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Objective： To investigate the feasibility and efficacy of one-stage debridement and two-stage total knee arthroplasty in the treatment of advanced complicated and severely active tuberculosis of the knee joint. Methods: A retrospective analysis was performed on the clinical data of 12 patients who underwent two stages of artificial knee replacement for advanced severely active tuberculosis of the knee in the department of Osteoarthrosis of our hospital from January 2015 to December 2019. The average age was 50.5 years (21-71 years). All patients received lesion removal and perioperative anti-tuberculosis drug therapy. In the first phase, debridement was performed after at least 2 weeks of anti-tuberculosis chemotherapy to remove abscesses and infected necrotic tissue as thoroughly as possible, and SPACER was implanted in 7 cases, followed by at least 3 months of anti-tuberculosis chemotherapy (mean 5.4 months). In the second stage, if CRP and ESR were reduced to less than 2 times of the normal value and the wound healed well, artificial knee replacement was performed. Anti-tuberculosis chemotherapy was continued for 8-9 months after the operation, and the total anti-tuberculosis chemotherapy lasted 12-20 months. HSS knee score and range of motion, as well as prosthesis stability, ESR and CRP, and X-ray were evaluated. Results: All patients received 18-76 months of follow-up and 12-20 months of regular anti-tuberculosis treatment. No pulmonary tuberculosis recurrence or co-infection was found in all patients, and ESR and CRP were reduced to within 2 times of normal after several months. At the last follow-up, no recurrence of tuberculosis was found in all patients, and no loosening of prosthesis was found in X-ray examination. HSS score of knee increased from (41.42±10.47) points before surgery to (82.58±9.14) points, and ROM of knee increased from (40.42°±15.73°) to (100.83°±9.73°). There were statistically significant differences before and after operation (PConclusions: For advanced complicated and severely active tuberculosis of the knee, one-stage debridement and two-stage total knee arthroplasty can effectively control infection, relieve pain and reconstruct the function of the knee joint

Nowadays, commercial polypropylene (PP) and polyethylene separators in lithium-ion batteries (LIBs) still remain significant challenges of irreversible deformation, thermal shrinkage or even melting phenomena under external forces and high operating temperature, resulting in short circuit and thermal runaway of the LIBs. Herein, a kind of biphenyl polyimide (PI) nanofiber separator coated with SiO2 nanoparticles (SiO2–PI) is prepared via a simple and effective in situ dispersion method coupled with electrospinning technology and used as the separator of LIBs. The combination effect of the three-dimensional network and the extremely high porosity of 92% originating from the electrospinning technology as well as the well-dispersed SiO2 nanoparticles provides an ultrahigh mechanical flexibility, thermal stability, electrolyte wettability and ionic conductivity of the obtained SiO2–PI separator compared to the classical PP separator. These superior properties of the SiO2–PI separator endow the obtained LIBs with much enhanced electrochemical performances. For example, the initial specific discharge capacity of the SiO2–PI-based LIB is up to 158.4 mAh g−1 at 0.1 C and 125.7 mAh g−1 at 1 C, which can be retained at 90% after 100 cycles. These values, are much better than those of the PP-based LIB, i.e., 156.1 mAh g−1, 100.8 mAh g−1 and 76%, respectively.

