3,082 results on '"Libra, A."'
Search Results
2. Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis
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Simona D’Aprile, Simona Denaro, Alessandro Lavoro, Saverio Candido, Sebastiano Giallongo, Filippo Torrisi, Lucia Salvatorelli, Giacomo Lazzarino, Angela Maria Amorini, Giuseppe Lazzarino, Gaetano Magro, Daniele Tibullo, Massimo Libra, Cesarina Giallongo, Nunzio Vicario, and Rosalba Parenti
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Glioblastoma ,Ferroptosis ,Iron overload ,Erastin ,Proneural subtype ,Mesenchymal subtype ,Medicine ,Science - Abstract
Abstract Glioblastoma (GBM) represents an aggressive brain tumor, characterized by intra- and inter-tumoral heterogeneity and therapy resistance, leading to unfavourable prognosis. An increasing number of studies pays attention on the regulation of ferroptosis, an iron-dependent cell death, as a strategy to reverse drug resistance in cancer. However, the debate on whether this strategy may have important implications for the treatment of GBM is still ongoing. In the present study, we used ferric ammonium citrate and erastin to evaluate ferroptosis induction effects on two human GBM cell lines, U-251 MG, with proneural characteristics, and T98-G, with a mesenchymal profile. The response to ferroptosis induction was markedly different between cell lines, indeed T98-G cells showed an enhanced antioxidant defence, with increased glutathione levels, as compared to U-251 MG cells. Moreover, using bioinformatic approaches and analysing publicly available datasets from patients’ biopsies, we found that GBM with a mesenchymal phenotype showed an up-regulation of several genes involved in antioxidant mechanisms as compared to proneural subtype. Thus, our results suggest that GBM subtypes differently respond to ferroptosis induction, emphasizing the significance of further molecular studies on GBM to better discriminate between various tumor subtypes and progressively move towards personalized therapy.
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- 2024
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3. Towards a high-quality fertilizer based on algae residues treated via hydrothermal carbonization. Trends on how process parameters influence inorganics
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Daniela Moloeznik Paniagua, Lina Maja Marie Krenz, Judy A. Libra, Nathalie Korf, and Vera Susanne Rotter
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Hydrochar ,Hydrothermal carbonization ,Distribution of elements ,Limit values ,Quality assessment ,Soil application ,Environmental sciences ,GE1-350 ,Agriculture - Abstract
Abstract The use of beach-cast macroalgae as a fertilizer (F) or soil amendment (SA) is coming back into focus, due to its highly efficient transformation of CO2, nutrients, salts and minerals from its aqueous surroundings into biomass. This research studied the hydrothermal carbonization (HTC) of Fucus vesiculosus macroalgae to hydrochar and evaluated its feasibility for use in soil applications. F. vesiculosus was submitted to HTC following a full factorial design of experiments with three HTC process parameters varied to assess their impact on the hydrochars: temperature (T: 160, 190, 220 °C), solid content (%So: 20, 35%), and process water recirculation (PWrec: yes and no). In general, F. vesiculosus and its hydrochars were rich in nutrients, but also contained regulated heavy metals. Investigation of the partitioning behavior of inorganic elements between the hydrochars and process water showed that heavy metals like Cr, Pb, Co and Cu tended to accumulate in the hydrochar, unaffected by HTC conditions. Nutrients such as P, N, B, and Mn were primarily found in the hydrochar and could be partially influenced to transfer to process water by changing %So and T. The correlation between the mass fractions of 22 elements in the hydrochar and HTC process parameters was studied. T was the most influential parameter, showing a significant positive correlation for eleven elements. %So and PWrec showed inconsistent effects on different elements. When process water was recirculated, some elements decreased (Ca, Cd, Fe) while others increased (K, Na, B, N) in the hydrochar. Assessment against various regulations and standards for F and SA revealed that F. vesiculosus complied with Cd limit values for most rules including the EURF and B, and was regulated only in the RAL for SA, over the limit value. In contrast, the limit value of Cd for both F and SA applications was surpassed in the 13 hydrochars. The contents of N, P, K, S, and Na in the feedstock and hydrochars complied with European F and SA rules, while they were too high for German rules on SA. The other limits for F rules were achieved (under certain HTC process parameters) except for P (lower than the requirements in F for F. vesiculosus and its hydrochars). Graphical Abstract
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- 2024
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4. Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis
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D’Aprile, Simona, Denaro, Simona, Lavoro, Alessandro, Candido, Saverio, Giallongo, Sebastiano, Torrisi, Filippo, Salvatorelli, Lucia, Lazzarino, Giacomo, Amorini, Angela Maria, Lazzarino, Giuseppe, Magro, Gaetano, Tibullo, Daniele, Libra, Massimo, Giallongo, Cesarina, Vicario, Nunzio, and Parenti, Rosalba
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- 2024
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5. Towards a high-quality fertilizer based on algae residues treated via hydrothermal carbonization. Trends on how process parameters influence inorganics
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Moloeznik Paniagua, Daniela, Krenz, Lina Maja Marie, Libra, Judy A., Korf, Nathalie, and Rotter, Vera Susanne
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- 2024
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6. Hydrochar stability: understanding the role of moisture, time and temperature in its physiochemical changes
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Marzban, Nader, Libra, Judy A., Ro, Kyoung S., Moloeznik Paniagua, Daniela, Rotter, Vera Susanne, Sturm, Barbara, and Filonenko, Svitlana
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- 2024
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7. Maximizing the value of liquid products and minimizing carbon loss in hydrothermal processing of biomass: an evolution from carbonization to humification
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Nader Marzban, Judy A. Libra, Vera Susanne Rotter, Christiane Herrmann, Kyoung S. Ro, Svitlana Filonenko, Thomas Hoffmann, and Markus Antonietti
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Hydrothermal carbonization ,Hydrothermal humification ,Artificial humic acids ,Aromatic compounds ,Anaerobic digestion ,Environmental sciences ,GE1-350 ,Agriculture - Abstract
Abstract Hydrothermal carbonization (HTC) converts wet biomass into hydrochar and a process liquid, but aromatic compounds in the products have been reported as a roadblock for soil applications as they can inhibit germination, plant growth, and soil microbial activity. Here, we compared HTC and hydrothermal humification (HTH) of cow manure digestate while varying the initial alkaline content by adding KOH. HTH converted 37.5 wt% of the feedstock to artificial humic acids (A-HAs) found in both solid and liquid, twice that of HTC. HTH reduced phenolic and furanic aromatic compounds by over 70% in solids and 90% in liquids. The A-HAs in HTH resemble natural humic acids (N-HA), based on FTIR, UV–vis spectra, and CHN and XRD analysis. The HTH liquid possesses 60% higher total organic carbon (TOC) than HTC. Although one-third of TOC can be precipitated as A-HA, a high TOC concentration remains in the liquid, which is shown to be mainly organic acids. Therefore, we also evaluated the HTC and HTH liquids for anaerobic biomethane production, and found that compared to the original cow manure digestate, the HTH liquids increased methane yield by 110.3 to 158.6%, a significant enhancement relative to the 17.2% increase seen with HTC liquid. The strong reduction in organic acids during biogas production from HTH liquid indicates the potential for converting soluble byproducts into methane, while maintaining high A-HAs levels in the solid product. Graphical Abstract
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- 2024
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8. Hydrochar stability: understanding the role of moisture, time and temperature in its physiochemical changes
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Nader Marzban, Judy A. Libra, Kyoung S. Ro, Daniela Moloeznik Paniagua, Vera Susanne Rotter, Barbara Sturm, and Svitlana Filonenko
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Hydrochar ,Stability ,Organic compounds ,Inorganic compounds ,Storage ,Application ,Environmental sciences ,GE1-350 ,Agriculture - Abstract
