Search

Your search keyword '"Li, Zhongwu"' showing total 1,394 results
Start Over Author "Li, Zhongwu"
1,394 results on '"Li, Zhongwu"'

1. Ion transport and ultra-efficient osmotic power generation in boron nitride nanotube porins

Author

Li, Zhongwu, Hall, Alex T, Wang, Yaqing, Li, Yuhao, Byrne, Dana O, Scammell, Lyndsey R, Whitney, R Roy, Allen, Frances I, Cumings, John, and Noy, Aleksandr

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Physical Sciences, Bioengineering, Nanotechnology
Abstract

Nanotube porins form transmembrane nanomaterial-derived scaffolds that mimic the geometry and functionality of biological membrane channels. We report synthesis, transport properties, and osmotic energy harvesting performance of another member of the nanotube porin family: boron nitride nanotube porins (BNNTPs). Cryo-transmission electron microscopy imaging, liposome transport assays, and DNA translocation experiments show that BNNTPs reconstitute into lipid membranes to form functional channels of ~2-nm diameter. Ion transport studies reveal ion conductance characteristics of individual BNNTPs, which show an unusual C1/4 scaling with ion concentration and pronounced pH sensitivity. Reversal potential measurements indicate that BNNTPs have strong cation selectivity at neutral pH, attributable to the high negative charge on the channel. BNNTPs also deliver very large power density up to 12 kW/m2 in the osmotic gradient transport experiments at neutral pH, surpassing that of other BNNT-based devices by two orders of magnitude under similar conditions. Our results suggest that BNNTPs are a promising platform for mass transport and osmotic power generation.

Published
2024

9. Fluids and Electrolytes under Confinement in Single-Digit Nanopores

Author

Aluru, Narayana R, Aydin, Fikret, Bazant, Martin Z, Blankschtein, Daniel, Brozena, Alexandra H, de Souza, J Pedro, Elimelech, Menachem, Faucher, Samuel, Fourkas, John T, Koman, Volodymyr B, Kuehne, Matthias, Kulik, Heather J, Li, Hao-Kun, Li, Yuhao, Li, Zhongwu, Majumdar, Arun, Martis, Joel, Misra, Rahul Prasanna, Noy, Aleksandr, Pham, Tuan Anh, Qu, Haoran, Rayabharam, Archith, Reed, Mark A, Ritt, Cody L, Schwegler, Eric, Siwy, Zuzanna, Strano, Michael S, Wang, YuHuang, Yao, Yun-Chiao, Zhan, Cheng, and Zhang, Ze

Subjects
Engineering, Affordable and Clean Energy, Chemical Sciences, General Chemistry, Chemical sciences
Abstract

Confined fluids and electrolyte solutions in nanopores exhibit rich and surprising physics and chemistry that impact the mass transport and energy efficiency in many important natural systems and industrial applications. Existing theories often fail to predict the exotic effects observed in the narrowest of such pores, called single-digit nanopores (SDNs), which have diameters or conduit widths of less than 10 nm, and have only recently become accessible for experimental measurements. What SDNs reveal has been surprising, including a rapidly increasing number of examples such as extraordinarily fast water transport, distorted fluid-phase boundaries, strong ion-correlation and quantum effects, and dielectric anomalies that are not observed in larger pores. Exploiting these effects presents myriad opportunities in both basic and applied research that stand to impact a host of new technologies at the water-energy nexus, from new membranes for precise separations and water purification to new gas permeable materials for water electrolyzers and energy-storage devices. SDNs also present unique opportunities to achieve ultrasensitive and selective chemical sensing at the single-ion and single-molecule limit. In this review article, we summarize the progress on nanofluidics of SDNs, with a focus on the confinement effects that arise in these extremely narrow nanopores. The recent development of precision model systems, transformative experimental tools, and multiscale theories that have played enabling roles in advancing this frontier are reviewed. We also identify new knowledge gaps in our understanding of nanofluidic transport and provide an outlook for the future challenges and opportunities at this rapidly advancing frontier.