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BackgroundTo evaluate the clinical outcomes of arthroscopic tight fibrous band release in the treatment of adult moderate-to-severe gluteal fibrosis using anterior and posterior portals during mid-term follow-up.MethodsThe data of 138 patients (58 males, 80 females) aged between 18 and 42 years (mean, 28.6 years), presenting with bilateral moderate-to-severe gluteal fibrosis (GF) from October 2013 to August 2019, was retrospectively analyzed. All patients underwent arthroscopic tight fibrous band release using anterior and posterior portals with radiofrequency energy. Under arthroscopic guidance through the posterior portal, we debrided the fatty tissue overlying the contracted band of the gluteal muscle and excised the contracted bands using a radiofrequency device introduced through the anterior portal. The pre- and post-operative gluteal muscle contracture disability (GD) scale and the patient satisfaction rate were compared to evaluate the curative effect of the operation.ResultsThe average operation time was 18 min (range, 10–30 min) and the average blood loss was 4 ml (range, 2–10 ml) for unilateral arthroscopic release. Two cases of post-operative minimal hematomas, 2 cases of bruising and 2 cases of local subcutaneous edema were observed as early complications and were cured by conservative treatment. After surgery, all incisions healed in stage I, and no other complications such as wound infection, nerve and blood vessel injury were detected. One hundred eighteen patients were followed up for 6 to 72 months (mean, 36 months). No lateral instability of the hip was observed and all patients returned to normal gait. The degree of adduction of the hip joint in all these 118 patients was significantly improved relative to their pre-operative conditions. One hundred fifteen patients (97.5%) were able to crouch with knees close to each other after surgery. One hundred fourteen patients (96.6%) were able to cross the affected leg completely without any support. The GD scale was improved from 55.5 ± 10.6 before operation to 90.1 ± 5.2 at the last follow-up (p ConclusionArthroscopic tight fibrous band release using anterior and posterior portals is minimally invasive for adult moderate-to-severe gluteal fibrosis, with a high success rate, quick recovery after surgery and reliable medium-term effect.

To investigate the influence of plasmakinetic energy transurethral resection of the prostate (PKRP) versus that of transurethral bipolar plasmakinetic enucleation and resection of the prostate (PKERP) on the bladder function, sexual function and incidence of complications in BPH patients with the prostate volume100 ml.We randomly assigned 140 BPH patients with the prostate volume100 ml to receive PKRP (n = 70) or PKERP (n = 70) in our hospital from July 2013 to July 2015. We compared the maximum urinary flow rate (Qmax), residual urine volume (RUV), and the rates of ED and retrograde ejaculation before and after surgery as well as the incidence of postoperative complications between the two groups of patients.The Qmax and RUV of the patients were (25.11 ± 7.12) ml/s and (4.06 ± 1.74) ml in the PKERP group postoperatively, significantly improved as compared with the baseline (［8.60 ± 2.33］ ml/s and ［66.85 ± 14.33］ ml, P0.05), and even better than (18.87 ± 4.07) ml/s and (9.45 ± 2.66) ml in the PKRP group (P0.05). The incidence rates of ED and retrograde ejaculation were 61.43% and 28.57% in the PKRP group, significantly higher than in the PKERP group (40.00% and 14.29%) (P0.05) and the baseline (35.71% and 10.00%) (P0.05). The postoperative incidence rate of transient urinary incontinence was remarkably higher in the PKERP than in the PKRP group (22.86% vs 8.57%, P0.05). There were no statistically significant differences between the two groups in the incidence rates of secondary hemorrhage, urethral injury, or genuine urinary incontinence after operation (P0.05).Compared with PKRP, PKERP can effectively improve the clinical symptoms and signs and protect the bladder function of the BPH patients with the prostate volume100 ml, but may increase the risk of transient urinary incontinence.

Steroid-induced avascular necrosis of the femoral head (SANFH) is a mainly bilateral complication of steroid therapy that involves extensive necrosis, and frequently occurs in young and middle-aged individuals, with a high disability rate. Autophagy is an intracellular lysosomal degradation process occurring in numerous diseases. However, the effect of dexamethasone (DXM)-induced autophagy on osteoblasts is unclear. The aim of the present study was to investigate the effects of autophagy on SANFH. In the present study, femoral head of SANFH patients was collected, and the autophagy in the samples was evaluated. In addition, cell proliferation, membrane integrity and differentiation of osteoblasts were also detected to confirm the effect of DXM on a mouse osteoblasts cell MC3T3-E1 in vitro. Beclin 1 and microtubule-associated protein 1 light chain 3 were used as the markers of autophagy, while the autophagy inhibitor 3-methyladenine (3-MA) was used to investigate the role of autophagy in DXM-challenged osteoblasts. Immunohistochemistry results demonstrated that Beclin1 was markedly increased in the femoral head of SANFH patients. Furthermore, the treatment of osteoblasts with DXM decreased cell viability, increased lactate dehydrogenase activity in the cell culture supernatant, and reduced the alkaline phosphatase activity and bone morphogenetic protein-2 expression in osteoblasts in vitro. By contrast, 3-MA treatment attenuated the cell injury induced by DXM. The present study indicates that overactivated autophagy may be an important factor contributing to SANFH, and autophagy may be a potential target for the prevention of SANFH.

