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6. KAT8/SIRT7‐mediated Fascin‐K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma

Author

Li, Da‐Jia, primary, Cheng, Yin‐Wei, additional, Pan, Jin‐Mei, additional, Guo, Zhen‐Chang, additional, Wang, Shao‐Hong, additional, Huang, Qing‐Feng, additional, Nie, Ping‐Juan, additional, Shi, Wen‐Qi, additional, Xu, Xiu‐E, additional, Wen, Bing, additional, Zhong, Jin‐Ling, additional, Zhang, Zhi‐Da, additional, Wu, Zhi‐Yong, additional, Zhao, Hui, additional, Liao, Lian‐Di, additional, Wu, Jian‐Yi, additional, Zhang, Kai, additional, Dong, Geng, additional, Li, En‐Min, additional, and Xu, Li‐Yan, additional

Published
2024
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9. Serine/threonine‐protein kinase D2‐mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression.

Author

Liu, Yin‐Qiao, Xu, Yi‐Wei, Zheng, Zheng‐Tan, Li, Die, Hong, Chao‐Qun, Dai, Hao‐Qiang, Wang, Jun‐Hao, Chu, Ling‐Yu, Liao, Lian‐Di, Zou, Hai‐Ying, Li, En‐Min, Xie, Jian‐Jun, and Fang, Wang‐Kai

Subjects
DESMOGLEINS, CADHERINS, SQUAMOUS cell carcinoma, PHOSPHORYLATION, THREONINE, CELL junctions, CELL migration
Abstract

Desmoglein‐2 (DSG2) is a transmembrane glycoprotein belonging to the desmosomal cadherin family, which mediates cell–cell junctions; regulates cell proliferation, migration, and invasion; and promotes tumor development and metastasis. We previously showed serum DSG2 to be a potential biomarker for the diagnosis of esophageal squamous cell carcinoma (ESCC), although the significance and underlying molecular mechanisms were not identified. Here, we found that DSG2 was increased in ESCC tissues compared with adjacent tissues. In addition, we demonstrated that DSG2 promoted ESCC cell migration and invasion. Furthermore, using interactome analysis, we identified serine/threonine‐protein kinase D2 (PRKD2) as a novel DSG2 kinase that mediates the phosphorylation of DSG2 at threonine 730 (T730). Functionally, DSG2 promoted ESCC cell migration and invasion dependent on DSG2‐T730 phosphorylation. Mechanistically, DSG2 T730 phosphorylation activated EGFR, Src, AKT, and ERK signaling pathways. In addition, DSG2 and PRKD2 were positively correlated with each other, and the overall survival time of ESCC patients with high DSG2 and PRKD2 was shorter than that of patients with low DSG2 and PRKD2 levels. In summary, PRKD2 is a novel DSG2 kinase, and PRKD2‐mediated DSG2 T730 phosphorylation promotes ESCC progression. These findings may facilitate the development of future therapeutic agents that target DSG2 and DSG2 phosphorylation. © 2024 The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Author

Liu, Wei, Xie, Lei, He, Yao-Hui, Wu, Zhi-Yong, Liu, Lu-Xin, Bai, Xue-Feng, Deng, Dan-Xia, Xu, Xiu-E, Liao, Lian-Di, Lin, Wan, Heng, Jing-Hua, Xu, Xin, Peng, Liu, Huang, Qing-Feng, Li, Cheng-Yu, Zhang, Zhi-Da, Wang, Wei, Zhang, Guo-Rui, Gao, Xiang, Wang, Shao-Hong, Li, Chun-Quan, Xu, Li-Yan, Liu, Wen, and Li, En-Min

Published
2021
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13. Supplementary Figure 1 from DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma

Author

Hou, Jian, primary, Liao, Lian-Di, primary, Xie, Yang-Min, primary, Zeng, Fa-Min, primary, Ji, Xia, primary, Chen, Bo, primary, Li, Li-Yan, primary, Zhu, Meng-Xiao, primary, Yang, Cui-Xia, primary, Chen, Tao, primary, Xu, Xiu-E, primary, Shen, Jian, primary, Guo, Ming-Zhou, primary, Li, En-Min, primary, and Xu, Li-Yan, primary

