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Clinically, patients with cardiovascular disease widely have psycho-psychological problems, which interact with each other and aggravate the disease state. Psycho-cardiology is a discipline formed by the intersection and integration of cardiology and psychology, which emphasizes the attention to cardiovascular diseases and the mental state of patients. Experts from the Psycho-cardiology Group of the Psychosomatic Medicine Society of the Chinese Medical Association formulated Chinese Expert Consensus on the Construction Standardization of Psycho-cardiology Outpatient after reviewing literature and conducting discussions, in order to improve the diagnosis and treatment capacity of psycho-cardiology in China, promote medical institutions at all levels to set up psycho-cardiology outpatient, and continuously improve the medical service system of psycho-cardiology in China.

The prognosis of lung adenocarcinoma (LUAD) is generally poor. Immunotherapy has emerged as a promising therapeutic modality, demonstrating remarkable potential for substantially prolonging the overall survival of individuals afflicted with LUAD. However, there is currently a lack of reliable signatures for identifying patients who would benefit from immunotherapy. We conducted a comparative analysis of two immunotherapy cohorts (OAK and POPLAR) and utilized single‐factor COX regression to identify genes that significantly impact the prognosis of LUAD. Based on the TCGA‐LUAD dataset, we employed a combination of 101 machine learning algorithms to construct a model and selected the optimal model. The model was validated on five GEO datasets and compared with 144 previously published signatures to assess its performance. Subsequently, we explored the underlying biological mechanisms through tumor mutation burden analysis, enrichment analysis, and immune infiltration analysis. An immunotherapy prognostic prediction signature (IPPS) was constructed based on 13 genes, showing robust performance in the TCGA‐LUAD dataset. IPPS exhibited consistent predictive accuracy in the validation cohorts. Compared to 144 previously published signatures, IPPS consistently ranked among the top in terms of C‐index values. Further exploration revealed differences between high and low‐IPPS groups in terms of tumor mutation burden, pathway enrichment, and immune infiltration. IPPS demonstrates strong predictive capabilities for the prognosis of LUAD patients, offering the potential to identify suitable candidates for immunotherapy and contribute to precision treatment strategies for LUAD. [ABSTRACT FROM AUTHOR]

High ion conductivity is required for polybenzimidazole ion solvating membranes (ISM) to decrease the operational KOH concentration, and thus, improve the alkaline stability of ISM in an electrolyzer. Herein, gel-state ISM with a sponge-like inner structure and a dense surface was developed based on poly (2,2′-(1,4-naphthalene)-5,5′-bibenzimidazole) (NPBI), yielding more volume for KOH uptake. As a result, the Gel-NPBI membrane exhibited excellent mechanical properties, outstanding alkaline stability (2 M KOH at 80 °C for 285 days), and impressive ion conductivity even in 2 M KOH solutions (190 mS cm−1 at 80 °C) as compared to the ISMs prepared with dense membranes with/without phosphoric acid pretreatment (PK-NPBI and K-NPBI). Thus, the resulting Gel-NPBI membrane achieved superior electrolyzer performance with a high current density of 2.5 A cm−2 at 1.8 V (80 °C, 2 M KOH) using platinum-group-metal catalysts. Impressively, we identified that the high operation voltage resulted in the thinning of ISMs during the working of in situ electrolyzer devices probably due to the oxidative degradation near the anodic side of ISMs that cannot have been gained from the previous reports. Following up on these findings, the cell with Gel-NPBI membrane in a KOH solution of low concentration demonstrated a lifetime of 1780 h under 0.5 A cm−2 using PGM-free electrodes. [ABSTRACT FROM AUTHOR]

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.

Mercury emissions from human activities persist in the environment, posing risks to humans and ecosystem, and are regulated by the Minamata Convention. Understanding the historical emissions of mercury is critical for explaining the presence of mercury in the environment. In recent years, some studies have looked at the historical trends of atmospheric emission inventory. The spatial resolution of inventories for relatively recent years have improved. However, limited inventories have combined both long time scales and high spatial resolution, which is essential for evaluating the legacy impacts of anthropogenic mercury emissions, particularly in regions with high levels of mercury emissions. Here we compile a new comprehensive point source database by fusing multiple data source, and integrate it with previous China Atmospheric Mercury Emission Model to create an annual point source and gridded emission inventory for China covering 1978–2021. Integrating point source emission inventory (P-CAME) improves the accuracy of the gridded emissions, reducing the normalized mean error for all grids by 108 % compared to not using point sources in the most recent year of 2021. The improved gridded emissions inventory notably enhances the simulation of atmospheric mercury concentrations, particularly in urban areas. P-CAME inventory resulted in a 20–23 % reduction in the normalized mean bias. The improved gridded emission data identifies potential polluted grids characterized by high cumulative emissions. It indicates that 20 % of cumulative emissions originate from just 0.3 % of the grids, primarily distributed in Gansu, Yunnan, and Hunan Provinces. These areas are predominantly dominated by non-ferrous metal smelters or a mix of emissions sources including coal-fired industries and cement production. With the improvements in simulation accuracy and the identification of highly polluted regions, this updated inventory would greatly facilitate the assessment of mercury exposure, legacy impacts, and effective management of cross-media mercury pollution. [ABSTRACT FROM AUTHOR]

Ubiquitination, a post-translational modification, refers to the covalent attachment of ubiquitin molecules to substrates. This modification plays a critical role in diverse cellular processes such as protein degradation. The specificity of ubiquitination for substrates is regulated by E3 ubiquitin ligases. Dysregulation of ubiquitination has been associated with numerous diseases, including cancers. In our study, we first investigated the protein expression patterns of E3 ligases across 12 cancer types. Our findings indicated that E3 ligases tend to be up-regulated and exhibit reduced tissue specificity in tumors. Moreover, the correlation of protein expression between E3 ligases and substrates demonstrated significant changes in cancers, suggesting that E3-substrate specificity alters in tumors compared to normal tissues. By integrating transcriptome, proteome, and ubiquitylome data, we further characterized the E3-substrate regulatory patterns in lung squamous cell carcinoma. Our analysis revealed that the upregulation of the SKP2 E3 ligase leads to excessive degradation of BRCA2, potentially promoting tumor cell proliferation and metastasis. Furthermore, the upregulation of E3 ubiquitin–protein ligase TRIM33 was identified as a biomarker associated with a favorable prognosis by inhibiting the cell cycle. This work exemplifies how leveraging multi-omics data to analyze E3 ligases across various cancers can unveil prognosis biomarkers and facilitate the identification of potential drug targets for cancer therapy. [ABSTRACT FROM AUTHOR]

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433. [ABSTRACT FROM AUTHOR]