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As China’s urbanization has shifted from high-speed to high-quality development, Urban Land Use Efficiency (ULUE) has become an important scale for evaluating urban connotative development. However, existing research has paid less attention to errors caused by different urban environmental factors and random disturbances in ULUE. Therefore, the purpose of this study is to eliminate the impact of environmental factors and random disturbances on ULUE measurement results by placing different cities under the same environmental conditions. First, a three-stage DEA envelopment analysis (T-DEA) model is introduced to calculate the ULUE of 16 prefecture-level cities in Anhui Province from 2001 to 2020. On this basis, the kernel density estimation model, gravity center model, and geographic detector models are used to study the spatial and temporal evolution and driving factors. The results show that (1) the ULUE increases nonlinearly with time, with an increase of 12.74%; (2) the overall peak of ULUE is on the rise, and changes from a single peak to a multi-peak, indicating that ULUE is constantly improving and that there is multi-level differentiation between different cities; (3) during the study period, the center of gravity of the ULUE value moved 22.66 km to the northwest; the overall moving distance was small, and the moving rate was slow; and (4) the influence of the interaction of double driving factors on ULUE is significantly greater than that of a single driving factor, and the factors of urban built-up area and degree of openness, as the key driving factors affecting ULUE, also have a degree of duality. In addition, to achieve efficient urban land use and to coordinate the environmental differences faced by different cities, the government must formulate systematic policies and development strategies considering the spatial characteristics of urban land use efficiency and the complexity of the driving factors.

To use vanadium–titanium magnetite (VTM) resources for sintering, a composite agglomeration process (CAP) is applied. This paper studies the effects of pelletizing parameters, including particle si...

In the ironmaking process, the addition of an organic binder to replace a portion of bentonite has the potential to improve the performance of pellets. The interaction between original bentonite (OB) and organic binder was investigated. Results indicated that the micromorphology of organic composite bentonite (OCB) became porous and the infrared difference spectrum exhibited a curved shape. In addition, the residual burning rates of OB and organic binder were determined to be 82.72% and 2.30%, respectively. Finally, the influence of OCB on the properties of pellets was investigated. The compressive strength of OCB-added green pellets (14.7 N per pellet) was better than that of OB-added pellets (10.3 N per pellet). Moreover, the range of melting temperature of OCB-added green pellets (173°C) was narrower than that of OB-added pellets (198°C). The compressive strength of OCB-added green pellets increased from 2156 to 3156 N per pellet with the increase in roasting temperature from 1200 to 1250°C.

In order to improve the accuracy of the porosity results of pellets, the reliability of three methods for measuring the pore structure was compared. The results show that there is a measurement error in the result of the traditional method, the mercury intrusion porosimetry (MIP) cannot detect closed pores, and the result of scanning electron microscope (SEM) method is more comprehensive. Additionally, three types of pore structures have been proposed to describe the pore formation mechanism of pellets, namely original pores, pores left by shrinkage of liquid phase and pores left by induration of mineral particles. Furthermore, the pore structures of pellets were analyzed by MIP and SEM. The results reveal that MIP can measure the pores with diameters less than 1 μm, and the pore diameters measured by SEM range from 1.2 to 89.2 μm. Finally, the curvature of the pores is measured to evaluate the consolidation degree of the pellet.

Charcoal-stripped fetal bovine serum (CS-FBS) is frequently used in studies on hormone-responsive cancers to provide hormone-free cell culture conditions. CS-FBS may influence the growth of cancer cells; however, the underlying mechanisms remain unclear. In this study, we aimed to clarify the effects of CS-FBS on distinct subtypes of breast cancer cells. We found that the crucial oncoprotein c-Myc was significantly inhibited in estrogen receptor alpha (ER-α)-positive breast cancer cells when cultured in CS-FBS-supplemented medium, but it was not suppressed in ER-α-negative cells. The addition of 17β-estradiol (E2) to CS-FBS-supplemented medium rescued the CS-FBS-induced inhibition of c-Myc, while treatment with 5α-dihydrotestosterone (DHT) suppressed c-Myc expression. Our data demonstrated that CS-FBS may impede the growth of ER-α-positive breast cancer cells via c-Myc inhibition, and this was possibly due to the removal of estrogen. These results highlighted that the core drivers of c-Myc expression were subtype-specific depending on the distinct cell context and special caution should be exercised when using CS-FBS in studies of hormone-responsive cancer cells.

