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Abstract Aiming at the shortcomings of the BP neural network in practical applications, such as easy to fall into local extremum and slow convergence speed, we optimized the initial weights and thresholds of the BP neural network using the particle swarm optimization (PSO). Additionally, cloud computing service, web technology, cloud database and numerical simulation were integrated to construct an intelligent feedback analysis cloud program for underground engineering safety monitoring based on the PSO-BP algorithm. The program could conveniently, quickly, and intelligently carry out numerical analysis of underground engineering and dynamic feedback analysis of surrounding rock parameters. The program was applied to the cloud inversion analysis of the surrounding rock parameters for the underground powerhouse of the Shuangjiangkou Hydropower Station. The calculated displacement simulated with the back-analyzed parameters matches the measured displacement very well. The posterior variance evaluation shows that the posterior error ratio is 0.045 and the small error probability is 0.999. The evaluation results indicate that the intelligent feedback analysis cloud program has high accuracy and can be applied to engineering practice.

[Objective] In light of a growing number of oil and gas pipelines crossing or running near power lines,the issue of lightning overvoltage at these locations has garnered increasing attention within these two industries. [Methods] In this study,a calculation model was developed using COMSOL Multiphysics software to depict the generation mechanism of potential difference between pipelines and their anticorrosive coatings at locations where these pipelines cross or run near power lines.Simulation calculations were performed to analyze the impact of soil resistivity and soil layering on pipeline overvoltage amplitude.As a result,a pipeline overvoltage protection method was proposed,considering the dispersion of current over the grounding grids at nearby towers/poles. [Results] The simulation results confirmed the effectiveness of the proposed optimization solution in limiting the voltage,establishing its practical application value.Although the potential on the pipelines and the withstand voltage of their anticorrosive coatings were generally balanced,the difference between them was notably influenced by the direction of current dispersion from the grounding electrodes.Under typical soil resistivity conditions,the withstand voltage difference between the pipelines and their anticorrosive coatings remained within limits.Additionally,it was observed that individual lightning discharges alone were insufficient to cause breakdown in the three-layer polyethylene (3PE) anticorrosive coatings.However,the withstand potential difference did contribute to the enlargement of local damage points that already existed within the coatings.To mitigate the withstand potential difference,an effective approach is proposed involving adjustments to the included angle and relative distance between the pipelines and grounding electrodes at nearby towers/poles. [Conclusion] It is proposed to effectively reduce the potential difference between pipelines and their anticorrosive coatings by modifying the configuration and current dispersion dimensions of the grounding grids at nearby towers/poles.With proven technical feasibility and economical efficiency,the findings of this study serve as a valuable reference for the design,construction,safe operation,and maintenance of oil and gas pipelines.

The underground powerhouse of the Shuangjiangkou hydropower station is one of the largest caverns under construction in China, and its stability during construction is crucial for safe construction. To study the stability of the surrounding rock during excavation, the displacement and stress of the surrounding rock were monitored by multi-point displacement meters and bolt stress meters. Based on the monitoring data, the elastic modulus, Poisson’s ratio, friction angle, and cohesion of surrounding rock were inversely analyzed by the PSO-BP algorithm. Then, the back-analyzed parameters were used to simulate the subsequent excavations and predict the stability of surrounding rock during the following construction. The analysis results show that the surrounding rocks were generally stable during the initial four stages of excavation, and the main factors affecting their stability were blasts and unfavorable geological structures, including the lamprophyre vein and the F1 fault. These unfavorable geological structures also significantly decrease the mechanical parameters of surrounding rock as demonstrated by back analysis, and the stability prediction results show that the omnibus bar cave and the tailrace tunnel were at the greatest risk of instability during the subsequent excavations. This study provides a practical analysis for engineering excavation of the underground caverns.

BackgroundThe antiprostate cancer effects of dietary ω-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Using an orthotopic tumor model and an ex-vivo model of bone marrow derived M2-like macrophages, we sought to determine if ω-3 FAs inhibit angiogenesis and activate T-cells, and if these effects are dependent on GPR120.MethodsGausia luciferase labeled MycCaP prostate cancer cells (MycCaP-Gluc) were injected into the anterior prostate lobe of FVB mice. After established tumors were confirmed by blood luminescence, mice were fed an ω-3 or ω-6 diet. Five weeks after tumor injection, tumor weight, immune cell infiltration and markers of angiogenesis were determined. An ex-vivo co-culture model of bone marrow derived M2-like macrophages from wild-type or GPR120 knockout mice with MycCap prostate cancer cells was used to determine if docosahexanoic acid (DHA, ω-3 FA) inhibition of angiogenesis and T-cell activation is dependent on macrophage GPR120.ResultsFeeding an ω-3 diet significantly reduced orthotopic MycCaP-Gluc tumor growth relative to an ω-6 diet. Tumors from the ω-3 group had decreased M2-like macrophage infiltration and decreased expression of angiogenesis factors. DHA significantly inhibited M2 macrophage-induced endothelial tube formation and reversed M2 macrophage-induced T-cell suppression, and these DHA effects were mediated, in part, by M2 macrophage GPR120.ConclusionOmega-3 FAs delayed orthotopic tumor growth, inhibited M2-like macrophage tumor infiltration, and inhibited M2-like macrophage-induced angiogenesis and T-cell suppression. Given the central role of M2-like macrophages in prostate cancer progression, GPR120-dependent ω-3 FA inhibition of M2-like macrophages may play an important role in prostate cancer therapeutics.

