Search

The present manuscript examines the way young Europeans represent Europe's history. A study conducted in 11 European countries (N = 1406 students in social sciences) shows that the characters considered most important in the history of Europe are mostly men linked either to WW2, authoritarianism, or conquests and empires. Although these appear later in the rankings and despite some imbalance between countries, Europe's history is also associated with religious figures, artists, scientists, and philosophers. These results show that the representations of the history of Europe currently shared by young Europeans correspond, in part, to historical narratives based on a specific set of experiences, events, and values supposedly common to the peoples of Europe that were promoted by European elites throughout the integration process. Further, these results suggest that beyond the negative narrative of war and the crimes of totalitarianism, the history of Europe is also embodied by positive characters transcending national boundaries and associated with a set of key elements of the EU identity: democracy, tolerance, solidarity, humanism, and the Enlightenment. Finally, we also highlight the near-total absence of characters unambiguously related to colonization and, especially, decolonization, and a strong overall under-representation of women.

Background: Luminal breast cancers with high proliferation (MKShi) and low ER-related signalling (ERSlo) have a poor prognosis. We investigated treatment responses and molecular features of MKShi/ERSlo tumours to inform potential therapies. Methods: Gene expression data from patients who received neoadjuvant chemotherapy (NAC) without (MDACC, N = 199) or with pembrolizumab (I-SPY2, N = 40), or endocrine therapy (NET) without (POETIC, N = 172) or with palbociclib (NeoPalAna, N = 32) were analyzed to assess treatment response by MKS/ERS-subgroups. TCGA was used to assess the mutational landscape and biomarkers associated with palbociclib-resistance (Cyclin-E, RBsig, IRPR) and immunotherapy-response (TMB, TILs, T-cell inflamed) by MKS/ERS-subgroups. Results: Compared to MKShi/ERShi tumours, MKShi/ERSlo tumours had higher pathological response rates to NAC (22% vs 8%, p = 0.06) but a higher recurrence risk (4-year metastasis-free survival 70% vs 94%, p = 0.01). MKShi/ERSlo tumours frequently harboured TP53 (34%) and PIK3CA (33%) mutations, and showed high expression of Cyclin-E, RBsig and IRPR, high TMB and elevated TIL and T-cell inflamed metagene expression. MKShi/ERSlo tumours retained high proliferation after NET with or without palbociclib but had higher pathological complete response rates when pembrolizumab was added to NAC (42% vs 21%, p = 0.07). Conclusions: MKShi/ERSlo tumours have dismal outcomes and are enriched in chemotherapy-sensitive but ET- and palbociclib-resistant tumours. Biomarker analysis and clinical data suggest a potential role for immunotherapy in this group.

In the article “A century of victimhood: Antecedents and current impacts of perceived suffering in World War I across Europe” (DOI: 100.1002/ejsp.2232) (Bouchat et al.,), published in the European Journal of Social Psychology, 47: 195:208, the affiliations for Silvia Mari, Nebojša Petrovic and Alice Krenn were provided incorrectly. The complete authors' affiliation list is shown below. Pierre Bouchat, Laurent Licata Research Center for Social and Cultural Psychology, Université Libre de Bruxelles, Brussels, Belgium Valérie Rosoux Université catholique de Louvain, Centre d'études des crises et conflits internationaux, Louvain-la-Neuve, Belgium Christian Allesch University of Salzburg, Fachbereich Psychologie, Salzburg, Austria Heinrich Ammerer University of Salzburg, Bundeszentrums für Gesellschaftliches Lernen, Salzburg, Austria Inna Bovina Moscow State University of Psychology and Education, Department of Clinical and Legal Psychology, Moscow, Russian Federation Susanne Bruckmüller University of Koblenz-Landau, Psychology Department, Landau, German Rosa Cabecinhas Universidade do Minho, Braga, Portugal Xenia Chryssochoou Panteion University of Social and Political Sciences, Psychology Department, Athens, Greece J. Christopher Cohrs Jacobs University Bremen, Germany István Csertő Hungarian Academy of Sciences, Budapest, Hungary Sylvain Delouvée Université Rennes 2, Psychology Department, Rennes, France Federica Durante University of Milano-Bicocca, Department of Psychology, Milano, Italy Andreea Ernst-Vintila Université Paris-Ouest Nanterre, Laboratoire Parisien de Psychologie Sociale, Paris, France Christine Flassbeck Helmut-Schmidt-Universitat, Universitat der Bundeswehr, Department of Psychology, Hamburg, Germany Denis Hilton Université de Toulouse II, Toulouse, France Chantal Kesteloot Centre for Historical Research and Documentation on War and Contemporary Society, Brussels, Belgium Resit Kislioglu Jacobs University, Bremen, Germany Alice Krenn University of Sa