Published
2023

12. Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations

Author

Wang, Wenxian, Lian, Bin, Xu, Chunwei, Wang, Qian, Li, Ziming, Zheng, Nan, Liu, Aijun, Yu, Jinpu, Zhong, Wenzhao, Wang, Zhijie, Zhang, Yongchang, Liu, Jingjing, Zhang, Shirong, Cai, Xiuyu, Liu, Anwen, Li, Wen, Mao, Lili, Zhan, Ping, Liu, Hongbing, Lv, Tangfeng, Miao, Liyun, Min, Lingfeng, Chen, Yu, Yuan, Jingping, Wang, Feng, Jiang, Zhansheng, Lin, Gen, Huang, Long, Pu, Xingxiang, Lin, Rongbo, Liu, Weifeng, Rao, Chuangzhou, Lv, Dongqing, Yu, Zongyang, Li, Xiaoyan, Tang, Chuanhao, Zhou, Chengzhi, Zhang, Junping, Xue, Junli, Guo, Hui, Chu, Qian, Meng, Rui, Liu, Xuewen, Wu, Jingxun, Zhang, Rui, Zhou, Jin, Zhu, Zhengfei, Li, Yongheng, Qiu, Hong, Xia, Fan, Lu, Yuanyuan, Chen, Xiaofeng, Feng, Jian, Ge, Rui, Dai, Enyong, Han, Yu, Pan, Weiwei, Pang, Fei, Huang, Xin, Hu, Meizhen, Hao, Qing, Wang, Kai, Wu, Fan, Song, Binbin, Xu, Bingwei, Wang, Liping, Zhu, Youcai, Lin, Li, Xie, Yanru, Lin, Xinqing, Cai, Jing, Xu, Ling, Li, Jisheng, Jiao, Xiaodong, Li, Kainan, Wei, Jia, Feng, Huijing, Wang, Lin, Du, Yingying, Yao, Wang, Shi, Xuefei, Niu, Xiaomin, Yuan, Dongmei, Yao, Yanwen, Huang, Jianhui, Feng, Yue, Zhang, Yinbin, Sun, Pingli, Wang, Hong, Ye, Mingxiang, Wang, Dong, Wang, Zhaofeng, Hao, Yue, Wang, Zhen, Wan, Bin, Lv, Donglai, Yang, Shengjie, Kang, Jin, Zhang, Jiatao, Zhang, Chao, Li, Wenfeng, Fu, Jianfei, Wu, Lizhi, Lan, Shijie, Ou, Juanjuan, Shi, Lin, Zhai, Zhanqiang, Wang, Yina, Li, Bihui, Zhang, Zhang, Wang, Ke, Ma, Xuelei, Li, Zhongwu, Liu, Zhefeng, Yang, Nong, Wu, Lin, Wang, Huijuan, Jin, Gu, Wang, Guansong, Wang, Jiandong, Shi, Hubing, Fang, Meiyu, Fang, Yong, Li, Yuan, Wang, Xiaojia, Chen, Jing, Zhang, Yiping, Zhu, Xixu, Shen, Yi, Ma, Shenglin, Wang, Biyun, Song, Yong, Song, Zhengbo, Fang, Wenfeng, Lu, Yuanzhi, and Si, Lu

Published
2024
Full Text
View/download PDF

22. Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

Author

Wang, Chen, Zeng, Qun, Gül, Zeynep Melis, Wang, Sisi, Pick, Robert, Cheng, Phil, Bill, Ruben, Wu, Yan, Naulaerts, Stefan, Barnoud, Coline, Hsueh, Pei-Chun, Moller, Sofie Hedlund, Cenerenti, Mara, Sun, Mengzhu, Su, Ziyang, Jemelin, Stéphane, Petrenko, Volodymyr, Dibner, Charna, Hugues, Stéphanie, Jandus, Camilla, Li, Zhongwu, Michielin, Olivier, Ho, Ping-Chih, Garg, Abhishek D., Simonetta, Federico, Pittet, Mikaël J., and Scheiermann, Christoph

Published
2024
Full Text
View/download PDF

31. High-Performance Nanofluidic Osmotic Power Generation Enabled by Exterior Surface Charges under the Natural Salt Gradient

Author

Ma, Long, Li, Zhongwu, Yuan, Zhishan, Wang, Haocheng, Huang, Chuanzhen, and Qiu, Yinghua

