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22 results on '"Liang, Xue-Yan"'

1. Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis

Author

Lin, Li-Yun, Huang, Hui-Ying, Liang, Xue-Yan, Xie, Dong-De, Chen, Jiang-Tao, Wei, Hua-Gui, Huang, Wei-Yi, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Li, Jian, Wang, Jun-Li, Zheng, Yu-Zhong, Zha, Guang-Cai, Wang, Yu-Ling, Chen, Wei-Zhong, Liu, Xiang-Zhi, Mo, Huan-Tong, Chen, Xin-Yao, and Lin, Min

Published
2021
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3. Preparation and property studies of enteric-soluble oral nattokinase microcapsules with halloysite nanotubes.

Author

Hu, Wen-song, Zhou, Meng-jie, Hu, Liu-xiu, Huang, Kai, Zhao, Shi-guang, Qian, Sen-he, Wang, Zhou, Huang, Xi-lin, Huang, Jun-Bao, Wang, Jian, Liang, Xue-yan, Luo, Wei, Xue, Zheng-lian, and Liu, Yan

Subjects
NANOTUBES, FOURIER transform infrared spectroscopy, HALLOYSITE, ORAL drug administration, FIBRINOLYTIC agents, OSMOTIC pressure
Abstract

Eudragit L100-55-halloysite nanotubes (EL100-55, HNTs) nanocomposite microcapsules were introduced to release nattokinase (NK) and avoid the limitations of oral and systemic administration of NK while increasing the entrapment efficiency and stability of NK. The drug loading capacity, stability, and shapes of the NK microcapsules (NK@HNTs-EL) were characterized with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The maximum loading rate of NK was 82.63%, and the encapsulation efficiency of NK was 31.6%. The formulation conditions did not adversely affect the NK tertiary structure. The maximum in vitro drug release in the simulated small intestine buffer was 93.3%, and the NK@HNTs-EL exhibited pH-dependent drug release. The drug release data were analyzed with different kinetic models, which showed that the NK@HNTs-EL drug-release mechanism involved erosion and osmotic pressure on the EL100-55. After 90 days of storage, the NK@HNTs-EL maintained an enzymatic activity greater than 95%. Hemolysis analyses indicated that NK@HNTs-EL was not cytotoxic at concentrations below 500 FU/mL. These findings indicate that NK@HNTs-EL is a promising oral thrombolytic agent. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Preparation and property studies of enteric-soluble oral nattokinase microcapsules with halloysite nanotubes

Author

Hu, Wen-song, primary, Zhou, Meng-jie, additional, Hu, Liu-xiu, additional, Huang, Kai, additional, Zhao, Shi-guang, additional, Qian, Sen-he, additional, Wang, Zhou, additional, Huang, Xi-lin, additional, Huang, Jun-Bao, additional, Wang, Jian, additional, Liang, Xue-yan, additional, Luo, Wei, additional, Xue, Zheng-lian, additional, and Liu, Yan, additional

Published
2023
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8. Trends in Molecular Markers Associated with Resistance to Sulfadoxine-Pyrimethamine (SP) Among Plasmodium falciparum Isolates on Bioko Island, Equatorial Guinea: 2011–2017

Author

Lin, Li-Yun, Li, Jian, Huang, Hui-Ying, Liang, Xue-Yan, Jiang, Ting-Ting, Chen, Jiang-Tao, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Zheng, Yu-Zhong, Zha, Guang-Cai, Xie, Dong-De, Wang, Yu-Ling, Chen, Wei-Zhong, Liu, Xiang-Zhi, and Lin, Min

Subjects
drug resistance, dihydrofolate reductase, parasitic diseases, malaria, dihydropteroate synthase, Original Research, sulfadoxine-pyrimethamine
Abstract

Purpose Antimalarial drug resistance is one of the major challenges in global efforts to control and eliminate malaria. In 2006, sulfadoxine-pyrimethamine (SP) replaced with artemisinin-based combination therapy (ACT) on Bioko Island, Equatorial Guinea, in response to increasing SP resistance, which is associated with mutations in the dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes. Patients and Methods To evaluate the trend of molecular markers associated with SP resistance on Bioko Island from 2011 to 2017, 179 samples collected during active case detection were analysed by PCR and DNA sequencing. Results Pfdhfr and Pfdhps gene sequences were obtained for 90.5% (162/179) and 77.1% (138/179) of the samples, respectively. For Pfdhfr, 97.5% (158/162), 95.7% (155/162) and 98.1% (159/162) of the samples contained N51I, C59R and S108N mutant alleles, respectively. And Pfdhps S436A, A437G, K540E, A581G, and A613S mutations were observed in 25.4% (35/138), 88.4% (122/138), 5.1% (7/138), 1.4% (2/138), and 7.2% (10/138) of the samples, respectively. Two classes of previously described Pfdhfr-Pfdhps haplotypes associated with SP resistance and their frequencies were identified: partial (IRNI-SGKAA, 59.4%) and full (IRNI-SGEAA, 5.5%) resistance. Although no significant difference was observed in different time periods (p>0.05), our study confirmed a slowly increasing trend of the frequencies of these SP-resistance markers in Bioko parasites over the 7 years investigated. Conclusion The findings reveal the general existence of SP-resistance markers on Bioko Island even after the replacement of SP as a first-line treatment for uncomplicated malaria. Continuous molecular monitoring and additional control efforts in the region are urgently needed.

