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The study on the absorber of flexural waves based on time-domine model coupling theory is not applicable to all models，and has complex design process，which is difficult for widespread application in industrial engineering. Therefore，a research method for elastic absorbers based on the acoustic impedance matching theory is proposed. The absorption curve of absorbers is verified with theoretical calculations，numerical simulations and experiment. The results show that the proposed method can quickly and easily realize the structural design of elastic absorbers，bringing new possibilities for the research on flexural waves absorption and vibration reduction design. The theoretical method and absorption structure proposed in this paper do not need additional damping materials，which is more conducive to meet the requirements of lightweight structures in aeronautical engineering. At the same time， it brings new possibilities for the field of vibration wave absorption，especially the design of efficient absorption and vibration reduction of curved waves.

Objective To systematically analyze and identify key risk factors for postoperative pulmonary hemorrhage using a combination of the random forest (RF) model and traditional logistic regression analysis, so as to provide data support for clinical practice. Methods This study included patients who underwent needle biopsy of lung masses from January 2020 to December 2023 in the Department of Interventional Therapy, Cancer Hospital, Tianjin Medical University. There were 844 cases, including 387 males and 457 females, ranging in age from 39 to 82 years. Clinical data and puncture-related characteristics were collected, including tumor size, puncture depth, puncture angle, presence of emphysema, lesion location in the lung, body position during puncture, whether the puncture passed through the interlobar fissure, and the number of punctures. The RF model was used to rank the importance of all variables, identifying those with the highest predictive value. Subsequently, a multivariate logistic regression model was applied to the top-ranked important variables to further evaluate their independent impact on postoperative pulmonary hemorrhage. Results The RF model results showed that tumor size and puncture depth had the highest importance in predicting the risk of postoperative pulmonary hemorrhage. Multivariate logistic regression analysis further confirmed that smaller tumor size (HR:0.980, 95% CI:0.971-0.989, P

AIM:To investigate the clinical efficacy of phakic implantable collamer lens(ICL)implantation in correcting low-to-moderate myopia.METHODS: Retrospective study. A total of 48 patients(85 eyes)with low to moderate myopia who underwent ICL implantation were included in the study. The changes in uncorrected visual acuity(LogMAR), corrected visual acuity(LogMAR), refractive outcomes, intraocular pressure, vault and endothelial cell were observed at 1 a postoperatively.RESULTS: At 12 mo postoperatively, uncorrected and best-corrected visual acuity were -0.10(-0.20, -0.10)and -0.10(-0.20, -0.10), respectively, with an efficacy index of 1.07±0.13 and a safe index of 1.10±0.14. The difference between the actual corrected diopter and the expected corrected diopter was 91%(77/85)in the range of ±0.50 D, and 100%(85/85)in the range of ±1.00 D. The mean vault was 501.16±210.46 μm at 12 mo postoperatively. There was no significant difference in corneal endothelial cell density between preoperative and 6 and 12 mo postoperatively(F=1.050, P=0.352). All patients had no anterior subcapsular opacification, cataract, pupillary block, or other sight threatening complications during follow-up.CONCLUSION: ICL implantation for the correction of low to moderate myopia has good efficacy, safety and predictability.

Background Acute coronary syndrome (ACS) represents a common cardiovascular disease that poses a significant threat to human health, with severe coronary artery lesions and myocardial fibrosis affecting patient prognosis. The use of non-invasive serological markers to assess the severity of coronary artery lesions and myocardial fibrosis can aid in the early risk stratification and management of ACS patients. Objective This study aimed to explore the relationship between serum levels of complement C1q/tumor necrosis factor-related protein-5 (CTRP5) and the severity of coronary artery lesions, as well as myocardial fibrosis markers in ACS patients, to provide guidance for the clinical assessment of coronary artery lesion severity and myocardial fibrosis. Methods A total of 184 patients with obstructive stenosis admitted to the Department of Cardiology, Hengshui People's Hospital from February 2021 to February 2022 were selected, along with 100 ACS patients without significant obstructive stenosis undergoing coronary angiography in the same period as controls. General patient data were collected, Doppler echocardiograms were performed, and serum levels of CTRP5, procollagen type Ⅰ (PC Ⅰ), and procollagen type Ⅲ (PC Ⅲ) were measured. The patients with obstructive stenosis were divided into unstable angina (UA) group (n=67), ST-segment elevation myocardial infarction (STEMI) group (n=57), and non-ST-segment elevation myocardial infarction (NSTEMI) group (n=61) ; based on the number of coronary artery lesions, they were categorized into single-vessel disease group (n=42), double-vessel disease group (n=69), and triple-vessel disease group (n=73). According to the SYNTAXⅡ score, they were classified into low-risk (n=77), intermediate-risk (n=73), and high-risk (n=34) groups. Based on the median levels of PCⅠ, patients were divided into low PCⅠ level group (n=95) and high PC I level group (n=89) ; similarly, based on PCⅢ median levels, into low PCⅢ level group (n=93) and high PCⅢ level group (n=91). Multiuariate Logistic regression analysis was used to explore the influencing factors of coronary artery lesion severity. Receiver operating characteristic (ROC) curves were drawn to analyze the diagnostic value of serum CTRP5 for coronary artery lesion severity. Results In ACS patients, white blood cell count, neutrophil count, neutrophil-to-lymphocyte ratio, fasting blood glucose (FBG), high-sensitivity cardiac troponin Ⅰ, serum CTRP5, hypersensitive C-reactive protein (hs-CRP), PC Ⅰ, and PC Ⅲ levels were higher than in control patients (P

ObjectivesThe demand for energy in outdoor work and survival is increasing, and there are some significant shortcomings in the existing conventional energy supply methods, such as the need to carry a large amount of fuel for conventional generators and heavy weight of cells. Solar photovoltaic/thermal (PV/T) technology can effectively solve the problem of lack of energy for outdoor survival and field work. However, most of the existing PV/T collectors are rigid structures with large weight and are not easy to carry.MethodsA light and thin PV/T module based on the combination of a Cu(In,Ga)Se2(CIGS) thin film battery and a piece of capillary network were proposed. The energy collection performance of the module and the impact of water flow rate on the photoelectric and photothermal conversion efficiency of the module were studied experimentally.ResultsUnder the typical Shanghai climate conditions, the all-day electrical efficiency and thermal efficiency of the module are 13.04% and 22.50%, respectively. Under experimental conditions with an average irradiance of 760 ‍W/m², the optimal energy collection performance of this PV/T is achieved when the water flow rate is 2.1 ‍L/min. The cooling water in the capillary network can effectively reduce the cell temperature (by 10 ℃) and improve the energy utilization efficiency (by 23.94%).ConclusionsThe module has the characteristics of high power density, light weight and flexibility, and can be used for energy supply during outdoor work and survival, providing a new idea for the design of outdoor energy equipment.

Vernonia volkameriifolia DC. 1836, is a woody shrub of the subfamily Vernonioideae within the family Asteraceae. The complete chloroplast genome of V. volkameriifolia spans 152,934 bp, comprising four subregions: a large single-copy region (84,035 bp), a small single-copy region (18,543 bp), and a pair of inverted repeats (25,178 bp). Within the chloroplast genome of V. volkameriifolia, 114 unique genes were identified, including 80 unique protein-encoding genes, four ribosomal RNA (rRNA) genes, and 30 transfer RNA (tRNA) genes. Phylogenetic analysis based on the complete chloroplast genome of six related taxa in the Vernonieae tribe indicates that V. volkameriifolia show closer relationships with Vernonia parishii and Strobocalyx arborea. The first chloroplast genome of V. volkameriifolia was reported in this work, contributing to the enrichment of genomic data for the genus Vernonia.

