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Nanoparticles are widely used in biomedical applications and cancer treatments due to their minute scale, multi-function, and long retention time. Among the various nanoparticles, the unique optical property derived from the localized surface plasmon resonance effect of metallic nanoparticles is a primary reason that metallic nanoparticles are researched and applied. Copper and Iron nanoparticles have the potential to generate hydroxyl radicals in excess H2O2 via Fenton or Fenton-like reactions. On the other hand, gold nanoparticles equipped with a photosensitizer can transfer the energy of photons to chemical energy and enhance the production of singlet oxygen, which is suitable for cancer treatment. With the actions of these two reactive oxygen species in the tumor microenvironment, cell apoptosis can further be induced. In this work, we first synthesized dual metal nanoparticles with poly[styrene-alt-(maleic acid, sodium salt)(Cu ferrite oxide-polymer) by a simple one-step hydrothermal reduction reaction. Then, gold(III) was reduced and doped into the structure, which formed a triple metal structure, Au-doped Cu ferrite nanoparticles (Au/Cu ferrite oxide-polymer NPs). The metal ratio of the product could be controlled by manipulating the Fe/Cu ratio of reactants and the sequence of addition of reactants. The core-shell structure was verified by transmission electron microscopy. Moreover, the hydroxyl radical and singlet oxygen generation ability of Au/Cu ferrite oxide-polymer was proved. The chemodynamic and photodynamic effect was measured, and the in vitro ROS generation was observed. Furthermore, the behavior of endocytosis by cancer cells could be controlled by the magnetic field. The result indicated that Au/Cu ferrite oxide-polymer core-shell nanoreactor is a potential agent for chemodynamic/photodynamic synergetic therapy.

Mie resonances have recently attracted much attention in research on dielectric metasurfaces, owning to their enriched multipole resonances, negligible optical loss, and efficient light emitter integration. Although there is a rapid advancement in this field, some fundamental developments are still required to provide a simpler and more versatile paradigm for photoluminescence (PL) control. In this work, we proposed that an all-dielectric coherent metasurface can engineer the PL response by tuning the array size. Such PL manipulation is attributed to the collective Mie resonances that mediate the inter-unit interactions between unit elements and alter the PL intensity. Metasurfaces with different chip sizes are utilized to explore the array size effect on the collective Mie resonances, field enhancement, and Q-factor in TiO2 metasurfaces. Incorporating the all-dielectric coherent metasurface with fluorescent photon emitters, we performed the dependence of PL enhancement on array size, which achieves an enhancement factor of ∼10 at the central area of a 90 × 90 μm2 TiO2 metasurface array. These findings provide an additional degree of freedom to engineer the near-field confinement and enhancement, allowing one to manipulate incoherent photon emission and tune light–matter interaction at the nanoscale.

The accumulation of amyloid fibrils is crucial in the development of amyloidosis. In addition, some hormone peptides, such as human calcitonin (hCT), have limited therapeutic potential owing to a high tendency of amyloid formation. Nowadays, nanotechnology offers many advantages in various scientific fields and can overcome some of the limitations in the development of traditional therapeutics. In the present study, we applied iron and copper chlorophyllin in the synthesis of iron-oxide nanoparticles to obtain porphyrin derivative-coated nanoparticles, namely, Fe3O4-Chl/Fe and Fe3O4-Chl/Cu, respectively. We observed that the two nanoparticles, especially Fe3O4-Chl/Fe, stabilized hCT and influenced hCT aggregation. To further confirm the applicability of Fe3O4-Chl/Fe, we utilized another benzothiazole-based fluorescent probe to monitor hCT amyloid formation. Several biophysical techniques, including transmission electron microscopy, dynamic light scattering, and isothermal titration calorimetry, were also implemented in our examinations. The fibrillar content of hCT after co-incubation was further determined using Bis-ANS and Nile red assays. The remaining soluble monomeric or oligomeric content of hCT was assessed by gel electrophoresis and biological assays. We believed that our findings would assist in the development of hCT drug formulation. Application of Fe3O4-Chl/Fe can increase the stability and bioactivity of hCT. [ABSTRACT FROM AUTHOR]

Thanks to the relatively broad photon emission response in NR, the resonant mode in TiO SB 2 sb metasurface is still able to interact with the emitted photon even the PL emission peak doesn't highly match with the electric resonant dip (refer to Figures 3 and 4A). Keywords: array size effect; coherent collective resonance; Mie resonance; photoluminescence enhancement; TiO2 metasurface EN array size effect coherent collective resonance Mie resonance photoluminescence enhancement TiO2 metasurface 2701 2709 9 05/19/22 20220601 NES 220601 1 Introduction Photoluminescence (PL) has been intensively utilized in versatile fields such as biological imaging and sensing [[1]], [[2]], [[3]], [[4]], nanolaser [[5]], [[6]], [[7]], and quantum technology [[8]]. The PL map represents that the PL emission is relatively weak for smaller metasurface arrays, and the PL intensity increases with increasing the array size. Instead of analyzing the PL enhancement by considering the contribution from a 10 × 10 m SP 2 sp area, the implementation of PL map enables us to investigate how the inter-unit coupling between TiO SB 2 sb nanofrustums and array size influence the PL intensity with higher spatial resolution. [Extracted from the article]

The combination of the functions of near infrared-triggered molecule release and chemo-photothermal therapy improved the therapeutic effect, but clarification of the cancer damage pathway in terms of protein molecule levels has yet to be well studied. In this study, we developed a polymer encapsulation synthesis of Au/Fe3O4@polymer nanoparticles as a Swiss army knife to integrate near infrared absorption, magnetism, and doxorubicin (DOX) loading ability into a single package. By exposing to near infrared absorption, the Au/Fe3O4@polymer nanoparticles possessed photothermal therapy, exhibiting anti-tumor growth suppression of HT-29 tumor-bearing nude mice with less body weight loss. To deeply understand the interactions between the drug-loaded nanocarriers and the protein structures of the treated cells, delivering therapeutic DOX agent combined with photothermal therapy with Au/Fe3O4@polymer nanostructures to cancer cells was investigated. Synchrotron-based FTIR imaging and confocal imaging showed direct observation of the efficient photo-chemotherapy impacting MCF7, MCF7/ADR, and HT-29 cells after the near infrared radiation-triggered DOX release. Our demonstration outlines how the cell destruction in the molecular mechanism was initiated by chemo-photothermal combination therapy after the translocation of DOX from the cytosol to the nuclei, leading to altered intracellular secondary proteins. For preclinical application of potential diagnosis to cancer cells, Au/Fe3O4@polymer nanoparticles performed integrated computed tomography/magnetic resonance imaging contrast enhancement and near infrared-triggered chemo-photothermal therapy. [ABSTRACT FROM AUTHOR]