Published
2020

9. Additional file 3 of Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (EBA-175) gene in Equatorial Guinea

Author

Yang, Pei-Kui, Liang, Xue-Yan, Lin, Min, Chen, Jiang-Tao, Huang, Hui-Ying, Lin, Li-Yun, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Zheng, Yu-Zhong, Xie, Dong-De, He, Jin-Quan, Mo, Huan-Tong, Chen, Xin-Yao, Liu, Xiang-Zhi, and Wu, Ying-E.

Abstract

Additional file 3. Recombination events of global PfEBA-175 genes.

Published
2021
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10. Additional file 6 of Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis

Author

Lin, Li-Yun, Huang, Hui-Ying, Liang, Xue-Yan, Dong-De Xie, Chen, Jiang-Tao, Wei, Hua-Gui, Huang, Wei-Yi, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Li, Jian, Wang, Jun-Li, Zheng, Yu-Zhong, Guang-Cai Zha, Wang, Yu-Ling, Chen, Wei-Zhong, Liu, Xiang-Zhi, Huan-Tong Mo, Xin-Yao Chen, and Lin, Min

Abstract

Additional file 6. Detail information of CD8+ T cell epitopes of PfTRAP.

Published
2021
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11. Population Genetic Analysis of the Plasmodium Falciparum Erythrocyte Binding Antigen-175 (EBA-175) Gene in Equatorial Guinea

Author

Yang, Pei-Kui, primary, Liang, Xue-Yan, additional, Lin, Min, additional, Chen, Jiang-Tao, additional, Huang, Hui-Ying, additional, Lin, Li-Yun, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Zheng, Yu-Zhong, additional, Xie, Dong-De, additional, He, Jin-Quan, additional, Mo, Huan-Tong, additional, Chen, Xin-Yao, additional, Liu, Xiang-Zhi, additional, and Wu, Ying-E, additional

Published
2021
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12. Reverse Transcription Recombinase-Aided Amplification Assay With Lateral Flow Dipstick Assay for Rapid Detection of 2019 Novel Coronavirus

Author

Zheng, Yu-Zhong, primary, Chen, Jiang-Tao, additional, Li, Jian, additional, Wu, Xian-Jing, additional, Wen, Jin-Zhou, additional, Liu, Xiang-Zhi, additional, Lin, Li-Yun, additional, Liang, Xue-Yan, additional, Huang, Hui-Ying, additional, Zha, Guang-Cai, additional, Yang, Pei-Kui, additional, Li, Lie-Jun, additional, Zhong, Tian-Yu, additional, Liu, Long, additional, Cheng, Wei-Jia, additional, Song, Xiao-Nan, additional, and Lin, Min, additional

Published
2021
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13. Genetic Diversity and Natural Selection on the Thrombospondin-Related Adhesive Protein (TRAP) Gene of Plasmodium Falciparum on Bioko Island, Equatorial Guinea and Global Comparative Analysis

Author

Lin, Li-Yun, primary, Huang, Hui-Ying, additional, Liang, Xue-Yan, additional, Xie, Dong-De, additional, Chen, Jiang-Tao, additional, Wei, Hua-Gui, additional, Huang, Wei-Yi, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Li, Jian, additional, Wang, Jun-Li, additional, Zheng, Yu-Zhong, additional, Zha, Guang-Cai, additional, Wang, Yu-Ling, additional, Chen, Wei-Zhong, additional, Liu, Xiang-Zhi, additional, Mo, Huan-Tong, additional, Chen, Xin-Yao, additional, and Lin, Min, additional

Published
2020
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14. Genetic polymorphism of Plasmodium falciparum circumsporozoite protein on Bioko Island, Equatorial Guinea and global comparative analysis

Author

Huang, Hui-Ying, primary, Liang, Xue-Yan, additional, Lin, Li-Yun, additional, Chen, Jiang-Tao, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Li, Jian, additional, Jiang, Ting-Ting, additional, Zheng, Yu-Zhong, additional, Zha, Guang-Cai, additional, Xie, Dong-De, additional, He, Jin-Quan, additional, Chen, Wei-Zhong, additional, Liu, Xiang-Zhi, additional, Mo, Huan-Tong, additional, Chen, Xin-Yao, additional, and Lin, Min, additional

