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3. Structural Diversity and Biological Activities of Indole Diketopiperazine Alkaloids from Fungi.

Author

Ma YM, Liang XA, Kong Y, and Jia B

Subjects
Animals, Diketopiperazines metabolism, Fungi metabolism, Humans, Indole Alkaloids metabolism, Diketopiperazines chemistry, Diketopiperazines pharmacology, Fungi chemistry, Indole Alkaloids chemistry, Indole Alkaloids pharmacology
Abstract

Indole diketopiperazine alkaloids are secondary metabolites of microorganisms that are widely distributed in filamentous fungi, especially in the genera Aspergillus and Penicillium of the phylum Ascomycota or sac fungi. These alkaloids represent a group of natural products characterized by diversity in both chemical structures and biological activities. This review aims to summarize 166 indole diketopiperazine alkaloids from fungi published from 1944 to mid-2015. The emphasis is on diverse chemical structures within these alkaloids and their relevant biological activities. The aim is to assess which of these compounds merit further study for purposes of drug development.

Published
2016
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