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648 results on '"Liao, Changrui"'

3. Multidimensional quantitative characterization of basal cell carcinoma by spectral- and time-resolved two-photon microscopy

Author

Guo Fangyin, Lin Fangrui, Shen Binglin, Wang Shiqi, Li Yanping, Guo Jiaqing, Chen Yongqiang, Liu Yuqing, Lu Yuan, Hu Rui, He Jun, Liao Changrui, Wang Yiping, Qu Junle, and Liu Liwei

Subjects
tumor diagnosis, non-invasive, label-free examination, optical imaging, fluorescence lifetime, spectral phasor, Physics, QC1-999
Abstract

Basal cell carcinoma (BCC) is a common type of skin cancer. Conventional approaches to BCC diagnosis often involve invasive histological examinations that can distort or even destroy information derived from the biomolecules in the sample. Therefore, a non-invasive, label-free examination method for the clinical diagnosis of BCC represents a critical advance. This study combined spectral- and time-resolved two-photon microscopy with a spectral phasor to extract rich biochemical information describing macroscopic tumor morphology and microscopic tumor metabolism. The proposed optical imaging technique achieved the rapid and efficient separation of tumor structures in systematic research conducted on normal and BCC human skin tissues. The results demonstrate that a combination of multidimensional data (e.g., fluorescence intensity, spectrum, and lifetime) with a spectral phasor can accurately identify tumor boundaries and achieve rapid separation. This label-free, real-time, multidimensional imaging technique serves as a complement to the conventional tumor diagnostic toolbox and demonstrates significant potential for the early diagnosis of BCC and wider applications in intraoperative auxiliary imaging.

Published
2024
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5. Electrically Tunable Four-Wave-Mixing in Graphene Heterogeneous Fiber for Individual Gas Molecule Detection

Author

An, Ning, Tan, Teng, Peng, Zheng, Qin, Chenye, Yuan, Zhongye, Bi, Lei, Liao, Changrui, Wang, Yiping, Rao, Yunjiang, Soavi, Giancarlo, and Yao, Baicheng

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Detection of individual molecules is the ultimate goal of any chemical sensor. In the case of gas detection, such resolution has been achieved in advanced nanoscale electronic solid-state sensors, but it has not been possible so far in integrated photonic devices, where the weak light-molecule interaction is typically hidden by noise. Here, we demonstrate a scheme to generate ultrasensitive down-conversion four-wave-mixing (FWM) in a graphene bipolar-junction-transistor heterogeneous D-shaped fiber. In the communication band, the FWM conversion efficiency can change steeply when the graphene Fermi level approaches 0.4 eV. In this condition, we exploit our unique two-step optoelectronic heterodyne detection scheme, and we achieve real-time individual gas molecule detection in vacuum. Such combination of graphene strong nonlinearities, electrical tunability, and all-fiber integration paves the way toward the design of versatile high-performance graphene photonic devices.

Published
2021
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19. An Optical Fiber-Based Nanomotion Sensor for Rapid Antibiotic and Antifungal Susceptibility Tests

Author

Zhou, Jiangtao, primary, Liao, Changrui, additional, Zou, Mengqiang, additional, Villalba, Maria Ines, additional, Xiong, Cong, additional, Zhao, Cong, additional, Venturelli, Leonardo, additional, Liu, Dan, additional, Kohler, Anne-Celine, additional, Sekatskii, Sergey K., additional, Dietler, Giovanni, additional, Wang, Yiping, additional, and Kasas, Sandor, additional

Published
2024
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26. A D-Shaped Polymer Optical Fiber Surface Plasmon Resonance Biosensor for Breast Cancer Detection Applications

Author

Wu, Xun, primary, Wang, Ying, additional, Zhang, Jiaxiong, additional, Zhang, Yunfang, additional, Rao, Xing, additional, Chen, Chen, additional, Liu, Han, additional, Deng, Yubin, additional, Liao, Changrui, additional, Smietana, Mateusz Jakub, additional, Chen, George Yuhui, additional, Liu, Liwei, additional, Qu, Junle, additional, and Wang, Yiping, additional

Published
2023
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29. Exploring the effect of photobiomodulation and gamma visual stimulation induced by 808 nm and visible LED in Alzheimer's disease mouse model

Author

Xu, Hao, primary, Luo, Ziyi, additional, Zhang, Renlong, additional, Golovynska, Iuliia, additional, Huang, Yanxia, additional, Samanta, Soham, additional, Zhou, Ting, additional, Li, Shaowei, additional, Guo, Bingang, additional, Liu, Liwei, additional, Weng, Xiaoyu, additional, He, Jun, additional, Liao, Changrui, additional, Wang, Yiping, additional, Ohulchanskyy, Tymish Y., additional, and Qu, Junle, additional

Published
2023
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33. A D-Shaped Polymer Optical Fiber Surface Plasmon Resonance Biosensor for Breast Cancer Detection Applications.