Based on the theory of children's TCM constitution “children are Zhi yang wei chong, and Zhi yin wei zhang”, combined with the etiology and pathogenesis of TCM in children with purpuric nephritis, Professor Zhang Jun uses The four methods of "Clearing heat, dampness, tonicity, and stasis" are used to treat children with purpuric nephritis, and it is advocated that the method of "resolving blood stasis" runs through the entire treatment process, and the clinical results are quite good.

Maize (Zea mays L.) yield depends not only on the conversion and accumulation of carbohydrates in kernels, but also on the supply of carbohydrates by leaves. However, the carbon metabolism process in leaves can vary across different leaf regions and during the day and night. Hence, we used Weighted Gene Co-expression Network analysis (WGCNA) with the gene expression profiles of carbon metabolism to identify the modules and genes that may associate with particular regions in a leaf and time of day. There were a total of 45 samples of maize leaves that were taken from three different regions of a growing maize leaf at five time points. Robust Multi-array Average analysis was used to pre-process the raw data of GSE85963 (accession number), and quality control of data was based on Pearson correlation coefficients. We obtained eight co-expression network modules. The modules with the highest significance of association with LeafRegion and TimePoint were selected. Functional enrichment and gene-gene interaction analyses were conducted to acquire the hub genes and pathways in these significant modules. These results can support the findings of similar studies by providing evidence of potential module genes and enriched pathways associated with leaf development in maize.

Non-heading Chinese cabbage (NHCC) is an important leafy vegetable cultivated worldwide. Here, we report the first high-quality, chromosome-level genome of NHCC001 based on PacBio, Hi-C, and Illumina sequencing data. The assembled NHCC001 genome is 405.33 Mb in size with a contig N50 of 2.83 Mb and a scaffold N50 of 38.13 Mb. Approximately 53% of the assembled genome is composed of repetitive sequences, among which long terminal repeats (LTRs, 20.42% of the genome) are the most abundant. Using Hi-C data, 97.9% (396.83 Mb) of the sequences were assigned to 10 pseudochromosomes. Genome assessment showed that thisB. rapaNHCC001 genome assembly is of better quality than other currently availableB. rapaassemblies and that it contains 48,158 protein-coding genes, 99.56% of which are annotated in at least one functional database. Comparative genomic analysis confirmed thatB. rapaNHCC001 underwent a whole-genome triplication (WGT) event shared with otherBrassicaspecies that occurred after the WGD events shared withArabidopsis. Genes related to ascorbic acid metabolism showed little variation among the threeB. rapasubspecies. The numbers of genes involved in glucosinolate biosynthesis and catabolism were higher in NHCC001 than in Chiifu and Z1, due primarily to tandem duplication. The newly assembled genome will provide an important resource for research onB. rapa, especiallyB. rapassp.chinensis.

Cut-like homeobox 1 (CUX1) is a highly conserved homeoprotein that functions as a transcriptional repressor of genes specifying terminal differentiation. We previously showed that liver-specific microRNA-122 (miR-122) regulates the timing of liver development by silencing CUX1 post-transcriptionally. Since the CUX1 protein is expressed in a subset of embryonic tissues, we hypothesized that it is regulated by specific microRNAs (miRNAs) in each cell type during development. Using a large-scale screening method, we identified ten tissue-specific miRNAs from different cell lineages that directly targeted CUX1. An analysis of the interaction between heart-specific microRNA-208a (miR-208a) and CUX1 in the hearts of developing mouse embryos and in P19CL6 cells undergoing cardiac differentiation indicated that CUX1 is regulated by miR-208a during heart development and cardiomyocyte differentiation. Functional analysis of miR-208a in P19CL6 cells using lentiviral-mediated over-expression showed that it regulates the transition between cellular proliferation and differentiation. These results suggest that these tissue-specific miRNAs might play a common role in timing the progression of terminal differentiation of different cell lineages, possibly by silencing the differentiation repressor CUX1.

