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1,151 results on '"Li Yaming"'

1. LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis

Author

Xu Shuoyan, Cheng Zhiming, Du Bulin, Diao Yao, Li Yaming, and Li Xuena

Subjects
long non-coding RNA, aerobic glycolysis, TEAD1, ceRNA, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

AP000695.2 is a novel long non-coding RNA (lncRNA). Its aberrant high expression is remarkably associated with poor prognosis of patients with lung adenocarcinoma (LUAD). However, its role and underlying mechanism in LUAD remains unclear. Previous bioinformatics analysis indicated that AP000695.2 may be closely related to the glycolysis of LUAD. This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship between AP000695.2 and miR-335-3p is confirmed by bioinformatics analysis and dual-luciferase reporter assays. Through the dual-luciferase reporter assay, TEA domain transcription factor 1 (TEAD1) is identified as a target gene of miR-335-3p. Rescue experiments are applied to verify the relationship among AP000695.2, miR-335-3p and TEAD1. Our study indicates that AP000695.2 is involved in the mechanism of LUAD through functioning as a ceRNA to competitively sponge miR-335-3p, thereby regulating the expression of TEAD1. In the in vivo models, AP000695.2 depletion restrains tumor growth and glycolysis. AP000695.2 promotes the glycolysis of LUAD by regulating the miR-335-3p/TEAD1 axis, and it may serve as a potential target of anti-tumor energy metabolism therapy.

Published
2023
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2. Full-Duplex ISAC-Enabled D2D Underlaid Cellular Networks: Joint Transceiver Beamforming and Power Allocation

Author

Jiang, Tao, Jin, Ming, Guo, Qinghua, Liu, Yinhong, and Li, Yaming

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Integrating device-to-device (D2D) communication into cellular networks can significantly reduce the transmission burden on base stations (BSs). Besides, integrated sensing and communication (ISAC) is envisioned as a key feature in future wireless networks. In this work, we consider a full-duplex ISAC- based D2D underlaid system, and propose a joint beamforming and power allocation scheme to improve the performance of the coexisting ISAC and D2D networks. To enhance spectral efficiency, a sum rate maximization problem is formulated for the full-duplex ISAC-based D2D underlaid system, which is non-convex. To solve the non-convex optimization problem, we propose a successive convex approximation (SCA)-based iterative algorithm and prove its convergence. Numerical results are provided to validate the effectiveness of the proposed scheme with the iterative algorithm, demonstrating that the proposed scheme outperforms state-of-the-art ones in both communication and sensing performance., Comment: This work has been submitted to IEEE Transactions on Wireless Communications on 7 June,2024

Published
2024

11. A Review of First-Principles Studies on Fe-Al Intermetallic Compounds

Author

CHEN Weiqian, LA Peiqing, LI Yaming, XU Shipeng

Subjects
first-principles； fe-al intermetallic compounds； mechanical properties； corrosion resistance； interfacial strength, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

Fe-Al intermetallic compounds have great potential to replace nickel-based superalloys in industry, which is attributed to their attractive properties such as low density,high specific strength,good high-temperature oxidation and corrosion resistance and especially low cost.In this paper, important advances in the application of first-principles calculations to study the effect of element doping and microalloying on the brittleness at room temperature, high-temperature strength, interface bonding, high-temperature oxidation resistance and corrosion resistance of Fe-Al intermetallic compounds and coatings were comprehensively reviewed.A theoretical calculation scheme for first-principles research on the chloride salt corrosion resistance mechanism of B2 type Fe-Al alloy was designed,and the development directions for the application of first-principles calculations to study Fe-Al alloy and coatings were prospected.

Published
2024
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14. LNMER-Net: A Metabolically Enhanced Lymph Node Metastasis Recognition Model Based on Lung Lymph Nodes and Microenvironment

Author

Wang, Lingyun, Jiang, Huiyan, Zhou, Yang, Luan, Qiu, Du, Bulin, Li, Yaming, Li, Xuena, Pei, Yan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Hung, Jason C., editor, Yen, Neil, editor, and Chang, Jia-Wei, editor

Published
2024
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22. Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history