Abstract Limited information is available about potential physicochemical changes that can occur in hydrochar post-production, e.g. during drying and storage. Understanding these changes is crucial not just for shaping future research plans, but also for future practical applications. Here we studied the effect of moisture (69.2% and 2.4%) and three storage temperatures (− 18, 4, and 20 °C) over a year on selected organic and inorganic compounds in hydrochar produced from the Hydrothermal carbonization (HTC) of digested cow manure. Comparison of the control wet hydrochars (WHs) and dry hydrochars (DHs) showed changes in organic compound composition due to drying. Overall, the total amount of the selected organic compounds was notably greater in WH (15.2 g kg−1 DM) compared to DH (11.8 g kg−1 DM), with variations observed in individual compound concentrations. Drying, however, had no significant influence on the identified inorganic compounds. Storage caused significant changes in both WH and DH, particularly in organic compounds after 12 weeks. Sugars (2–sevenfold), acids (36–371%), and aromatics (58–120%) in stored samples at week 52 were significantly higher than their control values. Changes in the inorganic elements (e.g., Co, K, Mg, Mn, P, S, Sr, and Zn) occurred faster in WH, with significant differences starting from week 1 compared to their control values, while DH showed fewer changes. Based on these changes in both organic and inorganic content, we recommend the optimal storage conditions for future HTC studies to preserve hydrochar properties. Finally, we discussed potential applications for stored hydrochars, with DH showing greater stability, especially at − 18 °C, making it suitable for various applications. Graphical Abstract
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- 2024
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9. Evaluation of Patient and Physician Satisfaction With the Zift eLevatIon of Facial Tissue Clinical Study (LIFT)
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Libra Medical
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- 2023
10. ¿Cuánto pagan los hogares en América Latina por los servicios de agua y saneamiento?
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López-Ruiz, Samara, primary, Cunial, Santiago, additional, Libra, Jesse Madden, additional, Naspolini, Giovanna, additional, and Pérez Urdiales, María, additional
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- 2024
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11. FS 2.1: 2023 Expansion of the OLAS Household Survey Data Set
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Libra, Jesse Madden, primary and Baquero, María Alejandra, additional
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- 2024
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12. Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Airway Stenosis
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Libra Medical
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- 2023
13. Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain
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Luca Falzone, Alessandro Lavoro, Saverio Candido, Mario Salmeri, Antonino Zanghì, and Massimo Libra
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Gut microbiota ,Probiotics ,Postbiotics ,probiotic safety ,Escherichia coli Nissle 1917 ,EcN ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Recently, the mounting integration of probiotics into human health strategies has gathered considerable attention. Although the benefits of probiotics have been widely recognized in patients with gastrointestinal disorders, immune system modulation, and chronic-degenerative diseases, there is a growing need to evaluate their potential risks. In this context, new concerns have arisen regarding the safety of probiotics as some strains may have adverse effects in humans. Among these strains, Escherichia coli Nissle 1917 (EcN) exhibited traits of concern due to a pathogenic locus in its genome that produces potentially genotoxic metabolites. As the use of probiotics for therapeutic purposes is increasing, the effects of potentially harmful probiotics must be carefully evaluated. To this end, in this narrative review article, we reported the findings of the most relevant in vitro and in vivo studies investigating the expanding applications of probiotics and their impact on human well-being addressing concerns arising from the presence of antibiotic resistance and pathogenic elements, with a focus on the polyketide synthase (pks) pathogenic island of EcN. In this context, the literature data here discussed encourages a thorough profiling of probiotics to identify potential harmful elements as done for EcN where potential genotoxic effects of colibactin, a secondary metabolite, were observed. Specifically, while some studies suggest EcN is safe for gastrointestinal health, conflicting findings highlight the need for further research to clarify its safety and optimize its use in therapy. Overall, the data here presented suggest that a comprehensive assessment of the evolving landscape of probiotics is essential to make evidence-based decisions and ensure their correct use in humans.
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- 2024
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14. Neurotronic Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities (NECTAR)
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Libra Medical
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- 2023
15. Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities (NECTAR IV)
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Libra Medical
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- 2023
16. Arterial Ablation for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities (NECTAR III)
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Libra Medical
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- 2023
17. Highlights on Future Treatments of IPF: Clues and Pitfalls
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Alessandro Libra, Enrico Sciacca, Giuseppe Muscato, Gianluca Sambataro, Lucia Spicuzza, and Carlo Vancheri
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idiopathic pulmonary fibrosis ,IPF ,pathogenesis ,molecular mechanism ,therapy ,clinical trials ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by irreversible scarring of lung tissue, leading to death. Despite recent advancements in understanding its pathophysiology, IPF remains elusive, and therapeutic options are limited and non-curative. This review aims to synthesize the latest research developments, focusing on the molecular mechanisms driving the disease and on the related emerging treatments. Unfortunately, several phase 2 studies showing promising preliminary results did not meet the primary endpoints in the subsequent phase 3, underlying the complexity of the disease and the need for new integrated endpoints. IPF remains a challenging condition with a complex interplay of genetic, epigenetic, and pathophysiological factors. Ongoing research into the molecular keystones of IPF is critical for the development of targeted therapies that could potentially stop the progression of the disease. Future directions include personalized medicine approaches, artificial intelligence integration, growth in genetic insights, and novel drug targets.
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- 2024
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18. Baseline Association between Healthy Eating Index-2015 and Health-Related Quality of Life in Breast Cancer Patients Enrolled in a Randomized Trial
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Giuseppe Porciello, Sergio Coluccia, Sara Vitale, Elvira Palumbo, Assunta Luongo, Maria Grimaldi, Rosa Pica, Melania Prete, Ilaria Calabrese, Serena Cubisino, Concetta Montagnese, Luca Falzone, Valentina Martinuzzo, Luigina Poletto, Emanuela Rotondo, Piergiacomo Di Gennaro, Michelino De Laurentiis, Massimiliano D’Aiuto, Massimo Rinaldo, Guglielmo Thomas, Francesco Messina, Francesca Catalano, Francesco Ferraù, Vincenzo Montesarchio, Diego Serraino, Anna Crispo, Massimo Libra, Egidio Celentano, Livia S. A. Augustin, and the DEDiCa Study Group
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healthy eating index ,diet quality ,health-related quality of life ,breast cancer survivors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Health-related quality of life (HRQoL) represents one of the most concerning aspects for cancer patients. The Healthy Eating Index (HEI) is an a priori diet quality index directly associated with health outcomes and HRQoL in cancer survivors in North American populations. We evaluated, in a Mediterranean population, the baseline associations between HEI-2015 and HRQoL in 492 women with breast cancer recruited in a DEDiCa lifestyle trial. Dietary data were obtained from 7-day food records; HRQoL was assessed through the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C30) and the C30 Summary Score (SumSc). Analysis of variance and multivariable linear and log-gamma regression models were performed. Mean and standard deviation for HEI-2015 score was 68.8 ± 11.2; SumSc was 81.5 ± 12.9. Women with lower HEI-2015 score had higher BMI, were more frequently exposed to tobacco smoke and had fewer years of education. Patients with a HEI-2015 score greater than 68.7 (median value) showed a significant increase in SumSc of 4% (p = 0.02). HEI-2015 components also associated with SumSc were beans and greens (β = 1.04; p = 0.02). Weak associations were found for total vegetables and saturated fats. Higher diet quality in breast cancer survivors was associated with higher overall HRQoL in this cross-sectional analysis.
