50 results on '"Libing Zhu"'
Search Results
2. Application of Smart Model in the Analysis of Opera Heritage Archiving and Protection
- Author
-
Xueying Liu, Wei Zhou, Yuting Dong, Libing Zhu, and Naijia Chen
- Subjects
opera heritage ,archiving and protection ,smart model ,traditional chinese opera. ,Technological innovations. Automation ,HD45-45.2 - Abstract
Objective: Opera Heritage in China is a rich and diverse cultural tradition passed down through generations. Today, Opera Heritage remains an essential part of Chinese culture and is celebrated through performances, festivals, and other cultural events. Efforts are being made to preserve and promote Opera Heritage through innovative technologies and approach such as digital archives, virtual reality, and community-based heritage management. Analysis: In this study, we suggested the SMART model that seeks to integrate these technologies and approaches into the preservation and promotion of Opera Heritage, ensuring that this rich cultural tradition can be enjoyed by future generations. We employed an ‘opera heritage’ using the Smart model in this study. In this research, "Smart Heritage" was defined as heritage experiences that used the word "Smart Heritage" or "similar terms" to describe the smart model. Findings: Opera Heritage analysis paid close attention to cutting-edge tools to record developments that showcase technical independence. Due to language barriers, this article could only interpret a clear convergence between SMART and opera heritage protection. For China's Opera Heritage to be properly archived and protected, a holistic and cooperative strategy that incorporates cutting-edge technologies and community-based heritage management practises are essential. Conclusion:Innovating technologies such as virtual reality and digital archives have been employed in efforts to promote and preserve China's rich Opera Heritage. This study emphasises the necessity for an extensive strategy for the efficient preservation and protection of Opera Heritage and suggests the SMART model to incorporate these methods. Doi: 10.28991/HIJ-2024-05-02-09 Full Text: PDF
- Published
- 2024
- Full Text
- View/download PDF
3. Monte Carlo performance study of virtual high performance computing cluster over cloud
- Author
-
Libing Zhu, Ze Xi, Peng Cong, Gongyi Yu, Yuan Liu, Xincheng Xiang, Wei Xu, and Xiangang Wang
- Subjects
Cloud computing ,Virtualization ,High performance computing (HPC) ,Virtual HPC ,Monte Carlo ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Objective: As a high computation cost discipline, nuclear science and engineering still relies heavily on traditional high performance computing (HPC) clusters. However, the usage of traditional HPC for nuclear science and engineering has been limited due to the poor flexibility, the software compatibility and the poor user interfaces. Virtualized/virtual HPC (vHPC) can mimic an HPC by using a cloud computing platform. In this work, we designed and developed a vHPC system for employment in nuclear engineering. Methods: The system is tested using the computation of the number π by Monte Carlo and an X-ray digital imaging system simulation. The performance of the vHPC system is compared with that of the traditional HPCs. Results: As the number of the simulated particles increases, the virtual cluster computing time grows proportionally. The time used for the simulation of the X-ray imaging was about 21.1 h over a 12 kernels virtual server. Experimental results show that the performance of virtual cluster computing and the actual physical machine is almost the same. Conclusions: From these tests, it is concluded that vHPC is a good alternative for employing in nuclear engineering. The proposed vHPC in this paper will make HPC flexible and easy to deploy.
- Published
- 2022
- Full Text
- View/download PDF
4. Stress analysis of aspherical TRISO-coated particle with X-ray computed tomography
- Author
-
Libing Zhu, Xincheng Xiang, and Xiangang Wang
- Subjects
Stress analysis ,Aspherical TRISO ,X-ray CT ,Finite element method ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
The failure probability of TRISO-coated particle is directly dependent on the asphericity and the layer thickness. Local asphericity of the SiC layer will contribute to the concentrated stress region, increasing failure probability of the particle. In this paper, we utilized micro X-ray computed tomography (CT) to obtain the 3D volume rendering of the SiC layer with the real geometric shape before irradiation. The stress distribution of the aspherical reconstructed SiC was then simulated with finite element method (FEM) based on the pressure vessel model. The maximum and mean principle stress were compared between the analytical methods and FEM simulation. The maximum deviation between the SiC principle stress with the real shape and ideal shape is 64.56 % for the inner gas pressure 17 MPa. The preliminary failure probability using the aforementioned stress was calculated and compared with the analytical solution. There is obvious increment with the maximum principle stress. The local stress concentration of the acquired aspherical model is 1.86. The stress discrepancy between the FEM simulation and the theoretical calculation increases with the inner gas pressure. The SiC asphericity measured with X-ray CT will contribute to a higher failure probability under irradiation.
- Published
- 2023
- Full Text
- View/download PDF
5. Mesocarbon microbead densified matrix graphite A3-3 for fuel elements in molten salt reactors
- Author
-
Haoran Wang, Liujun Xu, Yajuan Zhong, Xiaoyun Li, Hui Tang, Feng Zhang, Xu Yang, Jun Lin, Zhiyong Zhu, Yan You, Junqiang Lu, and Libing Zhu
- Subjects
Molten salt reactor ,Fuel element ,Matrix graphite ,Mesocarbon microbead (MCMB) ,FLiBe infiltration ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
This study aims to provide microstructural characterization for the matrix graphite which molten salt reactors (MSRs) use, and improve resistance to molten salt infiltration of the matrix graphite for fuel elements. Mesocarbon microbeads (MCMB) densified matrix graphite A3-3 (MDG) was prepared by a quasi-isostatic pressure process. After densification by MCMBs with average particle sizes of 2, 10, and 16 μm, the pore diameter of A3-3 decreased from 924 nm to 484 nm, 532 nm, and 778 nm, respectively. Through scanning electron microscopy, the cross-section energy spectrum and time-of-flight secondary ion mass spectrometry, resistance levels of the matrix graphite to molten salt infiltration were analyzed. The results demonstrate that adding a certain proportion of MCMB powders can improve the anti-infiltration ability of A3-3. Meanwhile, the closer the particle size of MCMB is to the pore diameter of A3-3, the smaller the average pore diameter of MDG and the greater the densification. As a matrix graphite of fuel elements in MSR was involved, the thermal and mechanical properties of matrix graphite MDG were also studied. When densified by the MCMB matrix graphite, MDGs can meet the molten salt anti-infiltration requirements for MSR operation.
- Published
- 2021
- Full Text
- View/download PDF
6. End-to-End QA with Polymer Gel Dosimeter for Photon Beam Radiation Therapy
- Author
-
Libing Zhu, Yi Du, Yahui Peng, Xincheng Xiang, and Xiangang Wang
- Subjects
end-to-end QA ,polymer gel dosimeter ,one delivery phantom ,photon beam ,Science ,Chemistry ,QD1-999 ,Inorganic chemistry ,QD146-197 ,General. Including alchemy ,QD1-65 - Abstract
With the complexity and high demands on quality assurance (QA) of photon beam radiation therapy, end-to-end (E2E) QA is necessary to validate the entire treatment workflow from pre-treatment imaging to beam delivery. A polymer gel dosimeter is a promising tool for three-dimensional (3D) dose distribution measurement. The purpose of this study is to design a fast “one delivery” polymethyl methacrylate (PMMA) phantom with a polymer gel dosimeter for the E2E QA test of the photon beam. The one delivery phantom is composed of ten calibration cuvettes for the calibration curve measurement, two 10 cm gel dosimeter inserts for the dose distribution measurement, and three 5.5 cm gel dosimeters for the square field measurement. The one delivery phantom holder is comparable in size and shape to that of a human thorax and abdomen. In addition, an anthropomorphic head phantom was employed to measure the patient-specific dose distribution of a VMAT plan. The E2E dosimetry was verified by undertaking the whole RT procedure (immobilization, CT simulation, treatment planning, phantom set-up, imaged-guided registration, and beam delivery). The calibration curve, field size, and patient-specific dose were measured with a polymer gel dosimeter. The positioning error can be mitigated with the one-delivery PMMA phantom holder. The delivered dose measured with a polymer gel dosimeter was compared with the planned dose. The gamma passing rate is 86.64% with the MAGAT-f gel dosimeter. The results ascertain the feasibility of the one delivery phantom with a polymer gel dosimeter for a photon beam in E2E QA. The QA time can be reduced with the designed one delivery phantom.
