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Suicide is a serious negative social phenomenon. In this study, we used Python technology to obtain suicide death data from a network and applied mathematical statistical and geographic spatial analyses to study the spatial-temporal characteristics of suicide deaths and the relationship between suicide rate and economic development in China from 2000 to 2018. Following conclusions were drawn from the results. (1) The number of suicide deaths in China is on the rise. Within a year, the high-incidence period of suicide deaths is from May to June, whereas the low-incidence period is from February to March. Within a month, the 1st, 10th, and 20th days have the highest incidences of suicide deaths. Within a day, 77.2% of the suicide deaths occur from 06:00 to 19:00, and 09:00 and 15:00 were the peak times in which suicide deaths take place. (2) A total of 90.98% of the suicide deaths occur in southeast China. The suicide rate is higher in the southeast than in the northwest, higher in the south than in the north, and decreases gradually from east to west. At county level, a relatively high suicide rate is seen in regions spanning from Great Khingan Mountains to Yunnan Guizhou Plateau, from Qinling-Dabashan Mountains to Dabie Mountains, and from the coast of northern Jiangsu to Hainan Island. (3) Most areas in China present a low-grade suicide rate. However, low-grade areas appeared to change to high-grade areas during the period 2000–2018. The hotspots of suicide deaths spread from east to west, except for the Beijing–Tianjin–Tangshan area, Yangtze River Delta, and Pearl River Delta, which have always been suicide hotspots. (4) The spatial and temporal characteristics of suicide deaths in China are closely related to economic development, and on a city scale, the suicide rate has a significant positive correlation with the per capita GDP and urbanization rate. The impact of economic factors on suicide rate is greater on the southeast coast than on the northwest inland. An important conclusion from this study is that the gap between the rich and poor is a key factor, leading to psychological imbalance and suicidal behavior in the poor; therefore, only the new development path based on common prosperity is the road for people to reach happiness and health. In addition, in this study, we prove that network suicide data, obtained using the web-crawler technology (Python), not only have the same consistency and credibility as sampling statistics but also have a better spatiotemporal resolution, with a temporal resolution of one hour and spatial resolution of a county. Therefore, by analyzing this spatiotemporal dataset, we can scientifically extract the time differences in suicide deaths at quarterly, monthly, daily, and hourly scales and the spatial differences in suicide deaths at regional, provincial, and county scales. In the future, network suicide data may become an important data source for suicide research, and the use of the Internet to monitor suicidal behavior may become an important method of suicide intervention.

Gastric carcinoma is a frequent malignant tumor worldwide. NM23 plays an important role in pathological processes, including in the occurrence and development of tumors. The purpose of this study is to examine the effect of NM23 transfection of human gastric carcinoma cells (BGC-823) on growth and metastases of BGC-823 abdominal cancer xenografts in nude mice. BGC-823 cells were transfected with an adenovirus vector for NM23 (NM23-OE), transfected with an empty vector (NC), or were not transfected (Ctrl). Eighteen female BALB/c-nu mice were randomly divided into three groups (six per group) according to the type of BGC-823 cells administered by intraperitoneal injection. After 2 weeks, necropsies of mice were performed, abdominal circumferences were measured, and abdominal cavities were searched by ultrasound. In order to observe the xenografts in nude mice, there were gross macroscopic observations and microscopic observations. In addition, immunohistochemical analysis and western blot of NM23 were also performed. Green fluorescence in the NM23-OE and NC cells indicated successful transfection. The multiplicity of infection is 80%. A comparison of the three groups of mice indicated the NM23-OE group had positive conditions (abdominal circumferences: 81.83 ± 2.40 mm), but the other groups had negative conditions and enlarged abdomens (NC: 90.83 ± 2.32 mm; Ctrl: 92.67 ± 2.07 mm). Ultrasound observations confirmed large tumors in the NC and Ctrl groups, but did not find in the NM23-OE group. There were no obvious ascites in the NM23-OE group, but the cytological examination of ascites exfoliation in NC and Ctrl groups indicated that there were large and deep-stained gastric carcinoma cells. Tumor expression of NM23 was greater in the NM23-OE group than in the NC and Ctrl groups (both p < 0.05). In conclusion, transfection of BCG-823 cells with NM23 rather than an empty vector (NC) or no vector (Ctrl) led to reduced growth and metastases of abdominal cancer xenografts in nude mice.