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- 2024
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19. FS 3.5: Water Footprint Estimation in Latin America
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Naspoli, Giovanna, primary and Libra, Jesse Madden, additional
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- 2024
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20. Water Footprint Estimation in Latin America
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Ferrazzo, Giovanna, primary, Libra, Jesse Madden, additional, and Pérez Urdiales, María, additional
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- 2024
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21. FS 1.2: Sanitation Access in Latin America and the Caribbean: Definitions and Data
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Libra, Jesse Madden, primary and Baquero, María Alejandra, additional
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- 2024
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22. Evaluation of the FreedomFlow™ Orbital Atherectomy System to Treat Peripheral Artery Disease (FASTII)
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Libra Medical
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- 2022
23. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
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Vollset, Stein Emil, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abd Al Magied, Abdallah H A, Abd ElHafeez, Samar, Abdelkader, Atef, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Absalan, Abdorrahim, Abualruz, Hasan, Abubakar, Bilyaminu, Abukhadijah, Hana Jihad Jihad, Addolorato, Giovanni, Adekanmbi, Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adhikary, Ripon Kumar, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afrashteh, Fatemeh, Afzal, Muhammad Sohail, Afzal, Saira, Agbozo, Faith, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Shahzaib, Ahmed, Anisuddin, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Safoora, Ahmed, Syed Anees, Akinosoglou, Karolina, Akkaif, Mohammed Ahmed, Akrami, Ashley E, Akter, Ema, Al Awaidy, Salah, Al Hasan, Syed Mahfuz, Al Mosa, Amjad S, Al Ta'ani, Omar, Al Zaabi, Omar Ali Mohammed, Alahdab, Fares, Alajlani, Muaaz M, Al-Ajlouni, Yazan, Alalalmeh, Samer O, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alam, Zufishan, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, Aldhaleei, Wafa A, Aldridge, Robert W, Alemohammad, Seyedeh Yasaman, Alemu, Yihun Mulugeta, Al-Gheethi, Adel Ali Saeed, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Amjad, Ali, Iman, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Victor Ekoche, Ali, Waad, Al-Ibraheem, Akram, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Alla, François, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Alqutaibi, Ahmed Yaseen, Alrawashdeh, Ahmad, Alrousan, Sahel Majed, Al-Sabah, Salman Khalifah, Alsabri, Mohammed A, Altaany, Zaid, Al-Tammemi, Ala'a B., Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Hany, Alyahya, Mohammad Sharif, Alzoubi, Karem H, Al-Zyoud, Walid, Amani, Reza, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Andrews, Erick Adrian, Anil, Abhishek, Anil, Sneha, Anoushiravani, Amir, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Boluwatife Stephen, Anvari, Saeid, Anyasodor, Anayochukwu Edward, Appiah, Francis, Aquilano, Michele, Arab, Juan Pablo, Arabloo, Jalal, Arafa, Elshaimaa A, Arafat, Mosab, Aravkin, Aleksandr Y, Ardekani, Ali, Areda, Demelash, Aregawi, Brhane Berhe, Aremu, Abdulfatai, Ariffin, Hany, Arkew, Mesay, Armani, Keivan, Artamonov, Anton A, Arumugam, Ashokan, Asghari-Jafarabadi, Mohammad, Ashbaugh, Charlie, Astell-Burt, Thomas, Athari, Seyyed Shamsadin, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Aujayeb, Avinash, Ausloos, Marcel, Awad, Hamzeh, Awotidebe, Adedapo Wasiu, Ayatollahi, Haleh, Ayuso-Mateos, Jose L, Azadnajafabad, Sina, Azeez, Fahad Khan, Azevedo, Rui M S, Badar, Muhammad, Baghdadi, Soroush, Bagheri, Mahboube, Bagheri, Nasser, Bai, Ruhai, Baker, Jennifer L, Bako, Abdulaziz T, Balakrishnan, Senthilkumar, Balcha, Wondu Feyisa, Baltatu, Ovidiu Constantin, Barchitta, Martina, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barqawi, Hiba Jawdat, Barteit, Sandra, Basiru, Afisu, Basso, João Diogo, Bastan, Mohammad-Mahdi, Basu, Sanjay, Bauckneht, Matteo, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Behnoush, Amir Hossein, Behzadi, Payam, Beiranvand, Maryam, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bemanalizadeh, Maryam, Bensenor, Isabela M, Benzian, Habib, Beran, Azizullah, Berezvai, Zombor, Bernstein, Robert S, Bettencourt, Paulo J G, Beyene, Kebede A, Beyene, Melak Gedamu, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Dinesh, Bharadwaj, Ravi, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhattacharjee, Natalia V, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhuiyan, Mohiuddin Ahmed, Bisignano, Catherine, Biswas, Bijit, Bjørge, Tone, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bonakdar Hashemi, Milad, Bora Basara, Berrak, Borhany, Hamed, Bosoka, Samuel Adolf, Botero Carvajal, Alejandro, Bouaoud, Souad, Boufous, Soufiane, Boxe, Christopher, Boyko, Edward J, Brady, Oliver J, Braithwaite, Dejana, Brauer, Michael, Brazo-Sayavera, Javier, Brenner, Hermann, Brown, Colin Stewart, Browne, Annie J, Brugha, Traolach, Bryazka, Dana, Bulamu, Norma B, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Çakmak Barsbay, Mehtap, Calina, Daniela, Campos, Luciana Aparecida, Cao, Shujin, Capodici, Angelo, Cárdenas, Rosario, Carreras, Giulia, Carugno, Andrea, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castelpietra, Giulio, Cattaruzza, Maria Sofia, Caye, Arthur, Cegolon, Luca, Cembranel, Francieli, Cenko, Edina, Cerin, Ester, Chadban, Steven J, Chadwick, Joshua, Chakraborty, Chiranjib, Chakraborty, Sandip, Chalek, Julian, Chan, Jeffrey Shi Kai, Chandika, Rama Mohan, Chandy, Sara, Charan, Jaykaran, Chaudhary, Anis Ahmad, Chaurasia, Akhilanand, Chen, An-Tian, Chen, Haowei, Chen, Meng Xuan, Chen, Simiao, Cherbuin, Nicolas, Chi, Gerald, Chichagi, Fatemeh, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, Daniel Youngwhan, Cho, William C S, Choi, Dong-Woo, Chong, Bryan, Chong, Chean Lin, Chopra, Hitesh, Chu, Dinh-Toi, Chung, Eric, Chutiyami, Muhammad, Clayton, Justin T, Cogen, Rebecca M, Cohen, Aaron J, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Connolly, Jon T, Cooper, Ezra E K, Cortese, Samuele, Cruz-Martins, Natália, da Silva, Alanna Gomes, Dadras, Omid, Dai, Xiaochen, Dai, Zhaoli, Dalton, Bronte E, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Das, Jai K, Das, Saswati, Das, Subasish, Dash, Nihar Ranjan, Davletov, Kairat, De la Hoz, Fernando Pio, De Leo, Diego, Debopadhaya, Shayom, Delgado-Enciso, Ivan, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Desai, Hardik Dineshbhai, Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman, Dhama, Kuldeep, Dhane, Amol S, Dhingra, Sameer, Dias da Silva, Diana, Diaz, Daniel, Diaz, Luis Antonio, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dodangeh, Masoud, Dodangeh, Milad, Doegah, Phidelia Theresa, Dohare, Sushil, Dong, Wanyue, D'Oria, Mario, Doshi, Rajkumar, Dowou, Robert Kokou, Dsouza, Haneil Larson, Dsouza, Viola, Dube, John, Dumith, Samuel C, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dushpanova, Anar, Dutta, Sulagna, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Eboreime, Ejemai, Ebrahimi, Alireza, Ebrahimi Kalan, Mohammad, Edinur, Hisham Atan, Efendi, Ferry, Eikemo, Terje Andreas, Eini, Ebrahim, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Sayed, Iman, Elamin, Osman, Elemam, Noha Mousaad, ElGohary, Ghada Metwally Tawfik, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, Elmoselhi, Adel B, Elshaer, Mohammed, Elsohaby, Ibrahim, Eltahir, Mohd. 