Precision oncology aims to offer the most appropriate treatments to cancer patients mainly based on their individual genetic information. Genomics has provided numerous valuable data on driver mutations and risk loci; however, it remains a formidable challenge to transform these data into therapeutic agents. Transcriptomics describes the multifarious expression patterns of both mRNAs and non-coding RNAs (ncRNAs), which facilitates the deciphering of genomic codes. In this review, we take breast cancer as an example to demonstrate the applications of these rich RNA resources in precision medicine exploration. These include the use of mRNA profiles in triple-negative breast cancer (TNBC) subtyping to inform corresponding candidate targeted therapies; current advancements and achievements of high-throughput RNA interference (RNAi) screening technologies in breast cancer; and microRNAs as functional signatures for defining cell identities and regulating the biological activities of breast cancer cells. We summarize the benefits of transcriptomic analyses in breast cancer management and propose that unscrambling the core signaling networks of cancer may be an important task of multiple-omic data integration for precision oncology. Keywords: Precision oncology, Transcriptomics, RNA interference, microRNA, Breast cancer

With the development of Internet technology and the increasing popularity of the Internet, the amount of information data of enterprises increased sharply. How to avoid unexpected data corruption and to improve the system of data security and data recovery capabilities has been the focus of attention of users and enterprises. Regular backups of the database is to restore the data the easiest and most effective guarantee method and is an effective measure database administrators to manage data. This paper proposes a plan of database scheduled tasks based on Linux environment. This plan can be timed to export the database, be sent automatically to a secure backup mailbox and complete the regular backup of the database finally.

Fragmentation is the most important trends across all media platforms, with the aim of reorganizing and disseminating information in a more personalized way according to the "Long Tail Demand" theory. This paper proposes a fragments reorganizing plan, which considering sequential video, UGC video, graphic, text and social media information as the equivalent information source, utilizing a unified metadata format to describe media resources multi-dimensionally. The implementation of virtual segmenting for video allows a more flexible control of the granularity and achieves a rich content presentation and interactive behavior when combined with interactive scripts.

Currently, the main disadvantages of OTT services are live video delay and video quality assurance while OTT services have many interactive contents. In contrast, IPTV reception effect is better however policy restrictions, incomplete standards and lack of content are the IPTV deficiencies. Therefore, this paper proposes a method of implanting OTT services into IPTV system. The design and implementation maintain the intrinsic IPTV services and ImageMagick is used to present OTT services in IPTV set-top box (STB) according to the current IPTV industry standards. Meanwhile, the services can be designed through the management software. Finally, the OTT services based on IPTV STB can enrich IPTV video content and enhance user interactive experience.

Conventional control of tunnel boring machine can't achieve the ideal effect because of the complexity of its work process, uncertainty of construction environment. In order to solve the question, the intelligent control is expected. The neural network control has many characteristics such as self-adaption, self-organization, and can modify the corresponding parameters by learning about external knowledge, so it becomes research focus of tunnel boring machine control system in recent years. In this paper the advantage and disadvantage of several kinds of neural network used in the tunnel boring machine control are introduced, the development trends of tunnel boring machine control is predicted.

To report the surgical management, complications and prognosis of patients with penoscrotal extramammary Paget's disease (EMPD) at different clinical stages. Between 2003 and 2008, a total of 30 male patients with penoscrotal EMPD were enrolled and evaluated. All enrolled subjects received frozen biopsy-guided local wide resection and immediate reconstruction. Patients were followed every 3 months postoperatively. Among the 30 patients who accepted and underwent frozen biopsy-guided local wide resection treatment and reconstruction, two (6.7%) cases exhibited positive margins, verified by pathological examination, and underwent re-excision after surgery. The technique of primary closure or an adjacent flap was used in 10 (33.3%) cases, split-thickness skin grafts were used in 15 (50%), and an anterolateral thigh perforator flap was used in five cases (16.7%). The postoperative complications were acceptable. The mean follow-up time was 64.9 ± 29.6 months. Of all 30 cases, 22 patients (73.3%) survived with no evidence of recurrence, four patients (13.3%) exhibited local recurrence, two patients (6.7%) exhibited both local recurrence and distant metastasis and the remaining two patients (6.7%) exhibited distant metastasis. Five patients died from metastasis or cachexia. Current surgical techniques, including primary closure, adjacent flaps, split-thickness skin flaps and anterolateral thigh perforator flaps are able to reconstruct all types of defects with acceptable complications. Some patients with negative margins went on to exhibit local recurrence, potentially due to adnexal carcinoma or internal malignancy.