- Published
- 2023
- Full Text
- View/download PDF
7. Gut microbial characteristics of adult patients with allergy rhinitis
- Author
-
Libing Zhu, Feng Xu, Wenrong Wan, Bin Yu, Lin Tang, Yiming Yang, Yanling Du, Zhangran Chen, and Hongzhu Xu
- Subjects
Allergy rhinitis ,Gut dysbiosis ,Total nasal symptom score ,Functional pathway ,Microbiology ,QR1-502 - Abstract
Abstract Background Although recent studies have indicated that intestinal microbiota dweller are involved in the pathogenesis of allergy rhinitis (AR), the influence of gut microbiota on AR adult has not been fully elucidated yet. Hence, we carried out this study to uncover the distinctive bacterial taxa that differentiate allergy rhinitis patients from healthy individuals. Feces samples from thirty three AR patients and thirty one healthy individuals were analyzed by 16S rRNA gene sequencing. Results Results showed that the bacterial diversity in AR group was significantly higher than that of the non-AR group. Bacterial communities between AR and non-AR group were significantly differentiated as revealed by Principal coordinates analysis (PCoA) and the variation within non-AR were higher than that of the counterpart. Firmicutes, Fusobacteria, Actinobacteria, Cyanobacteria and Chloroflexi were the significantly differed phyla taxa and the top significantly distinguished bacterial genus included Prevotella_9, Phascolarctobacterium, Roseburia, Megamonas, Alistipes, Lachnoclostridium and Fusobacterium. The higher network complexity in AR group were dominated by taxa belonging to Firmicutes. The predicted function, alpha linolenic acid metabolism and bacterial invasion of epithelial cells pathway were higher in non-AR group while gonadotropin-releasing hormone (GnRH) signaling pathway, Fc γ-R mediated phagocytosis and endocytosis were higher in AR patients. Although the bacterial diversity between moderate and severe AR patients showed no significant difference, the significant correlation between featured genus and total nasal symptom score or rhinoconjunctivitis quality of life questionnaire, such as Butyricicoccus and Eisenbergiella, revealed the potential to intervene the AR status by means of gut microbiota. Conclusions In conclusion, patients with allergy rhinitis had distinguished gut microbiota characteritics in comparison with healthy controls. The results suggest that gut microbiota might play crucial roles in influencing the course and different symptoms of AR. Trial registration ChiCTR, ChiCTR1900028613. Registered 29 December 2019, https://www.chictr.org.cn/showproj.aspx?proj=47650 .
- Published
- 2020
- Full Text
- View/download PDF
8. Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment
- Author
-
Libing Zhu, Yuning Wu, Chenglong Lin, Lin Tang, Bin Yu, Wenrong Wan, Jingxiu Xuan, Yanling Du, Zhangran Chen, and Wei Liang
- Subjects
Xiao-Qing-Long-Decoction ,allergic rhinitis ,long-term remission ,gut microbiota ,16S rRNA ,Immunologic diseases. Allergy ,RC581-607 - Abstract
A mixed Chinese herbal formula, Xiao-Qing-Long-Decoction (XQLD), may contribute to sustained remission in allergic rhinitis (AR), but it is unknown which factors determine such long-term effect. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples from AR patients at four different times were analyzed to compare the dynamic bacterial community and structure shifts. Diversity indices Chao1 showed significant difference across different time (p
- Published
- 2021
- Full Text
- View/download PDF
9. 3D Proton Bragg Peak Visualization and Spot Shape Measurement with Polymer Gel Dosimeters
- Author
-
Libing Zhu, Manzhou Zhang, Xincheng Xiang, and Xiangang Wang
- Subjects
proton pencil beam ,polymer gel dosimeters ,spot size ,3D visualization ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Proton pencil beam scanning is a dynamic beam delivery technique with excellent conformability to the tumor volume. The accuracy of spot size and scanning positions will have a significant effect on the delivered dose distribution. We employed polymer gel dosimeters to measure the spot size and the scanning positions for the Shanghai Advanced Proton Therapy facility (SAPT). Polymer gel dosimeters (MAGAT-f and PAGAT) were utilized to measure the full width at half maximum (FWHM) of the beam spot at various depths on the basis of their MRI readouts. The correlation between the spot FWHM and standard deviation (σ) was analyzed at different depths. The measured Bragg peak range was compared with the Monte Carlo (MC) simulation. Three-dimensional volume rendering of the Bragg peak was reconstructed for the 3D visualization to measure the spot size three-dimensionally. The R2 dose–response curve was investigated with polymer gel dosimeters. The deviations of the Bragg peak ranging between measurement and simulation were 0.13% and −0.53% for MAGAT-f and PAGAT, respectively. Our results ascertain the feasibility of a polymer gel dosimeter to measure the spot size and positions of a proton pencil beam.
- Published
- 2022
- Full Text
- View/download PDF
10. The Application of Auriculotherapy to the Treatment of Chronic Spontaneous Urticaria: A Systematic Review and Meta-analysis
- Author
-
Libing Zhu, Yunjin Kim, and Zongbao Yang
- Subjects
Other systems of medicine ,RZ201-999 - Abstract
Auriculotherapy has been extensively used for chronic spontaneous urticaria in China. However, the evidence of its effectiveness and safety for the treatment of chronic spontaneous urticaria is insufficient. Hence, we conducted this study to compare auriculotherapy or auriculotherapy joint treatment with Western medicine for the cure of chronic spontaneous urticaria. This meta-analysis of seven randomized controlled trials showed that auriculotherapy or auriculotherapy joint treatment was significantly superior to Western medicine in curing clinical signs and symptoms of chronic spontaneous urticaria [odds ration (OR), 2.61; 95% confidence interval (CI), 1.54–4.43; p = 0.0004) and also better in total effect rate (OR, 3.81; 95% CI, 2.07–7.01; p<0.0001). But, auriculotherapy or auriculotherapy joint treatment was similar to Western medicine in improving clinical signs and symptoms of chronic spontaneous urticaria (OR, 0.74; 95% CI, 0.35–1.56; p = 0.42). Auriculotherapy or auriculotherapy joint treatment was safer than Western medicine for curing chronic spontaneous urticaria (OR, 0.26; 95% CI, 0.09–0.80; p = 0.02). Auriculotherapy alone or auriculotherapy joint treatment appears to be more effective and safer than Western medicine that contains antihistamines in the treatment of chronic spontaneous urticaria. However, these findings should be interpreted with caution due to the unclear risk bias of methodological quality, and further studies with large-scale, better, and more rigorously designed protocol are necessary to prove these findings. Keywords: auricular acupuncture, auriculotherapy, urticaria, review, meta-analysis
- Published
- 2018
- Full Text
- View/download PDF
11. Failure Fraction Calculation of the TRISO-Coated Particle Using X-Ray Computed Tomography
- Author
-
Libing Zhu, Jianxun Zhao, Xincheng Xiang, Yu Zhou, and Xiangang Wang
- Subjects
Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The geometrical shape of the TRISO-coated particle is closely related to its performance and safety. In this paper, models were set up to study the failure fraction of TRISO particle, considering the real asphericity induced by manufacturing uncertainties. TRISO is simplified as a pressure vessel model, and micro X-ray CT was employed to detect the real geometrical shape. Key geometrical parameters, thickness and volume of the real particle, were then obtained with the 3D measurement method and input into PANAMA code (a German code for fuel performance simulation). Release fraction of fission gas and failure fraction of the TRISO-coated particle were revised with the aforementioned parameters with more accuracy and compared with those of the spherical particle. Obvious increment of failure fraction of the particle is found, which may contribute to the release of fission products.
- Published
- 2021
- Full Text
- View/download PDF
12. Dose-Area Product Determination and Beam Monitor Calibration for the Fixed Beam of the Shanghai Advanced Proton Therapy Facility
- Author
-
Libing Zhu, Manzhou Zhang, Xincheng Xiang, and Xiangang Wang
- Subjects
dose-area product ,reference dosimetry ,proton beam ,beam monitor calibration ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Research conducted to-date, makes use of the IBA-Lynx scintillating screen and radiochromic film to analyze the proton field uniformity for dose-area product (DAP) determination. In this paper, the machine log file based reconstruction is proposed to calculate the field uniformity to simplify the measurement. In order to calculate the field uniformity, the dose distribution is reconstructed based on the machine log file with matRad (an open source software for analytical dose calculation in MATLAB). After acquisition of the dose distribution, the field flatness and symmetry are calculated automatically for different proton energies. A comprehensive comparison of DAP determined with Bragg peak chamber (BPC) and Markus chamber (MC) is presented. The actual delivered dose is reconstructed with the log file to analyze the lateral dose distribution of the scanned field. DAP of different energies are calculated ranging from 70.6 MeV to 235 MeV. The percentage difference is calculated, illustrating the DAP discrepancy between the MC and BPC to the mean value. The percentage difference ranges from −0.19% to 1.26%. The variation between DAP measured with the BPC and MC peaks at −2.5%. The log file based reconstruction to calculate field uniformity can be an alternative for DAP determination. The direct method using a large-area Bragg peak chamber is investigated. The two methods to determine DAP and calibrate beam monitor illustrate consistent results.
- Published
- 2022
- Full Text
- View/download PDF
13. Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies
- Author
-
Randong Yang, Xiaoxiao Hu, Xianzheng Xie, Haiqiong Chen, Huangyi Fang, Libing Zhu, and Zhongrong Li
- Subjects
propionic acid ,lipopolysaccharide ,intestinal barrier ,cell migration ,NLRP3 inflammasome ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a variety of diseases. However, the exact role of PA in LPS-induced intestinal barrier dysfunction is still unclear. Accordingly, we examined the latent mechanism of PA and its protective role in LPS-induced intestinal barrier dysfunction by both in vitro and in vivo experiments. In vitro, we identified that PA treatment could strongly promote cell migration, inhibit activation of NLRP3 inflammasome and maintain intestinal barrier function in LPS-induced IEC-6 cells, indicating the protective effect on the intestinal barrier function of PA. Further investigation of the mechanism involved revealed that PA could suppress the activation of TLR4/NF-κB pathway. In vivo, in a LPS-induced rat model, PA-induced protective effects in intestinal barrier dysfunction could be detected. In summary, our findings clarify the role of PA in intestinal barrier dysfunction and suggest that it is promising for the treatment of LPS-related intestinal diseases.