Besides cast-rolling speed and casting temperature， the melt pressure in the cast-rolling zone is also an important factor affecting the process stability and interfacial bonding strength of horizontal two-roll cast Ti/Al composite plate. In this study， several Ti/Al composite plates were prepared under different melt pressures in the cast-rolling zone by adjusting the liquid level of the melt in the sluice during the cast-rolling composite process. The microstructure and interfacial bonding properties of the composite plates were characterized by metallography， scanning electron microscopy， microhardness， tensile test and T-type peeling test at room temperature. Results show that when the melt pressure is relatively high， composite plate with full filling， good plate shape and high bonding strength can be produced successfully. However， excessively high melt pressure will affect the stability of the cast-rolling composite process. When the melt pressure is too low， the transverse flow capacity of the melt decreases. As a result， the cast-rolling zone cannot be completely filled with the melt， and the defects such as misrun and side penetration occur. At the same time， some micropores and microcracks appear on the Ti/Al interface. Under relatively high melt pressure， the solid/liquid contact distance is long. In this condition， the wetting between the strip surface and the melt is more sufficient， the melt is more evenly distributed， and the diffusion between solid and liquid is more sufficient. As a result， the composite plate has high bonding strength， which reaches 20.1 N/mm.

Subclinical hypothyroidism (SCH) is closely related to insulin resistance, and thyroid-stimulating hormone (TSH) level is an independent factor for insulin resistance associated with subclinical hypothyroidism. This study aims to explore the effects of TSH levels on insulin signal transduction in adipocytes and to establish the role of endoplasmic reticulum (ER) stress in this process. In this study, the SCH mouse model was established, and 3T3-L1 adipocytes were treated with TSH or tunicamycin (TM), with or without 4-phenylbutyric acid (4-PBA), an inhibitor of ER stress. Subclinical hypothyroidism mice exhibited impaired glucose tolerance, inactivation of the IRS-1/AKT pathway, and activation of the IRE1/JNK pathway in adipose tissue, which can all be alleviated by 4-PBA. Supplementation with levothyroxine restored the TSH to normal, alongside alleviated ER stress and insulin resistance in SCH mice, which is characterized by improved glucose tolerance, decreased mRNA expression of IRE1, and decreased phosphorylation of JNK in adipose tissue. In 3T3-L1 adipocytes, TSH induces insulin resistance, leading to a decrease in glucose uptake. This effect is mediated by the downregulation of IRS-1 tyrosine phosphorylation, reduced AKT phosphorylation, and inhibited GLUT4 protein expression. Notably, all these effects can be effectively reversed by 4-PBA. Moreover, TSH induced TNF-α and IL-6 production and upregulated the expression of ER stress markers. Similarly, these changes can be recovered by 4-PBA. These findings indicate that TSH has the capability to induce insulin resistance in adipocytes. The mechanism through which TSH disrupts insulin signal transduction appears to involve the ER stress–JNK pathway.

The health status of the planetary gears in the cutting section of shearer's rocker arm directly affects the cutting efficiency. The strong noise interference caused by multiple impacts during the cutting of coal and rock by the shearer, the complex gear structure, and the variable transmission path make it difficult to extract fault features. In order to solve the above problems, a fault diagnosis method for planetary gears in shearer based on spectral average denoising and correlation spectrum is proposed. Based on the distribution features of signal spectrum and the random features of noise, the spectrum average denoising method is adopted to suppress the interference of noise on the signal spectrum and obtain the signal denoising spectrum. The method constructs relevant spectra to establish the intrinsic relationship between few sample denoising spectra and multi sample denoising spectra, and reduce the demand for sample size for average spectrum denoising. The method uses a one-dimensional convolutional neural network (1D CNN) to establish an accurate mapping relationship between correlation spectra and fault categories, with correlation spectra as input and fault categories as output, to achieve planetary gear fault classification and recognition. The experimental verification of the fault diagnosis method for planetary gears in shearer based on spectral average denoising and correlation spectrum is carried out on the drivetrain diagnostics simulator transmission system fault diagnosis experimental platform. The results show that the method can enhance the key frequency that characterizes the fault features. The overall recognition rate for five types of health status signals of planetary gears, including normal, broken teeth, wear, missing teeth, and cracks, reaches 96%. Gear fault diagnosis can be effectively and accurately achieved when the signal-to-noise ratio is not less than 15 dB.

ObjectiveTo investigate the pathogenic spectrum and molecular characteristics of infectious diarrhea among children in Putuo District of Shanghai from 2018 to 2023， and to provide scientific basis for the prevention and control of infectious diarrhea in children.MethodsFecal samples from the cases visited sentinel hospitals for children’s diarrheal disease in Putuo District， Shanghai， were collected from January 2018 to December 2023. A total of 11 species of bacteria were isolated and cultured， and 5 species of viruses were detected by real-time fluorescent polymerase chain reaction （PCR）. The molecular typing of some positive strains was analyzed by the standard pulsed-field gel electrophoresis （PFGE） method. The polymerase-capsid protein linkage region of some norovirus-positive samples was amplified by reverse transcription PCR， and was sequenced and analyzed by bioinformatics software. The Chi-square test and Fisher’s exact probability test were used to compare the pathogen-positive rates in 2018‒2019 and 2020‒2023.ResultsOf the 707 cases of children with infectious diarrhea， the total positive rate was 47.67%， with a single bacterial positivity rate of 16.27%， a single viral positivity rate of 22.63%， and a mixed positivity rate of 8.77%， respectively. The dominant pathogens were rotavirus （10.75%）， norovirus （10.33%）， enteropathogenic Escherichia coli （8.06%）， Salmonella （6.36%）， enteroaggregative Escherichia coli （5.52%）， and Campylobacter （5.23%）. Bacterial infections were predominant in summer and fall， and viral infections were predominant in winter and spring. The total positive rate decreased in 2020‒2023 compared with that of 2018‒2019 （χ2=5.753，P

After over 60 years of development, the space propulsion field in China has made tremendous progress in terms of technology system and product pedigree, and has supported major engineering applications including manned spaceflight, applied satellites, and deep space exploration. However, considering the requirements of future major aerospace missions in China, the technical level of current space propulsion systems is still insufficient, and it is urgent to plan directions for the innovative development and breakthroughs of the field. This study reviews the development status of the space propulsion systems from the aspects of electric, chemical, nuclear, and new-concept space propulsion, and analyzes the requirements of future applications. Specifically, high-performance, low-cost space propulsion systems are required to support the networking of low-Earth-orbit (LEO) small satellites; high-thrust, reusable low-temperature chemical propulsion technologies are required for new space-transportation systems; and multi-type, long-life space propulsion technologies are required for deep-space applications. The results demonstrate that the space propulsion field in China still faces multiple challenges. First, the system reliability and lifespan require further improvement. Second, the space propulsion systems of China still lag behind the advanced international level in terms of product maturity of some technologies. Third, this field typically has a high product cost. Fourth, there are few types of optional technologies, and the research progress of key technologies is lagging. Therefore, we propose the following suggestions: (1) optimizing technology options through top-level planning, (2) improving the development mechanism of the field by emphasizing basic research, and (3) clarifying and promoting scientific research and development in key technological directions, thereby achieving in-orbit applications of the propulsion systems for LEO small satellites, Earth–Moon space transfer, and deep space exploration (including manned spaceflight).