Author

Wu, Xun, Wang, Ying, Zhang, Jiaxiong, Zhang, Yunfang, Rao, Xing, Chen, Chen, Liu, Han, Deng, Yubin, Liao, Changrui, Smietana, Mateusz Jakub, Chen, George Yuhui, Liu, Liwei, Qu, Junle, and Wang, Yiping

Subjects
SURFACE plasmon resonance, OPTICAL fibers, APTAMERS, EARLY detection of cancer, HER2 protein, EPIDERMAL growth factor receptors, BIOSENSORS
Abstract

Fiber-optic biosensors have garnered significant attention and witnessed rapid development in recent years owing to their remarkable attributes such as high sensitivity, immunity to electromagnetic interference, and real-time monitoring. They have emerged as a potential tool in the realm of biomarker detection for low-concentration and small molecules. In this paper, a portable and cost-effective optical fiber biosensor based on surface plasmon resonance for the early detection of breast cancer is demonstrated. By utilizing the aptamer human epidermal growth factor receptor 2 (HER2) as a specific biomarker for breast cancer, the presence of the HER2 protein can be detected through an antigen-antibody binding technique. The detection method was accomplished by modifying a layer of HER2 aptamer on the flat surface of a gold-coated D-shaped polymer optical fiber (core/cladding diameter 120/490 μm), of which the residual thickness after side-polishing was about 245 μm, the thickness of the coated gold layer was 50 nm, and the initial wavelength in pure water was around 1200 nm. For low-concentration detection of the HER2 protein, the device exhibited a wavelength shift of ~1.37 nm with a concentration of 1 μg/mL (e.g., 5.5 nM), which corresponded to a limit of detection of ~5.28 nM. Notably, the response time of the biosensor was measured to be as fast as 5 s. The proposed biosensor exhibits the potential for early detection of HER2 protein in initial cancer serum and offers a pathway to early prevention of breast cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Encrypted optical fiber tag based on encoded fiber Bragg grating array

Author

cai, zhihao, primary, li, bozhe, additional, bai, zhiyong, additional, Liu, Dejun, additional, yang, kaiming, additional, liu, bonan, additional, zhao, cong, additional, zou, mengqiang, additional, zhou, jie, additional, jiang, shangben, additional, huang, jingyi, additional, Liu, Li, additional, zhang, xuming, additional, Qu, Junle, additional, wang, yiping, additional, and Liao, Changrui, additional

Published
2023
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46. Four-Dimensional Printing of a Fiber-Tip Multimaterial Microcantilever as a Magnetic Field Sensor

Author

Huang, Haoqiang, primary, Liao, Changrui, additional, Zou, Mengqiang, additional, Liu, Dejun, additional, Liu, Shen, additional, Wang, Ying, additional, Bai, Zhiyong, additional, Liu, Dan, additional, Li, Bozhe, additional, Huang, Jiabin, additional, Wang, Famei, additional, Zhou, Jie, additional, Zhao, Cong, additional, Weng, Xiaoyu, additional, Liu, Liwei, additional, Qu, Junle, additional, and Wang, Yiping, additional

Published
2023
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48. AdaUK-Means: An Ensemble Boosting Clustering Algorithm on Uncertain Objects

Author

Xu, Lei, Hu, Qinghua, Zhang, Xisheng, Chen, Yanshuo, Liao, Changrui, Diniz Junqueira Barbosa, Simone, Series editor, Chen, Phoebe, Series editor, Du, Xiaoyong, Series editor, Filipe, Joaquim, Series editor, Kara, Orhun, Series editor, Kotenko, Igor, Series editor, Liu, Ting, Series editor, Sivalingam, Krishna M., Series editor, Washio, Takashi, Series editor, Tan, Tieniu, editor, Li, Xuelong, editor, Chen, Xilin, editor, Zhou, Jie, editor, Yang, Jian, editor, and Cheng, Hong, editor

Published
2016
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