- Published
- 2020
- Full Text
- View/download PDF
14. Correction to: Gut microbial characteristics of adult patients with allergy rhinitis
- Author
-
Libing Zhu, Feng Xu, Wenrong Wan, Bin Yu, Lin Tang, Yiming Yang, Yanling Du, Zhangran Chen, and Hongzhi Xu
- Subjects
Microbiology ,QR1-502 - Abstract
An amendment to this paper has been published and can be accessed via the original article.
- Published
- 2020
- Full Text
- View/download PDF
15. Three-Dimensional Measurement of TRISO Coated Particle Using Micro Computed Tomography
- Author
-
Libing Zhu, Xincheng Xiang, Yahui Peng, and Xiangang Wang
- Subjects
Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The fuel safety and performance of high-temperature gas-cooled reactor (HTGR) are dependent on the integrity and geometric parameter of Tri-structural Isotropic (TRISO) coated particle. Micro X-ray computed tomography (CT) was used for nondestructive testing and three-dimensional measurement of the particle components which are composed of kernel, buffer layer, inner pyrolytic carbon layer (IPyC), silicon carbide (SiC) layer, and outer pyrolytic carbon (OPyC) layer. The thickness distribution and volume of kernel and coating layers are obtained by constructing 3D volume rendering of TRISO particle. Mean thickness of each layer is calculated for comparison with design value. A comparison between two-dimensional and three-dimensional measurement results is also made. It is found that the thickness distribution of all layers approximately obeys Gaussian distribution. Deviation of the thickness of kernel and coating layers between 3D measurement result and design value is 7.88%, -25.63%, -45.50%, 13.87%, and 14.73%, respectively. The deviation will affect the failure probability of TRISO particle. Obvious difference of the OPyC mean thickness between 3D measurement and 2D measurement is found, which proves that the proposed 3D measurement provides comprehensive information of the particle. However, 2D and 3D measured thickness of the kernel and IPyC layer tend to be similar.
- Published
- 2019
- Full Text
- View/download PDF
16. Uniformity Assessment of TRISO Fuel Particle Distribution in Spherical HTGR Fuel Element Using Voronoi Tessellation and Delaunay Triangulation
- Author
-
Libing Zhu, Xincheng Xiang, Yi Du, Gongyi Yu, Ziqiang Li, Yahui Peng, and Xiangang Wang
- Subjects
Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Nonuniform distribution of tri-structural-isotropic (TRISO) fuel particles in a spherical fuel element (SFE) may increase the failure probability of the SFE in the high-temperature gas-cooled reactor, leading to the release of fission products. To evaluate the uniformity of the TRISO particles nondestructively, 3-dimensional cone-beam computed tomography is used to image the SFE, and TRISO particles are segmented. After TRISO particle positions are identified, the Voronoi tessellation and Delaunay triangulation are used to extract several geometric metrics. Results indicate that both the Voronoi volume distribution and the nearest neighbor-distance distribution follow the log-normal distributions, which provide strong evidence that the TRISO particles are approximately randomly uniformly distributed. Further study will be focused on validating the conclusion with more SFE data.
- Published
- 2018
- Full Text
- View/download PDF
17. Efficacy and safety of Yinchenwuling powder for hyperlipidemia: a systematic review and Meta-analysis
- Author
-
Haiqiang, Yao, Zengliang, Zhang, Ji, Wang, Yu, Chen, Libing, Zhu, Xiaoke, Li, Zheng, Yang, Zisong, Wang, Ranran, Sun, Xuanxuan, Xu, Changming, Li, Yanling, Wu, Lingru, Li, Qi, Wang, and Jiacheng, Zuo
- Published
- 2016
- Full Text
- View/download PDF
18. Failure Fraction Calculation of the TRISO-Coated Particle Using X-Ray Computed Tomography
- Author
-
Jianxun Zhao, Yu Zhou, Xincheng Xiang, Xiangang Wang, and Libing Zhu
- Subjects
Fission products ,Materials science ,Article Subject ,Fission ,Fraction (chemistry) ,Mechanics ,Pressure vessel ,TK1-9971 ,Nuclear Energy and Engineering ,Volume (thermodynamics) ,X ray computed ,Particle ,Electrical engineering. Electronics. Nuclear engineering ,Tomography - Abstract
The geometrical shape of the TRISO-coated particle is closely related to its performance and safety. In this paper, models were set up to study the failure fraction of TRISO particle, considering the real asphericity induced by manufacturing uncertainties. TRISO is simplified as a pressure vessel model, and micro X-ray CT was employed to detect the real geometrical shape. Key geometrical parameters, thickness and volume of the real particle, were then obtained with the 3D measurement method and input into PANAMA code (a German code for fuel performance simulation). Release fraction of fission gas and failure fraction of the TRISO-coated particle were revised with the aforementioned parameters with more accuracy and compared with those of the spherical particle. Obvious increment of failure fraction of the particle is found, which may contribute to the release of fission products.
- Published
- 2021
19. Analysis Method to Predict Grid-to-Rod Fretting Wear of Fuel Rod in Pressurized Water Reactors
- Author
-
Libing Zhu, Shufeng Zhao, Jingya Sun, Shiyin Xu, Fujun Gan, and Sirui Li
- Abstract
Grid-to-rod fretting (GTRF) caused by flow induced vibration is one of the most important mechanisms of fuel rod failure in PWRs, which has a strong impact on the economy and safety of nuclear power plant. To avoid rod failure due to GTRF, several verification tests which are high costs and long term are always carried out for new design fuel assemblies. So as to deal with the disadvantages of tests and speed up progress in fuel design, a progressive analysis method to predict GTRF performance of fuel rod is developed, and systemic tests are carried out to verify the analysis method. The method consists of three main parts, including flow field analysis, structure vibration analysis and wear analysis. In the first part, the flow field excitation force is obtained by the large eddy simulation method, and this CFD method is verified by a particle image velocimetry (PIV) test with a 5 × 5 fuel bundle. In the second part, to get the vibration response of fuel rod, a nonlinear vibration model which can consider end-of-life gaps is established. Full scale fuel rod vibration in air and water conditions are tested to validate the predicted fuel rod response from analysis. In the third part, the fuel rod wear is estimated by tribological theory with fuel rod vibration response, the wear coefficient and the typical feature of wear scar. The GTRF method is finally verified by a long-term wear test of full-scale fuel assembly. It turns out that this method can effectively predict the wear characteristics of fuel rod cladding at the early stage of design. It provides a feasible solution for rapid design iteration of fuel assembly, and could reduce the development costs and risks.
- Published
- 2022
20. The transformation of fretting corrosion mechanism of zirconium alloy tube mating with 304 stainless steel in high temperature high pressure water
- Author
-
Wenhua Zhuang, Ping Lai, Hui Lu, Zhongli Han, Junqiang Lu, Lefu Zhang, Libing Zhu, and Xianglong Guo
- Subjects
Nuclear and High Energy Physics ,Nuclear Energy and Engineering ,General Materials Science - Published
- 2023
21. Gut microbial characteristics of adult patients with allergy rhinitis
- Author
-
Wenrong Wan, Feng Xu, Yiming Yang, Zhangran Chen, Lin Tang, Bin Yu, Libing Zhu, Yanling Du, and Hongzhu Xu
- Subjects
Adult ,Male ,China ,Firmicutes ,lcsh:QR1-502 ,Total nasal symptom score ,Bioengineering ,Gut flora ,Functional pathway ,Severity of Illness Index ,Applied Microbiology and Biotechnology ,lcsh:Microbiology ,Feces ,Young Adult ,03 medical and health sciences ,Gut dysbiosis ,0302 clinical medicine ,RNA, Ribosomal, 16S ,Surveys and Questionnaires ,Prevotella ,Humans ,Alistipes ,030304 developmental biology ,0303 health sciences ,biology ,Research ,Correction ,Allergy rhinitis ,Fusobacteria ,Biodiversity ,biology.organism_classification ,Rhinitis, Allergic ,Gastrointestinal Microbiome ,030228 respiratory system ,Fusobacterium ,Immunology ,Quality of Life ,Metagenome ,Female ,Roseburia ,Genome, Bacterial ,Biotechnology - Abstract
Background Although recent studies have indicated that intestinal microbiota dweller are involved in the pathogenesis of allergy rhinitis (AR), the influence of gut microbiota on AR adult has not been fully elucidated yet. Hence, we carried out this study to uncover the distinctive bacterial taxa that differentiate allergy rhinitis patients from healthy individuals. Feces samples from thirty three AR patients and thirty one healthy individuals were analyzed by 16S rRNA gene sequencing. Results Results showed that the bacterial diversity in AR group was significantly higher than that of the non-AR group. Bacterial communities between AR and non-AR group were significantly differentiated as revealed by Principal coordinates analysis (PCoA) and the variation within non-AR were higher than that of the counterpart. Firmicutes, Fusobacteria, Actinobacteria, Cyanobacteria and Chloroflexi were the significantly differed phyla taxa and the top significantly distinguished bacterial genus included Prevotella_9, Phascolarctobacterium, Roseburia, Megamonas, Alistipes, Lachnoclostridium and Fusobacterium. The higher network complexity in AR group were dominated by taxa belonging to Firmicutes. The predicted function, alpha linolenic acid metabolism and bacterial invasion of epithelial cells pathway were higher in non-AR group while gonadotropin-releasing hormone (GnRH) signaling pathway, Fc γ-R mediated phagocytosis and endocytosis were higher in AR patients. Although the bacterial diversity between moderate and severe AR patients showed no significant difference, the significant correlation between featured genus and total nasal symptom score or rhinoconjunctivitis quality of life questionnaire, such as Butyricicoccus and Eisenbergiella, revealed the potential to intervene the AR status by means of gut microbiota. Conclusions In conclusion, patients with allergy rhinitis had distinguished gut microbiota characteritics in comparison with healthy controls. The results suggest that gut microbiota might play crucial roles in influencing the course and different symptoms of AR. Trial registration ChiCTR, ChiCTR1900028613. Registered 29 December 2019, https://www.chictr.org.cn/showproj.aspx?proj=47650.