Subjects
Physics - Chemical Physics
Abstract

High-performance osmotic energy conversion (OEC) requires both high ionic selectivity and permeability in nanopores. Here, through systematical explorations of influences from individual charged nanopore surfaces on the performance of OEC, we find that the charged exterior surface on the low-concentration side (surfaceL) is essential to achieve high-performance osmotic power generation, which can significantly improve the ionic selectivity and permeability simultaneously. Detailed investigation of ionic transport indicates that electric double layers near charged surfaces provide high-speed passages for counterions. The charged surfaceL enhances cation diffusion through enlarging the effective diffusive area, and inhibits anion transport by electrostatic repulsion. Different areas of charged exterior surfaces have been considered to mimic membranes with different porosities in practical applications. Through adjusting the width of the charged ring region on the surfaceL, electric power in single nanopores increases from 0.3 to 3.4 pW with a plateau at the width of ~200 nm. The power density increases from 4200 to 4900 W/m2 and then decreases monotonously that reaches the commercial benchmark at the charged width of ~480 nm. While, energy conversion efficiency can be promoted from 4% to 26%. Our results provide useful guide in the design of nanoporous membranes for high-performance osmotic energy harvesting., Comment: 30 pages and 7 figures

Published
2021
Full Text
View/download PDF

37. Modulation of Ionic Current Rectification in Ultra-Short Conical Nanopores

Author

Ma, Long, Li, Zhongwu, Yuan, Zhishan, Huang, Chuanzhen, Siwy, Zuzanna S., and Qiu, Yinghua

Subjects
Physics - Chemical Physics, Physics - Applied Physics
Abstract

Nanopores that exhibit ionic current rectification (ICR) behave like diodes, such that they transport ions more efficiently in one direction than the other. Conical nanopores have been shown to rectify ionic current, but only those with at least 500 nm in length exhibit significant ICR. Here, through the finite element method, we show how ICR of conical nanopores with length below 200 nm can be tuned by controlling individual charged surfaces i.e. inner pore surface (surface_inner), and exterior pore surfaces on the tip and base side (surface_tip and surface_base). The charged surface_inner and surface_tip can induce obvious ICR individually, while the effects of the charged surface_base on ICR can be ignored. The fully charged surface_inner alone could render the nanopore counterion-selective and induces significant ion concentration polarization in the tip region, which causes reverse ICR compared to nanopores with all surface charged. In addition, the direction and degree of rectification can be further tuned by the depth of the charged surface_inner. When considering the exterior membrane surface only, the charged surface_tip causes intra-pore ionic enrichment and depletion under opposite biases which results in significant ICR. Its effective region is within ~40 nm beyond the tip orifice. We also found that individual charged parts of the pore system contributed to ICR in an additive way due to the additive effect on the ion concentration regulation along the pore axis. With various combinations of fully/partially charged surface_inner and surface_tip, diverse ICR ratios from ~2 to ~170 can be achieved. Our findings shed light on the mechanism of ionic current rectification in ultra-short conical nanopores, and provide a useful guide to the design and modification of ultra-short conical nanopores in ionic circuits and nanofluidic sensors., Comment: 25 pages, 8 figures

Published
2020
Full Text
View/download PDF

47. Effects of Surface Trapping and Contact Ion Pairing on Ion Transport in Nanopores

Author

Li, Zhongwu, Qiu, Yinghua, Zhang, Yan, Yue, Min, and Chen, Yunfei

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Fluid Dynamics
Abstract

Ion transport in highly-confined space is important to various applications, such as biosensing and seawater desalination with nanopores. All-atom molecular dynamics simulations are conducted to investigate the transport of Na$^+$ and Cl$^-$ ions through nanopores with the diameter below 6 nm. It is found that the formation of the contact ion pair plays a critical role in reducing the ion mobility inside a nanopore without surface charges. The mobility for both cations and anions decreases with the reduced pore size because it is easier to form the contact ion pairs inside the neutral nanopore with smaller diameter. Inside a charged nanopores, besides the contact ion pair formation, the surface charges also play a significant role in reducing the counterion mobility through surface trapping. It is uncovered that the mobility of Na$^+$ ions increases first and then decreases with the surface charge density, while Cl$^-$ ions have the opposite trend. A modified first-passage time model is proposed to take into account the ion pair formation and the trapped ions inside a nanopore, which provides a clear picture in describing ion transport through a nanopore.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results