Anti-sliding stability safety is a critical issue that must be given sufficient and widespread attention during the entire lifecycle of gravity dams. The calculated anti-sliding stability safety factor (ASS-SF) is usually compared with the allowable value required by the standards in the traditional method, which ignores the influence of material parameter uncertainties and leads to unreasonable safety evaluation results. Therefore, the nonlinear functional relationship between the stability safety factor (SF) and the random variable parameters is constructed based on the response surface equations, and the distribution types of SF sequences calculated by the Monte Carlo sampling are determined, then a probabilistic stability evaluation method for concrete gravity dams is proposed. Engineering application shows that the calculated SF obeys the normal distribution; the minimum guaranteed rate of different sliding paths in a gravity dam is 86.66%, and the guaranteed rate for the overload safety factor (OSF) is 36.00%. The results imply that a guaranteed rate for the allowable value of the ASS-SF should be provided when making the stability safety evaluation of the dams, especially the OSF. The outcome of this research will advance the understanding of stability evaluation of concrete dams, and reduce the potential risk of sliding instability of concrete dams.

In order to solve the problem of the low treatment efficiency of wastewater containing heavy metals in mining areas, straw biochar and graphene oxide enhanced external pressure ultrafiltration (SGU) was used to treat wastewater containing high concentrations of Pb2+. The operation parameters such as pH and temperature were optimized, and the removal efficiency of CODCr, NH3-N, turbidity and Pb2+ via SGU, straw biochar ultrafiltration (SU), ultrafiltration (UF), and conventional treatment (CT) were systematically investigated. The results showed that the pH and temperature of polluted water were 4.8–5.2 and 21–30 °C, respectively, the average removal rates of CODCr, NH3-N, turbidity and Pb2+ by SGU reached 91%, 97%, 98% and 95%, respectively, and the removal effect was better than that of other processes. In addition, under the backwash conditions of clean water, weak acid, and weak alkali, the membrane flux recovered 65%, 88%, and 89% of the new membrane, respectively. This study provides scientific and theoretical support for the advanced treatment of polluted water in mining areas.

Glycosylation is one of the most common and important modifications in natural products (NPs), which can alter the biological activities and properties of NPs, effectively increase structural diversity, and improve pharmacological activities. The biosynthesis of glycosylation in natural products involves multiple complex biological processes, which are coordinated by many enzymes. UDP-glycosyltransferases (UGTs) play a crucial role in glycosylation modification, and have attracted long-term and widespread research attention. UGTs can catalyze the O-, C-, S-, and N-glycosylation of different substrates, producing a variety of glycosides with broad biological activity, while improving the solubility, stability, bioavailability, pharmacological activity, and other functions of NPs. In recent years, the rapid development of synthetic biology and advanced manufacturing technologies, especially the widespread application of artificial intelligence in the field of synthetic biology, has led to a series of new discoveries in the biosynthesis of NP glycosides by UGT. This work summarizes the latest progress and challenges in the field of NP glycosylation, covering the research results and potential applications of glycosylated derivatives of terpenes, flavonoids, polyphenols, aromatic compounds, and other compounds in terms of biogenesis. Looking to the future, research may leverage artificial intelligence-driven synthetic biology techniques to decipher genes related to the synthetic pathway, which is expected to further promote the large-scale synthesis and application of glycosylated NPs, and increase the diversity of NPs in the pharmaceutical, functional food, and cosmetic industries.

The performance of corrosion-induced cracking of reinforced concrete members under transverse constraints was studied. Based on the theory of elastic-plastic mechanics and the hypothesis of uniform corrosion of a steel bar, a three-layer hollow cylinder model was established to predict the critical corrosion of the steel bar at the time of the cracking of the concrete cover. Taking the constraint of stirrups on surrounding concrete into consideration, it can be used to predict the corrosion rate of members with stirrups at the time of the cracking of the concrete cover, which further expands the application range of the corrosion-induced cracking models of concrete. On this basis, the critical corrosion rate of concrete under different stirrup ratios at the time of cracking was measured. The calculated results of the model are in accordance with experimental data. For corner steel bars, when the stirrup spacing is less than 100 mm, the existence of stirrups can effectively delay the occurrence of rust expansion cracks and enhance the durability of the structure. On the basis of this study, the problem of corrosion expansion and cracking of the concrete cover caused by non-uniform corrosion of steel bars along longitudinal and radial directions needs to be further studied in the future.

A growing body of evidence suggests that taste is not only an essential physical experience, but also an embodied cue of evaluation. The embodied gustatory experiences may affect ethical evaluation. However, it remains unclear how different forms of taste, such as the word sweet, the sweet food image and the actual sweet taste, are associated with ethical evaluation. Does the visual food taste have a priming effect on the moral-terms evaluation? Does the actual gustatory taste influence the ethical processing similarly to the taste images? All the questions will be answered by the three experiments introduced in this paper. Experiment 1 was to test the implicit association between taste words and ethical words. Experiments 2 and 3 were to test the prime-effect of the food image and the actual gustatory perception on ethical evaluation. The results supported our hypothesis that sweet taste words were strongly associated with moral words and bitter taste words with immoral words. Regarding the priming effect, food images and actual gustatory taste lead to different modifications of ethical evaluation. With food image priming, the bitter taste pictures up-regulated the ethical ratings, i.e., the moral phrases were rated more positive, and the immoral phrases were rated less negative, compared with sweet taste images. On the other hand, with actual taste priming, the sweet stimulation could indeed up-regulate the ethical ratings compared with the bitter stimulation. Such a seemingly conflicting influence of different forms of taste on moral evaluation is further considered., Author(s): Yingli Li [sup.1] [sup.2] , Lihong Liu [sup.2] [sup.3] , Zhiqiang Li [sup.1] [sup.2] , Qingguo Ding [sup.2] [sup.3] , Lina Huang [sup.2] [sup.4] , Jie Chen [sup.2] [sup.5] [...]