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24. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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Schumacher, Austin E, Kyu, Hmwe Hmwe, Aali, Amirali, Abbafati, Cristiana, Abbas, Jaffar, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abdurehman, Ame Mehadi, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abhilash, E S, Abiodun, Olugbenga Olusola, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abrigo, Michael R M, Abtahi, Dariush, Abu Rumeileh, Samir, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Acuna, Juan Manuel, Adair, Tim, Addo, Isaac Yeboah, Adebayo, Oladimeji M, Adegboye, Oyelola A, Adekanmbi, Victor, Aden, Bashir, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adeyeoluwa, Temitayo Esther, Adeyomoye, Olorunsola Israel, Adha, Rishan, Adibi, Amin, Adikusuma, Wirawan, Adnani, Qorinah 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Dora, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simões, Jorge Piano, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Aditya, Singh, Ambrish, Singh, Balbir Bagicha, Singh, Baljinder, Singh, Mahendra, Singh, Mayank, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Slepak, Erica Leigh N, Sohrabi, Hanye, Soleimani, Hamidreza, Soliman, Sameh S M, Solmi, Marco, Solomon, Yonatan, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Sreeramareddy, Chandrashekhar T, Starnes, Joseph R, Starodubov, Vladimir I, Starodubova, Antonina V, Stefan, Simona Cătălina, Stein, Dan J, Steinbeis, Fridolin, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Stranges, Saverio, Stroumpoulis, Konstantinos, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Sunkersing, David, Susanty, Sri, Swain, Chandan Kumar, Sykes, Bryan L, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabb, Karen M, Tabish, Mohammad, Taborda-Barata, Luis M, Tabuchi, Takahiro, Tadesse, Birkneh Tilahun, Taheri, Amirmasoud, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Tajbakhsh, Ardeshir, Talaat, Iman M, Talukder, Ashis, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tang, Hong K, Tat, Nathan Y, Tat, Vivian Y, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tebeje, Tsion Mulat, Tefera, Yibekal Manaye, Teimoori, Mojtaba, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesfaye, Solomon Hailemariam, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapa, Rajshree, Thapar, Rekha, Thomas, Nihal, Thrift, Amanda G, Thum, Chern Choong Chern, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tiruye, Tenaw Yimer, Tohidast, Seyed Abolfazl, Tonelli, Marcello, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tram, Khai Hoan, Tran, Nghia Minh, Trico, Domenico, Trihandini, Indang, Tromans, Samuel Joseph, Truong, Vien T, Truyen, Thien Tan Tri Tai, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Ubah, Chukwudi S, Udoakang, Aniefiok John, Udoh, Arit, Ulhaq, Inam, Ullah, Saeed, Ullah, Sana, Umair, Muhammad, Umar, Tungki Pratama, Umeokonkwo, Chukwuma David, Umesh, Anushri, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Urso, Daniele, Vacante, Marco, Vahdani, Amir Mohammad, Vaithinathan, Asokan Govindaraj, Valadan Tahbaz, Sahel, Valizadeh, Rohollah, Van den Eynde, Jef, Varavikova, Elena, Varga, Orsolya, Varma, Siddhartha Alluri, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Veerman, Lennert J, Venketasubramanian, Narayanaswamy, Venugopal, Deneshkumar, Verghese, Nicholas Alexander, Verma, Madhur, Verma, Pratibha, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Vieira, Rafael José, Villafañe, Jorge Hugo, Villani, Leonardo, Villanueva, Gabriela Ines, Villeneuve, Paul J, Violante, Francesco S, Visontay, Rachel, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Volovat, Simona Ruxandra, Volovici, Victor, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wado, Yohannes Dibaba, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Denny, Wang, Fang, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Ward, Paul, Watson, Stefanie, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weiss, Daniel J, Weldemariam, Abrha Hailay, Wells, Katherine M, Wen, Yi Feng, Werdecker, Andrea, Westerman, Ronny, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wijeratne, Tissa, Wilson, Shadrach, Wojewodzic, Marcin W, Wool, Eve E, Woolf, Anthony D, Wu, Dongze, Wulandari, Ratna Dwi, Xiao, Hong, Xu, Bin, Xu, Xiaoyue, Yadav, Lalit, Yaghoubi, Sajad, Yang, Lin, Yano, Yuichiro, Yao, Yao, Ye, Pengpeng, Yesera, Gesila Endashaw, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zahedi, Mohammad, Zahid, Muhammad Nauman, Zahir, Mazyar, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Burhan Abdullah, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zandi, Milad, Zandieh, Ghazal G Z, Zanghì, Aurora, Zare, Iman, Zastrozhin, Mikhail Sergeevich, Zeariya, Mohammed G M, Zeng, Youjie, Zhai, Chunxia, Zhang, Chen, Zhang, Haijun, Zhang, Hongwei, Zhang, Yunquan, Zhang, Zhaofeng, Zhang, Zhenyu, Zhao, Hanqing, Zhao, Yang, Zhao, Yong, Zheng, Peng, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Zhaohua, Ziaeefar, Pardis, Zielińska, Magdalena, Zou, Zhiyong, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Lim, Stephen S, and Murray, Christopher J L
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- 2024
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25. Household water bill perception in Brazil
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Pérez-Urdiales, María, Libra, Jesse M., Machado, Kleber B., Serebrisky, Tomás, and Sosa, Ben Solís
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- 2024
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26. Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model
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Cammarata, Francesco Paolo, Torrisi, Filippo, Vicario, Nunzio, Bravatà, Valentina, Stefano, Alessandro, Salvatorelli, Lucia, D’Aprile, Simona, Giustetto, Pierangela, Forte, Giusi Irma, Minafra, Luigi, Calvaruso, Marco, Richiusa, Selene, Cirrone, Giuseppe Antonio Pablo, Petringa, Giada, Broggi, Giuseppe, Cosentino, Sebastiano, Scopelliti, Fabrizio, Magro, Gaetano, Porro, Danilo, Libra, Massimo, Ippolito, Massimo, Russo, Giorgio, Parenti, Rosalba, and Cuttone, Giacomo