Objective To investigate the clinical features of malignant melanoma of nasal cavity and paranasal sinuses (sinonasal malignant melanoma, SNMM) and its correlation with prognosis. Methods A retrospective analysis was conducted on 30 cases of SNMM treated at the Second Hospital of Lanzhou University from July 2010 to March 2024. Kaplan-Meier method and Cox regression model were used for survival analysis to identify factors affecting patient prognosis.Results Among the 30 patients,15 were males and 15 were females,aged between 38 and 81 years with an average age of 60.37 years.Survival time ranged from 1 to 89 months,with a 1-year survival rate of 81.00%, 3-year survival rate of 54.09%, and 5-year survival rate of 37.86%.The median survival time was 28.13 months. Kaplan-Meier method suggested that age, time from initial symptoms to diagnosis, primary tumor site, orbital involvement, Ki-67 expression levels, tumor staging and treatment were associated with survival rates.Tumor staging was identified as an independent factor affecting the survival rate in SNMM patients. Conclusion SNMM has high malignancy and poor prognosis, with regular postoperative followup being critical to improving survival rates. Current treatment mainly consists of a combination of surgery,postoperative radiotherapy,chemotherapy,immunotherapy and biotherapy.

When piglets are exposed to pathogens for a long period, the immune system organs, among them the spleen, play a major role in combating the stress caused by those pathogens. In the present study, the effect on splenocyte function was investigated in a model of weaned piglets in which stress was induced by multiple low doses of lipopolysaccharide (LPS).

The miniaturization and lightweight development of aerospace systems have raised higher requirements for the strength and ductility of power shaft materials. In order to develop maraging steel with the strength exceeded 3 GPa，an experimental maraging steel with high contents of Co，Ni，and Mo elements was designed. Its chemical composition is 4Ni-15Co-9Mo-0.86Ti-0.35Al-Fe. Through the high-temperature and large-scale plastic deformation with forging ratio greater than 10，the grains were refined as much as possible. Combining with pre-stretching deformation and cryogenic treatment followed by aging treatment，the tensile strength of the experimental steel reached 3.076 GPa，with the elongation at break of 5.5%，exhibiting excellent strength and plasticity. The analysis and characterization of the microstructures indicated that the lath martensitic microstructure with high dislocation was formed in the experimental steel，and obtained extra fined grains with the average grain diameter of 0.47 μm. TEM and 3DAP results show that a large number of Ni3（Mo，Ti）precipitates is distributed in the matrix，with the average precipitate diameter of 6-7 nm. Precipitation strengthening，grain refinement strengthening and dislocation strengthening are the main strengthening mechanisms，which ensure an ultrahigh strength over 3 GPa of the experimental steel，while the extremely fine submicron grains also ensure the good ductility of the steel.

Exploitation of oxygen evolution reaction (OER) and urea oxidation reaction (UOR) catalysts with high activity and stability at large current density is a major challenge for energy-saving H2 production in water electrolysis. Herein, we use the pyridinic-N doping carbon layers coupled with tensile strain of FeNi alloy activated by NiFe2O4 (FeNi/NiFe2O4@NC) for efficiently increasing the performance of water and urea oxidation. Due to the tensile strain effect on FeNi/NiFe2O4@NC, it provides a favorable modulation on the electronic properties of the active center, thus enabling amazing OER (η100 = 196 mV) and UOR (E10 = 1.32 V) intrinsic activity. Besides, the carbon-coated layers can be used as armor to prevent FeNi alloy from being corroded by the electrolyte for enhancing the OER/UOR stability at large current density, showing high industrial practicability. This work thus provides a simple way to prepare high-efficiency catalyst for activating water and urea oxidation.

Porous carbonate reservoirs are characterized by strong heterogeneity and diverse pore types， with significant differences in waterflooding recovery and unclear main controlling factors. Based on the pore throat size distribution curves， the microscopic pore structure of the reservoir was qualitatively classified. Through digital core technology， a method for quantitative characterization of microscopic pore structure was established to clarify the pore throat characteristics of porous carbonate rocks in a region of the Middle Eastern， and indoor physical experiments on waterflooding were conducted to clarify the differences in the oil recovery of different types of cores and their main controlling factors. The results show that ① The microscopic pore structure of the reservoir in the study area can be classified into coarse unimodal type， fine unimodal type I， fine unimodal type II， coarse bimodal type， and multimodal type. There is no significant relationship between storage performance and core homogeneity； the single-phase flow capacity of non-unimodal type is better than that of unimodal type； unimodal type becomes worse with increasing core homogeneity. ②The average coordination number and pore-throat ratio of the non-unimodal type are higher than those of the unimodal type. The average coordination number and pore-throat ratio decreased with the increase of core homogeneity for the unimodal type. The upper limit of the pore-throat ratio tends to decrease with increasing throat radius for all types， and the upper limit of coordination number increases exponentially with increasing pore radius. ③Macroscopically， core homogeneity is the main controlling factor of oil displacement efficiency； microscopically， high connectivity at large pore-throat and large pore-throat ratio at small pore-throat are the fundamental reasons for non-unimodal type to have significantly lower oil displacement efficiency than unimodal type. Pore-throat size is the crucial factor of oil displacement efficiency of unimodal type.

Triterpenoids widely exist in nature, displaying a variety of pharmacological activities. Determining triterpenoids in different matrices, especially in biological samples holds great significance. High-performance liquid chromatography (HPLC) has become the predominant method for triterpenoids analysis due to its exceptional analytical performance. However, due to the structural similarities among botanical samples, achieving effective separation of each triterpenoid proves challenging, necessitating significant improvements in analytical methods. Additionally, triterpenoids are characterized by a lack of ultraviolet (UV) absorption groups and chromophores, along with low ionization efficiency in mass spectrometry. Consequently, routine HPLC analysis suffers from poor sensitivity. Chemical derivatization emerges as an indispensable technique in HPLC analysis to enhance its performance. Considering the structural characteristics of triterpenoids, various derivatization reagents such as acid chlorides, rhodamines, isocyanates, sulfonic esters, and amines have been employed for the derivatization analysis of triterpenoids. This review comprehensively summarized the research progress made in derivatization strategies for HPLC detection of triterpenoids. Moreover, the limitations and challenges encountered in previous studies are discussed, and future research directions are proposed to develop more effective derivatization methods.

In recent years, several research units have introduced solid-state nuclear magnetic resonance (NMR) spectrometers. So far, solid-state NMR spectrometers have not been domestically manufactured and the equipment is completely dependent on imports. Therefore, both the instruments and sample preparation systems are expensive. The sample loading rotor is the crucial consumable in the magic angle spinning (MAS) NMR experiment. However, the extremely tough requirement on dimensional precision poses a great challenge in the machining of rotors. By analyzing the characteristics and practical applications of the imported 3.2 mm rotor and its sample preparation tools, we optimized the connection between the rotor parts, improved the sealing of rotor, and developed the MAS rotor and its sample preparation tools independently. The test results show that the self-made MAS rotor can run normally at 12 kHz, which meets the requirements of conventional solid-state NMR experiments. The sample preparation toolbox has advantages of simplicity and safety.

The effect of hot isostatic pressing (HIP) on the microstructure and properties of hot dip aluminum coating cooled in a magnetic field was investigated in this study. In order to improve the microstructure and properties of magnetic dip aluminum coating, hot isostatic pressing technology was used for post-treatment. Initially, a traditional aluminum-impregnated coating was prepared on the surface of titanium alloy TA15, an alternating electromagnetic field was applied during the forming and solidification process of the coating. Finally, the coating was treated with hot isostatic pressing technology. Analyzed three different coatings of the microstructure and element distribution, and tested the microhardness of the coatings at various positions. The test results revealed that the TA15 titanium alloy hot-dip aluminum coatings obtained through the three different processes exhibited a gradient structure. Compared with the traditional hot-dipped aluminum air-cooled coating, when an appropriate intensity of alternating electromagnetic field was applied during the coating solidification process, the outer coating structure was enhanced, the number of holes was reduced, the microstructure density increased, and the number of cracks significantly decreased. The defects of the 800 °C hot isostatic magnetic cold and hot dip aluminum coating were repaired under high temperature and pressure, resulting in a uniform and fine microstructure. The comprehensive properties of the magnetic cold and hot dip aluminum coating on the surface of the titanium alloy were effectively enhanced through hot isostatic pressing.