In the article “A century of victimhood: Antecedents and current impacts of perceived suffering in World War I across Europe” (DOI: 100.1002/ejsp.2232) (Bouchat et al.,), published in the European Journal of Social Psychology, 47: 195:208, the affiliations for Silvia Mari, Nebojša Petrovic and Alice Krenn were provided incorrectly. The complete authors' affiliation list is shown below. Pierre Bouchat, Laurent Licata Research Center for Social and Cultural Psychology, Université Libre de Bruxelles, Brussels, Belgium Valérie Rosoux Université catholique de Louvain, Centre d'études des crises et conflits internationaux, Louvain-la-Neuve, Belgium Christian Allesch University of Salzburg, Fachbereich Psychologie, Salzburg, Austria Heinrich Ammerer University of Salzburg, Bundeszentrums für Gesellschaftliches Lernen, Salzburg, Austria Inna Bovina Moscow State University of Psychology and Education, Department of Clinical and Legal Psychology, Moscow, Russian Federation Susanne Bruckmüller University of Koblenz-Landau, Psychology Department, Landau, German Rosa Cabecinhas Universidade do Minho, Braga, Portugal Xenia Chryssochoou Panteion University of Social and Political Sciences, Psychology Department, Athens, Greece J. Christopher Cohrs Jacobs University Bremen, Germany István Csertő Hungarian Academy of Sciences, Budapest, Hungary Sylvain Delouvée Université Rennes 2, Psychology Department, Rennes, France Federica Durante University of Milano-Bicocca, Department of Psychology, Milano, Italy Andreea Ernst-Vintila Université Paris-Ouest Nanterre, Laboratoire Parisien de Psychologie Sociale, Paris, France Christine Flassbeck Helmut-Schmidt-Universitat, Universitat der Bundeswehr, Department of Psychology, Hamburg, Germany Denis Hilton Université de Toulouse II, Toulouse, France Chantal Kesteloot Centre for Historical Research and Documentation on War and Contemporary Society, Brussels, Belgium Resit Kislioglu Jacobs University, Bremen, Germany Alice Krenn Uni

Background The BOLERO-2 trial reported efficacy and safety of Everolimus (EVE) and Exemestane (EXE) combination in HR+ advanced breast cancer (ABC) patients. The BALLET trial further evaluated the safety of EVE-EXE in HR+ ABC patients, without reporting efficacy data. Aim of the EVA real-life study was to collect data of efficacy and safety of EVE-EXE combination in the clinical setting, as well as exploring efficacy according to EVE Dose-Intensity (DI) and to previous treatment with Fulvestrant. Patients and methods This study aimed to describe the outcome of ABC pts treated with EVE-EXE combination in terms of median duration of EVE treatment and ORR in a real-life setting. Results From July 2013 to December 2015, the EVA study enrolled 404 pts. Median age was 61 years (33–83). Main metastatic sites were: bone (69.1%), soft tissue (34.7%) and viscera (33.2%). Median number of previous treatments was 2 (1–7). 43.3% of the pts had received Fulvestrant. Median exposure to EVE was 31.0 weeks (15.4–58.3) in the whole population. No difference was observed in terms of EVE exposure duration according to DI (p for trend = 0.27) or type of previous treatments (p = 0.33). ORR and Disease Control Rate (DCR) were observed in 31.6% and 60.7% of the patients, respectively, with the lowest ORRs confined in CHT pre-treated patients or in those who received the lowest DI of EVE. Grade 3-4 adverse events (AEs) were reported in 37.9% of the patients. Main AEs were: stomatitis (11.2%), non-infectious pneumonitis - NIP (3.8%), anaemia (3.8%) and fatigue (3.2%). Conclusions The EVA study provided new insights in the use of EVE-EVE combination in HR+ ABC pts many years after the publication of the pivotal trial. The combination is safe and the best response could be obtained in patients receiving the full dose of EVE and/or after hormone-therapy as Fulvestrant in ABC.