Published
2023
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15. Supplementary Figure 3 from DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma

Author

Hou, Jian, primary, Liao, Lian-Di, primary, Xie, Yang-Min, primary, Zeng, Fa-Min, primary, Ji, Xia, primary, Chen, Bo, primary, Li, Li-Yan, primary, Zhu, Meng-Xiao, primary, Yang, Cui-Xia, primary, Chen, Tao, primary, Xu, Xiu-E, primary, Shen, Jian, primary, Guo, Ming-Zhou, primary, Li, En-Min, primary, and Xu, Li-Yan, primary

Published
2023
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16. Supplementary Table 1 from DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma

Author

Hou, Jian, primary, Liao, Lian-Di, primary, Xie, Yang-Min, primary, Zeng, Fa-Min, primary, Ji, Xia, primary, Chen, Bo, primary, Li, Li-Yan, primary, Zhu, Meng-Xiao, primary, Yang, Cui-Xia, primary, Chen, Tao, primary, Xu, Xiu-E, primary, Shen, Jian, primary, Guo, Ming-Zhou, primary, Li, En-Min, primary, and Xu, Li-Yan, primary

Published
2023
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17. Supplementary Table 2 from DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma

Author

Hou, Jian, primary, Liao, Lian-Di, primary, Xie, Yang-Min, primary, Zeng, Fa-Min, primary, Ji, Xia, primary, Chen, Bo, primary, Li, Li-Yan, primary, Zhu, Meng-Xiao, primary, Yang, Cui-Xia, primary, Chen, Tao, primary, Xu, Xiu-E, primary, Shen, Jian, primary, Guo, Ming-Zhou, primary, Li, En-Min, primary, and Xu, Li-Yan, primary

Published
2023
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20. Supplementary Figure S1-5 from The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma

Author

Zhang, Hai-Feng, primary, Chen, Ye, primary, Wu, Chengsheng, primary, Wu, Zhi-Yong, primary, Tweardy, David J., primary, Alshareef, Abdulraheem, primary, Liao, Lian-Di, primary, Xue, Yu-Jie, primary, Wu, Jian-Yi, primary, Chen, Bo, primary, Xu, Xiu-E, primary, Gopal, Keshav, primary, Gupta, Nidhi, primary, Li, En-Min, primary, Xu, Li-Yan, primary, and Lai, Raymond, primary

Published
2023
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21. Supplementary Materials and Methods from The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma

Author

Zhang, Hai-Feng, primary, Chen, Ye, primary, Wu, Chengsheng, primary, Wu, Zhi-Yong, primary, Tweardy, David J., primary, Alshareef, Abdulraheem, primary, Liao, Lian-Di, primary, Xue, Yu-Jie, primary, Wu, Jian-Yi, primary, Chen, Bo, primary, Xu, Xiu-E, primary, Gopal, Keshav, primary, Gupta, Nidhi, primary, Li, En-Min, primary, Xu, Li-Yan, primary, and Lai, Raymond, primary

Published
2023
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22. Supplementary Figures from LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Author

Zhan, Xiu-Hui, primary, Jiao, Ji-Wei, primary, Zhang, Hai-Feng, primary, Xu, Xiu-E, primary, He, Jian-Zhong, primary, Li, Run-Liu, primary, Zou, Hai-Ying, primary, Wu, Zhi-Yong, primary, Wang, Shao-Hong, primary, Wu, Jian-Yi, primary, Liao, Lian-Di, primary, Wang, Juan-Juan, primary, Cheng, Yin-Wei, primary, Zhang, Kai, primary, Neufeld, Gera, primary, Xu, Li-Yan, primary, and Li, En-Min, primary

Published
2023
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23. Supplementary Materials and Methods from LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Author