Published
2020
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15. Genetic polymorphism of Plasmodium falciparum circumsporozoite protein (PfCSP) on Bioko Island, Equatorial Guinea and global comparative analysis

Author

Huang, Hui-Ying, primary, Liang, Xue-Yan, additional, Lin, Li-Yun, additional, Chen, Jiang-Tao, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Li, Jian, additional, Jiang, Ting-Ting, additional, Zheng, Yu-Zhong, additional, Zha, Guang-Cai, additional, Xie, Dong-De, additional, He, Jin-Quan, additional, Chen, Wei-Zhong, additional, Liu, Xiang-Zhi, additional, Mo, Huan-Tong, additional, Chen, Xin-Yao, additional, and Lin, Min, additional

Published
2020
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16. Genetic polymorphism of Plasmodium falciparum circumsporozoite protein (PfCSP) and mismatches against RTS, S/AS01 malaria vaccine observed on Bioko Island, Equatorial Guinea and globally

Author

Huang, Hui-Ying, primary, Liang, Xue-Yan, additional, Lin, Li-Yun, additional, Chen, Jiang-Tao, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Li, Jian, additional, Jiang, Ting-Ting, additional, Zheng, Yu-Zhong, additional, Zha, Guang-Cai, additional, Xie, Dong-De, additional, He, Jin-Quan, additional, Chen, Wei-Zhong, additional, Liu, Xiang-Zhi, additional, Mo, Huan-Tong, additional, Chen, Xin-Yao, additional, and Lin, Min, additional

Published
2020
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17. Additional file 3 of Genetic polymorphism of Plasmodium falciparum circumsporozoite protein on Bioko Island, Equatorial Guinea and global comparative analysis

Author

Huang, Hui-Ying, Liang, Xue-Yan, Lin, Li-Yun, Chen, Jiang-Tao, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Li, Jian, Jiang, Ting-Ting, Zheng, Yu-Zhong, Guang-Cai Zha, Dong-De Xie, He, Jin-Quan, Chen, Wei-Zhong, Liu, Xiang-Zhi, Huan-Tong Mo, Xin-Yao Chen, and Lin, Min

Abstract

Additional file 3. Global pfcsp sequences acquired from NCBI.

Published
2020
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18. Trends in Molecular Markers Associated with Resistance to Sulfadoxine-Pyrimethamine (SP) Among Plasmodium falciparum Isolates on Bioko Island, Equatorial Guinea: 2011–2017

Author

Lin,Li-Yun, Li,Jian, Huang,Hui-Ying, Liang,Xue-Yan, Jiang,Ting-Ting, Chen,Jiang-Tao, Ehapo,Carlos Salas, Eyi,Urbano Monsuy, Zheng,Yu-Zhong, Zha,Guang-Cai, Xie,Dong-De, Wang,Yu-Ling, Chen,Wei-Zhong, Liu,Xiang-Zhi, Lin,Min, Lin,Li-Yun, Li,Jian, Huang,Hui-Ying, Liang,Xue-Yan, Jiang,Ting-Ting, Chen,Jiang-Tao, Ehapo,Carlos Salas, Eyi,Urbano Monsuy, Zheng,Yu-Zhong, Zha,Guang-Cai, Xie,Dong-De, Wang,Yu-Ling, Chen,Wei-Zhong, Liu,Xiang-Zhi, and Lin,Min

Abstract

Li-Yun Lin,1– 3,* Jian Li,4,* Hui-Ying Huang,5,6 Xue-Yan Liang,5,6 Ting-Ting Jiang,4 Jiang-Tao Chen,7,8 Carlos Salas Ehapo,9 Urbano Monsuy Eyi,9 Yu-Zhong Zheng,1 Guang-Cai Zha,1 Dong-De Xie,7,8 Yu-Ling Wang,7,8 Wei-Zhong Chen,5,6 Xiang-Zhi Liu,5,6 Min Lin1,5,6 1School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People’s Republic of China; 2University of Chinese Academy of Sciences, Beijing, People’s Republic of China; 3CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; 4Department of Human Parasitology, School of Basic Medical Sciences; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People’s Republic of China; 5Department of Medical Laboratory, Chaozhou People’s Hospital Affiliated to Shantou University Medical College, Chaozhou, Guangdong Province, People’s Republic of China; 6Department of Medical Genetics, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 7The Chinese Medical Aid Team to the Republic of Equatorial Guinea, Guangzhou, Guangdong Province, People’s Republic of China; 8Department of Medical Laboratory, Huizhou Central Hospital, Huizhou, Guangdong Province, People’s Republic of China; 9Department of Medical Laboratory, Malabo Regional Hospital, Malabo, Equatorial Guinea*These authors contributed equally to this workCorrespondence: Min LinSchool of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People’s Republic of ChinaTel/Fax +86 768-2317422Email konfutea@hotmail.comPurpose: Antimalarial drug resistance is one of the major challenges in global efforts to c

