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3. Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

Author

Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Jr, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, and Bont, Louis

Published
2023
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4. Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden

Author

Søgaard, Kirstine K., van Kassel, Merel N., Snoek, Linde, de Gier, Brechje, van der Ende, Arie, Hahné, Susan J M, Harden, Lois M., Ghoor, Azra, Mbatha, Sibongile, Lowick, Sarah, Laughton, Barbara, Jaye, Tamara, Lala, Sanjay G, Sithole, Pamela, Msayi, Jacqueline, Kumalo, Ntombifuthi, Msibi, Tshepiso Nompumelelo, Arumugam, Asha, Murugesan, Nandhini, Rajendraprasad, Nandhini, Priya, Mohana, Mabrouk, Adam, Katana, Patrick Vidzo, Mwangome, Eva, Newton, Charles R., Mucasse, Humberto, Aerts, Celine, Massora, Sergio, Medina, Valeria, Rojas, Andrea, Amado, Daniel, Llapur, Conrado J., Hossain, A. K. M. Tanvir, Rahman, Qazi Sadeq-ur, Ip, Margaret, Seale, Anna, Heath, Paul T., Le Doare, Kirsty, Khalil, Asma, Schrag, Stephanie J., Sobanjo-ter Meulen, Ajoke, Mason, Elizabeth, Blau, Dianna M, El Arifeen, Shams, Assefa, Nega, Onyango, Dickens, Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu, Kotloff, Karen L., Scott, J. Anthony G., Gurley, Emily S., Barr, Beth A. Tippet, Mahtab, Sana, Gonçalves, Bronner P, Procter, Simon R, Paul, Proma, Chandna, Jaya, Lewin, Alexandra, Seedat, Farah, Koukounari, Artemis, Dangor, Ziyaad, Leahy, Shannon, Santhanam, Sridhar, John, Hima B, Bramugy, Justina, Bardají, Azucena, Abubakar, Amina, Nasambu, Carophine, Libster, Romina, Sánchez Yanotti, Clara, Horváth-Puhó, Erzsébet, Sørensen, Henrik T, van de Beek, Diederik, Bijlsma, Merijn W, Gardner, William M, Kassebaum, Nicholas, Trotter, Caroline, Bassat, Quique, Madhi, Shabir A, Lambach, Philipp, Jit, Mark, and Lawn, Joy E

Published
2022
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5. Neurodevelopmental and growth outcomes after invasive Group B Streptococcus in early infancy: A multi-country matched cohort study in South Africa, Mozambique, India, Kenya, and Argentina

Author

Madhi, Shabir A., Dangor, Ziyaad, Leahy, Shannon, Harden, Lois, Ghoor, Azra, Mbatha, Sibongile, Lowick, Sarah, Laughton, Barbara, Jaye, Tamara, Lala, Sanjay G, Sithole, Pamela, Msayi, Jacqueline, Kumalo, Ntombifuthi, Msibi, Tshepiso Nompumelelo, Santhanam, Sridhar, John, Hima B., Arumugam, Asha, Murugesan, Nandhini, Rajendraprasad, Nandhini, Priya, Mohana, Abubakar, Amina, Nasambu, Carophine, Adan, Adam Mabrouk, Katana, Patrick Vidzo, Mwangome, Eva, Newton, Charles R., Bassat, Quique, Bardají, Azucena, Bramugy, Justina, Mucasse, Humberto, Aerts, Celine, Massora, Sergio, Libster, Romina, Yanotti, Clara Sánchez, Medina, Valeria, Rojas, Andrea, Amado, Daniel, Llapur, Conrado J., Hossain, A.K.M. Tanvir, Sadeq-ur Rahman, Qazi, Paul, Proma, Chandna, Jaya, Procter, Simon R., Seedat, Farah, Horváth-Puhó, Erzsébet, Jit, Mark, Milner, Kate, Gonçalves, Bronner P., and Lawn, Joy E.

Published
2022
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6. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

Author

Libster, Romina, Otieno, Grieven, Joundi, Imane, Broor, Shobha, Nicol, Mark, Amarchand, Ritvik, Shi, Ting, López-Labrador, F. Xavier, Baker, Julia M., Jamison, Alexandra, Choudekar, Avinash, Juvekar, Sanjay, Obermeier, Patrick, Schweiger, Brunhilde, Madrid, Lola, Thomas, Elizabeth, Lanaspa, Miguel, Nohynek, Hanna, Nokes, James, Werner, Marta, Danhg, Anh, Chadha, Mandeep, Puig-Barberà, Joan, Caballero, Mauricio T., Mathisen, Maria, Walaza, Sibongile, Hellferscee, Orienka, Laubscher, Matt, Higdon, Melissa M., Haddix, Meredith, Sawatwong, Pongpun, Baggett, Henry C., Seidenberg, Phil, Mwanayanda, Lawrence, Antonio, Martin, Ebruke, Bernard E., Adams, Tanja, Rahman, Mustafizur, Rahman, Mohammed Ziaur, Sow, Samboa O., Baillie, Vicky L., Workman, Lesley, Toizumi, Michiko, Tapia, Milagritos D., Nguyen, Thi hien anh, Morpeth, Susan, Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Ali, Asad, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Chittaganpitch, Malinee, Echavarria, Marcela, Fasce, Rodrigo A, Goswami, Doli, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mira-Iglesias, Ainara, Moore, David P, Moraleda, Cinta, Nunes, Marta, Oshitani, Histoshi, Owor, Betty E, Polack, Fernando P, O'Brien, Katherine L, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Scott, J Anthony G, Simões, Eric A F, Strand, Tor A, Thea, Donald M, Treurnicht, Florette K, Vaccari, Linda C, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
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7. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Author

Nair, Harish, Campbell, Harry, Wang, Xin, Li, You, Chung, Alexandria, Rahi, Manveer, Abbas, Qalab, Ali, Asad, Bhutta, Zulfiqar A, Saeed, Bushra, Soofi, Sajid B, Yousafzai, Mohammad Tahir, Zaidi, Anita K, Amu, Alberta, Awini, Elizabeth, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Chaves, Sandra S, Shang, Nong, Schrag, Stephanie J, Widdowson, Marc-Alain, Tempia, Stefano, Bassat, Quique, Lanaspa, Miguel, Acácio, Sozinho, Brooks, W Abdullah, Driscoll, Amanda, Knoll, Maria Deloria, O'Brien, Katherine L, Prosperi, Christine, Baqui, Abdullah H, Mullany, Luke, Byass, Peter, Cohen, Cheryl, von Gottberg, Anne, Hellferscee, Orienka, Treurnicht, Florette K, Walaza, Sibongile, Goswami, Doli, Rahman, Mustafizur, Connor, Nicholas E, El Arifeen, Shams, Echavarria, Marcela, Marcone, Débora N, Reyes, Noelia, Gutierrez, Andrea, Rodriguez, Ivan, Lopez, Olga, Ortiz, David, Gonzalez, Nathaly, Gentile, Angela, del Valle Juarez, Maria, Gordon, Aubree, Cutland, Clare, Groome, Michelle, Madhi, Shabir A, Nunes, Marta C, Nzenze, Susan, Heikkinen, Terho, Hirve, Siddhivinayak, Juvekar, Sanjay, Halasa, Natasha, Jara, Jorge H, Bernart, Chris, Katz, Mark A, Gofer, Ilan, Avni, Yonat Shemer, Khuri-Bulos, Najwa, Faori, Samir, Shehabi, Asem, Krishnan, Anand, Kumar, Rakesh, Amarchand, Ritvik, Contreras, Carmen L, de Leon, Oscar, Lopez, Maria R, McCracken, John P, Maldonado, Herberth, Samayoa, Antonio P, Gomez, Ana B, Lucero, Marilla G, Nillos, Leilani T, Lupisan, Socorro P, Nohynek, Hanna, Mira-Iglesias, Ainara, Puig-Barberà, Joan, Díez-Domingo, Javier, Gessner, Bradford D, Njanpop-Lafourcade, Berthe-Marie, Moïsi, Jennifer C, Tall, Haoua, Munywoki, Patrick K, Ngama, Mwanjuma, Nokes, D James, Omer, Saad B, Clark, Dayna R, Ourohiré, Millogo, Ali, Sié, Pascal, Zabré, Cheik, Bagagnan H, Caballero, Mauricio T, Libster, Romina, Polack, Fernando P, Rasmussen, Zeba A, Thomas, Elizabeth D, Baker, Julia M, Rath, Barbara A, Obermeier, Patrick E, Hassanuzzaman, MD., Islam, Maksuda, Islam, Mohammad S, Saha, Samir K, Panigrahi, Pinaki, Bose, Anuradha, Isaac, Rita, Murdoch, David, Nanda, Pritish, Qazi, Shamim A, Hessong, Danielle, Simőes, Eric AF, Sotomayor, Viviana, Thamthitiwat, Somsak, Chittaganpitch, Malinee, Dawood, Halima, Kyobutungi, Catherine, Wamukoya, Marylene, Ziraba, Abdhalah K, Yoshida, Lay-Myint, Yoshihara, Keisuke, Dand, Duc-Anh, Le, Minh-Nhat, Nicol, Mark P, Zar, Heather J, Broor, Shobha, Chadha, Mandeep, Madrid, Lola, Gresh, Lionel, Balmaseda, Angel, Kuan, Guillermina, Wairagkar, Niteen, Tapia, Milagritos D, Knobler, Stacey L, Barahona, Alfredo, Ferguson, Ericka, Schweiger, Brunhilde, Abdullah Brooks, W, Fasce, Rodrigo A, and Simões, Eric AF