- Published
- 2020
22. Microstructure and mechanical properties evolution of thermal-treated SiC layer with fine grain size in TRISO particles
- Author
-
Xu Yang, Lihua Guo, Feng Zhang, Yan You, Chao Yan, Junqiang Lu, Libing Zhu, Zhiyong Zhu, and Jun Lin
- Subjects
Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2023
23. A child with Kawasaki disease successfully treated with Chinese herbal medicine: A case report with 12-month follow up
- Author
-
Xinzhu Lin, Jianping Liu, Libing Zhu, Lixing Lao, and Yuanpeng Huang
- Subjects
Pediatrics ,medicine.medical_specialty ,Heart disease ,business.industry ,Incidence (epidemiology) ,Coronary artery ectasia ,Respiratory infection ,medicine.disease ,Asymptomatic ,030205 complementary & alternative medicine ,03 medical and health sciences ,0302 clinical medicine ,Complementary and alternative medicine ,Etiology ,Medicine ,Kawasaki disease ,030212 general & internal medicine ,medicine.symptom ,business ,Systemic vasculitis - Abstract
Introduction Kawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis of unknown etiology presenting predominantly in early childhood, most commonly in those under 5 years old. Although KD has been reported in almost all populations, it is especially common in North East Asia such as Japan, Korea and Taiwan which has the highest incidence worldwide that in contrast to the US, Europe and Australia. It is reported that more than 1 in 100 Japanese have had KD by 12 years of age. KD is a potentially life-threatening condition because it can cause serious pediatric-acquired heart disease such as asymptomatic coronary artery ectasia or an aneurysm. Intravenous immunoglobulin (IVIG) is a routine and effective treatment for KD and significantly reduces risk of coronary artery abnormalities during the acute phase of illness from approximately 15%–25% to 5%–8%. In spite of its effectiveness, some patient do not respond to this therapy and still develop coronary aneurysms. Chinese herbal medicine (CHM) as a therapy alone for KD was rare. The success of this patient with KD treated by CHM provided a new way of thinking for harmonizing Eastern-Western drug for KD and the potential utilization of CHM as a source of new drugs could be an alternative. Clinical features and outcome A 17 month-old boy suffered from persistent fever, poor appetite, vomiting diarrhea, slight cough, running nose and throat congestion for 2 days and was diagnosed with an upper respiratory infection. He had taken cefprozil suspension plus ankahuangmin 2 days for his symptoms before his final diagnosis of KD, but it was unsuccessful. He continued to have a fever, in addition, he presented with bilateral bulbar conjunctival congestion without exudate, labial and lingual erythema and was diagnosed with KD before his first CHM visit, his parents refused to continue receiving Western medicine. Therefore, his parents sought CHM for further intervention. His symptoms subsided, and the blood tests, electrocardiogram (ECG) and echocardiographies show completely normal after regular therapy with Xiao Chai Hu Tang (小柴胡汤) combined with Bu Yang Huan Wu Tang (补阳还五汤), Huang Lian Jie Du Tang (黄连解毒汤), and Wu Ling San (五苓散) for approximately 21 days. Neither complications nor side-effects were noted during the CHM treatment. Conclusions In this case, CHM may be an effective alternative therapy for the treatment of KD, and furthermore, may also be applied as an option to salvage failed intravenous immunoglobulin procedures. Further controlled trials are warranted to determine whether this is an effective treatment option for other cases of KD.
- Published
- 2019
24. Synchrotron phase-contrast CT to segment the structure boundaries of a TRISO-coated particle
- Author
-
Yahui Peng, Xiangang Wang, Xincheng Xiang, Libing Zhu, and Uwe Ewert
- Subjects
010302 applied physics ,Nuclear fission product ,Materials science ,Fission ,business.industry ,Mechanical Engineering ,Isotropy ,engineering.material ,Condensed Matter Physics ,01 natural sciences ,Synchrotron ,law.invention ,Coating ,law ,Nondestructive testing ,0103 physical sciences ,engineering ,Particle ,General Materials Science ,Composite material ,business ,Energy source ,010301 acoustics - Abstract
Tri-structural Isotropic (TRISO)-coated particle is the fission energy source and the first safety barrier in high temperature gas-cooled reactors (HTGRs). The integrity of TRISO particle should be carefully tested before operation because the shape may affect the failure possibility of the particles, leading to increased risk of fission product release. Due to the large difference in density between the kernel and the coating layers in TRISO particles, traditional X-ray radiography cannot achieve a good image quality in terms of identifying coating layers reliably, while phase-contrast CT has the advantage of being sensitive to boundaries. This paper presents a non-destructive test and evaluation (NDT&E) method to facilitate 3-dimensional (3D) measurement of a TRISO particle's structure, using a synchrotron phase-contrast CT. After reconstructed, the TRISO particle was rendered in a 3D space and the thickness and asphericity of the TRISO particle's layers were measured. It was found that the thickness of coating layers of the tested particle obeys Gaussian distribution. The deviation of thicknesses of the kernel and the other four layers is −2.42%, −16.32%, 26.51%, 0.98% and 7.49% compared with the design parameters. The deviation of asphericity of the kernel, IPyC and OPyC layers is −11.51%, −0.41% and 3.39%, respectively. The effect of the deviations on the temperature distribution and failure probability calculation of the particle will be investigated in the future.
- Published
- 2019
25. Three-Dimensional Measurement of TRISO Coated Particle Using Micro Computed Tomography
- Author
-
Yahui Peng, Libing Zhu, Xincheng Xiang, and Xiangang Wang
- Subjects
Materials science ,Article Subject ,020209 energy ,02 engineering and technology ,engineering.material ,01 natural sciences ,010305 fluids & plasmas ,chemistry.chemical_compound ,Coating ,Nondestructive testing ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Silicon carbide ,Pyrolytic carbon ,Composite material ,business.industry ,Isotropy ,Nuclear Energy and Engineering ,chemistry ,Kernel (statistics) ,engineering ,Particle ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,business ,lcsh:TK1-9971 ,Layer (electronics) - Abstract
The fuel safety and performance of high-temperature gas-cooled reactor (HTGR) are dependent on the integrity and geometric parameter of Tri-structural Isotropic (TRISO) coated particle. Micro X-ray computed tomography (CT) was used for nondestructive testing and three-dimensional measurement of the particle components which are composed of kernel, buffer layer, inner pyrolytic carbon layer (IPyC), silicon carbide (SiC) layer, and outer pyrolytic carbon (OPyC) layer. The thickness distribution and volume of kernel and coating layers are obtained by constructing 3D volume rendering of TRISO particle. Mean thickness of each layer is calculated for comparison with design value. A comparison between two-dimensional and three-dimensional measurement results is also made. It is found that the thickness distribution of all layers approximately obeys Gaussian distribution. Deviation of the thickness of kernel and coating layers between 3D measurement result and design value is 7.88%, -25.63%, -45.50%, 13.87%, and 14.73%, respectively. The deviation will affect the failure probability of TRISO particle. Obvious difference of the OPyC mean thickness between 3D measurement and 2D measurement is found, which proves that the proposed 3D measurement provides comprehensive information of the particle. However, 2D and 3D measured thickness of the kernel and IPyC layer tend to be similar.