Published
2020

19. MOESM2 of Natural selection and genetic diversity of domain I of Plasmodium falciparum apical membrane antigen-1 on Bioko Island

Author

Wang, Ya-Nan, Lin, Min, Liang, Xue-Yan, Chen, Jiang-Tao, Dong-De Xie, Wang, Yu-Ling, Ehapo, Carlos, Eyi, Urbano, Huang, Hui-Ying, Wu, Jing-Li, Xu, Dan-Yan, Zhi-Mao Chen, Cao, Yi-Long, and Chen, Hai-Bin

Abstract

Additional file 2: Recombination events in global PfAMA-1 genes. Linkage disequilibrium (LD) plots showed a non-random association between nucleotide variants in DI of PfAMA-1 at different polymorphic sites. R2 values were plotted against nucleotide distance using a two-tailed Fisherâ s exact test for statistical significance.

Published
2019
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20. Evidence of positively selected G6PD A‐ allele reduces risk ofPlasmodium falciparuminfection in African population on Bioko Island

Author

Liang, Xue‐Yan, primary, Chen, Jiang‐Tao, additional, Ma, Yan‐Bo, additional, Huang, Hui‐Ying, additional, Xie, Dong‐De, additional, Monte‐Nguba, Santiago‐m, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Zheng, Yu‐Zhong, additional, Liu, Xiang‐Zhi, additional, Zha, Guang‐Cai, additional, Lin, Li‐Yun, additional, Chen, Wei‐Zhong, additional, Zhou, Xia, additional, and Lin, Min, additional

Published
2019
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21. Kelch13 and MDR1 Polymorphisms, and Drug Effectiveness at Day 3 after Dihydroartemisinin-Piperaquine Treatment for Plasmodium falciparum Malaria on Bioko Island, Equatorial Guinea: 2014-2017

Author

Zheng, Yu-Zhong, primary, Chen, Jiang-Tao, additional, Liang, Xue-Yan, additional, Ehapo, Carlos Salas, additional, Eyi, Urbano Monsuy, additional, Huang, Hui-Ying, additional, Chen, Wei-Zhong, additional, Lin, Li-Yun, additional, Xie, Dong-De, additional, Wang, Yu-Ling, additional, Chen, Guo-Wei, additional, Liu, Xiang-Zhi, additional, Zha, Guang-Cai, additional, Mo, Huan-Tong, additional, Chen, Xin-Yao, additional, Li, Jian, additional, Jiang, Ting-Ting, additional, and Lin, Min, additional

Published
2019
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22. Evidence of positively selected G6PD A‐ allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island.

Author

Liang, Xue‐Yan, Chen, Jiang‐Tao, Ma, Yan‐Bo, Huang, Hui‐Ying, Xie, Dong‐De, Monte‐Nguba, Santiago‐m, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Zheng, Yu‐Zhong, Liu, Xiang‐Zhi, Zha, Guang‐Cai, Lin, Li‐Yun, Chen, Wei‐Zhong, Zhou, Xia, and Lin, Min

Subjects
*MALARIA, *PLASMODIUM falciparum, *ALLELES, *GLUCOSE-6-phosphate dehydrogenase, *NATURAL selection, *ERYTHROCYTES, *LINKAGE disequilibrium
Abstract

Background: Glucose‐6‐phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD‐deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting. Methods: A case–control study was conducted on Bioko Island, Equatorial Guinea and further genotyping analysis used to detect natural selection of the G6PD A‐ allele. Results: Our results showed G6PD A‐ allele could significantly reduce the risk of Plasmodium falciparum infection in male individuals (adjusted odds ratio [AOR], 0.43; 95% confidence interval [CI], 0.20–0.93; p <.05) and homozygous female individuals (AOR, 0.11; 95% CI, 0.01–0.84; p <.05). Additionally, the parasite densities were significantly different in the individuals with different G6PD A‐ alleles and individual levels of G6PD enzyme activity. The pattern of linkage disequilibrium and results of the long‐range haplotype test revealed a strong selective signature in the region encompassing the G6PD A‐ allele over the past 6,250 years. The network of inferred haplotypes suggested a single origin of the G6PD A‐ allele in Africans. Conclusion: Our findings demonstrate that glucose‐6‐phosphate dehydrogenase (G6PD) A‐ allele could reduce the risk of P. falciparum infection in the African population and indicate that malaria has a recent positive selection on G6PD A‐ allele. [ABSTRACT FROM AUTHOR]

Published
2020
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