The effect of pressure on the microstructure and properties of Ti–Al coating on titanium alloy surface is studied. Ti–Al coating is prepared on the surface of titanium alloy by pressure-assisted high-temperature thermal diffusion. The manufacturing method is simple and easy to operate. The microstructure and element distribution of the coating are analyzed under different processes, and the composition of the coating is tested. The test results show that the substrate alloy and the coating alloy are not connected when the coating is diffused at 650 °C. The coating diffused at 750 °C without pressure is mostly connected to the substrate, but there are microscopic gaps in some areas. The main components of the coating diffused at 750 °C under 80 Pa pressure are TiAl, Ti3Al, and other intermetallic compounds. The boundary between the substrate and the coating is flat, and there is no obvious micro gap, so the metallurgical connection is fundamentally realized. In addition, the maximum hardness can reach 334.9HV0.2. The thickness of the coating diffused at 750 °C under 160 Pa pressure was greatly reduced, showing a gradient form. The surface quality of the outer coating is poor, the structure density of the binding layer is also poor, and there are no obvious penetrating cracks. The bonding between the coating and the substrate is effectively enhanced by an auxiliary action under certain pressure, and then the microstructure and properties of the coating are improved.

ObjectiveA TaqMan-based real-time fluorescence quantitative polymerase chain reaction （PCR） method was established to detect Clostridium perfringens （C. perfringens） in tap water samples.MethodsThe highly conserved plc gene located in the pseudonucleus of the bacterium was amplified and specific primers and TaqMan probes were designed. After optimization， a TaqMan-based real-time fluorescence quantitative PCR detection method was established. Combined with the filter membrane method， simulated polluted water samples of standard strains containing plc genes were treated， and the established method was tested.ResultsThe established TaqMan-based method for detecting C. perfringens showed high specificity. Ct >40 were found in 13 foodborne pathogens， 3 Clostridium difficile and 1 Clostridium putrefaciens strain. The detection limit of this method was 1×10 copies/μL， showing high sensitivity. The minimum detection limit for the simulated polluted water sample was 1.0×102 CFU/mL. This method was also used to detect 4 simulated water contamination samples and 90 imported water samples. The results showed that C. perfringens could be detected in 2 simulated 1.0×102 CFU/mL-contaminated water samples， while not in 2 simulated 1.0×10 CFU/mL-contaminated and imported water samples.ConclusionThe TaqMan real-time fluorescence quantitative PCR method established in this study for the detection of C. perfringens has good specificity， high sensitivity， and practical value for detecting C. perfringens in water samples.

Objective The 509 Daobanxi deposit in the West Kunlun orogenic belt is a newly discovered large pegmatite-type lithium-polymetallic deposit in northwestern China. As a typical granite pegmatite lithium deposit in the region, the metallogenic characteristics and pegmatite evolution of the 509 Daobanxi deposits are of great significance for understanding the entire lithium-polymetallic mineralization process of the West Kunlun metallogenic belt. The granite pegmatites contain assemblages of plagioclase, spodumene, quartz, muscovite, etc., exhibiting strong mylonization and forming typical ductile deformation characteristics in the 509 Daobanxi deposit. Quartz, an essential mineral in granite pegmatite, is ideal for tracking pegmatite's mineralization process and studying the deformation behavior of continental rocks in long-term geological history. Methods To study the late-stage emplacement process of pegmatite evolution, comprehensive analyses were conducted on the quartz deformation structures measurements, fluid inclusion temperature, and quartz trace elements for the 509 Daobanxi granite pegmatites. Cathodoluminescence (CL) analysis of quartz in deformed granite pegmatite samples was performed to reveal the compositional zoning of Ti in quartz. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used to analyze 64 points from samples Zk2707-9 and Zk1107-2. Results The minerals of spodumene and plagioclase in deformed pegmatites primarily show brittle fracturing characteristics, with the features of rigid body deformation and the muscovite presence of mica-fish. Meanwhile, the conspicuous feature is that quartz grains mainly develop dynamic recrystallization and contain subgranis. According to the microstructural characteristics of spodumene, plagioclase, and quartz, the deformation temperature of mylonitized granite pegmatite is 300~400℃. The CL images of quartz bands in the granite pegmatite samples have no apparent zoning, indicating that the Ti content reaches a relative equilibrium state in the quartz deformation stage. The LA-ICP-MS analysis shows quartz from the 509 Daobanxi granite pegmatites contains a lower concentration of Ti (1.03 ×10−6 to 7.67×10−6 and 1.04 ×10−6 to 6.75×10−6), suggesting relatively lower deformation temperatures. The Ti-in-quartz thermobarometry indicates quartz deformation temperatures ranging from 371 to 398°C and 351 to 377°C, respectively. The thermometric measurement shows that homogenization temperatures of the quartz fluid inclusions in pegmatite varied from 260℃ to 283℃, likely recording the temperature of the late stage of pegmatite evolution. Conclusion Comprehensive analysis shows that the 509 Daobanxi granite pegmatites underwent a period of intense ductile deformation during the emplacement process, with low temperature and high strain rate. The emplacement of pegmatite is a product of the rapid cooling process, and the grain size reduction caused by dynamic recrystallization (GBM) under high-stress and low-temperature conditions profoundly changed the rheological properties of pegmatite. The supercooling process from ~400℃ to ~260℃ (ΔT=140℃±), resulting in less rapid mineral crystalline new nuclei in pegmatites, is more conducive to the formation of coarse quartz and other mineral particles, forming the significant characteristics of granite pegmatites. [ Significance ]In fact, the emplacement process of granitic pegmatites remains a puzzle, and high-quality, accurate systematic work is needed to understand the evolution process and behavior of granite pegmatite. By studying the 509 Daobanxi granite pegmatites, we proposed that the pegmatite emplacement was a product of the rapid cooling process, and supercooling plays an essential role in pegmatite emplacement. Similar deformation characteristics are widely developed in the Tugeman lithium deposit in the Altyn Tagh area and the Jiajika lithium deposit in the western Sichuan. Although the current work is preliminary, our study provides some clues for exploring the emplacement process of granitic pegmatites.

Abstract As a serious blood infection disease, sepsis is characterized by a high mortality risk and many complications. Accurate assessment of mortality risk of patients with sepsis can help physicians in Intensive Care Unit make optimal clinical decisions, which in turn can effectively save patients’ lives. However, most of the current clinical models used for assessing mortality risk in sepsis patients are based on conventional indicators. Unfortunately, some of the conventional indicators have been shown to be inapplicable in the accurate clinical diagnosis nowadays. Meanwhile, traditional evaluation models only focus on a small amount of personal data, causing misdiagnosis of sepsis patients. We refine the core indicators for mortality risk assessment of sepsis from massive clinical electronic medical records with machine learning, and propose a new mortality risk assessment model, DGFSD, for sepsis patients based on deep learning. The DGFSD model can not only learn individual clinical information about unassessed patients, but also obtain information about the structure of the similarity graph between diagnosed patients and patients to be assessed. Numerous experiments have shown that the accuracy of the DGFSD model is superior to baseline methods, and can significantly improve the efficiency of clinical auxiliary diagnosis.