Published
2020
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8. Assessing the Long-Term Economic Impact of Wheezing Episodes After Severe RSV Disease in Children from Argentina: A Cost of Illness Analysis

Author

Dvorkin, Julia, primary, Pecenka, Clint, additional, Sosa, Emiliano, additional, Sancilio, Andrea, additional, Duenas, Karina, additional, Rodriguez, Andrea, additional, Rojas Roque, Carlos, additional, Carruteiro, Patricia B., additional, Baral, Ranju, additional, Vodicka, Elisabeth, additional, Polack, Fernando Pedro, additional, Libster, Romina, additional, and Caballero, Mauricio T., additional

Published
2024
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9. Cost of illness due to Respiratory Syncytial Virus Acute Lower Respiratory Tract Infection Among Infants Hospitalized in Argentina

Author

Dvorkin, Julia, primary, Sosa, Emiliano, additional, Vodicka, Elizabeth, additional, Baral, Ranju, additional, Sancilio, Andrea, additional, Dueñas, Karina, additional, Rodriguez, Andrea, additional, Rojas-Roque, Carlos, additional, Carruitero, Patricia B., additional, Polack, Fernando P., additional, Pecenka, Clint, additional, Libster, Romina, additional, and Caballero, Mauricio T., additional

Published
2023
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10. COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization

Author

Levine, Adam C, Fukuta, Yuriko, Huaman, Moises A, Ou, Jiangda, Meisenberg, Barry R, Patel, Bela, Paxton, James H, Hanley, Daniel F, Rijnders, Bart Ja, Gharbharan, Arvind, Rokx, Casper, Zwaginga, Jaap Jan, Alemany, Andrea, Mitjà, Oriol, Ouchi, Dan, Millat-Martinez, Pere, Durkalski-Mauldin, Valerie, Korley, Frederick K, Dumont, Larry J, Callaway, Clifton W, Libster, Romina, Marc, Gonzalo Perez, Wappner, Diego, Esteban, Ignacio, Polack, Fernando, Sullivan, David J, Internal Medicine, Surgery, and Medical Microbiology & Infectious Diseases

Subjects
Microbiology (medical), Infectious Diseases
Abstract

Background Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results. Methods We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching Medline, Embase, medRxiv, World Health Organization COVID-19 Research Database, Cochrane Library, and Web of Science from January 2020 to September 2022. Results Five included studies from 4 countries enrolled and transfused 2620 adult patients. Comorbidities were present in 1795 (69%). The virus neutralizing antibody dilutional titer levels ranged from 8 to 14 580 in diverse assays. One hundred sixty of 1315 (12.2%) control patients were hospitalized, versus 111 of 1305 (8.5%) CCP-treated patients, yielding a 3.7% (95% confidence interval [CI], 1.3%–6.0%; P = .001) absolute risk reduction and 30.1% relative risk reduction for all-cause hospitalization. The hospitalization reduction was greatest in those with both early transfusion and high titer with a 7.6% absolute risk reduction (95% CI, 4.0%–11.1%; P = .0001) accompanied by at 51.4% relative risk reduction. No significant reduction in hospitalization was seen with treatment >5 days after symptom onset or in those receiving CCP with antibody titers below the median titer. Conclusions Among outpatients with COVID-19, treatment with CCP reduced the rate of all-cause hospitalization and may be most effective when given within 5 days of symptom onset and when antibody titer is higher.

Published
2023
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11. Respiratory Syncytial Virus Vaccination During Pregnancy and Effects in Infants

Author

Madhi, Shabir A., Polack, Fernando P., Piedra, Pedro A., Munoz, Flor M., Trenholme, Adrian A., Simões, Eric A. F., Swamy, Geeta K., Agrawal, Sapeckshita, Ahmed, Khatija, August, Allison, Baqui, Abdullah H., Calvert, Anna, Chen, Janice, Cho, Iksung, Cotton, Mark F., Cutland, Clare L., Englund, Janet A., Fix, Amy, Gonik, Bernard, Hammitt, Laura, Heath, Paul T., de Jesus, Joanne N., Jones, Christine E., Khalil, Asma, Kimberlin, David W., Libster, Romina, Llapur, Conrado J., Lucero, Marilla, Pérez Marc, Gonzalo, Marshall, Helen S., Masenya, Masebole S., Martinón-Torres, Federico, Meece, Jennifer K., Nolan, Terry M., Osman, Ayman, Perrett, Kirsten P., Plested, Joyce S., Richmond, Peter C., Snape, Matthew D., Shakib, Julie H., Shinde, Vivek, Stoney, Tanya, Thomas, D. Nigel, Tita, Alan T., Varner, Michael W., Vatish, Manu, Vrbicky, Keith, Wen, Judy, Zaman, Khalequ, Zar, Heather J., Glenn, Gregory M., and Fries, Louis F.

Published
2021
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12. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Author

Shi, Ting, McAllister, David A, O'Brien, Katherine L, Simoes, Eric A F, Madhi, Shabir A, Gessner, Bradford D, Polack, Fernando P, Balsells, Evelyn, Acacio, Sozinho, Aguayo, Claudia, Alassani, Issifou, Ali, Asad, Antonio, Martin, Awasthi, Shally, Awori, Juliet O, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Baillie, Vicky L, Balmaseda, Angel, Barahona, Alfredo, Basnet, Sudha, Bassat, Quique, Basualdo, Wilma, Bigogo, Godfrey, Bont, Louis, Breiman, Robert F, Brooks, W Abdullah, Broor, Shobha, Bruce, Nigel, Bruden, Dana, Buchy, Philippe, Campbell, Stuart, Carosone-Link, Phyllis, Chadha, Mandeep, Chipeta, James, Chou, Monidarin, Clara, Wilfrido, Cohen, Cheryl, de Cuellar, Elizabeth, Dang, Duc-Anh, Dash-yandag, Budragchaagiin, Deloria-Knoll, Maria, Dherani, Mukesh, Eap, Tekchheng, Ebruke, Bernard E, Echavarria, Marcela, de Freitas Lázaro Emediato, Carla Cecília, Fasce, Rodrigo A, Feikin, Daniel R, Feng, Luzhao, Gentile, Angela, Gordon, Aubree, Goswami, Doli, Goyet, Sophie, Groome, Michelle, Halasa, Natasha, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Jara, Jorge, Jroundi, Imane, Kartasasmita, Cissy B, Khuri-Bulos, Najwa, Kotloff, Karen L, Krishnan, Anand, Libster, Romina, Lopez, Olga, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Marcone, Debora N, McCracken, John P, Mejia, Mario, Moisi, Jennifer C, Montgomery, Joel M, Moore, David P, Moraleda, Cinta, Moyes, Jocelyn, Munywoki, Patrick, Mutyara, Kuswandewi, Nicol, Mark P, Nokes, D James, Nymadawa, Pagbajabyn, da Costa Oliveira, Maria Tereza, Oshitani, Histoshi, Pandey, Nitin, Paranhos-Baccalà, Gláucia, Phillips, Lia N, Picot, Valentina Sanchez, Rahman, Mustafizur, Rakoto-Andrianarivelo, Mala, Rasmussen, Zeba A, Rath, Barbara A, Robinson, Annick, Romero, Candice, Russomando, Graciela, Salimi, Vahid, Sawatwong, Pongpun, Scheltema, Nienke, Schweiger, Brunhilde, Scott, J Anthony G, Seidenberg, Phil, Shen, Kunling, Singleton, Rosalyn, Sotomayor, Viviana, Strand, Tor A, Sutanto, Agustinus, Sylla, Mariam, Tapia, Milagritos D, Thamthitiwat, Somsak, Thomas, Elizabeth D, Tokarz, Rafal, Turner, Claudia, Venter, Marietjie, Waicharoen, Sunthareeya, Wang, Jianwei, Watthanaworawit, Wanitda, Yoshida, Lay-Myint, Yu, Hongjie, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2017
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13. Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization:A Meta-analysis of Individual Participant Data From 5 Randomized Trials