Zhan, Xiu-Hui, primary, Jiao, Ji-Wei, primary, Zhang, Hai-Feng, primary, Xu, Xiu-E, primary, He, Jian-Zhong, primary, Li, Run-Liu, primary, Zou, Hai-Ying, primary, Wu, Zhi-Yong, primary, Wang, Shao-Hong, primary, Wu, Jian-Yi, primary, Liao, Lian-Di, primary, Wang, Juan-Juan, primary, Cheng, Yin-Wei, primary, Zhang, Kai, primary, Neufeld, Gera, primary, Xu, Li-Yan, primary, and Li, En-Min, primary

Published
2023
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24. Supplementary Figure Legends from LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Author

Zhan, Xiu-Hui, primary, Jiao, Ji-Wei, primary, Zhang, Hai-Feng, primary, Xu, Xiu-E, primary, He, Jian-Zhong, primary, Li, Run-Liu, primary, Zou, Hai-Ying, primary, Wu, Zhi-Yong, primary, Wang, Shao-Hong, primary, Wu, Jian-Yi, primary, Liao, Lian-Di, primary, Wang, Juan-Juan, primary, Cheng, Yin-Wei, primary, Zhang, Kai, primary, Neufeld, Gera, primary, Xu, Li-Yan, primary, and Li, En-Min, primary

Published
2023
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25. Supplementary Tables from LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Author

Zhan, Xiu-Hui, primary, Jiao, Ji-Wei, primary, Zhang, Hai-Feng, primary, Xu, Xiu-E, primary, He, Jian-Zhong, primary, Li, Run-Liu, primary, Zou, Hai-Ying, primary, Wu, Zhi-Yong, primary, Wang, Shao-Hong, primary, Wu, Jian-Yi, primary, Liao, Lian-Di, primary, Wang, Juan-Juan, primary, Cheng, Yin-Wei, primary, Zhang, Kai, primary, Neufeld, Gera, primary, Xu, Li-Yan, primary, and Li, En-Min, primary

Published
2023
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26. Supplementary Table S1-2 from The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma

Author

Zhang, Hai-Feng, primary, Chen, Ye, primary, Wu, Chengsheng, primary, Wu, Zhi-Yong, primary, Tweardy, David J., primary, Alshareef, Abdulraheem, primary, Liao, Lian-Di, primary, Xue, Yu-Jie, primary, Wu, Jian-Yi, primary, Chen, Bo, primary, Xu, Xiu-E, primary, Gopal, Keshav, primary, Gupta, Nidhi, primary, Li, En-Min, primary, Xu, Li-Yan, primary, and Lai, Raymond, primary

Published
2023
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27. Data from The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma

Author

Zhang, Hai-Feng, primary, Chen, Ye, primary, Wu, Chengsheng, primary, Wu, Zhi-Yong, primary, Tweardy, David J., primary, Alshareef, Abdulraheem, primary, Liao, Lian-Di, primary, Xue, Yu-Jie, primary, Wu, Jian-Yi, primary, Chen, Bo, primary, Xu, Xiu-E, primary, Gopal, Keshav, primary, Gupta, Nidhi, primary, Li, En-Min, primary, Xu, Li-Yan, primary, and Lai, Raymond, primary

Published
2023
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31. Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Author

Cao, Yu-Fei, primary, Xie, Lei, additional, Tong, Bei-Bei, additional, Chu, Man-Yu, additional, Shi, Wen-Qi, additional, Li, Xiang, additional, He, Jian-Zhong, additional, Wang, Shao-Hong, additional, Wu, Zhi-Yong, additional, Deng, Dan-Xia, additional, Zheng, Ya-Qi, additional, Li, Zhi-Mao, additional, Xu, Xiu-E, additional, Liao, Lian-Di, additional, Cheng, Yin-Wei, additional, Li, Li-Yan, additional, Xu, Li-Yan, additional, and Li, En-Min, additional

Published
2022
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32. LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression

