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Your search keyword '"Liang, Zhaodong"' showing total 16 results
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16 results on '"Liang, Zhaodong"'

1. Immunogenicity and Protective Efficacy of Psoralen-Inactivated SARS-CoV-2 Vaccine in Nonhuman Primates

Author

Sanders, John W., primary, Ewing, Daniel, additional, Sundaram, Appavu K., additional, Gamble, Christopher Scott, additional, Blevins, Maria, additional, Liang, Zhaodong, additional, Sanders, Leigh Ann, additional, Ornelles, David A., additional, Sun, Peifang, additional, Lenart, Klara, additional, Feuerstein, Hendrik, additional, Loré, Karin, additional, Petrovsky, Nikolai, additional, Williams, Maya, additional, and Porter, Kevin R., additional

Published
2024
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2. Enhanced Immunogenicity of Inactivated Dengue Vaccines by Novel Polysaccharide-Based Adjuvants in Mice

Author

Wu, Shuenn-Jue, primary, Ewing, Dan, additional, Sundaram, Appavu K., additional, Chen, Hua-Wei, additional, Liang, Zhaodong, additional, Cheng, Ying, additional, Jani, Vihasi, additional, Sun, Peifang, additional, Gromowski, Gregory D., additional, De La Barrera, Rafael A., additional, Schilling, Megan A., additional, Petrovsky, Nikolai, additional, Porter, Kevin R., additional, and Williams, Maya, additional

Published
2022
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5. Immunogenicity of Adjuvanted Psoralen-Inactivated SARS-CoV-2 Vaccines and SARS-CoV-2 Spike Protein DNA Vaccines in BALB/c Mice

Author

Sundaram, Appavu K., primary, Ewing, Daniel, additional, Liang, Zhaodong, additional, Jani, Vihasi, additional, Cheng, Ying, additional, Sun, Peifang, additional, Raviprakash, Kanakatte, additional, Wu, Shuenn-Jue, additional, Petrovsky, Nikolai, additional, Defang, Gabriel, additional, Williams, Maya, additional, and Porter, Kevin R., additional

Published
2021
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6. The [P2X.sub.7] receptor channel pore dilates under physiological ion conditions

Author

Yan, Zonghe, Li, Shuo, Liang, Zhaodong, Tomic, Melanija, and Stojilkovic, Stanko S.

Subjects
Cell receptors -- Properties, Ion channels -- Properties, Cells -- Permeability, Cells -- Research, Biological sciences, Health
Abstract

Activation of the purinergic [P2X.sub.7] receptor leads to the rapid opening of an integral ion channel that is permeable to small cations. This is followed by a gradual increase in permeability to fluorescent dyes by integrating the actions of the pannexin-1 channel. Here, we show that during the prolonged agonist application a rapid current that peaked within 200 ms was accompanied with a slower current that required tens of seconds to reach its peak. The secondary rise in current was observed under different ionic conditions and temporally coincided with the development of conductivity to larger organic cations. The biphasic response was also observed in cells with blocked pannexin channels and in cells not expressing these channels endogenously. The biphasic current was preserved in N-terminal T15A, T15S, and T15V mutants that have low or no permeability to organic cations, reflecting enhanced permeability to inorganic cations. In contrast, the T15E, T15K, and T15W mutants, and the [DELTA]18 mutant with deleted [P2X.sub.7] receptor-specific 18-amino acid C-terminal segment, were instantaneously permeable to organic cations and generated high amplitude monophasic currents. These results indicate that the [P2X.sub.7] receptor channel dilates under physiological ion conditions, leading to generation of biphasic current, and that this process is controlled by residues near the intracellular side of the channel pore.

Published
2008

12. Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus

Author

Sun, Peifang, primary, Fernandez, Stefan, additional, Marovich, Mary A., additional, Palmer, Dupeh R., additional, Celluzzi, Christina M., additional, Boonnak, Kobporn, additional, Liang, Zhaodong, additional, Subramanian, Hemavathy, additional, Porter, Kevin R., additional, Sun, Wellington, additional, and Burgess, Timothy H., additional

Published
2009
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16. Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation

Author

Jelínková, Irena, Yan, Zonghe, Liang, Zhaodong, Moonat, Sachin, Teisinger, Jan, Stojilkovic, Stanko S., and Zemková, Hana

Subjects
*PURINERGIC receptors, *ADENOSINE triphosphate, *IVERMECTIN, *ALLERGY desensitization
Abstract

Abstract: Ivermectin (IVM) applied extracellularly increases the sensitivity of P2X4 receptor (P2X4R) to ATP, enhances the maximum current amplitudes, and greatly prolongs the deactivation kinetics. In this manuscript, we focused on identification of receptor-specific residues responsible for IVM effects on channel gating using the wild-type rat homomeric P2X4R, several chimeric P2X2/P2X4 receptors, and single-point P2X4R-specific mutants in the ectodomain and two transmembrane domains. Experiments with chimeric receptors revealed that the Val49–Val61 but not the Val64–Tyr315 ectodomain sequence is important for the effects of IVM on channel deactivation. Receptor-specific mutations placed in the Gly29–Val61 and Asp338–Leu358 regions showed the importance of Trp50, Val60, and Val357 residues in IVM regulation of the rate of channel deactivation, but not on the maximum current amplitude. These results suggest that the transmembrane domains and the nearby ectodomain region contribute to the effects of IVM on channel deactivation. [Copyright &y& Elsevier]

Published
2006
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