The pollution of radionuclides is extremely harmful to the human environment, and it is of great significance to study its feasible treatment methods. There are few studies on the removal of Sr2+ by the combination of microorganisms and minerals. This experiment constructed the bacteria-mineral system with the previously screened thiobacillus denitrificans and montmorillonite, and liquid ion chromatography, multifunctional X-ray diffractometer(XRD), scanning electron microscopy(SEM) and other methods were used to characterize pH and SO42- changes in the system and the removal ability and curing ability of the montmorillonite-thiobacillus denitrificans system(Mont-TD) on Sr2+ in solution. The results show that the Mont-TD system has a high removal effect on Sr2+. Adding 6 g montmorillonite and 1∶100 bacterial solution to the medium with Sr2+ concentration of 1 000 mg/L and 150 mL, after 30 d, the removal rate of Sr2+ reaches 93.2%, the solidification rate reaches 71.1%, and SrSO4 crystals are produced in the product. By constructing the Mont-TD system, the effective removal of Sr2+ in the solution is achieved, and part of it is stably solidified. Montmorillonite-thiobacillus denitrificans system can provide an idea for the treatment of strontium ion pollution in the environment.

The effects of high temperature annealing on the interface microstructure and mechanical properties of cast-rolled Ti/Al composite plates were investigated by means of SEM, EBSD, XRD, microhardness, tensile test at room temperature and T-shaped peeling test, etc. The results show that the microstructure of Ti matrix hardly changes during annealing at 550 ℃, while the Al matrix recrystallizes and begins to grow after annealing for 1 h. During the annealing process, the diffusion layer at the interface gradually thickens, and the second phase TiAl3 is generated at 15 min, and the second phase TiAl3 is connected into flakes at 1 h, and the bonding strength of the Ti/Al composite plate interface is decreased rapidly. The bonding strength of Ti/Al composite plate reaches the maximum value of 23.6 N/mm after annealing for 30 min. At 1 h annealing, the tensile strength and elongation of the cast-rolled Ti/Al composite plate reach the peak values of 236 MPa and 27.6%, respectively, which are higher than those of the cast-rolled Ti/Al composite plate.

Phorate, a highly toxic organophosphorus pesticide, poses significant risks due to its efficiency, versatility, and affordability. Therefore, studying pretreatment and detection methods for phorate in complex samples is crucial. In this study, we synthesized core-shell phorate aptamer-functionalized magnetic nanoparticles using solvothermal and self-assembly techniques. Subsequently, we developed a magnetic dispersive solid-phase extraction and detection method to identifying phorate in plasma samples. Under optimal conditions, we achieved quantitation of phorate within a range of 2–700 ng·mL−1 using gas chromatography-mass spectrometry. The detection limit (S/N = 3) was 0.46 ng·mL−1, and the intraday and interday relative standard deviation were 3.4% and 4.1%, respectively. In addition, the material exhibited excellent specificity, an enrichment capacity (EF = 416), and reusability (≥15). During phorate extraction from real plasma samples, spiked recoveries ranged from 86.1% to 101.7%. These results demonstrate that our method offers superior extraction efficiency and detection capability for phorate in plasma samples.

[Objective] The influences of plants on reducing ditch erosion and C, N and P loss were studied in order to provide technical support for the prevention of ditch erosion and pollution control. [Methods] The study was conducted on ditches of the Nala River basin in the intensive sugarcane growing area of Southern Subtropical China. Vetiver (Vetiveria zizanioides, a herbaceous plant) was planted at different vegetation coverage amounts 〔bare ground. vegetation coverage of 0% (BG); somewhat covered, vegetation coverage of 1%—40% (SC); mostly covered, vegetation coverage of 41%—80% (MC); completely covered, vegetation coverage of 81%—100% (CC)〕 in the ditches. Regular field investigation and monitoring of planted ditches were conducted after rainfall events from April to October, and the characteristics of erosion and nutrient loss under different vegetation coverage were quantified. [Results] ① From April to October, the width, erosion amount, and nutrient loss of ditches with different vegetation coverage gradually increased over time. Values for all three parameters followed the same order of BG>SC>MC>CC; ② Compared with BG, the erosion amounts for SC, MC, and CC decreased by 37.01%, 71.60% and 75.04%; C loss decreased by 35.56%, 70.91% and 75.23%; N loss decreased by 35.89%, 71.01% and 74.39%, and P loss decreased by 34.22%, 70.59% and 77.01%, respectively; ③ Correlation analysis showed that the erosion amount for ditches was significantly negatively correlated with vetiver grass coverage and plant root density (p

[Objective] The suitable configuration ratios for contour planting and replanted sugarcane on slopes were determined in order to provide technical support for reducing slope ditch erosion and nutrient loss, improving cultivated land quality and rational sugarcane planting in sugarcane planting area. [Methods] Three configuration ratios (high, medium, and low) for contour planting and replanted sugarcane were evaluated. Slope-gully erosion and nutrient losses were determined by field measurements and laboratory experiments at the growth stages of establishment growth (EG), vegetative growth (VG), grand growth (GG), and ripening growth (RG), and the factors influencing erosion and nutrient loss were determined. [Results] ① During the total growth (TG) of sugarcane, the total nitrogen (TN) and total phosphorus (TP) losses caused by gully erosion on slopes planted to sugarcane in the Nala River basin were 31.3—66.3 t/hm2, 39.0—82.5 kg/hm2 and 18.0—38.4 kg/hm2, respectively. ② EG was the main stage of gully erosion and nutrient losses in the Nala River basin, accounting for 47.7%—57.7% of the total erosion and nutrient losses. ③ During TG, gully erosion and associated nutrient losses for higher contour ratios (HC) were 33.03%—35.42% lower than for lower contour ratios (LC) (p

In this paper, DEFORM-2D numerical simulation software is used to simulate the forming process parameters of C250 steel. Through the optimization of the metal flow law of the billet in the extrusion forming process and the strain evolution law of the strain zone of the big end, small end and rod in the extrusion process, studied on shape and extrusion ratio (lambda), lower die cone Angle (α4) initial temperature, extrusion speed (v), block (T0) and the sizing zone length (H2) for the peak load, forgings at the top of the building size Z strain zone width X, small head, big head end diameter end strain zone length, stem region Y strain uniformity, outlet temperature uniformity and forging parts where the head end set the influence law of temperature uniformity. Finally, the experiment is verified.

To reveal the typical features of text duplication in papers from four medical fields: basic medicine, health management, pharmacology and pharmacy, and public health and preventive medicine. To analyze the reasons for duplication and provide suggestions for the management of medical academic misconduct.

Despite substantial advancements in screening, surgery, and chemotherapy, colorectal cancer remains the second most lethal form of the disease. Nuclear factor kappa B (NF-κB) signaling is a critical driver facilitating the malignant transformation of chronic inflammatory bowel diseases. In this study, deregulated miRNAs that could play a role in colon cancer are analyzed and investigated for specific functions in vitro using cancer cells and in vivo using a subcutaneous xenograft model. miRNA downstream targets are analyzed, and predicted binding and regulation are verified. miR-1262, an antitumor miRNA, is downregulated in colon cancer tissue samples and cell lines. miR-1262 overexpression suppresses colon cancer malignant behaviors in vitro and tumor development and metastasis in a subcutaneous xenograft model and a lung metastasis mouse model in vivo. miR-1262 directly targets fibroblast growth factor receptor 1 (FGFR1) and inhibits FGFR1 expression. FGFR1 overexpression shows oncogenic functions through the regulation of cancer cell proliferation, invasion, and migration; when cotransfected, lv-FGFR1 partially attenuates the antitumor effects of agomir-1262. NF-κB binds to the miR-1262 promoter region and inhibits transcription activity. The NF-κB inhibitor CAPE exerts antitumor effects; miR-1262 inhibition partially reverses CAPE effects on colon cancer cells. Conclusively, miR-1262 serves as an antitumor miRNA in colon cancer by targeting FGFR1. The NF-κB/miR-1262/FGFR1 axis modulates colon cancer cell phenotypes, including proliferation, invasion, and migration.