Author

Levine, Adam C, Fukuta, Yuriko, Huaman, Moises A, Ou, Jiangda, Meisenberg, Barry R, Patel, Bela, Paxton, James H, Hanley, Daniel F, Rijnders, Bart Ja, Gharbharan, Arvind, Rokx, Casper, Zwaginga, Jaap Jan, Alemany, Andrea, Mitjà, Oriol, Ouchi, Dan, Millat-Martinez, Pere, Durkalski-Mauldin, Valerie, Korley, Frederick K, Dumont, Larry J, Callaway, Clifton W, Libster, Romina, Marc, Gonzalo Perez, Wappner, Diego, Esteban, Ignacio, Polack, Fernando, Sullivan, David J, Levine, Adam C, Fukuta, Yuriko, Huaman, Moises A, Ou, Jiangda, Meisenberg, Barry R, Patel, Bela, Paxton, James H, Hanley, Daniel F, Rijnders, Bart Ja, Gharbharan, Arvind, Rokx, Casper, Zwaginga, Jaap Jan, Alemany, Andrea, Mitjà, Oriol, Ouchi, Dan, Millat-Martinez, Pere, Durkalski-Mauldin, Valerie, Korley, Frederick K, Dumont, Larry J, Callaway, Clifton W, Libster, Romina, Marc, Gonzalo Perez, Wappner, Diego, Esteban, Ignacio, Polack, Fernando, and Sullivan, David J

Abstract

Background: Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results. Methods: We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching Medline, Embase, medRxiv, World Health Organization COVID-19 Research Database, Cochrane Library, and Web of Science from January 2020 to September 2022. Results: Five included studies from 4 countries enrolled and transfused 2620 adult patients. Comorbidities were present in 1795 (69%). The virus neutralizing antibody dilutional titer levels ranged from 8 to 14 580 in diverse assays. One hundred sixty of 1315 (12.2%) control patients were hospitalized, versus 111 of 1305 (8.5%) CCP-treated patients, yielding a 3.7% (95% confidence interval [CI], 1.3%-6.0%; P =. 001) absolute risk reduction and 30.1% relative risk reduction for all-cause hospitalization. The hospitalization reduction was greatest in those with both early transfusion and high titer with a 7.6% absolute risk reduction (95% CI, 4.0%-11.1%; P =. 0001) accompanied by at 51.4% relative risk reduction. No significant reduction in hospitalization was seen with treatment >5 days after symptom onset or in those receiving CCP with antibody titers below the median titer. Conclusions: Among outpatients with COVID-19, treatment with CCP reduced the rate of all-cause hospitalization and may be most effective when given within 5 days of symptom onset and when antibody titer is higher.

Published
2023

14. Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, CTI Bont, Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, Bont, Louis, Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, CTI Bont, Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, and Bont, Louis

Published
2023

18. COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials

Author

Levine, Adam C., primary, Fukuta, Yuriko, additional, Huaman, Moises A., additional, Ou, Jiangda, additional, Meisenberg, Barry R., additional, Patel, Bela, additional, Paxton, James H., additional, Hanley, Daniel F., additional, Rijnders, Bart JA, additional, Gharbharan, Arvind, additional, Rokx, Casper, additional, Zwaginga, Jaap Jan, additional, Alemany, Andrea, additional, Mitjà, Oriol, additional, Ouchi, Dan, additional, Millat-Martinez, Pere, additional, Durkalski-Mauldin, Valerie, additional, Korley, Frederick K., additional, Dumont, Larry J., additional, Callaway, Clifton W., additional, Libster, Romina, additional, Marc, Gonzalo Perez, additional, Wappner, Diego, additional, Esteban, Ignacio, additional, Polack, Fernando, additional, and Sullivan, David J., additional

Published
2022
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19. Neurodevelopmental and growth outcomes after invasive Group B Streptococcus in early infancy: A multi-country matched cohort study in South Africa, Mozambique, India, Kenya, and Argentina

Author

Paul, Proma, Chandna, Jaya, Procter, Simon R, Dangor, Ziyaad, Leahy, Shannon, Santhanam, Sridhar, John, Hima B, Bassat, Quique, Bramugy, Justina, Bardají, Azucena, Abubakar, Amina, Nasambu, Carophine, Libster, Romina, Yanotti, Clara Sánchez, Seedat, Farah, Horváth-Puhó, Erzsébet, Hossain, AKM Tanvir, Sadeq-Ur Rahman, Qazi, Jit, Mark, Newton, Charles R, Milner, Kate, Gonçalves, Bronner P, Lawn, Joy E, and GBS long term outcomes LMIC collaborative group

Abstract

Background: Data are limited regarding long-term consequences of invasive GBS (iGBS) disease in early infancy, especially from low- and middle-income countries (LMIC) where most cases occur. We aimed to estimate risk of neurodevelopmental impairment (NDI) in children with a history of iGBS disease. Methods: A multi-country matched cohort study was undertaken in South Africa, India, Mozambique, Kenya, and Argentina from October 2019 to April 2021. The exposure of interest was defined as a history of iGBS disease (sepsis or meningitis) before 90 days of age, amongst children now aged 1·5-18 years. Age and sex-matched, children without history of GBS were also recruited. Age-appropriate, culturally-adapted assessments were used to define NDI across multiple domains (cognitive, motor, hearing, vision, emotional-behaviour, growth). Pooled NDI risk was meta-analysed across sites. Association of iGBS exposure and NDI outcome was estimated using modified Poisson regression with robust variance estimator. Findings: Amongst 138 iGBS survivors and 390 non-iGBS children, 38·1% (95% confidence interval [CI]: 30·0% - 46·6%) of iGBS children had any NDI, compared to 21·7% (95% CI: 17·7% - 26·0%) of non- iGBS children, with notable between-site heterogeneity. Risk of moderate/severe NDI was 15·0% (95% CI: 3·4% - 30·8%) among GBS-meningitis, 5·6% (95% CI: 1·5% - 13·7%) for GBS-sepsis survivors. The adjusted risk ratio (aRR) for moderate/severe NDI among iGBS survivors was 1.27 (95% CI: 0.65, 2.45), when compared to non-GBS children. Mild impairment was more frequent in iGBS (27.6% (95% CI: 20.3 - 35.5%)) compared to non-GBS children (12.9% (95% CI: 9.7% - 16.4%)). The risk of emotional-behavioural problems was similar irrespective of iGBS exposure (aRR=0.98 (95% CI: 0.55, 1.77)). Interpretation: Our findings suggest that iGBS disease is on average associated with a higher risk of moderate/severe NDI, however substantial variation in risk was observed between sites and data are consistent with a wide range of values. Our study underlines the importance of long-term follow-up for at-risk neonates and more feasible, standardised assessments to facilitate diagnosis in research and clinical practice. Funding: This work was supported by a grant (INV-009018) from the Bill & Melinda Gates Foundation to the London School of Hygiene &Tropical Medicine.