In order to explore the influence of prefabricated cracks on coal rock mass induced by high voltage electric pulse in water, and improve the permeability of coal and rock strata in the mining area, the high voltage pulse cracking tests were carried out on similar samples of coal and rock mass with and without prefabricated cracks. On this basis, PFC numerical simulation software was used to build coal and rock mass models with and without prefabricated cracks under different peak pressures for fracture simulation. The experimental and simulation results show that the prefabricated cracks have a certain promoting effect on the fractured coal and rock mass caused by high pressure pulse discharge. The prefabricated crack has a certain guiding effect on the crack propagation, but the crack propagates along the direction parallel to the maximum principal stress. With the increase of the peak pressure, the crack network formed next to the prefabricated crack develops more fully, the crack length extending outward along the end of the prefabricated crack decreases, and the difference between the number of force chain fractures and those without the prefabricated crack also decreases.

A method for control of three-phase unbalanced load based on variable frequency power was proposed in this paper. The general idea was introduced firstly, and then the implementation of the scheme and the design method of variable frequency power supply and the realization scheme of the master control center at the side of low-voltage distribution network was described in details. When three-phase unbalance occurs in the power grid, the general control center sends phase-changing instructions, and the inverter power supply receives instructions to perform phase-changing, and the normal work of the load is not affected in the phase-changing process, which can effectively solve the problem of three-phase unbalance in the power grid. By setting up the basic model of low-voltage side commutation with variable frequency power as the core, the rationality of the commutation process is simulated and analyzed by MATLAB, and finally the feasibility of three-phase unbalanced control scheme with frequency conversion power as the core is verified by experiments.

Background and objectivesTo report final, 36-month safety and clinical outcomes from the PD-1101 trial of NBIb-1817 (VY-AADC01) in participants with moderately advanced Parkinson disease (PD) and motor fluctuations.MethodsPD-1101 was a phase 1b, open-label, dose escalation trial of VY-AADC01, an experimental AAV2 gene therapy encoding the human aromatic l-amino acid decarboxylase (AADC) enzyme. VY-AADC01 was delivered via bilateral, intraoperative MRI-guided putaminal infusions to 3 cohorts (n = 5 participants per cohort): cohort 1, ≤7.5 × 1011 vector genomes (vg); cohort 2, ≤1.5 × 1012 vg; cohort 3, ≤4.7 × 1012 vg.ResultsNo serious adverse events (SAEs) attributed to VY-AADC01 were reported. All 4 non-vector-related SAEs (atrial fibrillation and pulmonary embolism in 1 participant and 2 events of small bowel obstruction in another participant) resolved. Requirements for PD medications were reduced by 21%-30% in the 2 highest dose cohorts at 36 months. Standard measures of motor function (PD diary, Unified Parkinson's Disease Rating Scale III "off"-medication and "on"-medication scores), global impressions of improvement (Clinical Global Impression of Improvement, Patient Global Impression of Improvement), and quality of life (39-item Parkinson's Disease Questionnaire) were stable or improved compared with baseline at 12, 24, and 36 months following VY-AADC01 administration across cohorts.DiscussionsVY-AADC01 and the surgical administration procedure were well-tolerated and resulted in stable or improved motor function and quality of life across cohorts, as well as reduced PD medication requirements in cohorts 2 and 3 over 3 years.Trial registration informationNCT01973543.Classification of evidenceThis study provides Class IV evidence that, in patients with moderately advanced PD and motor fluctuations, putaminal infusion of VY-AADC01 is well tolerated and may improve motor function.

Abstract In this article, we consider the uniqueness of positive radial solutions to the Dirichlet boundary value problem Δ u + f ( | x | , u ) + g ( | x | ) x ⋅ ∇ u = 0 , x ∈ Ω , u = 0 , x ∈ ∂ Ω , where Ω denotes an annulus in ℝn (n ≥ 3). The uniqueness criterion is established by applying shooting method.