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- 2023
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27. Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
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Salemi, Rossella, Vivarelli, Silvia, Ricci, Daria, Scillato, Marina, Santagati, Maria, Gattuso, Giuseppe, Falzone, Luca, and Libra, Massimo
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- 2023
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28. Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy
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A. Fassio, G. Porciello, G. Carioli, E. Palumbo, S. Vitale, A. Luongo, C. Montagnese, M. Prete, M. Grimaldi, R. Pica, E. Rotondo, L. Falzone, I. Calabrese, A. Minopoli, B. Grilli, M. Cuomo, P.C. Fiorillo, C. Evangelista, E. Cavalcanti, M. De Laurentiis, D. Cianniello, C. Pacilio, M. Pinto, G. Thomas, M. Rinaldo, M. D’Aiuto, D. Serraino, S. Massarut, A. Steffan, F. Ferraù, R. Rossello, F. Messina, F. Catalano, G. Adami, F. Bertoldo, M. Libra, A. Crispo, E. Celentano, C. La Vecchia, L.S.A. Augustin, and D. Gatti
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Vitamin D ,cholecalciferol ,supplementation ,breast cancer ,chemotherapy ,obesity ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Objective. To report cross-sectionally serum levels of 25-hydroxyvitamin D [25(OH)D] in women living in Italy within 12 months from breast cancer (BC) diagnosis. Methods. Baseline data were obtained from 394 women diagnosed with primary BC, enrolled from 2016 to 2019 in a lifestyle trial conducted in Italy. Subjects’ characteristics were compared between two 25(OH)D concentrations (hypovitaminosis D30, and ≥35 versus
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- 2024
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29. High intraspecific variability and previous experience affect polyphenol metabolism in polyphagous Lymantria mathura caterpillars
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Martin Volf, Alyssa M. Fontanilla, Suvi Vanhakylä, Tomokazu Abe, Martin Libra, Ryosuke Kogo, Roll Lilip, Naoto Kamata, Masashi Murakami, Vojtech Novotny, Juha‐Pekka Salminen, and Simon T. Segar
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chemical defenses ,detoxification ,flavonoids ,frass ,habituation ,tannins ,Ecology ,QH540-549.5 - Abstract
Abstract Polyphagous insect herbivores feed on multiple host‐plant species and face a highly variable chemical landscape. Comparative studies of polyphagous herbivore metabolism across a range of plants is an ideal approach for exploring how intra‐ and interspecific chemical variation shapes species interactions. We used polyphagous caterpillars of Lymantria mathura (Erebidae, Lepidoptera) to explore mechanisms that may contribute to its ability to feed on various hosts. We focused on intraspecific variation in polyphenol metabolism, the fates of individual polyphenols, and the role of previous feeding experience on polyphenol metabolism and leaf consumption. We collected the caterpillars from Acer amoenum (Sapindaceae), Carpinus cordata (Betulaceae), and Quercus crispula (Fagaceae). We first fed the larvae with the leaves of their original host and characterized the polyphenol profiles in leaves and frass. We then transferred a subset of larvae to a different host species and quantified how host shifting affected their leaf consumption and polyphenol metabolism. There was high intraspecific variation in frass composition, even among caterpillars fed with one host. While polyphenols had various fates when ingested by the caterpillars, most of them were passively excreted. When we transferred the caterpillars to a new host, their previous experience influenced how they metabolized polyphenols. The one‐host larvae metabolized a larger quantity of ingested polyphenols than two‐host caterpillars. Some of these metabolites could have been sequestered, others were probably activated in the gut. One‐host caterpillars retained more of the ingested leaf biomass than transferred caterpillars. The pronounced intraspecific variation in polyphenol metabolism, an ability to excrete ingested metabolites and potential dietary habituation are factors that may contribute to the ability of L. mathura to feed across multiple hosts. Further comparative studies can help identify if these mechanisms are related to differential host‐choice and response to host‐plant traits in specialist and generalist insect herbivores.
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- 2024
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30. Epidemiological and clinical characteristics of nontuberculous mycobacterial infections: A retrospective female cohort study in an Italian population
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Andrea Marino, Michele Salvatore Paternò Raddusa, Maria Gussio, Giuseppe Sangiorgio, Vittoria Moscatt, Alessandro Libra, Serena Spampinato, Dafne Bongiorno, Bruno Cacopardo, and Giuseppe Nunnari
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Nontuberculous mycobacteria ,NTM infections ,Mycobacterium intracellulare ,Mycobacterium chelonae ,Mycobacterial pulmonary infections ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: This study aims to assess the characteristics and treatment outcomes of patients diagnosed with non-tuberculous mycobacteria (NTM) diseases at the Infectious Diseases Unit of ARNAS Garibaldi Hospital in Catania, Italy, focusing on demographics, clinical features, and treatment effectiveness. Methods: We conducted a retrospective observational study of 10 patients diagnosed with NTM diseases between 2019 and 2021. Data was collected from electronic medical records, including demographic information, comorbidities, treatment modalities, and outcomes. The study utilized descriptive statistics to analyze continuous and categorical variables. Treatment regimens were based on individual patient needs, incorporating a combination of antibiotics. Results: The median age of the patients was 55.44 years, all female, predominantly suffering from pulmonary NTM diseases. Mycobacterium intracellulare was the most common pathogen. Common comorbidities included COPD, bronchiectasis, GERD, and hypovitaminosis D. Patients showed symptoms like fever, cough, and asthenia. The treatment regimens were diverse, with macrolides, rifampicin, and ethambutol forming the core. Adverse effects were noted in 40 % of patients, including gastrointestinal and neurological disorders. All patients achieved microbiological cure, with 60 % showing clinical improvement and 36 % radiological improvement. Conclusion: The study highlights the complexity of diagnosing and treating NTM diseases, emphasizing the need for personalized treatment plans and vigilant monitoring of adverse effects. Despite achieving microbiological cure, challenges remain in achieving complete clinical and radiological resolution. Further research is needed to enhance the understanding and management of NTM diseases, particularly in diverse populations.