The present study examines current social representations associated with the origins of the Great War, a major event that has profoundly affected Europe. A survey conducted in 20 European countries (N = 1906 students in social sciences) shows a high consensus: The outbreak of the war is attributed to the warring nations’ leaders while the responsibility of the populations is minimized. Building on the concept of social representation of history (Liu & Hilton, 2005), we suggest that the social representations of the Great War fulfill social psychological functions in contemporary Europe. We suggest that WWI may function as a charter for European integration. Their content also suggests a desire to distinguish a positively valued ingroup ("the people") from powerful elites, construed as an outgroup.

In this article we use a social representational perspective on a large sample of European students to consider the interplay between pacifist attitudes and representations of World War I (WWI). WWI gave rise to pacifist movements across the globe. Across 10 European countries (N = 1,347 undergraduate students), we invited participants to report the first 5 words that came to their mind when thinking about this event and measured their level of pacifism. Analyses of the reported words revealed the presence of seven lexical classes corresponding to 2 main perspectives on WWI. The first main perspective was characterized by "analytical" representations of the war, with a focus on the places and actors of WWI. The second perspective highlighted negative emotions and appraisals associated with war. Overall, we found that the pacifist attitudes we analyzed were associated with a view of the conflict in terms of negatively valanced words, both at the emotional level and in terms of concrete consequences. Conversely lower pacifist attitudes were linked with an emphasis upon weapons. The present results help fill a gap in the literature on attitudes toward peace and war by evidencing their interplay with the way individuals view war. These findings allow us to establish a connection between mainstream, individualcentered approach to attitudes relying on individual premises and social representation theory. Moreover, in line with historical scholarship, these results suggest that a common interpretational framework underlies a view of the conflict associated with the pacifist wave that emerged 100 years ago and current pacifist attitudes. Finally, the present study is the first large scale psychology study of the social representations of the Great War.

European colonial powers invaded and then dominated a large part of the African continent from the sixteenth to the twentieth century. The influence of colonialism did not cease after independence as it still impregnates the cultures and identities of both formerly colonising and formerly colonised peoples. The question of how inhabitants of formerly colonised and formerly colonising countries represent the colonial past is a key issue in understanding this lasting influence. Social representations of European colonial action were investigated among young people (N = 1134) in three European countries and six African countries. Social representations of the colonial past were structured around two main dimensions across African and European samples: Exploitation and Development. Social representations of colonialism denoted by Exploitation were more strongly endorsed by the European compared to the African subsample, whereas those denoted by Development were more strongly endorsed by the African compared to the European subsample. However, while African participants considered colonialism less negatively than Europeans, they also had higher expectations concerning Europeans' collective guilt feeling and willingness to offer reparations. By contrast, European participants' social representations of colonialism were more negative but they were less likely to believe that present-day European peoples and governments are accountable for the misdeeds of colonialism in the past. Finally, national identification mediated the association between the Exploitation dimension of colonialism and both group-based emotions and support for reparation in the African, but not the European, subsample.

[Background]: Systems biologists study interaction data to understand the behaviour of whole cell systems, and their environment, at a molecular level. In order to effectively achieve this goal, it is critical that researchers have high quality interaction datasets available to them, in a standard data format, and also a suite of tools with which to analyse such data and form experimentally testable hypotheses from them. The PSI-MI XML standard interchange format was initially published in 2004, and expanded in 2007 to enable the download and interchange of molecular interaction data. PSI-XML2.5 was designed to describe experimental data and to date has fulfilled this basic requirement. However, new use cases have arisen that the format cannot properly accommodate. These include data abstracted from more than one publication such as allosteric/cooperative interactions and protein complexes, dynamic interactions and the need to link kinetic and affinity data to specific mutational changes. [Results]: The Molecular Interaction workgroup of the HUPO-PSI has extended the existing, well-used XML interchange format for molecular interaction data to meet new use cases and enable the capture of new data types, following extensive community consultation. PSI-MI XML3.0 expands the capabilities of the format beyond simple experimental data, with a concomitant update of the tool suite which serves this format. The format has been implemented by key data producers such as the International Molecular Exchange (IMEx) Consortium of protein interaction databases and the Complex Portal. [Conclusions]: PSI-MI XML3.0 has been developed by the data producers, data users, tool developers and database providers who constitute the PSI-MI workgroup. This group now actively supports PSI-MI XML2.5 as the main interchange format for experimental data, PSI-MI XML3.0 which additionally handles more complex data types, and the simpler, tab-delimited MITAB2.5, 2.6 and 2.7 for rapid parsing and dow