Published
2022

20. Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden

Author

Gonçalves, Bronner P, Procter, Simon R, Paul, Proma, Chandna, Jaya, Lewin, Alexandra, Seedat, Farah, Koukounari, Artemis, Dangor, Ziyaad, Leahy, Shannon, Santhanam, Sridhar, John, Hima B, Bramugy, Justina, Bardají, Azucena, Abubakar, Amina, Nasambu, Carophine, Libster, Romina, Sánchez Yanotti, Clara, Horváth-Puhó, Erzsébet, Sørensen, Henrik T, van de Beek, Diederik, Bijlsma, Merijn W, Gardner, William M, Kassebaum, Nicholas, Trotter, Caroline, Bassat, Quique, Madhi, Shabir A, Lambach, Philipp, Jit, Mark, Lawn, Joy E, GBS Danish and Dutch collaborative group for long term outcomes, GBS Low and Middle Income Countries collaborative group for long, GBS Scientific Advisory Group, epidemiological sub-group, and CHAMPS team

Abstract

BACKGROUND: Group B streptococcus (GBS) colonisation during pregnancy can lead to invasive GBS disease (iGBS) in infants, including meningitis or sepsis, with a high mortality risk. Other outcomes include stillbirths, maternal infections, and prematurity. There are data gaps, notably regarding neurodevelopmental impairment (NDI), especially after iGBS sepsis, which have limited previous global estimates. In this study, we aimed to address this gap using newly available multicountry datasets. METHODS: We collated and meta-analysed summary data, primarily identified in a series of systematic reviews published in 2017 but also from recent studies on NDI and stillbirths, using Bayesian hierarchical models, and estimated the burden for 183 countries in 2020 regarding: maternal GBS colonisation, iGBS cases and deaths in infants younger than 3 months, children surviving iGBS affected by NDI, and maternal iGBS cases. We analysed the proportion of stillbirths with GBS and applied this to the UN-estimated stillbirth risk per country. Excess preterm births associated with maternal GBS colonisation were calculated using meta-analysis and national preterm birth rates. FINDINGS: Data from the seven systematic reviews, published in 2017, that informed the previous burden estimation (a total of 515 data points) were combined with new data (17 data points) from large multicountry studies on neurodevelopmental impairment (two studies) and stillbirths (one study). A posterior median of 19·7 million (95% posterior interval 17·9-21·9) pregnant women were estimated to have rectovaginal colonisation with GBS in 2020. 231 800 (114 100-455 000) early-onset and 162 200 (70 200-394 400) late-onset infant iGBS cases were estimated to have occurred. In an analysis assuming a higher case fatality rate in the absence of a skilled birth attendant, 91 900 (44 800-187 800) iGBS infant deaths were estimated; in an analysis without this assumption, 58 300 (26 500-125 800) infant deaths from iGBS were estimated. 37 100 children who recovered from iGBS (14 600-96 200) were predicted to develop moderate or severe NDI. 40 500 (21 500-66 200) maternal iGBS cases and 46 200 (20 300-111 300) GBS stillbirths were predicted in 2020. GBS colonisation was also estimated to be potentially associated with considerable numbers of preterm births. INTERPRETATION: Our analysis provides a comprehensive assessment of the pregnancy-related GBS burden. The Bayesian approach enabled coherent propagation of uncertainty, which is considerable, notably regarding GBS-associated preterm births. Our findings on both the acute and long-term consequences of iGBS have public health implications for understanding the value of investment in maternal GBS immunisation and other preventive strategies. FUNDING: Bill & Melinda Gates Foundation.

Published
2022

21. Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors

Author

Geoghegan, Sarah, Erviti, Anabella, Caballero, Mauricio T., Vallone, Fernando, Zanone, Stella M., Losada, Juan Ves, Bianchi, Alejandra, Acosta, Patricio L., Talarico, Laura B., Ferretti, Adrian, Grimaldi, Luciano Alva, Sancilio, Andrea, Dueñas, Karina, Sastre, Gustavo, Rodriguez, Andrea, Ferrero, Fernando, Barboza, Edgar, Gago, Guadalupe Fernández, Nocito, Celina, Flamenco, Edgardo, Perez, Alberto Rodriguez, Rebec, Beatriz, Ferolla, Martin F., Libster, Romina, Karron, Ruth A., Bergel, Eduardo, and Polack, Fernando P.

Published
2017
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23. Neurodevelopmental and growth outcomes after invasive Group B Streptococcus in early infancy: A multi-country matched cohort study in South Africa, Mozambique, India, Kenya, and Argentina

Author

Paul, Proma, primary, Chandna, Jaya, additional, Procter, Simon R., additional, Dangor, Ziyaad, additional, Leahy, Shannon, additional, Santhanam, Sridhar, additional, John, Hima B., additional, Bassat, Quique, additional, Bramugy, Justina, additional, Bardají, Azucena, additional, Abubakar, Amina, additional, Nasambu, Carophine, additional, Libster, Romina, additional, Yanotti, Clara Sánchez, additional, Seedat, Farah, additional, Horváth-Puhó, Erzsébet, additional, Hossain, A.K.M. Tanvir, additional, Sadeq-ur Rahman, Qazi, additional, Jit, Mark, additional, Newton, Charles R., additional, Milner, Kate, additional, Gonçalves, Bronner P., additional, Lawn, Joy E., additional, Madhi, Shabir A., additional, Harden, Lois, additional, Ghoor, Azra, additional, Mbatha, Sibongile, additional, Lowick, Sarah, additional, Laughton, Barbara, additional, Jaye, Tamara, additional, Lala, Sanjay G, additional, Sithole, Pamela, additional, Msayi, Jacqueline, additional, Kumalo, Ntombifuthi, additional, Msibi, Tshepiso Nompumelelo, additional, Arumugam, Asha, additional, Murugesan, Nandhini, additional, Rajendraprasad, Nandhini, additional, Priya, Mohana, additional, Adan, Adam Mabrouk, additional, Katana, Patrick Vidzo, additional, Mwangome, Eva, additional, Mucasse, Humberto, additional, Aerts, Celine, additional, Massora, Sergio, additional, Medina, Valeria, additional, Rojas, Andrea, additional, Amado, Daniel, additional, and Llapur, Conrado J., additional

Published
2022
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25. Emotional and Behavioral Outcomes in Childhood for Survivors of Invasive Group B Streptococcus Disease in Infancy: Findings From 5 Low- and Middle-Income Countries

Author

Chandna, Jaya, Liu, Wan-Hsin, Dangor, Ziyaad, Leahy, Shannon, Sridhar, Santhanam, John, Hima B, Mucasse, Humberto, Bassat, Quique, Bardaji, Azucena, Abubakar, Amina, Nasambu, Carophine, Newton, Charles R, Sánchez Yanotti, Clara, Libster, Romina, Milner, Kate, Paul, Proma, Lawn, Joy E, and GBS Low and Middle income Collaborative Group for Long-term Outc

Abstract

BACKGROUND: Survivors of invasive group B Streptococcus (iGBS) disease, notably meningitis, are at increased risk of neurodevelopmental impairment. However, the limited studies to date have a median follow-up to 18 months and have mainly focused on moderate or severe neurodevelopmental impairment, with no previous studies on emotional-behavioral problems among iGBS survivors. METHODS: In this multicountry, matched cohort study, we included children aged 18 months to 17 years with infant iGBS sepsis and meningitis from health demographic surveillance systems, or hospital records in Argentina, India, Kenya, Mozambique, and South Africa. Children without an iGBS history were matched to iGBS survivors for sex and age. Our primary outcomes were emotional-behavioral problems and psychopathological conditions as measured with the Child Behavior Checklist (CBCL). The CBCL was completed by the child's primary caregiver. RESULTS: Between October 2019 and April 2021, 573 children (mean age, 7.18 years) were assessed, including 156 iGBS survivors and 417 non-iGBS comparison children. On average, we observed more total problems and more anxiety, attention, and conduct problems for school-aged iGBS survivors compared with the non-iGBS group. No differences were found in the proportion of clinically significant psychopathological conditions defined by the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). CONCLUSIONS: Our findings suggested that school-aged iGBS survivors experienced increased mild emotional behavioral problems that may affect children and families. At-risk neonates including iGBS survivors need long-term follow-up with integrated emotional-behavioral assessments and appropriate care. Scale-up will require simplified assessments that are free and culturally adapted.