Quantitative studies of the pore-throat structure (PTS) characteristics of tight sandstone reservoirs and their effects on fluid mobility were proposed to accurately evaluate reservoir quality and predict sweet spots for tight oil exploration. This study conducted high-pressure mercury injection (HPMI) and nuclear magnetic resonance (NMR) experiments on 14 tight sandstone samples from the Chang 7 member of the Yanchang Formation in the Jiyuan area of the Ordos Basin. The HPMI was combined with the piecewise fitting method to transform the NMR movable fluid transverse relaxation time (T 2) spectrum and quantitatively characterize the PTS characteristics and the full pore-throat size distribution (PSD). Then, movable fluid effective porosity (MFEP) was proposed to quantitatively evaluate the fluid mobility of tight sandstone reservoirs and systematically elucidate its main controlling factors. The results showed that the PTS could be divided into four types (I, II, III, and IV), which showed gradual decreases in average pore-throat radius (R a), continuous increases in the total fractal dimension (D t), and successive deterioration of reservoir fluid mobility and percolation capacity. Moreover, the full PSD (0.001–10 μm) showed unimodal and multi-fractal characteristics. According to the Swanson parameter (r apex), the reservoir space types can be divided into small and large pore-throat and the corresponding fractal dimension has a relationship where D 1 < D 2. Large pore-throat had higher permeability contribution and pore-throat heterogeneity but a lower development degree and MFEP than small pore-throat, which had a relatively uniform and regular PSD and represented the primary location of movable fluids. Moreover, the development degree and heterogeneity of small pore throat controlled the flowability of reservoir fluids. MFEP can overcome the constraints of tiny throats and clay minerals on movable fluid, quantify the movable fluid content occupying the effective reservoir space, and accurately evaluate the reservoir fluid mobility. The combination and development of various pore-throat sizes and types in tight sandstone reservoirs results in different PTS characteristics, whereas differences in the mineral composition and content of reservoirs aggravate PTS heterogeneity, which is the main factor controlling the fluid mobility.

A Ti/Al/Cu clad sheet was fabricated by using horizontal twin-roll casting (HTRC) with the application of pulsed electric field (PEF) and electromagnetic oscillation field (EOF), and the effects of different external fields on interfacial bonding strength were studied. The results show that the external electromagnetic fields have little influence on the stability of HTRC process. With the application of PEF and EOF, the width of diffusion layer at the Ti/Al and Cu/Al interface increases obviously. The interface bonding strength is significantly improved. When the EOF is applied, the electromagnetic volumetric force is generated in the liquid cavity of cast-rolling zone. Under the action of the electromagnetic volume force, aluminum melt oscillates repeatedly, which scours the surface of the strips and makes the newly formed crystal nuclei fall off the surface of strips. In addition, the oscillation effect reduces the temperature gradient at the contact area between strip and melt and slows down the solidification process, thus prolonging the contact time between aluminum and strips. All of these effects make the melt spread more sufficient on the surface of strips and promote the interdi-ffusion between atoms.As a result, more metallurgical bonding regions are formed and enhanced.

BackgroundSleep disorder can adversely affect human physical and mental health， with important implications for socioeconomic development. And higher vocational college students are subject to various pressures and stimuli exerted by academic studies， job seeking and family socioeconomic status， which may contribute to the onset insomnia symptom or sleep disorder.ObjectiveTo discuss the sleep status and influencing factors among higher vocational college students， and to provide references for improving their sleep status.MethodsIn January and February， 2022， a stratified random sampling method was utilized to enroll 3 300 students from five higher vocational colleges in Wenjiang district of Chengdu city. All the participants were assessed using Insomnia Severity Index （ISI）， Patient Health Questionnaire Depression Scale-9 item （PHQ-9） and Generalized Anxiety Disorder Scale-7 （GAD-7）. Pearson correlation analysis was conducted to test the correlation of ISI with PHQ-9 and GAD-7 scores， and the Logistic regression analysis was performed to identify the influencing factors of insomnia symptom in higher vocational college students.ResultInsomnia symptom was detected in 81.90% （2 497 / 3 300） of higher vocational college students. The detection rate of insomnia symptom among vocational college students yielded statistical difference in terms of gender， family socioeconomic status， being an only child or having siblings， degree of psychological pressure exerted by academic studies or job seeking， amount of hours spent on Internet per day， frequency of physical exercise， and the presence or absence of anxiety symptom and depression symptom （χ2=21.032， 22.172， 8.983， 75.939， 36.781， 32.350， 54.512， 86.561， P7 h on Internet per day， inadequate physical exercise and presence of depressive symptom are the risk factors for insomnia symptom in higher vocational college students.［Funded by Sichuan Provincial Primary Health Development Research Center in 2022， North Sichuan Medical College （number， SWFZ22-C-89）］

[Objective] The spatial and temporal characteristics and influencing factors of soil organic carbon loss from sugarcane in a typical small watershed in the red soil area of Guangxi Zhuang Autonomous Region were determined, and the spatial and temporal changes of organic carbon from watershed sediment entering the river during different growth periods of sugarcane were analyzed in order to identify the factors influencing soil organic carbon loss under natural rainfall erosion. [Methods] The experimental area was located in the Nala sub-basin of the water source area of Kailan Reservoir at Fusui County, Chongzuo City, Guangxi Zhuang Autonomous Region. The watershed was divided into the lower sub-basin (S1) and the upper sub-basins (S2 and S3). The organic carbon of incoming sediment and vegetation cover were monitored during four growth periods (seedling, tillering, elongation, and maturity) of sugarcane using UAV technology and an automatic runoff sediment monitoring-sampling system. Pearson correlation analysis was used to determine the relationship between organic carbon of incoming sediment and influencing factors such as rainfall runoff, vegetation cover, and fertilizer application. [Results] ① The organic carbon load of sediment into the river during the seedling stage of sugarcane accounted for 61.1% of the total loss during the entire growing season, and this value was significantly greater than values observed in the other growing periods. Organic carbon load followed the order of seedling stage (5.1 kg/hm2) > maturity stage (1.6 kg/hm2) > elongation stage (1.4 kg/hm2) > tillering stage (0.3 kg/hm2); ② rainfall runoff and vegetation cover were significantly correlated with organic carbon loss from incoming sediment, explaining 45% and 54%, respectively, of the variation in organic carbon loss from incoming sediment during the growing season. Fertilizer application and soil bulk density were significantly correlated with organic carbon loss from incoming sediment in the watershed, explaining 79% and 36%, respectively, of the variation in organic carbon loss from incoming sediment during the growing season. [Conclusion] Studies have shown that organic carbon loss from watershed sediments is mainly influenced by rainfall runoff, vegetation cover, fertilizer application, and soil bulk density. In small watersheds in sugarcane areas, increasing vegetation cover to reduce surface runoff and regulating the timing of fertilizer application can play an important role in reducing soil organic carbon loss.

On the rail transit lines designed for fully automatic operation (FAO), it is necessary to set up staff protection key switches (SPKS) in its signal system, to ensure the safety of personnel entering the automatic operation range. This paper first introduces the principles and methods of dividing protection areas respectively along the main line and at depots, and analyzes the SPKS-related operational process. In view of the safety loopholes that operators could enter the operation zone within the automatic operation range just by swiping the access control card given to them, it proposes a staff protection approach, which introduces a linkage function between SPKS and access control system (ACS) in the interlocking system, and presents designs for the interface circuit between SPKS and ACS, respectively under two types of interlocking systems: full-electronic interlocking and traditional computer-based interlocking. This approach aims to effectively avoid the potential safety risk that could arise due to operators straying into the unprotected zone of the automatic operation range.