- Published
- 2019
26. Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies
- Author
-
Huangyi Fang, Haiqiong Chen, Libing Zhu, Zhongrong Li, Randong Yang, Xiaoxiao Hu, and Xianzheng Xie
- Subjects
0301 basic medicine ,Lipopolysaccharide ,cell migration ,propionic acid ,Pharmacology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,In vivo ,medicine ,Pharmacology (medical) ,Barrier function ,Original Research ,lipopolysaccharide ,lcsh:RM1-950 ,Inflammasome ,Cell migration ,In vitro ,NLRP3 inflammasome ,intestinal barrier ,030104 developmental biology ,lcsh:Therapeutics. Pharmacology ,chemistry ,030220 oncology & carcinogenesis ,TLR4 ,Signal transduction ,medicine.drug - Abstract
Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a variety of diseases. However, the exact role of PA in LPS-induced intestinal barrier dysfunction is still unclear. Accordingly, we examined the latent mechanism of PA and its protective role in LPS-induced intestinal barrier dysfunction by both in vitro and in vivo experiments. In vitro, we identified that PA treatment could strongly promote cell migration, inhibit activation of NLRP3 inflammasome and maintain intestinal barrier function in LPS-induced IEC-6 cells, indicating the protective effect on the intestinal barrier function of PA. Further investigation of the mechanism involved revealed that PA could suppress the activation of TLR4/NF-κB pathway. In vivo, in a LPS-induced rat model, PA-induced protective effects in intestinal barrier dysfunction could be detected. In summary, our findings clarify the role of PA in intestinal barrier dysfunction and suggest that it is promising for the treatment of LPS-related intestinal diseases.
- Published
- 2020
27. Additional file 2 of Gut microbial characteristics of adult patients with allergy rhinitis
- Author
-
Libing Zhu, Xu, Feng, Wenrong Wan, Yu, Bin, Tang, Lin, Yiming Yang, Yanling Du, Chen, Zhangran, and Hongzhu Xu
- Abstract
Additional file 2: Figure S1. The rarefaction curves of all sample. (A) Observed species and (B) chao1. Figure S2. The bacterial community difference between AR and non-AR group. (A) The ANOSIM analysis are made to compare the intergroup and within group of samples. (B) The bacterial community variation comparison in AR and non-AR group. Figure S3. The predicted expression of distinguished pathway. The significantly distinguished pathway predicted by PICRUSt were screened by comparison between AR and non-AR individuals by Wilcox test and based on |logFC|>1. FC denotes fold change. Figure S4. Comparisons of bacterial diversity between moderate and severe AR patients. (A) The bacterial α diversity indexes comparison between moderate and severe AR, including Chao1, J and Shannon. Letters indicate the ANOVA groupings. (B) Differences in bacterial community structures between moderate and severe AR patients.
- Published
- 2020
- Full Text
- View/download PDF
28. Uniformity Assessment of TRISO Fuel Particle Distribution in Spherical HTGR Fuel Element Using Voronoi Tessellation and Delaunay Triangulation
- Author
-
Yahui Peng, Gongyi Yu, Ziqiang Li, Xiangang Wang, Xincheng Xiang, Yi Du, and Libing Zhu
- Subjects
Fission products ,Materials science ,Article Subject ,medicine.diagnostic_test ,Delaunay triangulation ,020209 energy ,Nuclear engineering ,Failure probability ,Computed tomography ,02 engineering and technology ,Distribution (mathematics) ,Nuclear Energy and Engineering ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Particle ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Voronoi diagram ,lcsh:TK1-9971 - Abstract
Nonuniform distribution of tri-structural-isotropic (TRISO) fuel particles in a spherical fuel element (SFE) may increase the failure probability of the SFE in the high-temperature gas-cooled reactor, leading to the release of fission products. To evaluate the uniformity of the TRISO particles nondestructively, 3-dimensional cone-beam computed tomography is used to image the SFE, and TRISO particles are segmented. After TRISO particle positions are identified, the Voronoi tessellation and Delaunay triangulation are used to extract several geometric metrics. Results indicate that both the Voronoi volume distribution and the nearest neighbor-distance distribution follow the log-normal distributions, which provide strong evidence that the TRISO particles are approximately randomly uniformly distributed. Further study will be focused on validating the conclusion with more SFE data.
- Published
- 2018
29. Fabrication of two 3D magnetic coordination polymers empolying 4,4′-Phosphinico-dibenzoate as ligand
- Author
-
Zhao-Xi Wang, Libing Zhu, and Li-Na Wu
- Subjects
chemistry.chemical_classification ,Fabrication ,Materials science ,Ligand ,Metal ions in aqueous solution ,Polymer ,Ion ,Inorganic Chemistry ,Crystallography ,chemistry ,Group (periodic table) ,Materials Chemistry ,Antiferromagnetism ,Physical and Theoretical Chemistry ,Monoclinic crystal system - Abstract
Two 3D coordination polymers with the formulas: [Mn(HL)(H2O)]·0.5H2O (1) and [Cu3(L)2(H2O)2]·2H2O (2), were harvested by self-assembly of Mn(II) and Cu(II) metal ions with 4,4′-phosphinicobis-dibenzoic acid (H3L) through solvothermal process. With various characterization methods, their structures were confirmed. Both 1 and 2 crystallize in the monoclinic P21/c space group. In 1, each quadrangular tube links four other ones by phosphinates to produce a porous three-dimensional (3D) framework. Compound 2 contains the inorganic chains formed by paddle-wheel [Cu2(COO)4] unit and Cu(II) ions in alternate arrangement concatenated by phosphinates. Those chains grow up to a 3D network with the total accessible volume being 49.2% per unit cell volume. Magnetic analysis reveals that 1 and 2 display antiferromagnetic behavior.
- Published
- 2021
30. Research on the particle dispersion in the particulate two-phase round jet
- Author
-
Jianzhong, Lin, Jiang, Lin, and Libing, Zhu
- Published
- 1999
- Full Text
- View/download PDF
31. Layer thickness measurement of the TRISO-coated particle based on U-Net
- Author
-
Xincheng Xiang, Xiangang Wang, Hang Zhang, and Libing Zhu
- Subjects
010302 applied physics ,Nuclear fission product ,Materials science ,Mechanical Engineering ,Isotropy ,Condensed Matter Physics ,01 natural sciences ,Thresholding ,Core (optical fiber) ,0103 physical sciences ,Particle ,General Materials Science ,Wafer ,Pyrolytic carbon ,Composite material ,010301 acoustics ,Layer (electronics) - Abstract
Tri-structural Isotropic (TRISO) coated particles are the core fuel of high temperature gas-cooled reactors (HTGR), with four layers encasing the kernel. The layer thickness measurement must be established in that the particle failure probability is directly dependent on the layer thickness. The buffer layer retains the fission product and gas. Herein, we employed X-ray computed tomography to test the particle non-destructively. However, the inner pyrolytic carbon (IPyC) and buffer layer in the slice are hard to segment with the traditional thresholding method. In order to obtain the thickness distribution of the two layers, we utilized U-Net, a deep learning network for the segmentation. After segmentation, the two layers were unwrapped from its mass center to calculate thickness distribution at different angles. The results demonstrate the preliminary feasibility of the layer segmentation based on U-Net.
- Published
- 2021
32. Correction to: Gut microbial characteristics of adult patients with allergy rhinitis
- Author
-
Lin Tang, Wenrong Wan, Feng Xu, Libing Zhu, Hongzhi Xu, Bin Yu, Zhangran Chen, Yanling Du, and Yimin Yang
- Subjects
Allergy ,medicine.medical_specialty ,Adult patients ,business.industry ,MEDLINE ,lcsh:QR1-502 ,Bioengineering ,medicine.disease ,Applied Microbiology and Biotechnology ,Dermatology ,lcsh:Microbiology ,Medicine ,business ,Biotechnology - Abstract
An amendment to this paper has been published and can be accessed via the original article.
- Published
- 2020
33. Spatial Uniformity Assessment of Particles Distributed in a Spherical Fuel Element Using a Non-Destructive Approach
- Author
-
Xiangang Wang, Xuzhi Zhao, Houjin Chen, Libing Zhu, and Yahui Peng
- Subjects
0301 basic medicine ,Multidisciplinary ,Materials science ,Particle number ,medicine.diagnostic_test ,Acoustics ,lcsh:R ,lcsh:Medicine ,Spherical space ,Image processing ,Computed tomography ,Space (mathematics) ,Article ,Electrical and electronic engineering ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Nuclear fuel ,Non destructive ,medicine ,lcsh:Q ,Element (category theory) ,lcsh:Science ,030217 neurology & neurosurgery ,Identical particles - Abstract
In many manufacturing procedures, a large number of identical particles need to be disseminated uniformly into a given space. The uniformity of the spatial distribution of the particles can be critical to the properties of the final products. We proposed an image processing-based non-destructive technique to evaluate the particles’ spatial uniformity in a spherical space imaged with computed tomography. Both graphic (qualitative) and numerical (quantitative) methods were developed to demonstrate the (non-) uniformity of the particles. Simulation results indicated that the technique helped detecting the non-uniformity in the particles’ spatial distribution accurately. We conclude that the proposed technique can be used to test whether a number of particles in a sphere are uniformly distributed statistically and graphically.