Published
2022

27. Fatal enhanced respiratory syncytial virus disease in toddlers

Author

Polack, Fernando P., primary, Alvarez-Paggi, Damián, additional, Libster, Romina, additional, Caballero, Mauricio T., additional, Blair, Robert V., additional, Hijano, Diego R., additional, de la Iglesia Niveyro, Paola X., additional, Menendez, Daniel R., additional, Gladwell, Wes, additional, Avendano, Luis M., additional, Velozo, Luis, additional, Wanek, Alanna, additional, Bergel, Eduardo, additional, Prince, Gregory A., additional, Kleeberger, Steven R., additional, Johnson, Joyce, additional, Pociask, Derek, additional, and Kolls, Jay K., additional

Published
2021
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29. TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

Author

Caballero, Mauricio T., Serra, Elina M., Acosta, Patricio L., Marzec, Jacqui, Gibbons, Luz, Salim, Maximiliano, Rodriguez, Andrea, Reynaldi, Andrea, Garcia, Alejandro, Bado, Daniela, Buchholz, Ursula J., Hijano, Diego R., Coviello, Silvina, Newcomb, Dawn, Bellabarba, Miguel, Ferolla, Fausto M., Libster, Romina, Berenstein, Ada, Siniawaski, Susana, Blumetti, Valeria, Echavarria, Marcela, Pinto, Leonardo, Lawrence, Andrea, Ossorio, Fabiana M., Grosman, Arnoldo, Mateu, Cecilia G., Bayle, Carola, Dericco, Alejandra, Pellegrini, Mariana, Igarza, Ignacio, Repetto, Horacio A., Grimaldi, Luciano Alva, Gudapati, Prathyusha, Polack, Norberto R., Althabe, Fernando, Shi, Min, Ferrero, Fernando, Bergel, Eduardo, Stein, Renato T., Peebles, Stokes R., Boothby, Mark, Kleeberger, Steven R., and Polack, Fernando P.

Published
2015
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30. Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children

Author

Libster, Romina Paula, Esteban, Ignacio, Bianchi, Alejandra Silvina, Alva Grimaldi, Luciano, Dueñas, Karina, Sancillo, Andrea, Rodriguez, Andrea, Ferrero, Fernando, Stein, Katherine, Acosta, Patricio Leandro, Ferolla, Fausto Martín, Bergel, Eduardo, Caballero, Mauricio Tomás, Polack, Fernando Pedro, Pellegrino, Gustavo, Fernandez Gago, Guadalupe, Pozzolo, Cecilia, Castro, Laura, Almeida, Rodrigo Egues, Rebec, Beatriz, González, Mariela, Calvo, Mariel, Henrichsen, Julieta, Nocito, Celina, Barbero, Guillermo, Ves Losada, Juan, Bonina, Angel, Flamenco, Edgardo, Rodriguez Perez, Alberto, Kobylarz, Alicia, Raggio, Mirta, Schavlosky, Graciela, Caria, Adriana, Barboza, Edgar, and Sastre, Gustavo

Subjects
maternal asthma, viruses, Argentina, CHILDREN, purl.org/becyt/ford/3.3 [https], Human metapneumovirus, children, Lower respiratory tract infection, medicine, Major Article, Immunology and Allergy, Humans, risk factors, Maternal asthma, Lung, Respiratory Tract Infections, Asthma, MATERNAL ASTHMA, Paramyxoviridae Infections, human metapneumovirus, biology, business.industry, HUMAN METAPNEUMOVIRUS, virus diseases, Infant, medicine.disease, biology.organism_classification, respiratory tract diseases, Infectious Diseases, BURDEN OF ILLNESS, Lung disease, Child, Preschool, LOWER RESPIRATORY TRACT INFECTION, RISK FACTORS, Immunology, burden of illness, lower respiratory tract infection, purl.org/becyt/ford/3 [https], Disease Susceptibility, Metapneumovirus, business
Abstract

Background Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, suggesting the degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that hMPV may preferentially affect asthmatic subjects. Methods In a population-based surveillance study in children aged, In a population-based surveillance study in children aged

Published
2021
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32. Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa

Author

Paul, Proma, primary, Procter, Simon R., additional, Dangor, Ziyaad, additional, Bassat, Quique, additional, Abubakar, Amina, additional, Santhanam, Sridhar, additional, Libster, Romina, additional, Gonçalves, Bronner P., additional, Madhi, Shabir A., additional, Bardají, Azucena, additional, Mwangome, Eva, additional, Mabrouk, Adam, additional, John, Hima B., additional, Sánchez Yanotti, Clara, additional, Chandna, Jaya, additional, Sithole, Pamela, additional, Mucasse, Humberto, additional, Katana, Patrick V., additional, Koukounari, Artemis, additional, Harden, Lois M., additional, Aerts, Celine, additional, Ghoor, Azra, additional, Leahy, Shannon, additional, Mbatha, Sibongile, additional, Lowick, Sarah, additional, Lala, Sanjay G., additional, Bramugy, Justina, additional, Newton, Charles, additional, Hossain, A. K. M. Tanvir, additional, Sadeq-ur Rahman, Qazi, additional, Lambach, Philipp, additional, Jit, Mark, additional, and Lawn, Joy E., additional

Published
2021
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33. Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes

Author

Monsalvo, Ana Clara, Batalle, Juan P, Lopez, M Florencia, Krause, Jens C, Klemenc, Jennifer, Hernandez, Johanna Zea, Maskin, Bernardo, Bugna, Jimena, Rubinstein, Carlos, Aguilar, Leandro, Dalurzo, Liliana, Libster, Romina, Savy, Vilma, Baumeister, Elsa, Aguilar, Liliana, Cabral, Graciela, Font, Julia, Solari, Liliana, Weller, Kevin P, Johnson, Joyce, Echavarria, Marcela, Edwards, Kathryn M, Chappell, James D, Crowe, Jr, James E, Williams, John V, Melendi, Guillermina A, and Polack, Fernando P

Published
2011
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34. Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina

Author

Libster, Romina, Bugna, Jimena, Coviello, Silvina, Hijano, Diego R., Dunaiewsky, Mariana, Reynoso, Natalia, Cavalieri, Maria L., Guglielmo, Maria C., Areso, M. Soledad, Gilligan, Tomas, Santucho, Fernanda, Cabral, Graciela, Gregorio, Gabriela L., Moreno, Rina, Lutz, Maria I., Panigasi, Alicia L., Saligari, Liliana, Caballero, Mauricio T., Almeida, Rodrigo M. Egues, 0Meyer, Maria E. Gutierrez, Neder, Maria D., Davenport, Maria C., Del Valle, Maria P., Santidrian, Valeria S., Mosca, Guillermina, Dominguez, Mercedes Gracia, Alvarez, Liliana, Landa, Patricia, Pota, Ana, Bolonati, Norma, Dalamon, Ricardo, Mercol. Victoria I. Sanchez, Espinoza, Marco, Peuchot, Juan Carlos, Karolinski, Ariel, Bruno, Miriam, Borsa, Ana, Ferrero, Fernando, Bonina, Angel, Ramonet, Margarita, Albano, Lidia C., Luedicke, Nora, Alterman, Elias, Savy, Vilma, Baumeister, Elsa, Chappel, James D., Edwards, Katheryn M., Melendi, Guillermina A., and Polack, Fernando P.

Subjects
Company business management, Market trend/market analysis, Children's hospitals -- Management, Polymerase chain reaction -- Usage, Swine influenza -- Patient outcomes, Swine influenza -- Demographic aspects, Infants -- Patient outcomes, Infants -- Causes of, Infants -- Forecasts and trends
Abstract

A study was conducted to investigate the effects of the 2009 pandemic influenza A (H1N1) on children in six pediatric hospitals in Argentina. Results indicated that the H1N1 virus resulted in pediatric death rates that were ten times higher than normal seasonal influenza.