We compared plasmakinetic resection with holmium laser enucleation of the prostate for the treatment of benign prostatic hyperplasia by analyzing 2-year followup data from a prospective randomized clinical trial.A total of 280 patients were randomly treated with plasmakinetic resection or holmium laser enucleation of the prostate. Perioperative and postoperative outcome data were obtained during a 2-year followup.No significant differences between the 2 surgical groups were observed in the preoperative data. Both groups displayed significant improvements after surgery. However, we identified no significant differences between the 2 groups in the 2-year followup data for I-PSS (International Prostate Symptom Score), quality of life scores or maximum flow rate values. Patients in the holmium laser enucleation group displayed a lower risk of hemorrhage, shorter bladder irrigation and catheter times, and shorter hospital stays. A larger amount of prostate tissue was retrieved in the holmium laser enucleation group, but the operation time was longer for this group than for the plasmakinetic resection group.Plasmakinetic resection and holmium laser enucleation of the prostate are effective and safe treatments for benign prostatic hyperplasia. Holmium laser enucleation of the prostate can be applied to prostates of all sizes, and involves less risk of hemorrhage, decreased bladder irrigation and catheter times, as well as reduced hospital stay. Thus, we believe holmium laser enucleation of the prostate should be proposed as a potential new gold standard surgical therapy instead of transurethral resection of the prostate for patients with benign prostatic hyperplasia.

27-hydroxycholesterol (27-HC), the most abundant metabolite of cholesterol, is a risk factor for breast cancer. It can increase the proliferation of breast cancer cells and promote the metastasis of breast tumours in mouse models. Myc is a critical oncoprotein overexpressed in breast cancer. However, whether 27-HC affects Myc expression has not been reported. In the current study, we aimed to investigate the effects of 27-HC on Myc and the underlying mechanisms in MCF-7 breast cancer cells. Our data demonstrated that 27-HC activated Myc via increasing its protein stability. Three key negative modulators of Myc protein stability, PP2A, SCP1 and FBW7, were suppressed by 27-HC at the transcriptional level. We performed a data-mining analysis of the chromatin immunoprecipitation with next-generation DNA sequencing (ChIP-Seq) data in the ChIPBase, and discovered that a number of putative transcription factors (TFs), including Myc itself, were involved in the transcriptional regulation of PP2A, SCP1 and FBW7. Our results provide a novel mechanistic insight into the activation of Myc by 27-HC via transcriptional repression of PP2A, SCP1 and FBW7 to increase Myc protein stability in breast cancer cells.

In this paper the structural characteristics of TG200 bridge machine was introduced, the overall design scheme of control system was determined and the electrical control system, which was mainly made up of PLC, inverter, remote controller and human-machine interface, was designed. Industrial test proved that the control system is stable and easy to operate, and that it can provide an important safeguard for the long-term safe operation of the bridge machine.

Accumulating evidence has implicated the deregluation of miRNAs in tumorigenesis. Previous studies have reported that microRNA-195 (miR-195) is markedly down-regulated in human glioblastoma cells, compared with normal brain tissue, but the biological role of miR-195 in glioblastoma development is currently unknown. In this study, we define a tumor-suppressor role for miR-195 in human glioblastoma cells. Over-expression of miR-195 in glioblastoma cell lines robustly arrested cell cycle progression and significantly repressed cellular invasion. We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells. Through knockdown studies, we demonstrated that E2F3 was the dominant effector of miR-195-mediated cell cycle arrest and that CCND3 was a key mediator of miR-195-induced inhibition of glioblastoma cell invasion. Furthermore, we showed that p27(Kip1) was an important regulator downstream of CCND3 and that the accumulation of p27(Kip1) in the cytoplasm might be responsible for the miR-195-mediated cell invasion inhibition in glioblastoma cells. This work provides evidence for the initial mechanism by which miR-195 negatively regulates both the proliferation and invasion of glioblastoma cells, suggesting that the down-regulation of miR-195 might contribute to the malignant transformation of glioblastoma cells and could be a molecular signature associated with glioblastoma progression.

This paper reports the occurrence of two new species of Digamasellidae from Taiwan, Dendroseius vulgaris n. sp. and Dendrolaelaps (Foveodendrolaelaps) linjianzheni n. sp. Dendroseius vulgaris is described based on the morphology of adult females, adult males and deutonymph, and D. linjianzheni is based on the morphology of adult females and males. This is the first report on the mite species of Digamasellidae from Taiwan.