The aim of the present study was to investigate the effects of phosphorylated osteopontin (p-OPN) on apoptosis and pro-inflammatory cytokine expression in human knee osteoarthritis (OA) chondrocytes. Human knee OA chondrocytes obtained from patients who underwent total knee arthroplasty were treated with p-OPN, OPN or buffer. Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) and western blot analysis were used to assess the expression levels of proinflammatory factors, including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6 and nuclear factor (NF)-κB. Apoptosis of human knee OA chondrocytes was detected by Annexin V-fluorescein isothiocyanate/propidium iodide flow cytometry. Compared with the controls, chondrocytes treated with OPN exhibited higher mRNA and protein expression levels of proinflammatory factors (IL-1β, TNF-α, IL-6 and NF-κB), and a higher percentage of apoptotic chondrocytes. Furthermore, chondrocytes treated with p-OPN exhibited the highest mRNA and protein expression levels of proinflammatory factors (IL-1β, TNF-α, IL-6, NF-κB) and the highest percentage of apoptotic chondrocytes. p-OPN induces chondrocyte apoptosis and proinflammatory factor release, which suggests that p-OPN may contribute to OA pathogenesis, and inhibition of p-OPN may provide a novel effective strategy to slow or halt OA progression.

A novel intumescent flame retardant oligomer containing phosphorous-nitrogen structure (PSPTR) was synthesized and characterized by Fourier Transform Infrared (FTIR) and Mass Spectrometry (MS). The thermal behavior of PSPTR was investigated by thermogravimetric analysis (TGA). The TGA data shows that PSPTR has a high initial temperature of thermal degradation and a high char residue of 41.18wt% at 700 . A novel intumescent flame retardant (IFR) system, which is composed of PSPTR and novolac phenol (NP), was used to impart flame retardancy of ABS. The combustion behaviors of the ABS/IFR composites were investigated by Limiting Oxygen Index (LOI) and UL-94 tests. When the content of IFR (PSPTR:NP=1:1 mass ratio) is 30 wt%, the LOI value of ABS/IFR reaches 28.2, and the vertical burning test reaches UL-94 V-1 rating.

The intumescent flame retardant poly-pentaerythritol diphosphonate dichloride- hexamethylendiamine (PSPHD) grafting sepiolite (PSPHD-SEP) and LDPE/PSPHD-SEP/IFR composites have been prepared. Cone calorimeter technique was employed to characterize the combustion behavior of LDPE/PSPHD-SEP/IFR composites. The results show that the peak and average heat release rates decreased significantly when 5% PSPHD-SEP was added in LDPE. The PSPHD-SEP can promote the char layer to form earlier and be more compact and increase the char residue yield. The compact char residue layer can prohibit the transfer of gas and heat during the burning, showing the improvement of flame retardance.

A simple and effective method for synthesis of glucose-d-13C6 by fermentation using the methylotrophic yeast Hansenula polymorpha with 99% abundance methanol-13C is described. Using methanol-13C as a sole source of carbon, H. polymorpha can accumulate large amounts of α,α-trehalose-13C12 under unfavourable growth conditions; the trehalose can then be hydrolysed to give glucose-d-13C6 with 98.5% abundance 13C. Copyright © 2011 John Wiley & Sons, Ltd.