Published
2009

35. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Author

Venkatesan, Sudhir, Muthuri, Stella G., Al Khuwaitir, Tarig, Bajjou, Tahar, Bassetti, Matteo, Beovic, Bojana, Bonmarin, Isabelle, Booy, Robert, Burgmann, Heinz, Cao, Bin, Carratala, Jordi, Chinbayar, Tserendorj, Cilloniz, Catia, Dubnov-Raz, Gal, Gao, Zhancheng, Giannella, Maddalena, Gubbels, Sophie, Herberg, Jethro, Higuera Iglesias, Anjarath Lorena, Hu, Xiao Yun, Keijzers, Gerben, Khalili, Hossein, Kusznierz, Gabriela, Kuzman, Ilija, Langenegger, Eduard, Leo, Yee-Sin, Libster, Romina P., Linko, Rita, Madanat, Faris, Maltezos, Efstratios, Mamun, Abdullah, Manabe, Toshie, Metan, Gokhan, Mickiene, Auks?, Ozkan, Mehpare, Parekh, Dhruv, Refaey, Samir, Rodriguez, Alejandro H., Sertogullarindan, Bunyamin, Skr?t-Magier?o, Joanna, Somer, Ayper, Talarek, Ewa, Tang, Julian W., Tran, Dat, Vaudry, Wendy, Vidmar, Tjasa, Zarogoulidis, Paul, PRIDE Consortium Investigators, Nguyen-Van-Tam, Jonathan S., Myles, Puja R, Bolton, Kirsty J, Anovadiya, Ashish P, Azziz-Baumgartner, Eduardo, Bertisch, Barbara, Borja-Aburto, Victor H, Denholm, Justin T, Dominguez, Samuel R, Duarte, Pericles A D, Fanella, Sergio, Hoeger, Peter H, Islam, Quazi T, Lankarani, Kamran B, Miki?, Dragan, Mohn, Kristin G I, Oliva, Maria E, Rath, Barbara A, To, Kelvin, Uyeki, Timothy M, and Khandaker, Gulam

Subjects
Infectious Diseases, Immunology and Allergy
Abstract

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of

Published
2020

36. Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Author

Libster, Romina, primary, Pérez Marc, Gonzalo, additional, Wappner, Diego, additional, Coviello, Silvina, additional, Bianchi, Alejandra, additional, Braem, Virginia, additional, Esteban, Ignacio, additional, Caballero, Mauricio T., additional, Wood, Cristian, additional, Berrueta, Mabel, additional, Rondan, Aníbal, additional, Lescano, Gabriela, additional, Cruz, Pablo, additional, Ritou, Yvonne, additional, Fernández Viña, Valeria, additional, Álvarez Paggi, Damián, additional, Esperante, Sebastián, additional, Ferreti, Adrián, additional, Ofman, Gastón, additional, Ciganda, Álvaro, additional, Rodriguez, Rocío, additional, Lantos, Jorge, additional, Valentini, Ricardo, additional, Itcovici, Nicolás, additional, Hintze, Alejandra, additional, Oyarvide, M. Laura, additional, Etchegaray, Candela, additional, Neira, Alejandra, additional, Name, Ivonne, additional, Alfonso, Julieta, additional, López Castelo, Rocío, additional, Caruso, Gisela, additional, Rapelius, Sofía, additional, Alvez, Fernando, additional, Etchenique, Federico, additional, Dimase, Federico, additional, Alvarez, Darío, additional, Aranda, Sofía S., additional, Sánchez Yanotti, Clara, additional, De Luca, Julián, additional, Jares Baglivo, Sofía, additional, Laudanno, Sofía, additional, Nowogrodzki, Florencia, additional, Larrea, Ramiro, additional, Silveyra, María, additional, Leberzstein, Gabriel, additional, Debonis, Alejandra, additional, Molinos, Juan, additional, González, Miguel, additional, Perez, Eduardo, additional, Kreplak, Nicolás, additional, Pastor Argüello, Susana, additional, Gibbons, Luz, additional, Althabe, Fernando, additional, Bergel, Eduardo, additional, and Polack, Fernando P., additional

Published
2021
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37. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

Author

Wang, Xin, primary, Li, You, additional, Deloria-Knoll, Maria, additional, Madhi, Shabir A, additional, Cohen, Cheryl, additional, Ali, Asad, additional, Basnet, Sudha, additional, Bassat, Quique, additional, Brooks, W Abdullah, additional, Chittaganpitch, Malinee, additional, Echavarria, Marcela, additional, Fasce, Rodrigo A, additional, Goswami, Doli, additional, Hirve, Siddhivinayak, additional, Homaira, Nusrat, additional, Howie, Stephen R C, additional, Kotloff, Karen L, additional, Khuri-Bulos, Najwa, additional, Krishnan, Anand, additional, Lucero, Marilla G, additional, Lupisan, Socorro, additional, Mira-Iglesias, Ainara, additional, Moore, David P, additional, Moraleda, Cinta, additional, Nunes, Marta, additional, Oshitani, Histoshi, additional, Owor, Betty E, additional, Polack, Fernando P, additional, O'Brien, Katherine L, additional, Rasmussen, Zeba A, additional, Rath, Barbara A, additional, Salimi, Vahid, additional, Scott, J Anthony G, additional, Simões, Eric A F, additional, Strand, Tor A, additional, Thea, Donald M, additional, Treurnicht, Florette K, additional, Vaccari, Linda C, additional, Yoshida, Lay-Myint, additional, Zar, Heather J, additional, Campbell, Harry, additional, Nair, Harish, additional, Libster, Romina, additional, Otieno, Grieven, additional, Joundi, Imane, additional, Broor, Shobha, additional, Nicol, Mark, additional, Amarchand, Ritvik, additional, Shi, Ting, additional, López-Labrador, F. Xavier, additional, Baker, Julia M., additional, Jamison, Alexandra, additional, Choudekar, Avinash, additional, Juvekar, Sanjay, additional, Obermeier, Patrick, additional, Schweiger, Brunhilde, additional, Madrid, Lola, additional, Thomas, Elizabeth, additional, Lanaspa, Miguel, additional, Nohynek, Hanna, additional, Nokes, James, additional, Werner, Marta, additional, Danhg, Anh, additional, Chadha, Mandeep, additional, Puig-Barberà, Joan, additional, Caballero, Mauricio T., additional, Mathisen, Maria, additional, Walaza, Sibongile, additional, Hellferscee, Orienka, additional, Laubscher, Matt, additional, Higdon, Melissa M., additional, Haddix, Meredith, additional, Sawatwong, Pongpun, additional, Baggett, Henry C., additional, Seidenberg, Phil, additional, Mwanayanda, Lawrence, additional, Antonio, Martin, additional, Ebruke, Bernard E., additional, Adams, Tanja, additional, Rahman, Mustafizur, additional, Rahman, Mohammed Ziaur, additional, Sow, Samboa O., additional, Baillie, Vicky L., additional, Workman, Lesley, additional, Toizumi, Michiko, additional, Tapia, Milagritos D., additional, Nguyen, Thi hien anh, additional, and Morpeth, Susan, additional

Published
2021
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38. Macronutrients during Pregnancy and Life-Threatening Respiratory Syncytial Virus Infections in Children

Author

Ferolla, Martín F., Hijano, Diego R., Acosta, Patricio L., Rodríguez, Andrea, Dueñas, Karina, Sancilio, Andrea, Barboza, Edgar, Caría, Adriana, Gago, Guadalupe Fernández, Almeida, Rodrigo Egües, Castro, Laura, Pozzolo, Cecilia, Martínez, María V., Grimaldi, Luciano Alva, Rebec, Beatriz, Calvo, Mariel, Henrichsen, Julieta, Nocito, Celina, González, Mariela, Barbero, Guillermo, Losada, Juan Ves, Caballero, Mauricio T., Zurankovas, Valeria, Raggio, Mirta, Schavlovsky, Graciela, Kobylarz, Alicia, Wimmenauer, Vera, Bugna, Jimena, Williams, John V., Sastre, Gustavo, Flamenco, Edgardo, Pérez, Alberto Rodríguez, Ferrero, Fernando, Libster, Romina, Grijalva, Carlos G., and Polack, Fernando P.

Published
2013
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41. A Mechanistic Role for Type III IFN-λ1 in Asthma Exacerbations Mediated by Human Rhinoviruses

Author

Miller, Kathryn E., Hernandez, Johanna Zea, Wimmenauer, Vera, Shepherd, Bryan E., Hijano, Diego, Libster, Romina, Serra, Elina M., Bhat, Niranjan, Batalle, Juan P., Mohamed, Yassir, Reynaldi, Andrea, Rodriguez, Andrea, Otello, Monica, Pisapia, Nestor, Bugna, Jimena, Bellabarba, Miguel, Kraft, David, Coviello, Silvina, Ferolla, Martin F., Chen, Aaron, London, Stephanie J., Siberry, George K., Williams, John V., and Polack, Fernando P.

