Search

INTRODUCTION: Long‐term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pNfL, and their association with the comorbidity of AD and CSVD remains unknown. METHODS: Participants with normal cognition and mild cognitive impairment from the Alzheimer's Disease Neuroimaging Initiative study were included in the data analysis. Linear mixed‐effects regression models and causal mediation analyses were conducted to investigate the relationship among BPV, pNfL, comorbidity‐related brain structural changes (hippocampal atrophy and white matter hyperintensities [WMH]), and cognitive function. RESULTS: BPV was associated with pNfL, volumes of hippocampus and WMH, and cognition. pNfL mediated the effects of BPV on brain structural changes and cognition. DISCUSSION: Our findings suggest a potential role of BPV and pNfL in the mechanism of comorbidity between AD and CSVD, underscoring the importance of BPV intervention in the general population. Highlights: Individuals with both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) pathologies had elevated blood pressure variability (BPV) and plasma neurofilament light (pNfL).The association between different components of BPV and brain structural changes may vary.BPV was associated with pNfL levels independent of average blood pressure.pNfL mediated the effects of BPV on comorbidity‐related brain structural changes and cognitive performance. [ABSTRACT FROM AUTHOR]

Dental bonding technology and materials have been used widely in dentistry because of their excellent properties. The development of novel bonding technology and materials is constantly being performed to improve the effect of dental bonding restorations. Observation and analysis of the dental bonding interface is one of the most important methods for laboratory evaluation of bonding efficiency. This paper aims to review the methods of observation and analysis of dental bonding interfaces to provide a reference for the selection of evaluation methods in dental bonding research. The features of 6 methods, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), Raman spectroscopy (RS), optical coherence tomography (OCT) and atomic force microscopy (AFM), were described and summarized. Among these methods, SEM and TEM are used most often in the analysis of fine structures; CLSM and OCT are used for the acquisition of characteristic image signals, such as microleakage and exogenous and endogenous fluorescence; and RS and AFM can test chemical composition and mechanical properties.

[Purpose/Significance] E-commerce platforms take critical part in the promotion of the sale of agricultural products in poor areas and achieve poverty alleviation goals. It is essential to identify the characteristics and influences of the marketing information in the platforms and will provide a realistic reference for the establishment of sustainable targeted poverty alleviation. [Method/Process] Based on qualitative data collected from three typical WeChat e-commerce platforms, characteristics of marketing information have been concluded. Besides on the basis of constructing the experimental design and the interview to college students, the influence and sustainability of different approaches has been discussed. [Results/Conclusions] There are at least six marketing approaches, including promotion marketing, health marketing, star marketing, direct marketing, news marketing and emotional marketing. As for college students, the effects of different marketing methods vary greatly, and emotional marketing may lead to the deviation of poverty alleviation discourse, and there is a risk of trust crisis of poverty alleviation and rural assistance if emotional marketing is abused.

In order to study the stress on the joints of excavator under asymmetric load and carry out a fatigue life test on the key structural parts, an experimental device of fatigue dynamic loading system of an excavator is designed in this paper. The excavation gesture under the lifting and turning of the arm is selected as the research object, and the experimental device has been simplified as two-force bar, based on AMESim, the model of the hydraulic loading system is simulated, and the step response characteristic of the loading system under 20Hz sinusoidal excitation signal are obtained. The results show the attitude selection of excavator specimens is representative, and the hydraulic loading system can meet the system response requirements under different loading frequencies, which can be used for performance test simulation research. [ABSTRACT FROM AUTHOR]

Statement of Problem: A consensus regarding how to effectively remove residual resin cement and polish the restoration margin during the cementation of porcelain laminate veneers (PLVs) is lacking., Purpose: The purpose of this in vitro study was to evaluate the effect of different cleaning and polishing techniques on the removal of residual resin cement and margin surface roughness of PLVs., Material and Methods: PLVs were bonded to prepared buccal surfaces of extracted human premolars. All specimens were randomly divided by using a random number table into 8 groups (n=6): curette (C); brush (B); curette + polisher (CP); curette + rotary instrument (CR); curette + rotary instrument + polisher (CRP); brush + polisher (BP); brush + rotary instrument (BR); brush + rotary instrument + polisher (BRP). The relative amount of residual cement along the PLV margins were observed with a stereomicroscope and evaluated with a software program of Image J. The surface roughness and 3-dimensional (3D) morphology of the restoration margins were evaluated with a 3D topography scanner. Scanning electron microscopy (SEM) was used to detect the microscopic morphological characteristics of the restoration margins. Statistical analysis was performed by 2-way analysis of variance (α=.05)., Results: Different techniques were associated with significantly different efficiencies in terms of removing residual cement and the surface roughness at the restoration margins (P<.001). The lowest relative amount of residual cement, as well as the lowest surface roughness, was detected in the BRP group (P<.001). SEM observation indicated that the BRP technique also maintained the integrity of the cement layer., Conclusions: The removal of excess cement before polymerization using a brush, followed by sequential polishing with high-speed rotary instruments and low-speed polishers represents an effective technique in the removal of residual cement and smoothing the restoration margin without impairing the integrity of the bonded interface., (Copyright © 2024. Published by Elsevier Inc.)

Introduction: Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pNfL, and their association with the comorbidity of AD and CSVD remains unknown., Methods: Participants with normal cognition and mild cognitive impairment from the Alzheimer's Disease Neuroimaging Initiative study were included in the data analysis. Linear mixed-effects regression models and causal mediation analyses were conducted to investigate the relationship among BPV, pNfL, comorbidity-related brain structural changes (hippocampal atrophy and white matter hyperintensities [WMH]), and cognitive function., Results: BPV was associated with pNfL, volumes of hippocampus and WMH, and cognition. pNfL mediated the effects of BPV on brain structural changes and cognition., Discussion: Our findings suggest a potential role of BPV and pNfL in the mechanism of comorbidity between AD and CSVD, underscoring the importance of BPV intervention in the general population., Highlights: Individuals with both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) pathologies had elevated blood pressure variability (BPV) and plasma neurofilament light (pNfL). The association between different components of BPV and brain structural changes may vary. BPV was associated with pNfL levels independent of average blood pressure. pNfL mediated the effects of BPV on comorbidity-related brain structural changes and cognitive performance., (© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

A highly chemo- and regioselective intermolecular 1,2-aryl-aminoalkylation of alkenes by photoredox/nickel dual catalysis is described here. This three-component conjunctive cross-coupling is highlighted by its first application of primary alkyl radicals, which were not compatible in previous reports. The readily prepared α-silyl amines could be transferred to α-amino radicals by photo-induced single electron transfer step. The radical addition/cross-coupling cascade reaction proceeds under mild, base-free and redox-neutral conditions with good functional group tolerance, and importantly, provides an efficient and concise method for the synthesis of structurally valuable α-aryl substituted γ-amino acid derivatives motifs., (© 2020 Wiley-VCH GmbH.)