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- 2024
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31. The Evidence of Malay Ethnicity in Sedanau and Its Surrounding, Natuna, 18–19 Century
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Inagurasi, Libra Hari, Sarjiyanto, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, and Hasyim, Muhammad, editor
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- 2023
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32. Towards Early Diagnosis of Mixed Connective Tissue Disease: Updated Perspectives
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Ferrara CA, La Rocca G, Ielo G, Libra A, and Sambataro G
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mixed connective tissue disease ,diagnosis ,raynaud’s phenomenon ,nailfold videocapillaroscopy ,anti-rnp ,inflammatory arthritis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Chiara Alfia Ferrara,1 Gaetano La Rocca,2 Giuseppe Ielo,1 Alessandro Libra,1 Gianluca Sambataro1 1Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-San Marco”, University of Catania, Catania, Italy; 2Department of Rheumatology, University of Pisa, Pisa, ItalyCorrespondence: Gianluca Sambataro, Regional Referral Center for Rare Lung Disease, University of Catania, via S. Sofia 68, Catania, 95123, Italy, Email dottorsambataro@gmail.comAbstract: Mixed Connective Tissue Disease (MCTD) is an autoimmune disease first described by Sharp et al in 1972, characterized by the presence of anti-Ribonucleoprotein antibodies directed against the U1 complex (anti-U1RNP). The condition shares clinical characteristics with Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis. Diagnosis is quite difficult due to its rarity, the lack of validated classification criteria, and its heterogeneous clinical presentation. While in the early stages its nuanced clinical features might lead to it being incorrectly classified as other Connective Tissue Diseases (CTDs) or even not recognized, in cases of longstanding disease its classification as a CTD is clear but challenging to discriminate from overlap syndromes. MCTD should be considered a distinct entity due to the presence of a specific genetic substrate and the presence of the high titer of a specific autoantibody, anti-U1RNP, present in all the commercial kits for Extractable Nuclear Antigens, and almost always associated with Antinuclear Antibody positivity with a coarse speckled pattern. Except for anti-U1RNP, no specific biomarkers are available to guide clinicians to a correct classification of MCTD, which is arrived at by the association of clinical, serological and instrumental evaluation. In the first stages, the disease is mainly characterized by Raynaud’s phenomenon, inflammatory arthritis, puffy fingers, myalgia and/or myositis, and rarely, trigeminal neuropathy. Longstanding disease is generally associated with the development of Pulmonary Hypertension and Interstitial Lung Disease, which are the two main causes of mortality in MCTD. The aim of this review is to summarize current knowledge on the early recognition of MCTD.Keywords: mixed connective tissue disease, diagnosis, Raynaud’s phenomenon, nailfold videocapillaroscopy, anti-RNP, inflammatory arthritis
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- 2023
33. Prostate Artery Embolization as Minimally Invasive Treatment for Benign Prostatic Hyperplasia: An Updated Systematic Review
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Corrado Ini’, Tiziana Vasile, Pietro Valerio Foti, Concetta Timpanaro, Davide Giuseppe Castiglione, Federica Libra, Daniele Falsaperla, Francesco Tiralongo, Francesco Giurazza, Cristina Mosconi, Emanuele David, Stefano Palmucci, Salvatore Lavalle, Massimo Venturini, and Antonio Basile
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benign prostatic hyperplasia (C12.100.500.565.500, C12.200.294.565.500) ,embolization ,therapeutic (E02.520.360, E02.926.500) ,transurethral resection of prostate (E04.950.774.860.625.750) ,Medicine - Abstract
Background/Objectives: Benign prostatic hyperplasia (BPH) has a significant impact on the quality of life of symptomatic patients. In patients manifesting lower urinary tract symptoms (LUTS), prostatic arterial embolization (PAE) has become a topic of interest in recent years. The purpose of this systematic review is to analyze and review techniques and clinical outcomes of patients who underwent endovascular treatment of BPH, with a special focus on the comparison of surgical and endovascular procedures. Methods: Through the major scientific databases, 1225 articles were selected from the initial research utilizing specific keywords and medical subject headings. Based on the inclusion and exclusion criteria established for selecting relevant studies for our purposes, the systematic analysis of the literature was conducted on a total of seven articles. Results: We collected data on 718 male patients (408 patients underwent PAE and 310 received TURP). The technical success rate varied from 86% to 100% for TAE and was 100% for TURP. During a 12-month follow-up period, both PAE and TURP were comparable on the reduction in IPSS and QoL questionnaire, while TURP showed significant improvements in Qmax and in the reduction in prostate volume. Length and cost of hospitalization were lower for PAE. Complication and adverse events rates were higher in the TURP group rather than in the PAE group (60.6% vs. 35.5%). Conclusions: Prostatic artery embolization represents an emerging minimally invasive procedure for BPH. According to previously released clinical studies, quality-of-life and urological symptom scores of the PAE group were comparable to those of the TURP group. Our research strengthens the evidence supporting the effectiveness and safety of PAE as a therapy for LUTS related to BPH.
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- 2024
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34. Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus
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Alessandro Lavoro, Giovanni Cultrera, Giuseppe Gattuso, Cinzia Lombardo, Luca Falzone, Candido Saverio, Massimo Libra, and Mario Salmeri
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oral microbiota ,oral lichen planus ,autoimmune disease ,oral dysbiosis ,oral diseases ,oral cavity ,Medicine - Abstract
Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease of the oral cavity with malignant potential affecting 1.01% of the worldwide population. The clinical patterns of this oral disorder, characterized by relapses and remissions of the lesions, appear on buccal, lingual, gingival, and labial mucosa causing a significant reduction in the quality of life. Currently, there are no specific treatments for this disease, and the available therapies with topical and systemic corticosteroids only reduce symptoms. Although the etiopathogenesis of this pathological condition has not been completely understood yet, several exogenous and endogenous risk factors have been proposed over the years. The present review article summarized the underlying mechanisms of action involved in the onset of OLP and the most well-known triggering factors. According to the current data, oral microbiota dysbiosis could represent a potential diagnostic biomarker for OLP. However, further studies should be undertaken to validate their use in clinical practice, as well as to provide a better understanding of mechanisms of action and develop novel effective intervention strategies against OLP.