Published
2012
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43. Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants

Author

Madhi, Shabir A., primary, Polack, Fernando P., additional, Piedra, Pedro A., additional, Munoz, Flor M., additional, Trenholme, Adrian A., additional, Simões, Eric A.F., additional, Swamy, Geeta K., additional, Agrawal, Sapeckshita, additional, Ahmed, Khatija, additional, August, Allison, additional, Baqui, Abdullah H., additional, Calvert, Anna, additional, Chen, Janice, additional, Cho, Iksung, additional, Cotton, Mark F., additional, Cutland, Clare L., additional, Englund, Janet A., additional, Fix, Amy, additional, Gonik, Bernard, additional, Hammitt, Laura, additional, Heath, Paul T., additional, de Jesus, Joanne N., additional, Jones, Christine E., additional, Khalil, Asma, additional, Kimberlin, David W., additional, Libster, Romina, additional, Llapur, Conrado J., additional, Lucero, Marilla, additional, Pérez Marc, Gonzalo, additional, Marshall, Helen S., additional, Masenya, Masebole S., additional, Martinón-Torres, Federico, additional, Meece, Jennifer K., additional, Nolan, Terry M., additional, Osman, Ayman, additional, Perrett, Kirsten P., additional, Plested, Joyce S., additional, Richmond, Peter C., additional, Snape, Matthew D., additional, Shakib, Julie H., additional, Shinde, Vivek, additional, Stoney, Tanya, additional, Thomas, D. Nigel, additional, Tita, Alan T., additional, Varner, Michael W., additional, Vatish, Manu, additional, Vrbicky, Keith, additional, Wen, Judy, additional, Zaman, Khalequ, additional, Zar, Heather J., additional, Glenn, Gregory M., additional, and Fries, Louis F., additional

Published
2020
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44. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Author

Wang, Xin, primary, Li, You, additional, O'Brien, Katherine L, additional, Madhi, Shabir A, additional, Widdowson, Marc-Alain, additional, Byass, Peter, additional, Omer, Saad B, additional, Abbas, Qalab, additional, Ali, Asad, additional, Amu, Alberta, additional, Azziz-Baumgartner, Eduardo, additional, Bassat, Quique, additional, Abdullah Brooks, W, additional, Chaves, Sandra S, additional, Chung, Alexandria, additional, Cohen, Cheryl, additional, Echavarria, Marcela, additional, Fasce, Rodrigo A, additional, Gentile, Angela, additional, Gordon, Aubree, additional, Groome, Michelle, additional, Heikkinen, Terho, additional, Hirve, Siddhivinayak, additional, Jara, Jorge H, additional, Katz, Mark A, additional, Khuri-Bulos, Najwa, additional, Krishnan, Anand, additional, de Leon, Oscar, additional, Lucero, Marilla G, additional, McCracken, John P, additional, Mira-Iglesias, Ainara, additional, Moïsi, Jennifer C, additional, Munywoki, Patrick K, additional, Ourohiré, Millogo, additional, Polack, Fernando P, additional, Rahi, Manveer, additional, Rasmussen, Zeba A, additional, Rath, Barbara A, additional, Saha, Samir K, additional, Simões, Eric AF, additional, Sotomayor, Viviana, additional, Thamthitiwat, Somsak, additional, Treurnicht, Florette K, additional, Wamukoya, Marylene, additional, Yoshida, Lay-Myint, additional, Zar, Heather J, additional, Campbell, Harry, additional, Nair, Harish, additional, Wang, Xin, additional, Bhutta, Zulfiqar A, additional, Saeed, Bushra, additional, Soofi, Sajid B, additional, Yousafzai, Mohammad Tahir, additional, Zaidi, Anita K, additional, Awini, Elizabeth, additional, Baggett, Henry C, additional, Shang, Nong, additional, Schrag, Stephanie J, additional, Tempia, Stefano, additional, Lanaspa, Miguel, additional, Acácio, Sozinho, additional, Brooks, W Abdullah, additional, Driscoll, Amanda, additional, Knoll, Maria Deloria, additional, Prosperi, Christine, additional, Baqui, Abdullah H, additional, Mullany, Luke, additional, von Gottberg, Anne, additional, Hellferscee, Orienka, additional, Walaza, Sibongile, additional, Goswami, Doli, additional, Rahman, Mustafizur, additional, Connor, Nicholas E, additional, El Arifeen, Shams, additional, Marcone, Débora N, additional, Reyes, Noelia, additional, Gutierrez, Andrea, additional, Rodriguez, Ivan, additional, Lopez, Olga, additional, Ortiz, David, additional, Gonzalez, Nathaly, additional, del Valle Juarez, Maria, additional, Cutland, Clare, additional, Nunes, Marta C, additional, Nzenze, Susan, additional, Juvekar, Sanjay, additional, Halasa, Natasha, additional, Bernart, Chris, additional, Gofer, Ilan, additional, Avni, Yonat Shemer, additional, Faori, Samir, additional, Shehabi, Asem, additional, Kumar, Rakesh, additional, Amarchand, Ritvik, additional, Contreras, Carmen L, additional, Lopez, Maria R, additional, Maldonado, Herberth, additional, Samayoa, Antonio P, additional, Gomez, Ana B, additional, Nillos, Leilani T, additional, Lupisan, Socorro P, additional, Nohynek, Hanna, additional, Puig-Barberà, Joan, additional, Díez-Domingo, Javier, additional, Gessner, Bradford D, additional, Njanpop-Lafourcade, Berthe-Marie, additional, Tall, Haoua, additional, Ngama, Mwanjuma, additional, Nokes, D James, additional, Clark, Dayna R, additional, Ali, Sié, additional, Pascal, Zabré, additional, Cheik, Bagagnan H, additional, Caballero, Mauricio T, additional, Libster, Romina, additional, Thomas, Elizabeth D, additional, Baker, Julia M, additional, Obermeier, Patrick E, additional, Hassanuzzaman, MD., additional, Islam, Maksuda, additional, Islam, Mohammad S, additional, Panigrahi, Pinaki, additional, Bose, Anuradha, additional, Isaac, Rita, additional, Murdoch, David, additional, Nanda, Pritish, additional, Qazi, Shamim A, additional, Hessong, Danielle, additional, Simőes, Eric AF, additional, Chittaganpitch, Malinee, additional, Dawood, Halima, additional, Kyobutungi, Catherine, additional, Ziraba, Abdhalah K, additional, Yoshihara, Keisuke, additional, Dand, Duc-Anh, additional, Le, Minh-Nhat, additional, Nicol, Mark P, additional, Broor, Shobha, additional, Chadha, Mandeep, additional, Madrid, Lola, additional, Gresh, Lionel, additional, Balmaseda, Angel, additional, Kuan, Guillermina, additional, Wairagkar, Niteen, additional, Tapia, Milagritos D, additional, Knobler, Stacey L, additional, Barahona, Alfredo, additional, Ferguson, Ericka, additional, and Schweiger, Brunhilde, additional

Published
2020
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45. Respiratory Failure and Death in Vulnerable Premature Children With Lower Respiratory Tract Illness

Author

Ofman, Gaston, primary, Pradarelli, Brad, additional, Caballero, Mauricio T, additional, Bianchi, Alejandra, additional, Grimaldi, Luciano Alva, additional, Sancilio, Andrea, additional, Duenas, Karina, additional, Rodriguez, Andrea, additional, Ferrero, Fernando, additional, Ferretti, Adrian, additional, Coviello, Silvina, additional, Ferolla, Fausto M, additional, Acosta, Patricio L, additional, Bergel, Eduardo, additional, Libster, Romina, additional, and Polack, Fernando P, additional

Published
2020
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47. Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina

Author

Libster, Romina, Bugna, Jimena, Coviello, Silvina, Hijano, Diego R., Dunaiewsky, Mariana, Reynoso, Natalia, Cavalieri, Maria L., Guglielmo, Maria C., Areso, Soledad M., Gilligan, Tomas, Santucho, Fernanda, Cabral, Graciela, Gregorio, Gabriela L., Moreno, Rina, Lutz, Maria I., Panigasi, Alicia L., Saligari, Liliana, Caballero, Mauricio T., Almeida, Rodrigo M. Egües, Meyer, Maria E. Gutierrez, Neder, Maria D., Davenport, Maria C., Del Valle, Maria P., Santidrian, Valeria S., Mosca, Guillermina, Domínguez, Mercedes Garcia, Alvarez, Liliana, Landa, Patricia, Pota, Ana, Boloñati, Norma, Dalamon, Ricardo, Mercol, Victoria I. Sanchez, Espinoza, Marco, Peuchot, Juan Carlos, Karolinski, Ariel, Bruno, Miriam, Borsa, Ana, Ferrero, Fernando, Bonina, Angel, Ramonet, Margarita, Albano, Lidia C., Luedicke, Nora, Alterman, Elias, Savy, Vilma, Baumeister, Elsa, Chappell, James D., Edwards, Kathryn M., Melendi, Guillermina A., and Polack, Fernando P.