Colonialism, that Loomba calls “the most complex and traumatic relationship in human history” (2005, 8), has left its mark on international relations, social relationships within nations, and the ideologies and imaginaries of virtually all the peoples of the world. Understanding colonialism and its con¬sequences is therefore essential to comprehending the dynamics and conflicts of the contemporary world. This special focus was born out of a desire to bring social psychological studies on colonialism to broader attention.

This special thematic section aims to bring together current research on the connections between collective memories – or representations of history – and present-day intergroup relations. Drawing from a multitude of geographical and historical contexts as well as different methodologies, we bring forth ten articles focusing on distinct aspects of the relations between representations of the past and present day intergroup dynamics. The topics covered in these articles focus on one or more of the four research lines identified within this field: 1) the antecedents of collective memories; 2) the contents and structure of collective memories; 3) the official or institutional transmission of collective memories; and 4) distinct socio-psychological correlates of collective memories in present-day societies. Together, the contributions in this special thematic section showcase current directions of research within the field and highlight the need to consider the role of representations of the past for understanding present day instances of intergroup conflict or harmony. We discuss the need for more interdisciplinary work in this field, as well as more applied research in the future.

The present study addresses antecedents and consequences of collective victimhood in the context of World War I (WWI) across 15 European nations (N = 2423 social science students). Using multilevel analysis, we find evidence that collective victimhood is still present a hundred years after the onset of the war and can be predicted by WWI-related objective indicators of victimization at national and family levels. This suggests that collective victimhood is partly grounded in the actual experience of WWI. In addition, we show that sense of collective victimhood positively predicts acknowledgment of the suffering inflicted by one's nation on other countries during WWI. This is consistent with a social representation of WWI as involving a vast massacre in which nations were both victim and perpetrator. Finally, we find that objective indicators of victimization predict pacifism in divergent ways, with an indicator at the national level associated with more pacifist attitudes and an indicator at the family level being associated with less pacifist attitudes. This finding suggests that war-torn societies may have developed social representations favouring peaceful coexistence whereas, at the family level, victimization may still foster retaliatory tendencies.

Contains fulltext : 171819.pdf (publisher's version ) (Open Access), Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment. In support of these discoveries, a plethora of databases and tools are deployed, in technically complex and diverse implementations, across a spectrum of scientific disciplines. The corpus of documentation of these resources is fragmented across the Web, with much redundancy, and has lacked a common standard of information. The outcome is that scientists must often struggle to find, understand, compare and use the best resources for the task at hand.Here we present a community-driven curation effort, supported by ELIXIR-the European infrastructure for biological information-that aspires to a comprehensive and consistent registry of information about bioinformatics resources. The sustainable upkeep of this Tools and Data Services Registry is assured by a curation effort driven by and tailored to local needs, and shared amongst a network of engaged partners.As of November 2015, the registry includes 1785 resources, with depositions from 126 individual registrations including 52 institutional providers and 74 individuals. With community support, the registry can become a standard for dissemination of information about bioinformatics resources: we welcome everyone to join us in this common endeavour. The registry is freely available at https://bio.tools.

Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment. In support of these discoveries, a plethora of databases and tools are deployed, in technically complex and diverse implementations, across a spectrum of scientific disciplines. The corpus of documentation of these resources is fragmented across the Web, with much redundancy, and has lacked a common standard of information. The outcome is that scientists must often struggle to find, understand, compare and use the best resources for the task at hand. Here we present a community-driven curation effort, supported by ELIXIR-the European infrastructure for biological information-that aspires to a comprehensive and consistent registry of information about bioinformatics resources. The sustainable upkeep of this Tools and Data Services Registry is assured by a curation effort driven by and tailored to local needs, and shared amongst a network of engaged partners. As of November 2015, the registry includes 1785 resources, with depositions from 126 individual registrations including 52 institutional providers and 74 individuals. With community support, the registry can become a standard for dissemination of information about bioinformatics resources: we welcome everyone to join us in this common endeavour. The registry is freely available at https://bio.tools.