After thousands of years of evolution and innovation, transportation has become one of the most indispensible industrial products. Along with the increasing demand for transportation, its industrial scale is increasing and it is also a trend for the flourish development of relative disciplines. Based in the innovative method, this article discusses on the means and belief for creative thinking of transportation from a brand new perspective, which in order to promote and contribute to independent innovation of China transportation design.

In text association classification research, feature distribution of the training sample collection impacts greatly on the classification results, even with a same classification algorithm classification results will have obvious differences using different sample collections. In order to solve the problem, the stability of association classification is improved by the weighing method in the paper, the design realizes the association classification algorithms (WARC) based on rule weight. In the WARC algorithm, this paper proposes the concept of classification rule intensity and gives the concrete formula. Using rule intensity defines the rule adjustment factors that adjust uneven classification rules. Experimental results show the accuracy of text classification can be improved obviously by self-adaptive weighting.

The artifact, which embodies the culture of the Tujia minority group at the Yangtze River basin, is the directest manifestation of Tujia people's idea of creating and designing tools. Bei Jia Zi is the very typical one of those artifacts. This article investigates the influence of traditional artifacts culture on the sustainable design of modern products, and concludes the crutial design elements affecting modern products from the develpmental trend of current ergonomics, based on the analysis of the emerging background, function and structure of Bei Jia Zi.

A special high-performance structured packing, PACK- 13 C, with the surface area high as 1135 m 2 m −3 was developed, and the first stable isotope 13 C pilot-scale plant using structured packing was designed and constructed by carbon monoxide cryogenic distillation, which has run smoothly over 6 months. The height and inner diameter of the distillation column were respectively, 20 m and 45 mm and the height of packing bed was 18 m. The column was well insulated by vacuum multilayer insulation and the total heat leakage of the column was less than 30 W. When the F -factor changes from 0.18 to 0.90 ms −1 (kg m −3 ) 1/2 , the numbers of theoretical plates per meter decreases from 30 to 20, the pressure drop is less than 25 Pa for each theoretical plate, the dynamic liquid holdup is between 11% and 21%, and the pilot-scale plant produces 2.1 g 15% isotope 13 C each day. The fluid mechanical and mass transfer empirical equations were developed according to the experimental data of PACK- 13 C. The PACK- 13 C structured packing exhibits very high performances in isotope separation efficiency and operational flexibility, which is far superior to the traditional random packing. PACK- 13 C is a perfect packing to serve in 13 C separation to increase productivity and reduce consumption.

We discuss remote-sensing-image fusion based on a multi-band wavelet and RGB feature fusion method. The fused data can be used to monitor the dynamic evolution of mining induced subsidence. High resolution panchromatic image data and multi-spectral image data were first decomposed with a multi-ary wavelet method. Then the high frequency components of the high resolution image were fused with the features from the R, G, B bands of the multi-spectral image to form a new high frequency component. Then the newly formed high frequency component and the low frequency component were inversely transformed using a multi-ary wavelet method. Finally, color images were formed from the newly formed R, G, B bands. In our experiment we used images with a resolution of 10 m (SPOT), and TM30 images, of the Huainan mining area. These images were fused with a trinary wavelet method. In addition, we used four indexes—entropy, average gradient, wavelet energy and spectral distortion—to assess the new method. The result indicates that this new method can improve the clarity and resolution of the images and also preserves the information from the original images. Using the fused images for monitoring mining induced subsidence achieves a good effect.

A great idea always needs a certain shape to express itself. Meanwhile, a nice product design conveys its own connotation through a certain kind of material and manufacturing. As for all kinds of materials today, how to choose the most appropriate material through its own physical characteristics, which accords with our design idea and will not jeopardize our environment in the using process in its whole life span, is the emphasis of this paper.