Objective To construct an early diagnosis model of acute pulmonary thromboembolism (PTE) based on chest pain center database. Methods According to the database of Chest Pain Center of Affiliated Hospital of Jining Medical University, the clinical data of patients who visited the emergency department from January to December 2020 were retrospectively collected, and the patients were divided into PTE group and non-PTE chest pain group according to whether diagnosed PTE. The clinically relevant indicators of the two groups were compared, and the study indicators with statistical differences between the two groups were included in the multivariate logistic regression analysis, and a nomogram model for the early diagnosis of PTE was established. The receiver operating characteristic (ROC) curve of the model was plotted to assess the predictive accuracy, and the model was tested for goodness of fit using the Hosmer-Lemeshow test. An additional 654 patients presenting with chest pain between January 2021 and March 2021 were collected to externally validate the model. Results A total of 2 738 patients were included for the construction of the model, of whom 117 (4.27%) had confirmed PTE. On multivariate analysis, a history of surgical trauma, ＞ 3 d of immobilization / bed rest on the lower extremities, with dyspnea, syncope, low pulse oxygen staturation (SpO2) at admission, high D-dimer, right deviation of electrocardiographic axis, and complete right bundle branch block were independent factors for the diagnosis of PTE in patients with chest pain (P＜0.05) . ROC curve analysis showed that the area under the curve was 0.985 (95%CI: 0.969-0.999) in internal validation data and 0.924 (95%CI: 0.872-0.977) in external validation data, showing that the model had a good discrimination. The goodness of fit test was performed using Hosmer-Lemeshow, and validated internally (χ2=14.077, P=0.080) and external validation (χ2=615.690, P=0.986) both indicating a good fit of the model. Conclusion This study constructed a nomogram model for the diagnosis of PTE in patients with acute chest pain, and this model could effectively predict the risk probability of PTE in patients with acute chest pain.

Patulin, a toxic secondary metabolite of fungi, exists widely and stably in fruits, vegetables, grains, nuts and Chinese medicinal materials. Patulin enters the body through skin contact or food intake, posing a great threat to the health of humans and animals. Previous studies have shown that patulin can induce genotoxicity, immunotoxicity and reproductive toxicity, damaging the intestine, kidney, liver and other organs in the body. The toxic mechanism of patulin involves inducing damage to biological macromolecular structures, oxidative stress injury and cell autophagy as well as damaging intestinal flora homeostasis. In this article, the recent status of patulin contamination in foods is reviewed, with an emphasis on the latest progress in research on the toxicity and mechanism of action of patulin. It is hoped that this review will provide a theoretical basis for patulin detoxification.

As an important part of university physical education, table tennis teaching occupies a crucial position in physical education reform and requires continuous innovation and reform. This paper first starts from the current situation of table tennis teaching and proposes the application of a binocular stereo vision system based on a binocular stereo vision system for university table tennis teaching, which lays the foundation for three-dimensional reconstruction and skill learning. Secondly, the mathematical model of the 3D reconstruction algorithm is constructed by the tangential distortion of least squares, which avoids the complex algorithm of iteratively solving the 3D world coordinates of table tennis and improves the speed of the 3D reconstruction algorithm while the accuracy meets the subsequent prediction requirements. Finally, students in the experimental and control groups were compared in the technical evaluation of table tennis backhand pushing, attacking techniques, and left pushing and right attacking to verify the effectiveness of the table tennis binocular stereo vision teaching system. The study results showed that the experimental group students trained by the binocular stereo vision system for table tennis had 41.77% higher accuracy, 23.13% higher coordination, 12.31% higher return speed, and 14.84% higher hitting power compared to the control group. Applying a binocular stereo-vision system to table tennis teaching is novel and is conducive to stimulating students’ curiosity and challenge, enhancing their interest in learning, and effectively improving their understanding and knowledge of table tennis techniques.

BackgroundTo measure the beam positions of High Energy Photon Source (HEPS), different types of beam position monitors (BPMs) have been developed. The position sensitivity coefficient is an important parameter of BPMs by which the position of the beam can be calculated.PurposeThis study aims to establish a method for calculating the position sensitivity coefficient of BPMs.MethodsThe position sensitivity coefficients of various types of BPMs, such as round, elliptical, and octagonal pipes, were determined by using the boundary element method (BEM). The azimuth button angles in the elliptical BPM of the HEPS booster and the button distances in an octagonal BPM on the Beijing Electron Positron Collider II (BEPCII) storage ring were derivated by the application of BEM. Furthermore, the position sensitivity mappings of the BPMs was calculated.ResultsThe difference in sensitivity results of the round BPM calculated by the BEM and the analytical value is approximately 1%. The error between the calculated and experimental measurement results of the position sensitivity coefficients of the elliptical and octagonal sections is approximately 2%.ConclusionsThe BEM is a reliable method for calculating the position sensitivity coefficient of BPMs, which can be used in BPM design.

In order to solve the problem of rapid iterative interaction between multiple versions and services under the cloud native architecture, a full-link grayscale publishing technology scheme for cloud native is designed. Using traffic dyeing technology, an isolated environment from the gateway to all back-end business services is constructed to achieve grayscale publishing supporting multiple versions and multiple services. Flexible and rich gray scale strategy is designed to realize precise control of gray scale publishing. Full-link grayscale publishing capability is implemented through gateways and sidecar module that are relied upon by all back-end business services. Engineering practice shows that this scheme can effectively isolate the environment logically, provide precise control and full link capability, and effectively reduce the impact of demand release and improve the efficiency of online release.

Aiming at the problem that the non-stationary of airborne bistatic radar clutter reduces the performance of traditional clutter suppression algorithm, this paper first formulates airborne bistatic radar clutter model, and then analyzes the bistatic radar clutter characteristics in four typical combat scenarios. In addition, in order to reduce the computation burden of the STAP algorithm, a three-dimensional cross-beam clutter suppression algorithm is proposed, which uses the transformation matrix to convert the space-time two-dimensional data into azimuth-elevation-Doppler three-dimensional data. By eliminating auxiliary beam clutter data, only the main beam clutter data which plays a major role in dual-basis clutter suppression is retained to form a three-dimensional cross-beam for local adaptive clutter suppression. The proposed algorithm can greatly reduce the amount of calculation and the demand of training samples, while trying to ensure that the clutter suppression performance does not degrade. The effectiveness of the proposed algorithm is verified by analyzing the clutter suppression effect and computation amount of various algorithms in typical combat scenarios. Therefore, the algorithm has great potential in the applications of airborne bistatic and non-stationary clutter suppression.