Author

Jiao, Ji-Wei, primary, Zhan, Xiu-Hui, additional, Wang, Juan-Juan, additional, He, Li-Xia, additional, Guo, Zhen-Chang, additional, Xu, Xiu-E, additional, Liao, Lian-Di, additional, Huang, Xin, additional, Wen, Bing, additional, Xu, Yi-Wei, additional, Hu, Hai, additional, Neufeld, Gera, additional, Chang, Zhi-Jie, additional, Zhang, Kai, additional, Xu, Li-Yan, additional, and Li, En-Min, additional

Published
2022
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35. Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer

Author

Li, Rong-Yao, primary, Zheng, Zhen-Yuan, additional, Li, Zhi-Mao, additional, Heng, Jing-Hua, additional, Zheng, Ya-Qi, additional, Deng, Dan-Xia, additional, Xu, Xiu-E, additional, Liao, Lian-Di, additional, Lin, Wan, additional, Xu, Hong-Yao, additional, Huang, He-Cheng, additional, Li, En-Min, additional, and Xu, Li-Yan, additional

Published
2022
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36. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

Author

Jiang, Yuan, Jiang, Yan-Yi, Xie, Jian-Jun, Mayakonda, Anand, Hazawa, Masaharu, Chen, Li, Xiao, Jin-Fen, Li, Chun-Quan, Huang, Mo-Li, Ding, Ling-Wen, Sun, Qiao-Yang, Xu, Liang, Kanojia, Deepika, Jeitany, Maya, Deng, Jian-Wen, Liao, Lian-Di, Soukiasian, Harmik J., Berman, Benjamin P., Hao, Jia-Jie, Xu, Li-Yan, Li, En-Min, Wang, Ming-Rong, Bi, Xin-Gang, Lin, De-Chen, and Koeffler, H. Phillip

Published
2018
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40. Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 Δe13, in esophageal squamous cell carcinoma

Author

Lv, Guo-Qing, Zou, Hai-Ying, Liao, Lian-Di, Cao, Hui-Hui, Zeng, Fa-Min, Wu, Bing-Li, Xie, Jian-Jun, Fang, Wang-Kai, Xu, Li- Yan, and Li, En-Min

Subjects
Oncology, Experimental, Genetic research, Squamous cell carcinoma -- Genetic aspects, Genetic engineering -- Research, Oxidases -- Health aspects, Cancer -- Research, Esophageal cancer -- Genetic aspects, Biological sciences
Abstract

Lysyl oxidase-like 2 (LOXL2) participates in every stage of cancer progression and promotes invasion and metastasis. In this study, we identified a novel alternative splicing isoform of LOXL2, namely LOXL2 Δe13, which lacked exon 13. Deletion of exon 13 caused an open reading frame shift and produced a truncated protein. LOXL2 Δe13 was expressed ubiquitously in cell lines and tissues and was mainly localized to the cytoplasm. Although it showed impaired deamination enzymatic activity compared with full-length LOXL2, LOXL2 Δe13 promoted the cell mobility and invasion of esophageal squamous cell carcinoma (ESCC) cells to greater degrees. In further research on the mechanisms, gene expression profiling and signaling pathway analysis revealed that LOXL2 Δe13 induced the expression of MAPK8 without affecting the FAK, AKT, and ERK signaling pathways. RNAi-mediated knockdown of MAPK8 could block the cell migration promoted by LOXL2De13, but it had little effect on that of full-length LOXL2. Our data suggest that LOXL2 Δe13 modulates the effects of cancer cell migration and invasion through a different mechanism from that of full-length LOXL2 and that it may play a very important role in tumor carcinogenesis and progression. Key words: LOXL2, ESCC, alternative splicing, deamination enzymatic activity, migration and invasion. La proteine LOXL2 (lysyl oxidase-like 2) participe a toutes les etapes de la progression du cancer et favorise l'invasion et la metastase. Dans cette etude, les auteurs ont identifie une nouvelle isoforme de LOXL2 epissee de maniere alternative, soit LOXL2 Δe13, qui est depourvue d'exon 13. La deletion de l'exon 13 causait un deplacement du cadre de lecture ouvert et produisait une proteine tronquee. LOXL2 Δe13 etait exprimee de fa^on ubiquiste dans les lignees cellulaires et les tissus, et elle etait principalement localisee dans le cytoplasme. Meme si elle presentait une activite de desaminase plus faible, LOXL 2Δe13 favorisait la mobilite cellulaire et l'invasion des cellules de carcinome squameux resophagien (ESCC) a un degre plus eleve. Une recherche plus approfondie portant sur le mecanisme, le profil d'expression genique et la signalisation a revele que LOXL2 Δe13 induisait l'expression de MAPK8 sans affecter les voies signaletiques de FAK, AKT et ERK. Le knockdown de MAPK8 par un pARNi pouvait bloquer la migration cellulaire induite par LOXL2 Δe13, mais il n'avait que peu d'effet sur celle induite par LOXL2 de pleine longueur. Ces donnees suggerent que LOXL2 Δe13 module la migration et l'invasion des cellules cancereuses par un mecanisme different de celui de LOXL2 de pleine longueur, et qu'elle pourrait jouer un role tres important dans la carcinogenese et la progression des tumeurs. [Traduit par la Redaction] Mots-cles: LOXL2, ESCC, epissage alternatif, activite de desaminase, migration et invasion., Introduction The lysyl oxidase (LOX) family is composed of 5 members: LOX and lysyl oxidase-like 1-4 (LOXL 1-4). All of these are secreted, copper-dependent amine oxidases that catalyze the crosslinking [...]

