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C40H18F8N4NiO8, triclinic, P1̅ (No. 2), a = 11.5061(2) Å, b = 11.8003(3) Å, c = 14.5181(3) Å, α = 111.888(2)°, β = 101.867(2)°, γ = 95.595(2)°, V = 1756.8 Å3, Z = 2, Rgt(F) = 0.0490, wRref(F2) = 0.1169, T = 296 K.

C43H32N4O18, monoclinic, C2/c (o. 15), a = 22.409(3) Å, b = 8.280(1) Å, c = 22.146(3) Å, β = 105.242(1)°, V = 3964.7 Å3, Z = 4, Rgt(F) = 0.0482, wRref(F2) = 0.1411, T = 296 K.

C32H21F4N4NiO6.5, monoclinic, C2/c (no. 15), a = 16.201(3) Å, b = 14.831(3) Å, c = 25.798(5) Å, β = 105.16(3)°, V = 5983.0 Å3, Z = 8, Rgt(F) = 0.0363, wRref(F2) = 0.0891, T = 293 K.

C36H18F8N4O8Zn, triclinic, P1̄ (no. 2), a = 10.618(2) Å, b = 12.026(2) Å, c = 15.399(2) Å, α = 81.574(2)°, β = 85.344(2)°, γ = 87.642(2)°, V = 1937.7 Å3, Z = 2, Rgt(F) = 0.0566, wRref(F2) = 0.1366, T = 293 K.

A brief daily body-mind-spirit (BMS) workplace well-being program has been developed for community mental health workers (CMHW). Aiming to evaluate the program's efficacy, this study adopted a multi-site randomized controlled trial design. Primary outcome measures included work engagement and burnout. The data analysis included 175 participants. ANOVA revealed significant group x time interaction effects on work engagement (η2 = 0.037, p = 0.039) and on one of its sub-scores: absorption (η2 = 0.048, p = 0.014). Regarding burnout, ANOVA revealed that at T4 there were significant group x time effects on burnout total score and all three of its sub-scores, including work-related burnout, client-related burnout and personal burnout. Partial eta squared ranged between 0.028 and 0.071, suggesting a small-to-medium effect size. Overall findings demonstrated the protective effect of the Brief Daily BMS program in preserving work engagement during challenging conditions, and to a lesser extent in reducing burnout among CMHW. [ABSTRACT FROM AUTHOR]

Background: The kidney-brain crosstalk has been involved in Alzheimer's disease (AD) with the mechanism remaining unclear. The anti-aging factor Klotho was reported to attenuate both kidney injury and AD pathologies. Objective: To investigate whether plasma Klotho participated in kidney-brain crosstalk in AD. Methods: We enrolled 33 PiB-PET-positive AD patients and 33 amyloid-β (Aβ)-negative age- and sex-matched cognitively normal (CN) controls from the Chongqing Ageing & Dementia Study (CADS). The levels of plasma Klotho, Aβ, and tau in the cerebrospinal fluid (CSF) were measured by enzyme-linked immunosorbent assay. Results: We found higher plasma Klotho and lower estimated glomerular filtration rate (eGFR) levels in AD patients compared with CN. The eGFR was positively associated with Aβ42, Aβ40 levels in CSF and negatively associated with CSF T-tau levels. Plasma Klotho levels were both negatively correlated with CSF Aβ42 and eGFR. Mediation analysis showed that plasma Klotho mediated 24.96% of the association between eGFR and CSF Aβ42. Conclusion: Renal function impacts brain Aβ metabolism via the kidney-brain crosstalk, in which the plasma Klotho may be involved as a mediator. Targeting Klotho to regulate the kidney-brain crosstalk provides potential therapeutic approaches for AD. [ABSTRACT FROM AUTHOR]

Introduction and Aims: Alzheimer's disease (AD) is the most common form of dementia with a complex genetic background. The cause of sporadic AD (sAD) remains largely unknown. Increasing evidence shows that genetic variations play a crucial role in sAD. P75 neurotrophin receptor (p75NTR, encoded by NGFR) plays a critical role in the pathogenesis of AD. Yet, the relationship between NGFR gene polymorphisms and AD was less studied. This study aims to analyze the relationship of NGFR gene polymorphism with the risk of AD in the Chinese Han population and amyloid‐β deposition in the ADNI cohort. Methods: This case–control association study was conducted in a Chinese Han cohort consisting of 366 sporadic AD (sAD) patients and 390 age‐ and sex‐matched controls. Twelve tag‐SNPs were selected and genotyped with a multiplex polymerase chain reaction‐ligase detection reaction (PCR‐LDR) method. The associations between tag‐SNPs and the risk of AD were analyzed by logistic regression. Moreover, another cohort from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database was included to examine the association of one tag‐SNP (rs2072446) with indicators of amyloid deposition. Kaplan–Meier survival analysis and Cox proportional hazards models were used to test the predictive abilities of rs2072446 genotypes for AD progression. The mediation effects of Aβ deposition on this association were subsequently tested by mediation analyses. Results: After multiple testing corrections, one tag‐SNP, rs2072446, was associated with an increased risk of sAD (additive model, OR = 1.79, Padjustment = 0.0144). Analyses of the ADNI cohort showed that the minor allele (T) of rs2072446 was significantly associated with the heavier Aβ burden, which further contributed to an increased risk of AD progression in APOE ε4 non‐carrier. Conclusion: Our study found that rs2072446 in NGFR is associated with both the risk of sAD in the Chinese Han population and the amyloid burden in the ADNI cohort, which reveals the role of p75NTR in AD from a genetic perspective. [ABSTRACT FROM AUTHOR]

The metabolic fuel hypothesis explains infertility in females during conditions such as famine, cold exposure, eating disorders and overexertion through exercise. Reproduction is affected by short-term metabolic changes rather than by body composition or size. For example, reproductive processes are deferred when food intake is low. The gonadotropin-releasing hormone (GnRH) mediates the effects on reproduction. Metabolic signals are detected in the viscera and caudal hindbrain and transmitted to the forebrain neurons that secrete GnRH. The inhibition of sexual behavior is due to a reduction in the ventromedial hypothalamus estrogen receptors.

Previous studies suggest that gut microbiota is associated with neuropsychiatric disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, and depression. However, whether the composition and diversity of gut microbiota is altered in patients with Alzheimer's disease (AD) remains largely unknown. In the present study, we collected fecal samples from 43 AD patients and 43 age- and gender-matched cognitively normal controls. 16S ribosomal RNA sequencing technique was used to analyze the microbiota composition in feces. The composition of gut microbiota was different between the two groups. Several bacteria taxa in AD patients were different from those in controls at taxonomic levels, such as Bacteroides, Actinobacteria, Ruminococcus, Lachnospiraceae, and Selenomonadales. Our findings suggest that gut microbiota is altered in AD patients and may be involved in the pathogenesis of AD. [ABSTRACT FROM AUTHOR]