Published
2010
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48. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Author

Venkatesan, Sudhir, Myles, Puja R, Bolton, Kirsty J, Muthuri, Stella G, Al Khuwaitir, Tarig, Anovadiya, Ashish P, Azziz-Baumgartner, Eduardo, Bajjou, Tahar, Bassetti, Matteo, Beovic, Bojana, Bertisch, Barbara, Bonmarin, Isabelle, Booy, Robert, Borja-Aburto, Victor H, Burgmann, Heinz, Cao, Bin, Carratala, Jordi, Chinbayar, Tserendorj, Cilloniz, Catia, Denholm, Justin T, Dominguez, Samuel R, Duarte, Pericles A D, Dubnov-Raz, Gal, Fanella, Sergio, Gao, Zhancheng, Gérardin, Patrick, Giannella, Maddalena, Gubbels, Sophie, Herberg, Jethro, Higuera Iglesias, Anjarath Lorena, Hoeger, Peter H, Hu, Xiao Yun, Islam, Quazi T, Jiménez, Mirela F, Keijzers, Gerben, Khalili, Hossein, Kusznierz, Gabriela, Kuzman, Ilija, Langenegger, Eduard, Lankarani, Kamran B, Leo, Yee-Sin, Libster, Romina P, Linko, Rita, Madanat, Faris, Maltezos, Efstratios, Mamun, Abdullah, Manabe, Toshie, Metan, Gokhan, Mickiene, Auksė, Mikić, Dragan, Mohn, Kristin G I, Oliva, Maria E, Ozkan, Mehpare, Parekh, Dhruv, Paul, Mical, Rath, Barbara A, Refaey, Samir, Rodríguez, Alejandro H, Sertogullarindan, Bunyamin, Skręt-Magierło, Joanna, Somer, Ayper, Talarek, Ewa, Tang, Julian W, To, Kelvin, Tran, Dat, Uyeki, Timothy M, Vaudry, Wendy, Vidmar, Tjasa, Zarogoulidis, Paul, Nguyen-Van-Tam, Jonathan S, PRIDE Consortium Investigators, Imperial College London, HUS Perioperative, Intensive Care and Pain Medicine, Department of Diagnostics and Therapeutics, Clinicum, Venkatesan S., Myles P.R., Bolton K.J., Muthuri S.G., Al Khuwaitir T., Anovadiya A.P., Azziz-Baumgartner E., Bajjou T., Bassetti M., Beovic B., Bertisch B., Bonmarin I., Booy R., Borja-Aburto V.H., Burgmann H., Cao B., Carratala J., Chinbayar T., Cilloniz C., Denholm J.T., Dominguez S.R., Duarte P.A.D., Dubnov-Raz G., Fanella S., Gao Z., Gerardin P., Giannella M., Gubbels S., Herberg J., Higuera Iglesias A.L., Hoeger P.H., Hu X.Y., Islam Q.T., Jimenez M.F., Keijzers G., Khalili H., Kusznierz G., Kuzman I., Langenegger E., Lankarani K.B., Leo Y.-S., Libster R.P., Linko R., Madanat F., Maltezos E., Mamun A., Manabe T., Metan G., Mickiene A., Mikic D., Mohn K.G.I., Oliva M.E., Ozkan M., Parekh D., Paul M., Rath B.A., Refaey S., Rodriguez A.H., Sertogullarindan B., Skret-Magierlo J., Somer A., Talarek E., Tang J.W., To K., Tran D., Uyeki T.M., Vaudry W., Vidmar T., Zarogoulidis P., and Nguyen-Van-Tam J.S.

Subjects
0301 basic medicine, Male, pandemic influenza, OSELTAMIVIR TREATMENT, IMPACT, Neuraminidase/antagonists & inhibitors, CHILDREN, medicine.disease_cause, 0302 clinical medicine, antivirals, Influenza A Virus, H1N1 Subtype, Adrenal Cortex Hormones, IPD meta-analysi, Influenza A virus, Immunology and Allergy, 030212 general & internal medicine, IPD meta-analysis, Young adult, Enzyme Inhibitors, Child, 11 Medical and Health Sciences, RISK, 11832 Microbiology and virology, Antiviral Agents/therapeutic use, OUTCOMES, COMPLICATIONS, biology, Neuraminidase inhibitor, Enzyme inhibitors, Middle Aged, Antivirals, antiviral, 3. Good health, Anti-Bacterial Agents, Infectious Diseases, Treatment Outcome, Meta-analysis, Cohort, Viruses, Enzyme Inhibitors/pharmacology/therapeutic use, Female, Pandemic influenza, Adult, medicine.medical_specialty, Adolescent, medicine.drug_class, 030106 microbiology, IPD meta-analysis, Neuraminidase inhibitors, antivirals, length of stay, pandemic influenza, Neuraminidase, Adrenal Cortex Hormones/therapeutic use, Microbiology, Antiviral Agents, PRIDE Consortium Investigators, Grip, 03 medical and health sciences, Major Articles and Brief Reports, Young Adult, Pharmacotherapy, Internal medicine, Influenza, Human, medicine, Humans, COHORT, Pandemics, ddc:613, Aged, Neuraminidase inhibitors, business.industry, CLINICAL-FEATURES, ADULTS, 06 Biological Sciences, Influenza, Human/drug therapy/epidemiology, Length of Stay, Confidence interval, Influenza, Editor's Choice, Anti-Bacterial Agents/therapeutic use, Inhibidors enzimàtics, 3121 General medicine, internal medicine and other clinical medicine, biology.protein, business, RESISTANCE
Abstract

Background The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. Methods We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of, We found that neuraminidase inhibitor (NAI) treatment initiated on hospital admission to patients with clinically diagnosed or laboratory-confirmed A(H1N1)pdm09 virus infection was associated with a reduction in hospital length of stay when compared to later or no NAI treatment.

Published
2018

50. Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children.

Author

Libster, Romina, Esteban, Ignacio, Bianchi, Alejandra, Grimaldi, Luciano Alva, Dueñas, Karina, Sancillo, Andrea, Rodriguez, Andrea, Ferrero, Fernando, Stein, Katherine, Acosta, Patricio L, Ferolla, Fausto M, Bergel, Eduardo, Caballero, Mauricio T, Polack, Fernando P, Network, for the INFANT Respiratory, Alva Grimaldi, Luciano, and INFANT Respiratory Network

Subjects
HUMAN metapneumovirus infection, LUNG diseases, JUVENILE diseases, DISEASE susceptibility, INFLUENZA, RESPIRATORY infections, RESPIRATORY syncytial virus, RNA virus infections, RESEARCH, ASTHMA, LUNGS, RESEARCH methodology, EVALUATION research, COMPARATIVE studies, RNA viruses, DISEASE complications
Abstract

Background: Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, suggesting the degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that hMPV may preferentially affect asthmatic subjects.Methods: In a population-based surveillance study in children aged <2 years admitted for severe LRTI in Argentina, nasopharyngeal aspirates were tested by RT-PCR for hMPV, RSV, influenza A, and human rhinovirus.Results: Of 3947 children, 383 (10%) were infected with hMPV. The hospitalization rate for hMPV LRTI was 2.26 per 1000 children (95% confidence interval [CI], 2.04-2.49). Thirty-nine (10.2%) patients infected with hMPV experienced life-threatening disease (LTD; 0.23 per 1000 children; 95% CI, .16-.31/1000), and 2 died (mortality rate 0.024 per 1000; 95% CI, .003-.086). In hMPV-infected children birth to an asthmatic mother was an increased risk for LTD (odds ratio, 4.72; 95% CI, 1.39-16.01). We observed a specific interaction between maternal asthma and hMPV infection affecting risk for LTD.Conclusions: Maternal asthma increases the risk for LTD in children <2 years old hospitalized for severe hMPV LRTI. [ABSTRACT FROM AUTHOR]

Published
2021
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