- Published
- 2019
34. Chinese Herbal Medicine as an Adjunctive Therapy for Breast Cancer: A Systematic Review and Meta-Analysis
- Author
-
Lingru Li, Libing Zhu, Qi Wang, Yingshuai Li, and Ji Wang
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Nausea ,medicine.medical_treatment ,Review Article ,Tumor response ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,medicine ,In patient ,Chemotherapy ,business.industry ,lcsh:Other systems of medicine ,lcsh:RZ201-999 ,medicine.disease ,Surgery ,030104 developmental biology ,Complementary and alternative medicine ,030220 oncology & carcinogenesis ,Meta-analysis ,Toxicity ,Vomiting ,medicine.symptom ,business - Abstract
Chinese herbal medicine (CHM) has been widely used as an adjunctive therapy for breast cancer, while its efficacy remains unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with chemotherapy for breast cancer. The study results showed that CHM combined with chemotherapy significantly increased tumor response and KPS as compared to using chemotherapy alone (RR = 1.36; 95% CI = 1.24–1.48;P<0.00001; RR = 1.38; 95% CI = 1.26–1.52;P<0.00001, resp.). Besides, CHM as an adjunctive therapy significantly reduced the nausea and vomiting at toxicity grade of III–IV (RR = 0.37; 95% CI = 0.27–0.52;P<0.00001). Moreover, the combined therapy significantly prevented the decline of WBC in patients under chemotherapy at toxicity grade of III–IV (RR = 0.49; 95% CI = 0.34–0.69;P<0.00001) and prevented the decline of platelet at toxicity grade of III–IV or I–IV (RR = 0.29; 95% CI = 0.12–0.73;P=0.008; RR = 0.77; 95% CI = 0.63–0.94;P=0.009, resp.). This study suggests that CHM combined with chemotherapy in comparison with chemotherapy alone can significantly enhance tumor response, improve KPS, and alleviate toxicity induced by chemotherapy in breast cancer patients. However, a firm conclusion could not be reached due to the lack of high quality trials and large-scale RCTs, so further trials with higher quality and larger scale are needed.
- Published
- 2016
35. Development and Application of Cobalt Adjuster Rod for 60Co Medical Radioactive Sources Production in CANDU-6 Reactor
- Author
-
Dang Yu, Li Hui, Huimin Qin, Chuntao Tang, Ding Jie, and Libing Zhu
- Subjects
Materials science ,chemistry ,Waste management ,Production (economics) ,chemistry.chemical_element ,Cobalt - Abstract
60Co radioactive sources are widely used in industrial and medical field. In 2008, Cobalt adjuster rod assemblies were loaded in the core of CANDU-6 reactor in order to produce industrial radioactive sources. Based on successful production and application of 60Co industrial radioactive sources, the program of developing cobalt adjuster rod for 60Co medical radioactive sources production was launched. Comparing with industrial radioactive sources, medical radioactive sources require higher activity ∼220Ci/g and smaller sources size, which cause challenges to cobalt adjuster rod design and manufacturing. In this paper, several types of cobalt pellets have been developed to match the medical radioactive sources size and the corresponding nuclear design, TH design & safety analysis, shielding design & safety analysis was also completed to prove that the design requirements could be satisfied. By now the development of cobalt adjuster rod for 60Co medical radioactive sources production has finished and the first batch of cobalt adjuster rod assemblies have been successfully loaded in core. The first batch of 60Co medical radioactive sources is expected to be put into application in 2019.
- Published
- 2017
36. Research and Engineering Application of Repaired Fuel Assembly Reusing Technique
- Author
-
Lihua Wang, Zhe Wang, Qingxiang Yang, Jiazheng Liu, Yang Bo, Ding Yang, Yang Ping, Libing Zhu, Ding Jie, and Hong Cao
- Subjects
Engineering drawing ,Engineering ,business.industry ,Computer software ,Reuse ,Design methods ,business ,Manufacturing engineering - Abstract
Due to debris in the coolant against clad, fuel clad wear, fuel handling fault and so on, fuel rods maybe be damaged during the operation of nuclear power plants, in order that the fuel assemblies with damaged fuel rods are discharged before scheduled. If the damaged fuel assemblies are not reloaded into the core of the nuclear power plant, the fuel utilization decreases and the economy of the nuclear power plant is partly lost. For retrieving the loss of the economy, the damaged fuel assemblies can be repaired by replacing damaged fuel rods with dummy rods which don’t include fissile nuclides. Then, the repaired fuel assemblies can be reloaded into the core. As the repaired fuel assemblies are different with the normal fuel assemblies, especially the number of the damaged fuel rods is considerable, a whole quantitative analysis is very necessary to evaluate the effects from the reuse of the repaired fuel assemblies. In this paper, a full scope evaluation of reload design are performed including nuclear design, fuel design, thermal hydraulic design and safety evaluation, and some necessary improvements are done for the software system, design methods and progress which have been used in the normal reload design. As results, an integrated evaluation technique is developed to evaluate the feasibility and safety of reusing the repaired fuel assemblies, and the key effects due to the reuse of the repaired fuel assemblies are extracted, and the different effects are studied for the different materials of the dummy rods which can be used to conduct how to choose the proper material of dummy rods. In addition, this technique has been successfully applied in the engineering and the loss of economy due to the damage of fuel assemblies was retrieved partly. Therefore, the integrated evaluation technique has also important directive to other nuclear power plants if the repaired fuel assemblies are planned to reuse.
- Published
- 2017
37. Test Reactor Irradiation Fuel Assembly Development in China
- Author
-
Jiazheng Liu, Zheng Yixiong, Ding Yang, Song Liu, Ding Jie, and Libing Zhu
- Subjects
Waste management ,Creep ,Nuclear engineering ,technology, industry, and agriculture ,Environmental science ,Irradiation ,equipment and supplies ,Test (assessment) - Abstract
During the development of zirconium alloys, the irradiation in the test reactor is a critical step to comparison the irradiation properties of candidate alloys, such as corrosion, creep and irradiation growth. In this paper, a small scaled fuel assembly for test reactor irradiation is designed, which meets the needs of new zirconium alloys development. The irradiation fuel assembly (IFA) can be easily disassembled, and the test fuel rods or irradiation specimen can be easily replaced, which makes it possible to do the further post-irradiation examination in the hot cell to obtain the irradiation performance data. Now the IFA has finish fabrication and the test reactor irradiation program is planned to launch in 2017.
- Published
- 2017
38. CAP1400 Fuel Assembly Development and PWR Fuel Assembly Technology Progress in China
- Author
-
Yunqing Zhou, Li Jiwei, Fujun Gan, Zheng Yixiong, Lu Junqiang, Ding Yang, Song Liu, Zhou Qin, Ding Jie, Libing Zhu, and Zeng Qifeng
- Subjects
Engineering ,Waste management ,business.industry ,Zirconium alloy ,China ,business ,Corrosion - Abstract
In 1990s the first generation of PWR fuel assembly FA300 was developed in China. With constantly design improvements over the following 20 years, three types of FA300 fuel assemblies have been developed with max fuel assembly average burnup reach 40000 MWd/tU and successfully used in 300MWe PWRs. By now over 1100 fuel assemblies of FA300 series have been successfully operated in three different 300MWe PWRs with satisfied operation reliability. The CAP1400 fuel assembly development program was launched in 2010 which includes new zirconium cladding material development, UO2 pellet development, high performance fuel assembly mechanical structure development, fuel rod performance code and fuel assembly seismic analysis code development, out-of-pile fuel assembly test facility construction and in core irradiation program. The main purpose of CAP1400 fuel assembly development program is to meet the needs of self-sufficient fuel supply to CAP1400 reactor. Based on FA300 and CAP1400 fuel assembly development, a full series of PWR Fuel R&D technology and test system has been successfully established by SNERDI which will continuously support the fuel assembly improving and new type of fuel development. This paper will mainly describe the PWR fuel technology including cladding technology, pellet technology, fuel assembly mechanical design technology, fuel assembly test facility and test technology, fuel rod and fuel assembly code development progress. Furthermore, the development progress of CAP1400 fuel assembly will also be introduced. By now two types of new zirconium alloys have been selected as candidate alloys, all of the out-of pile performance tests have been finished. Both two alloys show good corrosion resistance. Through full series of fuel assembly components performance tests, the fuel assembly has finished design finalization. Most of the fuel assembly mechanical and hydraulic tests will be finished by the end of 2016. The test reactor irradiation program and commercial PWR irradiation program are also on the schedule. After the LTA program and commercial application licensing, the CAP1400 fuel assembly is anticipated to provide adequate burnup capability and operation reliability to CAP1400 reactor in China.
- Published
- 2017
39. Investigation Into the Influence of Fuel Rods on the Anti-Seismic Mechanical Characteristics of Fuel Assembly Spacer Grid by FEM Method
- Author
-
Jiazheng Liu, Dang Yu, Libing Zhu, Sun Jingya, and Liu Song
- Subjects
Engineering drawing ,Materials science ,genetic structures ,business.industry ,Stiffness ,Structural engineering ,Rod ,Finite element method ,Stress (mechanics) ,Buckling ,medicine ,medicine.symptom ,business ,Spacer grid - Abstract
The anti-seismic performance of fuel assembly is mainly determined by the critical crush load and the stiffness of spacer grids. To comprehensive know about the influence of fuel rods on the spacer grid, a 5×5 spacer grid FEM model which including fuel rods is established. Basing the fact that the grid spring has remarkable influence on the grid crush strength which is found in experiment, some cases are carried out, which are used to analyze effects of grid with/without fuel rod, friction between the grid spring/dimple and the fuel rod, the deflection of grid spring on the static buckling strength. Results show that grids with fuel rods will have higher crush strength than those without fuel rods; at certain range, increasing grid spring deflection at working point will do help to increase the grid crush strength; higher friction coefficient of grid spring and fuel rod can enhance the crush strength. Comparing with experimental results in literatures, results from simulations show the same tendency with the experimental results. The conclusion and the simulation method involved in this paper can provide some guidelines to optimize the performance of spacer grid assembly.
