carcinoma" in Acta Scientiarum. Health Sciences. [Extracted from the article]

A recent study conducted at Sharad Pawar Dental College in Maharashtra, India, focuses on oral lichen planus (OLP), a chronic mucocutaneous immune-mediated disease classified as a Potentially Malignant Disorder (PMD). The research aims to evaluate and compare serum concentrations of Interleukin-1 beta (IL-1b) and Vitamin D in patients with OLP and healthy subjects. The study will be conducted from August 2024 to August 2026, with patients undergoing clinical examinations and providing written consent for sample collection and analysis. Statistical analysis will be performed to assess the significance of the findings. [Extracted from the article]

A recent study conducted at the Affiliated Stomatological Hospital of Nanjing Medical University in China explored the expression of neutrophil extracellular trap-related proteins in patients with oral lichen planus (OLP) and their correlation with interleukin-17 (IL-17) and tumor necrosis factor a (TNF-a). The research found that OLP patients had elevated levels of NET-related proteins in lesion tissues and peripheral blood, with higher rates of NET formation in erosive-stage OLP compared to non-erosive OLP and healthy controls. The study suggests that IL-17 and TNF-a may play a role in mediating the formation of NETs in OLP patients, potentially contributing to the development of the condition. [Extracted from the article]

A recent study from the University of Aberdeen focused on disease severity scoring systems in mucosal lichen planus, a skin condition. The researchers identified 11 clinical severity scoring systems for oral lichen planus that have undergone validity or reliability testing, with the most reported systems being the Thongprasom score, the Oral Disease Severity Score (ODSS), and the REU scoring systems. The study highlighted the need for the development and validation of scoring systems for extraoral mucosal lichen planus. The research was supported by the University of Aberdeen Elphinstone Scholarship Scheme and has been peer-reviewed. [Extracted from the article]

A study conducted at Shanghai Jiao Tong University examined the presence of innate lymphoid cells (ILCs) in oral mucosa of individuals with oral lichen planus (OLP) and oral lichenoid lesions (OLL). The research found increased infiltration of ILCs, specifically ILC1 and ILC3, in OLP and OLL mucosa, while the ratio of ILC2/ILCs was reduced. These changes in ILC distribution may contribute to persistent inflammation in local tissues. The study was supported by various research grants and has been peer-reviewed. [Extracted from the article]

Researchers from Sichuan University in the People's Republic of China have developed an improved scoring system, called the RHU scoring system, for monitoring Oral Lichen Planus (OLP) in patients. This new system considers reticulation, hyperemia, and ulceration to provide a more accurate assessment of OLP severity. The research, funded by various organizations, concluded that the RHU scoring system could be widely used to monitor OLP patients effectively. The study, which has been peer-reviewed, was published in Oral Diseases and can be accessed online for further information. [Extracted from the article]

A recent study conducted at the University of Turin in Italy focused on assessing gingival lesions in 1319 patients with Lichen Planus, a chronic immune disease. The study found that while most patients had multiple oral sites affected, gingival lesions were the sole location in some cases. Only a small percentage of patients experienced total clinical signs remission, and gum lesions appeared to precede oral lesions. Patients with less frequent dental check-ups were more likely to receive specific therapy for Lichen Planus. [Extracted from the article]

A recent study conducted at Southern Medical University focused on oral lichen planus, a condition affecting the mucosal lining of the mouth. The research examined the role of mucosal-associated invariant T (MAIT) cells in both recent-onset and long-term cases of oral lichen planus. Findings indicated that MAIT cells in patients with oral lichen planus displayed activation and exhaustion, with differences observed between recent-onset and long-term cases. This study sheds light on the immunological background of oral lichen planus and highlights potential differences in MAIT cell function based on disease duration. [Extracted from the article]

Researchers at Tehran University of Medical Sciences conducted a systematic review and meta-analysis on the identification of common salivary microRNAs in oral lichen planus (OLP) and oral squamous cell carcinoma. The study aimed to find non-invasive diagnostic biomarkers for OLP, which is associated with an increased risk of malignant transformation. Salivary microRNAs showed promising results with high sensitivity and specificity for OLP diagnosis, highlighting their potential as valuable biomarkers in differentiating OLP patients from healthy controls and assessing the risk of malignant transformation. The findings were published in BMC Oral Health and can be accessed for further information. [Extracted from the article]

A recent study conducted by researchers at Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, explores the topic of oral lichen planus (OLP), a complex condition with various clinical manifestations. The study focuses on familial cases of OLP, where the condition appears among members of the same family. The researchers found that genetic factors may play a role in the development of OLP, and they present the clinical characteristics and treatment response of eight cases from four different families. The study highlights the need for further research to better understand the specific manifestation patterns and treatment response of familial OLP cases, as well as the potential for malignant transformation. [Extracted from the article]

A recent study conducted by researchers at Sankalchand Patel University in Gujarat, India, explored the relationship between psychological stress and the severity of oral lichen planus (OLP), oral submucous fibrosis (OSMF), and leukoplakia. The study involved 280 patients aged 35-60, who were divided into four groups: leukoplakia, OSMF, OLP, and a control group. The researchers found that OLP patients had higher levels of serum cortisol, indicating higher levels of stress, anxiety, and depression compared to patients with OSMF and leukoplakia. The study highlights the role of stress and anxiety as predisposing factors in the occurrence and progression of OSMF and OLP. [Extracted from the article]

Researchers at the University of Wuerzburg have conducted a study on oral lichen planus, a chronic autoimmune disease that affects the oral mucosa and is considered a potentially malignant disorder. The study aimed to examine the presence of cancer stem cells (CSCs) bearing the marker CD147 in oral lichen planus compared to oral leukoplakia and healthy tissues. The researchers found that CD147 expression was significantly higher in the erosive lichen planus subgroup compared to the dysplastic leukoplakia subgroup, suggesting the presence of epithelial cells with CSC characteristics. However, CD147 expression was lower in oral leukoplakias, indicating a stronger association with inflammation rather than dysplastic progression. [Extracted from the article]

A recent report from Shanghai Jiao Tong University School of Medicine discusses the potential therapeutic efficacy of tinidazole mouth rinse for the treatment of oral lichen planus (OLP). The study involved a pilot study with 27 OLP patients who used thrice-daily tinidazole mouth rinse for one week. The results showed a significant decrease in visual analog scale (VAS) scores for both reticular and erosive OLP patients, as well as a decrease in the abundance of Fusobacterium nucleatum on the damaged mucosa surface. The researchers concluded that tinidazole mouth rinse could be a viable local therapeutic option for OLP, but further randomized controlled studies are needed to confirm these findings. [Extracted from the article]