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15 results on '"Liao, Leen"'

7. A novel screening method of DNA methylation biomarkers helps to improve the detection of colorectal cancer and precancerous lesions.

Author

Li, Yuan, Li, Bin, Jiang, Rou, Liao, Leen, Zheng, Chunting, Yuan, Jie, Zeng, Liuhong, Hu, Kunling, Zhang, Yuyu, Mei, Weijian, Hong, Zhigang, Xiao, Binyi, Kong, Lingheng, Han, Kai, Tang, Jinghua, Jiang, Wu, Pan, Zhizhong, Zhang, Shenyan, and Ding, Peirong

Subjects
DNA methylation, COLORECTAL cancer, MEDICAL screening, EARLY detection of cancer, RECTAL cancer, CURATIVE medicine, PRECANCEROUS conditions, ADENOMATOUS polyps
Abstract

Background: Colorectal cancer (CRC) is one of the most common malignancies, and early detection plays a crucial role in enhancing curative outcomes. While colonoscopy is considered the gold standard for CRC diagnosis, noninvasive screening methods of DNA methylation biomarkers can improve the early detection of CRC and precancerous lesions. Methods: Bioinformatics and machine learning methods were used to evaluate CRC‐related genes within the TCGA database. By identifying the overlapped genes, potential biomarkers were selected for further validation. Methylation‐specific PCR (MSP) was utilized to identify the associated genes as biomarkers. Subsequently, a real‐time PCR assay for detecting the presence of neoplasia or cancer of the colon or rectum was established. This screening approach involved the recruitment of 978 participants from five cohorts. Results: The genes with the highest specificity and sensitivity were Septin9, AXL4, and SDC2. A total of 940 participants were involved in the establishment of the final PCR system and the subsequent performance evaluation test. A multiplex TaqMan real‐time PCR system has been illustrated to greatly enhance the ability to detect precancerous lesions and achieved an accuracy of 87.8% (95% CI 82.9–91.5), a sensitivity of 82.7% (95% CI 71.8–90.1), and a specificity of 90.1% (95% CI 84.3–93.9). Moreover, the detection rate of precancerous lesions of this assay reached 55.0% (95% CI 38.7–70.4). Conclusion: The combined detection of the methylation status of SEPT9, SDC2, and ALX4 in plasma holds the potential to further enhance the sensitivity of CRC detection. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Efficacy of Pd-1 Inhibitors for Colorectal Cancer and Polyps in Lynch Syndrome Patients

Author

Yu, Jiehai, primary, Xiao, Binyi, additional, Tang, Jinghua, additional, Li, Dandan, additional, Wang, Fang, additional, Ding, Ya, additional, Han, Kai, additional, Kong, Lingheng, additional, Ling, Yihong, additional, Mei, Weijian, additional, Hong, Zhigang, additional, Liao, Leen, additional, Yang, Wanjun, additional, Pan, Zhizhong, additional, Zhang, Xiaoshi, additional, Jiang, Wu, additional, and Ding, Peirong, additional

Published
2023
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9. DNA ploidy and stroma predicted the risk of recurrence in low-risk stage III colorectal cancer

Author

Li, Yuan, primary, Liao, Leen, additional, Kong, Lingheng, additional, Jiang, Wu, additional, Tang, Jinghua, additional, Han, Kai, additional, Hou, Zhenlin, additional, Zhang, Chenzhi, additional, Zhou, Chi, additional, Zhang, Linjie, additional, Sui, Qiaoqi, additional, Xiao, Binyi, additional, Mei, Weijian, additional, Xu, Yanbo, additional, Yu, Jiehai, additional, Hong, Zhigang, additional, Pan, Zhizhong, additional, and Ding, Peirong, additional

Published
2022
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10. B2M and JAK1/2–mutated MSI-H Colorectal Carcinomas Can Benefit From Anti-PD-1 Therapy

Author

Zhang, Chenzhi, primary, Li, Dandan, additional, Xiao, Binyi, additional, Zhou, Chi, additional, Jiang, Wu, additional, Tang, Jinghua, additional, Li, Yuan, additional, Zhang, Rongxin, additional, Han, Kai, additional, Hou, Zhenlin, additional, Zhang, Linjie, additional, Sui, Qiaoqi, additional, Liao, Leen, additional, Pan, Zhizhong, additional, Zhang, Xiaoshi, additional, and Ding, Peirong, additional

Published
2022
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11. Inflammatory Conditions Promote Resistance to Immune Checkpoint Inhibitors in High Microsatellite Instability Colorectal Cancer

Author

Yuan Li, Yanbo Xu, Kai Han, Qiaoqi Sui, Wu Jiang, Liao Leen, Jian Zheng, Xi Zhang, Wei-Jian Mei, Lingheng Kong, Pei-Rong Ding, Chi Zhou, Zhi-Zhong Pan, Zhenlin Hou, Linjie Zhang, Jinghua Tang, Chenzhi Zhang, and Binyi Xiao

Subjects
Colorectal cancer, business.industry, Immune checkpoint inhibitors, medicine, Cancer research, Microsatellite instability, medicine.disease, business, neoplasms, digestive system diseases
Abstract

Inflammatory conditions are common complications in colorectal cancer (CRC) and play significant roles in tumor progression and immunosuppression. However, the influence of inflammatory conditions on the tumor response to immune checkpoint inhibitors (ICIs) remains unclear. We included a high microsatellite instability (MSI-H) CRC patient whose primary tumor progressed and liver metastasis regressed after Pembrolizumab treatment. An organoid-T cell coculture model demonstrated an inhibited local immune response instead of systemic immunosuppression. Single-cell RNA sequencing suggested that neutrophils suppress the immune microenvironment, mostly through CTLA-4-associated pathways. A cohort of 73 patients with MSI-H CRC who received ICIs were enrolled, among whom inflammatory conditions were correlated with a poor tumor response. We demonstrated that inflammatory conditions in MSI-H CRCs correlate with resistance to ICIs through neutrophil-associated immunosuppression. Additional CTLA-4 blockade may improve the sensitivity to PD-1 blockade. Clinically, inflammatory conditions could predict a poor response to ICIs in MSI-H CRCs.

Published
2021

12. Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Author

Sui, Qiaoqi, primary, Liu, Dingxin, additional, Jiang, Wu, additional, Tang, Jinghua, additional, Kong, Lingheng, additional, Han, Kai, additional, Liao, Leen, additional, Li, Yuan, additional, Ou, Qingjian, additional, Xiao, Binyi, additional, Liu, Guochen, additional, Ling, Yihong, additional, Chen, Jiewei, additional, Liu, Zexian, additional, Zuo, Zhixiang, additional, Pan, Zhizhong, additional, Zhou, Penghui, additional, Zheng, Jian, additional, and Ding, Pei-Rong, additional

Published
2021
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