To efficiently use the array aperture and avoid the complicated parameter pairing computation, this paper proposes a new cumulant-based algorithm for localizing near-field narrowband sources. Firstly, the algorithm proposes a symmetric uniform linear array (ULA), and constructs three cumulant matrices by using the fourth-order cumulants of some properly chosen sensor outputs; secondly, unlike the conventional parallel fctor (PARAFAC) analysis models in data or subspace domain, it forms a three-way array (TWA) in the fourth-order cumulant domain using the three matrices, and analyzies the uniqueness of its low-rank decomposition; thirdly, it jointly estimates the frequency, the direction-of arrival (DOA), and the range of each near-field source from the matrices via a low rank decomposition of the, TWA The simulation results, are, presented to validate the performance of our proposed method.

Jun-Li Liang,1 Xiao-Cang Ren,2 Qiang Lin2 1Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang, People’s Republic of China; 2Department of Oncology, North China Petroleum Bureau General Hospital of Hebei Medical University, Renqiu, Hebei Province, People’s Republic of China Abstract: Icotinib hydrochloride is an orally administered small-molecule reversible tyrosine kinase inhibitor that has been independently researched and developed and has independent intellectual property rights in the People’s Republic of China. Clinical trials have demonstrated that the response to icotinib among advanced non-small-cell lung cancer (NSCLC) patients who received at least one platinum-based chemotherapy regimen was not inferior to gefitinib. Since being launched August 2011 in the People’s Republic of China, icotinib has been widely used in clinics, and has become an important treatment option for Chinese patients with advanced NSCLC. The present study presents the Phase I, II, and III clinical trials of icotinib and discusses current clinical applications in the People’s Republic of China and future research directions. Keywords: targeted therapy, EGFR-TKI, NSCLC

Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.

Ethnopharmacological relevance Si-Miao-Yong-An (Trade name: Mai-Luo-Ning), a Chinese herbal formulation comprising Flos Lonicerae Japonicae, Radix Scrophulariae Ningpoensis, Radix Angelicae Sinensis and Radix Glycyrrhizae Uralensis, has been used in treating ischemic cardiovascular and cerebrovascular diseases for many years. Clinical and experimental studies have shown that Si-Miao-Yong-An can inhibit the inflammatory response and antagonize the blood clotting process. Aim of the study To investigate the effect of Si-Miao-Yong-An on atherosclerotic plaque stability in rabbit model. Materials and methods Seventy male rabbits were divided into four groups. Rabbits in the normal group were fed with normal diet, while rabbits in model group and drug treatment groups were fed with high cholesterol diet, underwent BSA-induced immunologic injury and balloon-induced mechanical injury. After atherosclerotic rabbits were treated with simvastatin or Si-Miao-Yong-An for 16 weeks, blood and aorta in four groups were collected for analysis. Results Si-Miao-Yong-An reduced the level of triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) in blood after treatment for 16 weeks. Compared with model group, Si-Miao-Yong-An decreased the content of many inflammatory cytokines in blood and plaque. Morphological analysis of abdominal aorta showed that Si-Miao-Yong-An increased fibrous cap thickness and smooth muscle cells, reduced lipid core area and macrophages, and contributed to inhibit matrix degradation and inflammatory response. Conclusion In this study, we provided evidence for that Si-Miao-Yong-An could promote the stability of atherosclerotic plaque in the rabbit model, indicating that this medicine was a reasonable drug treating cardiovascular diseases in clinical.

This study investigates the dynamic linear, nonlinear responses, and shock damage of two kinds of submerged cylindrical shell models exposed to underwater spherical trinitrotoluene (TNT) charge explosions in a circular lake. Two endplates and a middle plate are mounted on the cylindrical shells to provide support and create two enclosed spaces. The two kinds of cylindrical shell models are unfilled and main hull sand-filled, respectively. Fifteen different tests are carried out according to changing the TNT explosive weights of 1 kg and 2 kg, standoff distances ranging from 3 m to 0.3 m, and two explosion positions, and the measured experimental results are compared with each other. Detailed discussions on the experimental results show that the dynamic responses and damage modes are much different, and the main hull sand-filled cylindrical shell is more difficult to be damaged by the shock wave loading than the unfilled model. The edge cracks are mainly observed at the instrument hull of the main hull sand-filled model, but surface tearing and cracks take place both on the main and instrumental hulls of the unfilled model, respectively.