Published
2014
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41. P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

Author

Cheng, Yin‐Wei, primary, Zeng, Fa‐Min, additional, Li, Da‐Jia, additional, Wang, Shao‐Hong, additional, He, Jian‐Zhong, additional, Guo, Zhen‐Chang, additional, Nie, Ping‐Juan, additional, Wu, Zhi‐Yong, additional, Shi, Wen‐Qi, additional, Wen, Bing, additional, Xu, Xiu‐E, additional, Liao, Lian‐Di, additional, Li, Zhi‐Mao, additional, Wu, Jian‐Yi, additional, Zhan, Jun, additional, Zhang, Hong‐Quan, additional, Chang, Zhi‐Jie, additional, Zhang, Kai, additional, Xu, Li‐Yan, additional, and Li, En‐Min, additional

Published
2021
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44. STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma

Author

Zheng, Zhen-Yuan, primary, Yang, Ping-Lian, additional, Luo, Wei, additional, Yu, Shuai-Xia, additional, Xu, Hong-Yao, additional, Huang, Ying, additional, Li, Rong-Yao, additional, Chen, Yang, additional, Xu, Xiu-E, additional, Liao, Lian-Di, additional, Wang, Shao-Hong, additional, Huang, He-Cheng, additional, Li, En-Min, additional, and Xu, Li-Yan, additional

Published
2021
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48. Characterization of super‐enhancer‐associated functional lncRNAs acting as ceRNAs in ESCC

Author

Wang, Qiu‐Yu, primary, Peng, Liu, additional, Chen, Yang, additional, Liao, Lian‐Di, additional, Chen, Jia‐Xin, additional, Li, Meng, additional, Li, Yan‐Yu, additional, Qian, Feng‐Cui, additional, Zhang, Yue‐Xin, additional, Wang, Fan, additional, Li, Chun‐Quan, additional, Lin, De‐Chen, additional, Xu, Li‐Yan, additional, and Li, En‐Min, additional

Published
2020
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50. Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma

Author

Chen, Yang, primary, Liao, Lian-Di, additional, Wu, Zhi-Yong, additional, Yang, Qian, additional, Guo, Jin-Cheng, additional, He, Jian-Zhong, additional, Wang, Shao-Hong, additional, Xu, Xiu-E, additional, Wu, Jian-Yi, additional, Pan, Feng, additional, Lin, De-Chen, additional, Xu, Li-Yan, additional, and Li, En-Min, additional

Published
2020
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