Author

Xia, Anqi, Wang, Xiaojie, He, Jiaying, Wu, Wei, Jiang, Weiyu, Xue, Song, Zhang, Qianqian, Gao, Yidan, Han, Yuru, Li, Yaming, Peng, Xiaofang, Xie, Minxiang, Mayer, Christian T., Liu, Jie, Hua, Chen, Sha, Yiou, Xu, Wei, Huang, Jinghe, Ying, Tianlei, Jiang, Shibo, Xie, Youhua, Cai, Qiliang, Lu, Lu, Silva, Israel T., Yuan, Zhenghong, Zhang, Yixiao, and Wang, Qiao

Published
2023
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32. Concomitant pulmonary and thyroid tumors identified by FDG PET/CT and immunohistochemical techniques

Author

Liang Shujun, Li Yaming, Zhang Yanjun, Li Hong, Zhu Guangwen, and Liu Jia

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The exact diagnosis of double primary papillary adenocarcinoma of thyroid and lung is even rarer, to our knowledge no report in the literature by [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography/X-ray CT(FDG PET/CT) with surgical specimens immunohistochemistry(IHC). We report a patient with abnormal FDG PET/CT in thyroid and lung, this unusual presentation may lead to misdiagnosis without surgical specimens IHC. Case presentation A 56-year-old man with coughing three months. FDG PET/CT was performed, and resection specimens of lung and thyroid were detected by hematoxylin eosin staining (HE) and IHC. PET/CT: lung tumor SUVmax: 3.69, delay: 5.17; and thyroid tumor SUVmax 19.97. HE reveal papillary adenocarcinoma, but histological differentiation of primary pulmonary adenocarcinoma from metastatic adenocarcinoma is sometimes difficult because of their phenotypic similarities. So IHC was performed, the IHC of lung tumor: cytokeratin 20 (CK20)(-), thyroglobulin(Tg)(-), cytokeratin7(CK7)(+), thyroid transcription factor-1 (TTF-1)(+); thyroid tumor: CK7(+), TTF-1(+), thyroglobulin (+), CK20(-). Therefore, the final diagnosis was double primary adenocarcinomas of thyroid and lung. Conclusion FDG PET/CT has preliminary diagnostic capacity of multiple primary tumors; the final diagnosis should be adopted for specimens after tumor-specific markers IHC to obtain. Consequently, effective therapeutic approaches can be designed and conducted.

Published
2011
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33. Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles

Author

Klein-Seetharaman Judith, Srinivasan Alagarsamy, Yanamala Naveena, Li Yaming, Dempsey Timothy M, Le Thien, Tastan Oznur, Walker Leah A, Venkatachari Narasimhan J, Montelaro Ronald C, and Ayyavoo Velpandi

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract HIV-1 Vpr, a nonstructural viral protein associated with virus particles, has a positive role in the efficient transport of PIC into the nucleus of non-dividing target cells and enhances virus replication in primary T cells. Vpr is a 96 amino acid protein and the structure by NMR shows three helical domains. Vpr has been shown to exist as dimers and higher order oligomers. Considering the multifunctional nature of Vpr, the contribution of distinct helical domains to the dimer/oligomer structure of Vpr and the relevance of this feature to its functions are not clear. To address this, we have utilized molecular modeling approaches to identify putative models of oligomerization. The predicted interface residues were subjected to site-directed mutagenesis and evaluated their role in intermolecular interaction and virion incorporation. The interaction between Vpr molecules was monitored by Bimolecular Fluorescence complementation (BiFC) method. The results show that Vpr forms oligomers in live cells and residues in helical domains play critical roles in oligomerization. Interestingly, Vpr molecules defective in oligomerization also fail to incorporate into the virus particles. Based on the data, we suggest that oligomerization of Vpr is essential for virion incorporation property and may also have a role in the events associated with virus infection.

Published
2010
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47. An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

Author

Liu, Zezhong, Xu, Wei, Chen, Zhenguo, Fu, Wangjun, Zhan, Wuqiang, Gao, Yidan, Zhou, Jie, Zhou, Yunjiao, Wu, Jianbo, Wang, Qian, Zhang, Xiang, Hao, Aihua, Wu, Wei, Zhang, Qianqian, Li, Yaming, Fan, Kaiyue, Chen, Ruihong, Jiang, Qiaochu, Mayer, Christian T., Schoofs, Till, Xie, Youhua, Jiang, Shibo, Wen, Yumei, Yuan, Zhenghong, Wang, Kang, Lu, Lu, Sun, Lei, and Wang, Qiao

Published
2022
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