Objective To evaluate the effects of intraperitoneal injection of sodium iodate on the physiological indexes and retinal histopathological characteristics of SD rats comprehensively. Methods A total of 64 rats were randomly divided into negative control group and model group, half male and half female. The model group was intraperitoneally injected with 6 mg/mL sodium iodate once at the dose of 10 mL/kg and the negative control group was injected with 10 mL/kg 0.9% NaCl once. The body weight of all surviving rats was detected on the day of injection (0 day) and the 2nd, 6th, 9th, 13th, 16th, 20th, 23rd, 27th, 29th, 36th, 43rd, 50th and 57th days after injection. On the 3rd, 7th, 21st, 28th, 41st and 62nd days after injection, the rats were randomly selected (12 rats in each group on the 28th day, and 4 rats in each group at other time points, those in each group were half male and half female) for serum biochemical indexes detection. The organs were dissected and weighed, and then the main organs and tissues were stained with HE, and the eyes were stained with HE and TUNEL. Blood routine indexes were detected on the 28th and 62nd day after injection. Results After injection of sodium iodate, 88% of the rats in the model group had transient loose stools. During the observation period, the body weight of the rats increased slightly and was more obvious in male rats. On the 28th day after injection, compared with the negative control group, the red blood cell volume (RDW) of female rats and blood urea nitrogen (BUN), reticulocyte count (Retic#) and reticulocyte percentage (Retic%) of male rats in the model group increased significantly (all P＜0.05). The white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB) and hematocrit (HCT) of male and female rats showed decreasing trends, but there were no significant differences between the two groups (all P >0.05). The thymus weight and coefficient of male rats in the model group were smaller than those in the negative control group except for the 7th day after injection, but there were no significant differences between the two groups (all P ＞0.05). Histopathological examination showed that the retina of the model group gradually developed from wavy changes to abnormal electrocardiogram (ECG)-like changes, with disordered arrangement of each layer, focal thinning of the outer nuclear layer, and apoptosis of the outer nuclear layer of the retina. The incidence of lesions, lesion score and the number of apoptotic cells in the model group were significantly higher than or more than those in the negative control group at the same time, and the difference between the groups on the 28th day was statistically significant (all P＜0.01). Conclusion In addition to retinal degeneration in rats, intraperitoneal injection of sodium iodate also had a certain degree of influence on serum biochemical and blood routine indexes, and also showed a slight slow growth of body weight and transient changes in fecal traits. Therefore, when using this model to evaluate drug safety, the effects of modeling reagents on animals should be paid to attention.

Herbal medicine has been widely valued because of its remarkable efficacy and minimal side effects. The quantitative analysis of herbal medicines is essential to ensure their safety and efficacy. The simultaneous detection of multiple quality markers (Q-markers) has emerged as an important approach and trend in herbal medicine quality control. In recent years, non-targeted screening has become an effective strategy for the discovery and identification of unknown compounds. This study developed a non-targeted screening and quantitative analysis strategy to discover, identify and quantify the multiple components that truly represent the efficacy of Wuling capsule. Within this strategy, 18 types of flavonoids were tentatively discovered and identified from Wuling capsule by analyzing mass cleavage pathways, the precise molecular weights of compounds, and comparing the data with a database. Ten types of flavonoids were determined after the comparison of the standards. Additionally, following the evaluation of the regression equation, linear range, limit of detection (LOD), limit of quantitation (LOQ), precision, repeatability, and recovery of the proposed quantitative method, six flavonoids were quantified. This method successfully screened, identified, and quantified the potential active components in Wuling capsule, providing insights for improving the quality control standards in other herbal medicines.

To improve transmission line load capacity and prevent power grid accidents, an online sag monitoring system for overhead transmission lines based on spontaneous Brillouin scattering is designed using the principles of Brillouin scattering and coherent detection. Brillouin Optical Time Domain Reflection (BOTDR) technology is used to collect the strain signal distributed along the optical fiber in real time, extract the key features of strain sensing, and realize the accurate positioning and early warning of sag anomaly points. Laboratory data and substation test results show that the system can detect and accurately locate strain change information in real time. The strain monitoring system is simple in single-end measurement and can accurately locate the strain mutation point. It can realize the early warning of cable sag abnormalities, and can timely detect and deal with potential faults to ensure the safe and stable operation of the transmission line.

ObjectiveTo investigate the association between the concentration of perchlorate in drinking water and the height and weight of children and adolescents in Sichuan Province.MethodsPerchlorate in the drinking water of 24 counties in Sichuan Province from 2021 to 2022 was detected and analyzed, 66 drinking water samples were collected, and the content of perchlorate in drinking water during the wet season and dry season was detected by ultra-high performance liquid chromatography in series. The linear mixed effect model was used to estimate the relationship between perchlorate in drinking water and the height and weight of 144,644 children and adolescents, and 33 pieces of local average wage data were used as confounding factors for quality control.ResultsAfter controlling the age, gender, and local economic situation, we found that the concentration of perchlorate in drinking water increased by 10 μg/L is associated with a 1.0 cm decrease in height and a 1.6 kg decrease in weight in children and adolescents (p

Ti–Al composite coating was prepared on the surface of a titanium alloy by the laser cladding technology and coaxial powder feeding under argon protection. The cladding material was AlSi10Mg aluminum alloy powder. The intermediate sample was thermally diffused at high temperature for 6 h and then placed in a certain intensity of the alternating electromagnetic field until completely cooled. The alloy substrate and coating solidified under the action of the alternating electromagnetic field, and the surface coating of a high strength titanium alloy was obtained. The morphology and microstructure of the composite coating were analyzed by SEM, XRD, and energy dispersive spectroscopy (EDS), and the hardness of the coating was measured. The results showed that the high temperature thermal diffusion promoted the interatomic diffusion; repaired some defects, such as cracks and pores; and eliminated the elemental metals that did not participate in the reaction, and the surface hardness of the coating joint reached the maximum. The electromagnetic stirring makes the titanium alloy coating and substrate bond well, the joint is relatively straight, the number of cracks and pores is obviously reduced, and the comprehensive performance of the coating is improved.

To prepare excellent radiation protection material, bismuth tungstate nanocrystals were synthesized by hydrothermal method, and polyurethane based bismuth tungstate composites were prepared. The effects of crystal structure and morphology on the gamma ray shielding properties of bismuth tungstate were studied. The results indicated that the pH value of precursor solution had a large effect on the synthesis of bismuth tungstate, orthorhombic Bi2WO6 were obtained under acidic and neutral conditions, and tetragonal Bi0.875W0.125O1.6875 were obtained under strong alkali condition. With the increase of pH value, the morphology of bismuth tungstate changed from flower like microspheres to persimmon like microstructures, and then to randomly stacked nanosheets. It was found that orthorhombic persimmon-like Bi2WO6 showed higher shielding properties to 81 keV gamma rays, whereas tetragonal Bi0.875W0.125O1.6875 showed higher shielding properties to 59.5 and 121.8 keV gamma rays, obvious differences were observed between the mechanical properties of the composites prepared by different crystalline bismuth tungstate. The results of this study provide a reference for the development of new radiation shielding materials with non-toxic, light weight and high efficiency.

Solitary pulmonary nodules (SPNs) are one of the most common chest computed tomography (CT) abnormalities clinically. We aimed to investigate the value of non-contrast enhanced CT (NECT), contrast enhanced CT (CECT), CT perfusion imaging (CTPI), and dual- energy CT (DECT) used for differentiating benign and malignant SPNs with a multi-institutional and prospective study.

In this study, a zebra-crossing detection method based on cascaded Hough transform (CHT) and vanishing point (VP) characteristics is proposed. In this method, the principle of detecting straight lines in the parallel coordinate system is applied to zebra-crossing detection. Each edge point of the image obtained by edge detection is represented in the parallel coordinate system to find the VP. Using the VP coordinate as the judgment condition, those straight lines that do not pass through the VP but meet the straight-line condition are excluded to obtain the straight lines passing through both sides of the zebra crossing, and finally fit the edge points on the straight line, and get the zebra-crossing fitting line segment. Experiments show that CHT has obvious advantages in detection accuracy and speed compared with the Hough transform. At the same time, VPs can be used to eliminate interference segments, which provide support for the accuracy of zebra-crossing detection. This method can get zebra-crossing location information without using region of interest extraction, which also provides a reference method for road detection in some specific cases.