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- 2024
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35. The Pattern and Progression of 'Usual' Interstitial Pneumonia with Autoimmune Features: Comparison with Patients with Classic Interstitial Pneumonia with Autoimmune Features and Idiopathic Pulmonary Fibrosis
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Alessandro Libra, Michele Colaci, Lucia Spicuzza, Giuliana Luca, Sefora Fischetti, Giorgio Pashalidis, Chiara Alfia Ferrara, Giuseppe Ielo, Domenico Sambataro, Giuliana La Rosa, Federica Libra, Stefano Palmucci, Carlo Vancheri, and Gianluca Sambataro
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interstitial pneumonia with autoimmune features ,idiopathic pulmonary fibrosis ,usual interstitial pneumonia ,connective tissue disease ,diagnosis ,Medicine - Abstract
Background: We proposed the term “UIPAF” to define patients with Usual Interstitial Pneumonia (UIP) associated with only one domain of the classification called “Interstitial Pneumonia with Autoimmune Features” (IPAF). The objective of this study was to evaluate the clinical presentation and prognosis of UIPAF patients, compared with two cohorts, composed of IPAF and idiopathic pulmonary fibrosis (IPF) patients, respectively. Methods: The patients were enrolled as IPAF, UIPAF, or IPF based on clinical, serological, and radiological data and evaluated by a multidisciplinary team. Results: We enrolled 110 patients with IPF, 69 UIPAF, and 123 IPAF subjects. UIPAF patients were similar to IPAF regarding autoimmune features, except for the prevalence of Rheumatoid Factor in UIPAF and anti-SSA in IPAF. A similar proportion of the two cohorts progressed toward a specific autoimmune disease (SAD), with differences in the kind of SAD developed. The real-life management and prognosis of UIPAF patients proved to be almost identical to IPF. Conclusions: UIPAF shared with IPAF similar autoimmune features, suggesting the opportunity to be considered IPAF, excluding the morphological domain by the classification. However, the real-life management and prognosis of UIPAF are similar to IPF. These data suggest a possible modification in the therapeutic management of UIPAF.
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- 2024
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36. Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: therapeutic implications
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Matthew Moghaddam, Silvia Vivarelli, Luca Falzone, Massimo Libra, and Benjamin Bonavida
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rkip ,pten ,cross-talks ,signaling ,bioinformatics ,resistance ,Internal medicine ,RC31-1245 - Abstract
The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell resistance to cytotoxic drugs/cells. Likewise, the tumor suppressor, phosphatase and tensin homolog (PTEN), which inhibits the phosphatidylinositol 3 kinase (PI3K)/AKT pathway, is either mutated, underexpressed, or deleted in many cancers and shares with RKIP its anti-tumor properties and its regulation in resistance. The transcriptional and posttranscriptional regulations of RKIP and PTEN expressions and their roles in resistance were reviewed. The underlying mechanism of the interrelationship between the signaling expressions of RKIP and PTEN in cancer is not clear. Several pathways are regulated by RKIP and PTEN and the transcriptional and post-transcriptional regulations of RKIP and PTEN is significantly altered in cancers. In addition, RKIP and PTEN play a key role in the regulation of tumor cells response to chemotherapy and immunotherapy. In addition, molecular and bioinformatic data revealed crosstalk signaling networks that regulate the expressions of both RKIP and PTEN. These crosstalks involved the mitogen-activated protein kinase (MAPK)/PI3K pathways and the dysregulated nuclear factor-kappaB (NF-κB)/Snail/Yin Yang 1 (YY1)/RKIP/PTEN loop in many cancers. Furthermore, further bioinformatic analyses were performed to investigate the correlations (positive or negative) and the prognostic significance of the expressions of RKIP or PTEN in 31 different human cancers. These analyses were not uniform and only revealed that there was a positive correlation between the expression of RKIP and PTEN only in few cancers. These findings demonstrated the existence of signaling cross-talks between RKIP and PTEN and both regulate resistance. Targeting either RKIP or PTEN (alone or in combination with other therapies) may be sufficient to therapeutically inhibit tumor growth and reverse the tumor resistance to cytotoxic therapies.
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- 2023
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37. Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model
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Francesco Paolo Cammarata, Filippo Torrisi, Nunzio Vicario, Valentina Bravatà, Alessandro Stefano, Lucia Salvatorelli, Simona D’Aprile, Pierangela Giustetto, Giusi Irma Forte, Luigi Minafra, Marco Calvaruso, Selene Richiusa, Giuseppe Antonio Pablo Cirrone, Giada Petringa, Giuseppe Broggi, Sebastiano Cosentino, Fabrizio Scopelliti, Gaetano Magro, Danilo Porro, Massimo Libra, Massimo Ippolito, Giorgio Russo, Rosalba Parenti, and Giacomo Cuttone
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Proton boron capture therapy (PBCT) in a preclinical glioblastoma model exhibits increased therapeutic effectiveness with an increased cell death and mitophagy, supporting its use as a scalable strategy to treat glioblastoma.
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- 2023
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38. Prebiotics and the Risk of Upper Digestive Tract and Stomach Cancers: The PrebiotiCa Study
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Turati, Federica, Concina, Federica, Bertuccio, Paola, Fiori, Federica, Parpinel, Maria, Garavello, Werner, Crispo, Anna, Libra, Massimo, Negri, Eva, Serraino, Diego, and La Vecchia, Carlo
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- 2023
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39. Pendampingan Gerakan Religi Literasi dan Budaya di Surau Rumah Gadang
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Isnaini Isnaini, Libra Dui Putra, and Nadia Nadia
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anak surau ,literasi ,pendidikan karakter ,budaya minangkabau ,Social history and conditions. Social problems. Social reform ,HN1-995 ,Communities. Classes. Races ,HT51-1595 - Abstract
Perkembangan teknologi terutama smartphone mempengaruhi perilaku remaja hingga melakukan perilaku yang menyimpang. Berbagai upaya dilakukan untuk meghindari remaja dari dampak negatif penggunaan smartphone, salah satunya melalui surau. Surau merupakan pusat pendidikan bagi masyarakat Sumatera Barat yang sekarang sudah banyak berubah nama menjadi mushola.Namun ada satu surau yangterletak di kelurahan Gunung Sarik Kota Padang yaitu surau rumah gadang. Surau Rumah Gadang sudah berdiri sejak tahun 2015, namun kegiatan surau hanya sebatas kegiatan keagamaan seperti sholat dan mengaji yang dilakukan oleh orang yang sudah lanjut usia. Kegiatan pengabdian masyarakat ini menimbulkan berbagai kegiatan yang dilakukan oleh anak-anak dan remaja di surau. Kegiatan tersebut meliputi pembentukan kelompok anak surau, baca tulis Al Quran, Pelatihan Adzan, Pantun dan puisi islami serta pendampingan kesenian tradisonal Minangkabau. Hasil dari kegiatan ini adalah anak-anak sudah memiliki kegiatan rutin setiap hari minggu dan menjadikan surau sebagai pusat kegiatan.