Stromal cells play a decisive role in regulating tumor progression. In this study, we assessed the significance of normal prostate-derived stromal cells (PSCs) in prostate cancer development. An in vivo s.c. tumor model was established as follows: Group 1, DU145 cells alone; Group 2, DU145 + PSCs; Group 3, DU145 cells alone injected into pre-castrated mice; and Group 4, DU145 + PSCs injected into pre-castrated mice. Following injection, tumors were only detectable in the first two groups, with more aggressive growth in Group 2 than in Group 1 (P < 0.05). Immunohistochemical analysis revealed significantly higher proliferation (P < 0.05), but not apoptosis or altered expression of androgen receptor in Group 2, as compared with Group 1. In vitro, DU145 cells isolated from Group 1 tumors showed lower viability and migratory capability than those from Group 2. cDNA microarray on isolated DU145 cells from Groups 1 and 2 revealed the differential expression of genes regulating cell cycle progression and cell mobility, including GADD45A, RHOV, KLK11, and PCK1. Our results suggest that stromal cells derived from normal prostate potentiate the development of tumor growth in vivo, which is achieved at least in part through the regulation of cell-cycle- and migration-related gene expression within the tumor cells.

Biological, physical and chemical methods have been extensively used to treat paper mill effluent and effectively decreased the pollution level of the effluent. But some poorly- or non-biodegradable organic compounds cannot be degraded through these traditional treatment methods. The objective of this study is to investigate the chemical oxygen demand (COD) degradation kinetics of the paper mill effluent when the effluent was treated by single ozonation and catalytic ozonation with activated carbon (AC), TiO2/AC, Al2O3 and TiO2/Al2O3. Results show that CODcr degradation process of the paper mill effluent studied in this paper with single ozonation and catalytic ozonation should follow apparent second-order kinetics, and catalytic ozonation with AC, TiO2/AC, Al2O3 and TiO2/Al2O3 effectively enhances the reaction rate constant of CODcr degradation of the effluent, compared with single ozonation. The CODcr. removal rate and reaction rate constant by single ozonation are 34% and 1.21698×10-4 (mg/L)-1·min-1 and CODcr removal rates and reaction rate constants increase to 35-55% and 1.27775-2.64412×10-4 (mg/L)-1·min-1 by catalytic ozonation with AC, TiO2/AC, Al2O3 and TiO2/Al2O3 respectively. It is also found that the content of TiO2 loaded on AC or Al2O3 has important effect on the enhancement of CODcr removal rate and reaction rate constant of the paper mill effluent investigated in this study in the process of ozonation and catalytic ozonation.

Although traditional biological treatments effectively reduce the pollution level of paper mill effluent, biologically treated effluent usually can not meet the effluent emission standard. The objective of this study is to investigate the treatment efficiency of the biologically treated effluent by single ozonation and ozonation in the presence of activated carbon (AC), TiO2/AC, Al2O3 and TiO2/Al2O3 catalysts. Results showed that treatment efficiency was enhanced by the simultaneous use of ozone and the catalysts, evaluated as chemical oxygen demand (COD) and color removal rates. The COD and color removal rates reached 51% and 91% for ozonation with TiO2/AC, 55% and 92% for ozonation with TiO2/Al2O3 catalyst, compared with 37% and 83% for single ozonation. It was also found that BOD5/COD effectively increased after ozonation and catalytic ozonation, indicating obvious enhancement of the biodegradability of the effluent.

Chemithermomechanical pulping becomes an important development direction for pulp and papermaking industry. But the treatment of its effluent is very difficult because of its high concentration of organic pollutants and the deep color. In this study, eucalyptus chemithermomechanical pulp (CTMP) chemical pretreatment effluent was treated with electrocoagulation, and its treatment efficiency was compared with the traditional chemical coagulation. Results showed that under the conditions of 7.5v cell voltage or 4.43mA/cm2 current density, effluent pH of 6, 25 min treatment time, and 1.0g NaCl addition, CODcr and color removal rates in electrocoagulation treatment reached 40.8% and 90.1% respectively, which were much higher than those of the aluminium chloride and ferric chloride treatment. Based on these results, it is expected that electrocoagulation is a more effective method than chemical coagulation to remove the pollution materials existed in the CTMP chemical pretreatment effluent examined in this study.

BACKGROUND: MicroRNAs (miRNAs) are approximately 22-nt small non-coding regulatory RNAs that have generally been considered to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in the nucleus. METHODOLOGY/PRINCIPAL FINDINGS: To determine the number of miRNAs localized to the nucleus, we systematically investigated the subcellular distribution of small RNAs (sRNAs) by independent deep sequencing sequenced of the nuclear and cytoplasmic pools of 18- to 30-nucleotide sRNAs from human cells. We identified 339 nuclear and 324 cytoplasmic known miRNAs, 300 of which overlap, suggesting that the majority of miRNAs are imported into the nucleus. With the exception of a few miRNAs evidently enriched in the nuclear pool, such as the mir-29b, the ratio of miRNA abundances in the nuclear fraction versus in the cytoplasmic fraction vary to some extent. Moreover, our results revealed that a large number of tRNA 3' trailers are exported from the nucleus and accumulate in the cytoplasm. These tRNA 3' trailers accumulate in a variety of cell types, implying that the biogenesis of tRNA 3' trailers is conserved and that they have a potential functional role in vertebrate cells. CONCLUSION/SIGNIFICANCE: Our results provide the first comprehensive view of the subcellular distribution of diverse sRNAs and new insights into the roles of miRNAs and tRNA 3' trailers in the cell.

