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Few studies have examined young people’s attitudes toward death escape acceptance and its relationship to mindfulness. This study addressed this issue and examined the mediating role of emotion regulation. In Study 1, 61 undergraduate students aged 19–22 years participated in a mindfulness intervention program, and the results showed that increasing young people’s levels of mindfulness could improve their attitudes toward death escape acceptance. The Study 2, which recruited 440 young people aged 18–26 years to complete a cross-sectional survey, replicated the main effect and showed that young people’s difficulty in emotion regulation fully mediated the coping effect of mindfulness. These findings suggest that individuals with high levels of mindfulness may have low levels of difficulty in emotion regulation and in turn promote healthy attitudes toward death escape acceptance. [ABSTRACT FROM AUTHOR]