To determine the influence of artificial disc replacement on the stability of lumbar.Ten fresh human cadaveric lumbar spine specimens (9 males, 1 female) were tested. The donors had a mean age of 29.3 years old. The segments were fixed on a special testing device mounted in a universal testing machine. Physiological load with a maximum of 10 Nm was applied in the flexion, extension, right and left side bending. Moments were applied in 6 load steps: 0, 2, 4, 6, 8, and 10 Nm. Linearity migration and angle migration were recorded,and the mean flexibility coefficients were calculated. Four procedures of measurement were performed in every specimen: intact segments, segments after discectomy, segments after the artificial disc replacement, and segments after the artificial disc replacement with cutting posterior longitudinal ligament locally.The indexes we calculated of the segments after the discectomy were statistically different compared with the intact segments (P0.05, P0.01). The linearity migration,angle migration and mean flexibility coefficient in flexion/extension direction of the segments after the artificial disc replacement were statistically different compared with the segments after the discectomy (P0.05, P0.01), and there was a statistically significant increase in angle migration and mean flexibility coefficient in the extension direction compared with the intact situation (P0.05). There was no statistically significant difference in 4 directions between the segments after the artificial disc replacement and the segments after the artificial disc replacement with cutting posterior longitudinal ligament locally (P0.05).Artificial intervertebral disc replacement could keep the stability of the lumbar functional spine unit. There was no harmful effect of cutting posterior longitudinal ligament locally on the stability of lumbar while performing artificial intervertebral disc replacement when it is necessary.

To investigate the actual condition of the sexual physiological and psychological development of the high school students in Yibin in order to get a reliable basis for sexual education of the teenagers.With a proportion of 1% to the whole, 2,770 students were randomly selected from eight high schools in the urban and rural areas of the city. We devised a questionnaire and asked each student to fill in his or her answers presently.So far as sexual physiological and psychological development was concerned, the high school students of Yibin were found rather precocious, with very little sexual knowledge and psychological endurance in sexual affairs and a relative lack of sexual education.It is imperative to extend the scope of puberty sexual education in high schools. Teenagers must be taught different kinds of sexual knowledge at different periods of growth as well as how to avoid sexually transmitted diseases and gestation. The sexual knowledge level of the teachers must also be raised. It is a must to establish service or specialist consultation hot lines about sexual knowledge for teenagers. Parents are expected to change their traditional views and assume an active role in the joint efforts of sexual education for their children.

Background Si Miao Yong An decoction and its medicine Mailuoning injection are proved-effect medicine treating ischaemic cardiovascular disease, but whether it can stabilise the atherosclerotic plaque is currently no clear conclusions. We want to explore the role of Si Miao Yong An decoction interventing on rabbit aortic atherosclerotic plaque instability. Methods Japanese white rabbits were divided into control group, model group, Simvastatin group and Si Miao Yong An group. The animals were killed at the end of the experiment. The pathological changes in aortic was observed by HE colouring, masson staining and oil red staining. CRP, MMP-9, ICAM-1 and NF-κB/p65 were tested with ELISA, immunochemistry or RT-PCR. Results Pathological observation showed that thin fibrous cap and big lipid core area was the feature of plaque in the model group. The main components of plaque were macrophages and fat, collagen and actin content of plaque was little, which had showed the pathological characteristics of unstable plaque. We found atherosclerotic lesions of aorta in two drug groups were lighter than in model group (p 0.05). Conclusions Based on these results, we believe that Si Miao Yong An decoction can promotes atherosclerotic plaque stability by fighting against inflammatory, inhibiting matrix degradation and lipid deposition.