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- 2023
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40. Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
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Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone, and Massimo Libra
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Lactobacillus rhamnosus GG ,LGG ,Cancer ,Adjuvant ,Combination therapies ,Medicine - Abstract
Abstract Background Gut microbiota modulation has been demonstrated to be effective in protecting patients against detrimental effects of anti-cancer therapies, as well as to improve the efficacy of certain anti-cancer treatments. Among the most characterized probiotics, Lactobacillus rhamnosus GG (LGG) is currently utilized in clinics to alleviate diarrhea, mucositis or intestinal damage which might be associated with several triggers, including Clostridium difficile infections, inflammatory gut diseases, antibiotic consumption, chemotherapy or radiation therapy. Here, we investigate whether LGG cell-free supernatant (LGG-SN) might exert anti-proliferative activity toward colon cancer and metastatic melanoma cells. Moreover, we assess the potential adjuvant effect of LGG-SN in combination with anti-cancer drugs. Methods LGG-SN alone or in combination with either 5-Fuorouracil and Irinotecan was used to treat human colon and human melanoma cancer cell lines. Dimethylimidazol-diphenyl tetrazolium bromide assay was employed to detect cellular viability. Trypan blue staining, anti-cleaved caspase-3 and anti-total versus anti-cleaved PARP western blots, and annexin V/propidium iodide flow cytometry analyses were used to assess cell death. Flow cytometry measurement of cellular DNA content (with propidium iodide staining) together with qPCR analysis of cyclins expression were used to assess cell cycle. Results We demonstrate that LGG-SN is able to selectively reduce the viability of cancer cells in a concentration-dependent way. While LGG-SN does not exert any anti-proliferative activity on control fibroblasts. In cancer cells, the reduction in viability is not associated with apoptosis induction, but with a mitotic arrest in the G2/M phase of cell cycle. Additionally, LGG-SN sensitizes cancer cells to both 5-Fluorouracil and Irinotecan, thereby showing a positive synergistic action. Conclusion Overall, our results suggest that LGG-SN may contain one or more bioactive molecules with anti-cancer activity which sensitize cancer cells to chemotherapeutic drugs. Thus, LGG could be proposed as an ideal candidate for ground-breaking integrated approaches to be employed in oncology, to reduce chemotherapy-related side effects and overcome resistance or relapse issues, thus ameliorating the therapeutic response in cancer patients.
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- 2023
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41. Love and Duty: Confederate Widows and the Emotional Politics of Loss by Angela Esco Elder (review)
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Hilde, Libra R.
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- 2023
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42. Reduced real lifetime of PV panels – Economic consequences
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Libra, Martin, Mrázek, David, Tyukhov, Igor, Severová, Lucie, Poulek, Vladislav, Mach, Jiří, Šubrt, Tomáš, Beránek, Václav, Svoboda, Roman, and Sedláček, Jan
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- 2023
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43. Reactive Magnetron Sputtering of ITO Layers
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Baránková, H., primary, Bárdoš, L., additional, Cabalka, P., additional, and Libra, M., additional
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- 2023
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44. Endovascular treatment of cesarean scar pregnancy: a retrospective multicentric study
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Failla, Giovanni, Libra, Federica, Giurazza, Francesco, Lucarelli, Nicola Maria, Coniglio, Giovanni, Vacirca, Francesco, Santonocito, Serafino Maria, Dell’Atti, Cristian, Camerano, Francesco, Palmucci, Stefano, Niola, Raffaella, Basile, Antonio, and Patanè, Domenico
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- 2022
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45. Research Collaboration of ITENAS Bandung – Indonesia and MATE Godollo – Hungary on the Photovoltaic Thematic Field: Achievements and Future Plan
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Rusirawan Dani, Hartawan Liman, Lidyawati Lita, Bozikova Monika, Hlavacova Zuzana, Libra Martin, Seres Istvan, Vig Piroska, and Farkas Istvan
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Environmental sciences ,GE1-350 - Abstract
Since the agreement was signed officially in 2013, Institut Teknologi Nasional Bandung (ITENAS Bandung) – Indonesia and Hungarian University of Agriculture and Life Sciences (MATE Godollo) – Hungary have implemented a lot of scholarly activities, and one of them is research collaboration in the field of solar energy, especially in the thematic field of photovoltaic (PV). A set of experimental facilities has been developed and constructed to support related research. Basic facilities to understand the principle of electricity generated by PV, i.e., having the solar power plant (SPP) laboratory scale have been fulfilled by both universities. MATE Godollo has a 10 kWp SPP installation and uses polycrystalline and amorphous silicon PV modules, meanwhile, ITENAS Bandung has 1 kWp SPP and uses monocrystalline silicon PV modules. In this paper, a set of activities related to PV research collaboration between ITENAS Bandung and MATE Godollo will be elaborated, including the output and the outcome of the activities, and plan activities involving other university partners, Slovak University of Agriculture in Nitra – Slovakia and Czech University of Life Science Prague, Czech Republic.
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- 2024
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46. Influence of Temperature on Important Characteristics of Photovoltaic Cells
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Libra, Martin, Poulek, Vladislav, Al-Ahmed, Amir, editor, Inamuddin, editor, Al-Sulaiman, Fahad A., editor, and Khan, Firoz, editor
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- 2022
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47. Feasibility Clinical Trial of the Cardio Flow Orbital Atherectomy System to Treat Peripheral Artery Disease (PAD) (FAST)
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Libra Medical
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- 2021
48. Removal of RhB from water by Fe-modified hydrochar and biochar – An experimental evaluation supported by genetic programming
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Kohzadi, Shadi, Marzban, Nader, Libra, Judy A., Bundschuh, Mirco, and Maleki, Afshin
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- 2023
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49. In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity
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Alessandro Lavoro, Luca Falzone, Barbara Tomasello, Giuseppe Nicolò Conti, Massimo Libra, and Saverio Candido
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cancer ,TCGA ,DNA methylation ,epigenetics ,solute carrier ,SLCs ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Introduction: The oncogenic transformation is driven by genetic and epigenetic alterations influencing cancer cell fate. These alterations also result in metabolic reprogramming by modulating the expression of membrane Solute Carrier (SLC) transporters involved in biomolecules trafficking. SLCs act as tumor suppressors or promoters influencing cancer methylome, tumor growth, immune-escape, and chemoresistance.Methods: This in silico study aimed to identify the deregulated SLCs in various tumor types compared to normal tissues by analyzing the TCGA Target GTEx dataset. Furthermore, the relationship between SLCs expression and the most relevant tumor features was tackled along with their genetic regulation mediated by DNA methylation.Results: We identified 62 differentially expressed SLCs, including the downregulated SLC25A27 and SLC17A7, as well as the upregulated SLC27A2 and SLC12A8. Notably, SLC4A4 and SLC7A11 expression was associated with favorable and unfavorable outcome, respectively. Moreover, SLC6A14, SLC34A2, and SLC1A2 were linked to tumor immune responsiveness. Interestingly, SLC24A5 and SLC45A2 positively correlated with anti-MEK and anti-RAF sensitivity. The expression of relevant SLCs was correlated with hypo- and hyper-methylation of promoter and body region, showing an established DNA methylation pattern. Noteworthy, the positive association of cg06690548 (SLC7A11) methylation with cancer outcome suggests the independent predictive role of DNA methylation at a single nucleotide resolution.Discussion: Although our in silico overview revealed a wide heterogeneity depending on different SLCs functions and tumor types, we identified key SLCs and pointed out the role of DNA methylation as regulatory mechanism of their expression. Overall, these findings deserve further studies to identify novel cancer biomarkers and promising therapeutic targets.
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- 2023
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50. Maximizing the value of liquid products and minimizing carbon loss in hydrothermal processing of biomass: an evolution from carbonization to humification
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Marzban, Nader, primary, Libra, Judy A., additional, Rotter, Vera Susanne, additional, Herrmann, Christiane, additional, Ro, Kyoung S., additional, Filonenko, Svitlana, additional, Hoffmann, Thomas, additional, and Antonietti, Markus, additional
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- 2024
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