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Your search keyword '"Liao, Xin-Mei"' showing total 6 results
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6 results on '"Liao, Xin-Mei"'

3. CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1

Author

Jiang, You, Wu, Shui-Yan, Chen, Yan-Ling, Zhang, Zi-Mu, Tao, Yan-Fang, Xie, Yi, Liao, Xin-Mei, Li, Xiao-Lu, Li, Gen, Wu, Di, Wang, Hai-Rong, Zuo, Ran, Cao, Hai-Bo, Pan, Jing-Jing, Yu, Juan-Juan, Jia, Si-Qi, Zhang, Zheng, Chu, Xin-Ran, Zhang, Yong-Ping, Feng, Chen-xi, Wang, Jian-Wei, Hu, Shao-Yan, Li, Zhi-Heng, Pan, Jian, Fang, Fang, and Lu, Jun

Published
2021
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4. MI‑773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1

Author

Chen, Yan-Ling, primary, Zhang, Zi-Mu, additional, Li, Xiao-Lu, additional, Tao, Yan-Fang, additional, Wu, Shui-Yan, additional, Fang, Fang, additional, Xie, Yi, additional, Liao, Xin-Mei, additional, Li, Gen, additional, Wu, Di, additional, Wang, Hai-Rong, additional, Zuo, Ran, additional, Cao, Hai-Bo, additional, Pan, Jing-Jing, additional, Yu, Juan-Juan, additional, Zhang, Zheng, additional, Chu, Xin-Ran, additional, Zhang, Yong-Ping, additional, Feng, Chen-Xi, additional, Wang, Jian-Wei, additional, Lu, Jun, additional, Hu, Shao-Yan, additional, Li, Zhi-Heng, additional, and Pan, Jian, additional

Published
2021
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5. Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663

Author

Wang Jian, Wu Shui Yan, Pan Jian, Zhou Zhuan, Tao Yan Fang, Liao Xin Mei, Zhao Wen Li, and Ni Jian

Subjects
Cancer Research, Time Factors, Cellular differentiation, Lymphocyte, Retinoic acid, Antineoplastic Agents, HL-60 Cells, Tretinoin, Biology, Transfection, lcsh:RC254-282, chemistry.chemical_compound, Downregulation and upregulation, microRNA, medicine, Humans, Promoter Regions, Genetic, Molecular Biology, Spleen Focus-Forming Viruses, Cell Proliferation, Oligonucleotide Array Sequence Analysis, lcsh:RC633-647.5, Gene Expression Regulation, Leukemic, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Research, Lentivirus, Myeloid leukemia, Cell Differentiation, lcsh:Diseases of the blood and blood-forming organs, Hematology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Up-Regulation, MicroRNAs, medicine.anatomical_structure, Oncology, chemistry, Cell culture, Cancer research
Abstract

Background Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized. Methods Using bioinformatics and in vitro experiments, we identified the microRNA gene expression profile of HL-60 cells during ATRA induced granulocytic differentiation. Results Six microRNAs were upregulated by ATRA treatment, miR-663, miR-494, miR-145, miR-22, miR-363* and miR-223; and three microRNAs were downregulated, miR-10a, miR-181 and miR-612. Additionally, miR-663 expression was regulated by ATRA. We used a lentivirus (LV) backbone incorporating the spleen focus forming virus (SFFV-F) promoter to drive miR-663 expression, as the CMV (Cytomegalovirus) promoter is ineffective in some lymphocyte cells. Transfection of LV-miR-663 induced significant HL-60 cell differentiation in vitro. Conclusions Our results show miR-663 may play an important role in ATRA induced HL-60 cell differentiation. Lentivirus delivery of miR-663 could potentially be used directly as an anticancer treatment in hematological malignancies

Published
2011

6. Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663.

Author

Pan Jian, Zhao Wen Li, Tao Yan Fang, Wang Jian, Zhou Zhuan, Liao Xin Mei, Wu Shui Yan, and Ni Jian

Subjects
ACUTE myeloid leukemia, GENE expression, LYMPHOID tissue, TRETINOIN, CELL lines, GENETIC transformation, BIOINFORMATICS
Abstract

Background: Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all transretinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized. Methods: Using bioinformatics and in vitro experiments, we identified the microRNA gene expression profile of HL-60 cells during ATRA induced granulocytic differentiation. Results: Six microRNAs were upregulated by ATRA treatment, miR-663, miR-494, miR-145, miR-22, miR-363* and miR-223; and three microRNAs were downregulated, miR-10a, miR-181 and miR-612. Additionally, miR-663 expression was regulated by ATRA. We used a lentivirus (LV) backbone incorporating the spleen focus forming virus (SFFV-F) promoter to drive miR-663 expression, as the CMV (Cytomegalovirus) promoter is ineffective in some lymphocyte cells. Transfection of LV-miR-663 induced significant HL-60 cell differentiation in vitro. Conclusions: Our results show miR-663 may play an important role in ATRA induced HL-60 cell differentiation. Lentivirus delivery of miR-663 could potentially be used directly as an anticancer treatment in hematological malignancies [ABSTRACT FROM AUTHOR]

Published
2011
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