AIM: To assess the variability of adhesin gene hpaA between different Helicobacter pylori (H pylori) strains with PCR-restriction fragment length polymorphism (RFLP). METHODS: Twelve different H pylori strains were chosen to amplify the 710-bp segments of gene hpaA. These strains were NCTC11637, SS1; Chongqing clinical isolates CCS9801, CCS9802, CCS9803, CCS9806, CCS9809, CCS9810, CCS9813, which were gained from patients of gastritis; Mongolia gerbil adapted H pylori strains (abbreviation MG), which were gained from the following steps: gastric mucosal specimens of Mongolia gerbils infected by clinical isolate CCS9803 were cultured and detected, the positive H pylori strains were named as the first generation of Mongolia gerbil adapted H pylori strains (abbreviation MG1) and then were subcultured with healthy Mongolia gerbil to generate MG2, in turn to gain the ninth generation (abbreviation MG9). All hpaA segments, obtained from 12 different H pylori strains, were digested by HhaI and HaeIII individually and analyzed by agarose gel electrophoresis. RESULTS: In all 12 strains, the 710-bp PCR products were successfully amplified and products were cloned to pMD18-T vector respectively, then the recombinant plasmids were digested simultaneously with NcoI and XhoI to recover the small fragments. The objective fragments from 12 different H pylori strains digested with Hae III could be seen as 4 types of bands and 5 types with Hha I. According to the hpaA RFLP patterns, the 12 H pylori strains could be divided into 5 groups: group I, NCTC11637 and SS1; group II, CCS9809, which RFLP type digested with HaeIII was the same as strains of group I, but HhaI RFLP showed difference compared with the other groups; group III, CCS9810; group IV, CCS9803; group V: CCS9801, CCS9802, CCS9806, CCS9813, MG1, MG3 and MG9. The sequence data of 12 hpaA segments were analyzed by DNAsis software and it was observed that: (1) The homologies of base pair and amino acid sequence between strains NCTC11637, SS1, CCS9809 were 99.6% and 98.9%, respectively; (2) The homology of base pair and amino acid sequence between CCS9803 and CCS9810 was 97.7% and 99.1%; (3) That of the rest strains, CCS9801, CCS9802, CCS9806, CCS9813, MG1, MG3, MG9 reached 99.4% and 98.4%; (4) The base pair homologies between all hpaA fragments of different sources were higher than 94.6%, therefore the correspondence of deduced amino acid sequence was higher than 96.8% between each other. CONCLUSION: The gene hpaA from different H pylori strains revealed variation, and this might provide an effective method for molecular epidemiological survey of H pylori.

This paper reports the occurrence of two new species of Digamasellidae from Taiwan, Dendroseius vulgaris n. sp. and Dendrolaelaps (Foveodendrolaelaps) linjianzheni n. sp. Dendroseius vulgaris is described based on the morphology of adult females, adult males and deutonymph, and D. linjianzheni is based on the morphology of adult females and males. This is the first report on the mite species of Digamasellidae from Taiwan.

Parashunsennia Kumada, 1956 is as a subgenus of the genus Shunsennia Jameson et Toshioka, 1953 in the present article. Shunsennia (Parashunsennia) marmota, sp.nov. is described from a larva parasitic on marmota in Taojiang, Gansu, China. A key to the species of the genus in China is given.

Deposition of collagen IV in proximal tubule cells (PTCs) plays an important role during diabetic nephropathy, but the mechanism underlying excessive production of collagen IV remains poorly understood. In this study, we examined the miRNA profile of HK-2 cells and found that high glucose/TGF-β1 induced significant down-regulation of miR-29a. We then showed that miR-29a negatively regulated collagen IV by directly targeting the 3′UTRs of col4a1 and col4a2. These results suggest that miR-29a acts as a repressor to fine-tune collagen expression and that the reduction of miR-29a caused by high glucose may increase the risk of excess collagen deposition in PTCs.