- Published
- 2017
40. Preliminary study of normoxic PAGAT polymer gel dosimeter by adding formaldehyde
- Author
-
Song Zou, Xincheng Xiang, Yi Du, Xiangang Wang, and Libing Zhu
- Subjects
History ,chemistry.chemical_compound ,Materials science ,Dosimeter ,chemistry ,Formaldehyde ,Polymer gel ,Computer Science Applications ,Education ,Nuclear chemistry - Published
- 2019
41. CHOP deficiency results in elevated lipopolysaccharide-induced inflammation and kidney injury
- Author
-
Jian Chen, Feng Zheng, Libing Zhu, Liangfu Huang, Jianming Tan, Huabao Xiong, Gary E. Striker, Vittoria Esposito, and Fabrizio Grosjean
- Subjects
Lipopolysaccharides ,Nephrology ,medicine.medical_specialty ,genetic structures ,Physiology ,Kidney Glomerulus ,Inflammation ,CHOP ,Mice ,immune system diseases ,Stress, Physiological ,Sepsis ,hemic and lymphatic diseases ,Internal medicine ,polycyclic compounds ,medicine ,Animals ,Cells, Cultured ,Transcription Factor CHOP ,Kidney ,Podocytes ,business.industry ,Endoplasmic reticulum ,Acute kidney injury ,Articles ,Acute Kidney Injury ,Endoplasmic Reticulum Stress ,medicine.disease ,eye diseases ,Mice, Inbred C57BL ,Endocrinology ,medicine.anatomical_structure ,Macrophages, Peritoneal ,Unfolded protein response ,Female ,medicine.symptom ,business - Abstract
C/EBP homologous protein (CHOP) is an important mediator of endoplasmic reticulum (ER) stress-induced cell and organ injury. Here we show that lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with ER stress and elevated CHOP. We postulated that CHOP−/−mice would be protected against LPS-induced-AKI. Unexpectedly, while Toll-like receptor 4 (TLR4) expression levels were comparable in kidneys of CHOP−/−and wild-type (WT) mice, CHOP−/−mice developed more severe AKI after LPS injection. Furthermore, the severe kidney injury in CHOP−/−mice was associated with an exaggerated inflammatory response. Serum TNF-α levels were more elevated in LPS-treated CHOP−/−mice. There was a 3.5-fold higher amount of renal neutrophil infiltrates in LPS-treated CHOP−/−than in WT mice. Additionally, the kidneys of LPS-treated CHOP−/−mice had a more prominent increase in NF-κB activation and further upregulation of proinflammatory genes, i.e., c-x-c motif ligand 1 (CXCL-1), macrophage inflammatory protein-2 (MIP-2), and IL-6. Finally, proximal tubules, glomeruli, and podocytes isolated from CHOP−/−mice also had an exaggerated proinflammatory response to LPS. Since LPS directly increased CHOP in glomeruli and podocytes of WT mice, together these data suggest that the LPS-induced increase of CHOP in kidneys may inhibit inflammatory response in renal cells and provide protection against AKI.
- Published
- 2013
42. MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40
- Author
-
Libing Zhu, Dong Wang, Tengyue Zeng, Wenli Zhuo, Min Liao, Shunliang Yang, and Weizhen Wu
- Subjects
0301 basic medicine ,Male ,Cancer Research ,MAP Kinase Signaling System ,Down-Regulation ,Apoptosis ,Biology ,Small hairpin RNA ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,DU145 ,Cancer stem cell ,Cell Movement ,Cell Line, Tumor ,medicine ,Humans ,Phosphorylation ,RNA, Small Interfering ,Adaptor Proteins, Signal Transducing ,Cell Proliferation ,Gene knockdown ,Oncogene ,Myosin Heavy Chains ,Cell growth ,Cancer ,Prostatic Neoplasms ,General Medicine ,Cell Cycle Checkpoints ,medicine.disease ,Molecular biology ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Gene Knockdown Techniques ,Cancer research ,RNA Interference ,Poly(ADP-ribose) Polymerases ,Signal Transduction - Abstract
Prostate cancer is the second most frequently diagnosed cancer among males around the world. Myosin VI (MYO6), as a motor protein, has been reported to be implicated in cancer-related cell migration and cellular functions. To investigate the role of MYO6 in prostate cancer, immunohistochemical analysis was firstly applied to prostate cancer tissues and revealed that MYO6 was closely related with the Gleason score in prostate cancer. Then we used specific short hairpin RNA (shRNA) to downregulate MYO6 expression in DU145 and PC-3 cells and found that decreased MYO6 expression significantly suppressed cell proliferation, as determined by MTT and colony formation assays. Flow cytometry confirmed that the suppression of MYO6 promoted cell cycle arrest at the G2/M and sub-G1 phase in the DU145 cells. Furthermore, PathScan intracellular signaling array analysis demonstrated that the phosphorylation of ERK1/2 and PRAS40 was downregulated in the DU145 cells following MYO6 knockdown. Knockdown of MYO6 downregulated the expression of AKT3 and upregulated the expression of PARP, as confirmed by western blot analysis. These results suggest that MYO6 plays an essential role in the progression of prostate cancer and silencing of MYO6 may be a promising therapeutic approach for prostate cancer.
- Published
- 2015
43. Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer
- Author
-
Weizhen Wu, Dong Wang, Wenli Zhuo, Min Liao, Libing Zhu, Shunliang Yang, and Tengyue Zeng
- Subjects
0301 basic medicine ,Male ,Cancer Research ,Cell cycle checkpoint ,Cell ,Apoptosis ,Biology ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,DU145 ,Cell Line, Tumor ,LNCaP ,medicine ,Humans ,RNA, Small Interfering ,Cell Proliferation ,Gene knockdown ,Cyclin-dependent kinase 1 ,Cell growth ,Prostatic Neoplasms ,Hematology ,General Medicine ,Cell cycle ,Middle Aged ,Cell biology ,G2 Phase Cell Cycle Checkpoints ,030104 developmental biology ,medicine.anatomical_structure ,HEK293 Cells ,Oncology ,Receptors, Androgen ,030220 oncology & carcinogenesis ,Gene Knockdown Techniques ,M Phase Cell Cycle Checkpoints ,Pyrroline Carboxylate Reductases ,Signal Transduction - Abstract
Pyrroline-5-carboxylate reductase 1 (PYCR1) is an enzyme involved in cell metabolism, which has been shown to be up-regulated in cancers. However, the functions of PYCR1 in prostate cancers (PCa) are still largely unknown. In the present study, we found that PYCR1 was highly expressed in prostate cancer tissues and then knocked down PYCR1 in PCa cell lines (DU145, PC-3 and LNCap) via lentivirus-mediated gene delivery and analyzed its biological function. Both qRT-PCR and western blotting indicated that PYCR1 was suppressed efficiently after sh-PYCR1 infection. Further analysis indicated knockdown of PYCR1 significantly inhibited PCa cell growth and colony formation ability. The inhibition effects on growth were likely due to G2/M-phase arrest and enhanced cell apoptosis, as determined by flow cytometer analysis. At last, we verified the expression levels of cell cycle regulatory proteins, including CDK1, CDK2, CDK4 and Cyclin B1 were all downregulated and cell apoptotic-related proteins, including cleaved caspase 3 and cleaved PARP were increased in PCa cells after PYCR1 knockdown. Furthermore, PYCR1 has been shown not to be directly regulated by androgen receptor (AR) levels. These results show the functions of PYCR1 in PCa tumorigenesis for the first time and suggest that PYCR1 might be a good potential therapy approach for treating PCa.
- Published
- 2015
44. Tianjiu therapy for patients with chronic asthma : an evaluation of efficacy and exploration of the optimal treatment duration
- Author
-
Libing Zhu
- Subjects
Pediatrics ,medicine.medical_specialty ,Chronic asthma ,business.industry ,Optimal treatment ,medicine ,Physical therapy ,Duration (project management) ,business - Published
- 2015
45. Randomized Trial of Tian Jiu Therapy in San Fu Days for Patients with Chronic Asthma
- Author
-
Libing Zhu, Waichung Chen, Kwaicing Lo, and Lei Li
- Abstract
Background: Tian Jiu Therapy (a medicinal vesiculation therapy according to traditional Chinese medicine theory) in San Fu Days (the three hottest days in a year is calculated by the Chinese ancient calendar) is widely used by patients with chronic asthma in China although from modern medicine perspective there is insufficient evidence of its effectiveness and safety issues. We investigated the efficacy and safety of Tian Jiu Therapy compared with placebo in patients with chronic asthma. Methods: Patients with chronic asthma were randomly assigned to Tian Jiu treatment group (n=165), placebo control group (n=158). Registered Chinese Medicine practitioners, in Orthopedics-Traumatology, Acupuncture, and Tui-na Clinical Centre for Teaching and Research, School of Chinese Medicine, The University of Hong Kong, administered Tian Jiu Therapy and placebo treatment in 3 times over 2 months. Patients completed questionnaires and lung function test before treatment and after treatment, 3, 6, 9, and 11 months, respectively. The primary outcome was the no of asthma-related sub-healthy symptoms and the percentage of patients with twenty-three symptoms. Results: 451 patients were recruited totally, 111 patients refused or did not participate according the appointment time and 17 did not meet the inclusion criteria. Consequently, 323 of eligible patients were enrolled. There was nothing difference between Tian Jiu Therapy group and placebo control group at the end of all treatments neither primary nor secondary outcomes. While Tian Jiu Therapy as compared with placebo significantly reduced the percentage of participants who are susceptible waken up by asthma symptoms from 27% to 14% at 2nd follow-up (P < 0.05). Similarly, Tian Jiu Therapy significantly reduced the proportion of participants who had the symptom of running nose and sneezing before onset from 18% to 8% at 2nd follow-up (P < 0.05). Additionally, Tian Jiu Therapy significantly reduced the level of asthma, the proportion of participants who don't need to processed during asthma attack increased from 6% to 15% at 1st follow-up and 0% to 7% at 3rd follow-up (P < 0.05). Improvements also occurred with Tian Jiu Therapy group, it reduced the proportion of participants who were spontaneously sweating at 3rd follow up and diarrhea after intake of oily food at 4th follow-up (P < 0.05). Conclusion: When added to a regimen of foundational therapy for chronic asthma participants, Tian Jiu Therapy further reduced the need for medications to control asthma, improved the quality of participants' life, and significantly reduced the level of asthma. What is more, this benefit seems to have an accumulative effect over time was in accordance with the TCM theory of 'winter disease is being cured in summer'.
- Published
- 2014
- Full Text
- View/download PDF
46. Protective effect of a polysaccharide from stem of Codonopsis pilosula against renal ischemia/reperfusion injury in rats
- Author
-
Meng Junping, Yang Feng, Zhao Jie, Zhang Han, Yang Jie, Libing Zhu, Sun Jifeng, Dewei Du, Yanlong Zhao, and Zhanting Li
- Subjects
Male ,Polymers and Plastics ,Kidney ,Blood Urea Nitrogen ,chemistry.chemical_compound ,Residue (chemistry) ,Polysaccharides ,Lactate dehydrogenase ,Materials Chemistry ,medicine ,Animals ,Rats, Wistar ,Blood urea nitrogen ,Codonopsis ,Renal ischemia ,biology ,L-Lactate Dehydrogenase ,Plant Stems ,Codonopsis pilosula ,Tumor Necrosis Factor-alpha ,Organic Chemistry ,Kidney metabolism ,Alanine Transaminase ,biology.organism_classification ,Molecular biology ,Rats ,medicine.anatomical_structure ,Biochemistry ,Alanine transaminase ,chemistry ,Creatinine ,Reperfusion Injury ,biology.protein - Abstract
In this study, we purified a homogeneous polysaccharide (S-CPPA1) with a molecular weight (Mw) of 133.2 kDa from the stem of Codonopsis pilosula for the first time. Gas chromatography (GC) analysis identified that S-CPPA1 contained glucose, galactose, and arabinose with a molar ratio of 10.5:3.4:1.7, along with a trace of mannose. Methylation analysis suggested S-CPPA1 was a branched polysaccharide, with five glucosidic linkage forms, namely (1→4)-linked Glcp (residue A), (1→6)-linked Galp (residue B), (1→2,6)-linked Glcp (residue C), (1→5)-linked Araf (residue D), and non-reducing terminal (1→)-linked Glcp (residue E). The protective effect of S-CPPA1 on kidney ischemia/reperfusion (I/R) injury was also evaluated. Blood urea nitrogen (BUN), creatinine and TNF-α levels, as well as lactate dehydrogenase (LDH) and alanine transaminase (AST) activities were elevated in the I/R group as compared to the sham group. On the other hand, S-CPPA1 treatment reversed all these biochemical indices, as well as histopathological alterations, which were induced by I/R. The findings imply that S-CPPA1 plays a causal role in the protection against I/R-induced renal injury and its renoprotective effect is probably mediated by inhibiting the proinflammatory cytokine TNF-α release.
- Published
- 2012
47. MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40.
- Author
-
DONG WANG, LIBING ZHU, MIN LIAO, TENGYUE ZENG, WENLI ZHUO, SHUNLIANG YANG, and WEIZHEN WU
- Published
- 2016
- Full Text
- View/download PDF
48. CHOP deficiency results in elevated lipopolysaccharide-induced inflammation and kidney injury.
- Author
-
Esposito, Vittoria, Grosjean, Fabrizio, Jianming Tan, Liangfu Huang, Libing Zhu, Jian Chen, Huabao Xiong, Striker, Gary E., and Feng Zheng
- Abstract
C/EBP homologous protein (CHOP) is an important mediator of endoplasmic reticulum (ER) stress-induced cell and organ injury. Here we show that lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with ER stress and elevated CHOP. We postulated that CHOP-/- mice would be protected against LPS-induced-AKI. Unexpectedly, while Toll-like receptor 4 (TLR4) expression levels were comparable in kidneys of CHOP-/- and wild-type (WT) mice, CHOP-/- mice developed more severe AKI after LPS injection. Furthermore, the severe kidney injury in CHOP-/- mice was associated with an exaggerated inflammatory response. Serum TNF-α levels were more elevated in LPS-treated CHOP-/- mice. There was a 3.5-fold higher amount of renal neutrophil infiltrates in LPS-treated CHOP-/- than in WT mice. Additionally, the kidneys of LPS-treated CHOP-/- mice had a more prominent increase in NF-κB activation and further upregulation of proinflammatory genes, i.e., c-x-c motif ligand 1 (CXCL-1), macrophage inflammatory protein-2 (MIP-2), and IL-6. Finally, proximal tubules, glomeruli, and podocytes isolated from CHOP-/- mice also had an exaggerated proinflammatory response to LPS. Since LPS directly increased CHOP in glomeruli and podocytes of WT mice, together these data suggest that the LPSinduced increase of CHOP in kidneys may inhibit inflammatory response in renal cells and provide protection against AKI. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
49. Preliminary study of normoxic PAGAT polymer gel dosimeter by adding formaldehyde.
- Author
-
Libing Zhu, Yi Du, Xincheng Xiang, Song Zou, and Xiangang Wang
- Published
- 2019
- Full Text
- View/download PDF
50. Randomized trial of acupoints herbal patching in Sanfu Days for asthma in clinical remission stage
- Author
-
Vivian C. W. Wong, Wei Zhang, Lei Li, Kwaiching Lo, Libing Zhu, Ziea Eric, Lixing Lao, To Yau, and Waichung Chan
- Subjects
medicine.medical_specialty ,Medicine (miscellaneous) ,Traditional Chinese medicine ,030204 cardiovascular system & hematology ,Placebo ,Pulmonary function testing ,law.invention ,Acupoints herbal patching ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Internal medicine ,medicine ,030212 general & internal medicine ,Stage (cooking) ,Nose ,Sanfu days ,Asthma ,Traditional medicine ,business.industry ,Research ,medicine.disease ,medicine.anatomical_structure ,Molecular Medicine ,Randomized trial ,business - Abstract
Background Although China has a long history of using acupoints herbal patching (acupoints herbal patching means applying herbal patch on special acupoints to stimulate skin to form blisters, hyperemia, and even suppuration) in Sanfu Days (Sanfu Days are supposed to be the three hottest days in a year which is calculated by the ancient calendar) for the treatment of asthma, there is insufficient evidence to support its effectiveness and safety issues. This study investigated the efficacy and safety of acupoints herbal patching compared with placebo in participants with asthma in clinical remission stage. Methods We enrolled participants with asthma in clinical remission stage, above 13 years old and both genders in a randomized, double-blind and placebo-control trial at clinical center, School of Chinese Medicine, The University of Hong Kong to assess the effectiveness and safety of acupoints herbal patching, as compared with placebo, when added to guidelines-based therapy. The trial was conducted for three times (these three times were 19 July, 29 July and 8 August 2010), and the primary outcome was pulmonary function test. Secondary outcome was self-made questionnaire which were designed based on Traditional Chinese Medicine theory and clinical experience summary. Results Three hundred and twenty three eligible participants were enrolled, they were randomly assigned to acupoints herbal patching group (n = 165), placebo control group (n = 158). There was no significant difference in primary and secondary outcome as compared with placebo group at the end of 3rd treatment and four times follow ups. But sub-analysis of secondary outcome in four times follow ups showed that acupoints herbal patching significantly reduced the proportion of participants who didn’t need medical treatment when they had a small rise in asthma-related symptoms increased from 6–15 % at 1st follow up and 0–7 % at 3rd follow up (P
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.