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18 results on '"Li, Zheng-Tu"'

5. Serum sphingolipids aid in diagnosing adult HIV-negative patients with pulmonary cryptococcosis: a clinical cohort study

Author

Yau, Lee-Fong, primary, Chan, Wai-Him, additional, Li, Yuan-Xiang, additional, Zhan, Yang-Qing, additional, Huang, Jie, additional, Lin, Xin-Qing, additional, Li, Shao-Qiang, additional, Yang, Jing-Lu, additional, Pan, Hu-Dan, additional, Wang, Xi-Dong, additional, Qiu, Ye, additional, Fang, Gao-Neng, additional, Jiang, Zhi-Hong, additional, Ye, Feng, additional, Wang, Jing-Rong, additional, and Li, Zheng-Tu, additional

Published
2023
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6. Genetic characterization of highly pathogenic avian influenza a(H5N6) virus, Guangdong, China

Author

Mok, Chris Ka Pun, Guan, Wen Da, Liu, Xiao Qing, Lamers, Mart Matthias, Li, Xiao Bo, Zhang, Tami Jing Shu, Zhang, Qing Ling, Li, Zheng Tu, Huang, Ji Cheng, Lin, Jin Yan, Zhang, Yong Hui, Zhao, Ping, Lee, Horace Hok Yeung, Chen, Ling, Li, Yi Min, Peiris, Joseph Sriyal Malik, Chen, Rong Chang, Zhong, Nan Shan, and Yang, Zi Feng

Subjects
Health
Abstract

To the Editor: Since the first detection of the influenza A(H5N1) virus in geese in China during 1996 (http://www. cdc.gov/flu/avianflu/h5n1-virus.htm), H5 subtype viruses have continued to reassort and evolve, giving [...]

Published
2015

8. Anti-Interferon-γ Autoantibodies Impair T-Lymphocyte Responses in Patients with Talaromyces marneffei Infections

Author

Chen,Zhao-Ming, Yang,Xiao-Yun, Li,Zheng-Tu, Guan,Wei-Jie, Qiu,Ye, Li,Shao-Qiang, Zhan,Yang-Qing, Lei,Zi-Ying, Liu,Jing, Zhang,Jian-Quan, Wang,Zhong-Fang, Ye,Feng, Chen,Zhao-Ming, Yang,Xiao-Yun, Li,Zheng-Tu, Guan,Wei-Jie, Qiu,Ye, Li,Shao-Qiang, Zhan,Yang-Qing, Lei,Zi-Ying, Liu,Jing, Zhang,Jian-Quan, Wang,Zhong-Fang, and Ye,Feng

Abstract

Zhao-Ming Chen,1,* Xiao-Yun Yang,1,2,* Zheng-Tu Li,1,* Wei-Jie Guan,1,3 Ye Qiu,4 Shao-Qiang Li,1 Yang-Qing Zhan,1 Zi-Ying Lei,5 Jing Liu,4 Jian-Quan Zhang,6 Zhong-Fang Wang,1,2 Feng Ye1 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Guangzhou Laboratory, Bio-Island, Guangzhou, Guangdong, People’s Republic of China; 3Department of Thoracic Surgery, Guangzhou Institute for Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 4Department of Comprehensive Internal Medicine, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 5Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China; 6Department of Infectious Diseases, the Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Ye, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86-020-83062836, Fax +86-020-83062836, Email yefeng@gird.cnBackground: Although anti-IFN-γ autoantibodies predispose patients to Talaromyces marneffei infection, whether this is mediated by T cell attenuation remains elusive.Methods: Total peripheral blood mononuclear cells (PBMCs) from healthy donors or patients with T. marneffei infection were stimulated with M158− 66, and immunodominant influenza H1N1 peptide, or heat-inactivated T. marneffei in the

Published
2022

10. Characteristics of traveler with middle east respiratory syndrome, China, 2015

Author

Guan, Wen Da, Mok, Chris Ka Pun, Chen, Zi Lin, Feng, Li Qiang, Li, Zheng Tu, Huang, Ji Cheng, Ke, Chang Wen, Deng, Xilong, Ling, Yun, Wu, Shi Guan, Niu, Xue Feng, Perera, Ranawaka A., Xu, Yuan Da, Zhao, Jincun, Zhang, Lin Qi, Li, Yi Min, Chen, Rong Chang, Peiris, Malik, Chen, Ling, and Zhong, Nan Shan

Subjects
Health
Abstract

To the Editor: A traveler returning from the Middle East initiated an outbreak of Middle East respiratory syndrome (MERS) in South Korea in 2015, which resulted in 186 cases and [...]

Published
2015

11. Serum Sphingolipids Aiding the Diagnosis of Adult HIV-Negative Patients with Talaromyces marneffei Infection

Author

Li, Zheng-Tu, primary, Yau, Lee-Fong, additional, Qiu, Ye, additional, Li, Shao-Qiang, additional, Zhan, Yang-Qing, additional, Chan, Wai-Him, additional, Chen, Zhao-Ming, additional, Li, Zhun, additional, Li, Yongming, additional, Lin, Ye, additional, Cheng, Jing, additional, Zhang, Jian-Quan, additional, Jiang, Zhi-Hong, additional, Wang, Jing-Rong, additional, and Ye, Feng, additional

Published
2021
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12. Clinical findings of Talaromyces marneffei infection among patients with anti-interferon-γ immunodeficiency: a prospective cohort study

Author

Chen, Zhao-Ming, primary, Li, Zheng-Tu, additional, Li, Shao-Qiang, additional, Guan, Wei-Jie, additional, Qiu, Ye, additional, Lei, Zi-Ying, additional, Zhan, Yang-Qing, additional, Zhou, Hua, additional, Lin, Sheng, additional, Wang, Xinni, additional, Li, Zhun, additional, Yang, Feng, additional, Zeng, Wen, additional, Lin, Ye, additional, Liu, Jing, additional, Zhang, Jian-Quan, additional, and Ye, Feng, additional

Published
2021
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13. Coinfection with SARS‐CoV‐2 and other respiratory pathogens in COVID‐19 patients in Guangzhou, China

Author

Li, Zheng‐tu, Chen, Zhao‐ming, Chen, Ling‐dan, Zhan, Yang‐qing, Li, Shao‐qiang, Cheng, Jing, Zhu, Ai‐ru, Chen, Li‐yan, Zhong, Nan‐shan, Li, Shi‐yue, Lu, Wen‐ju, and Ye, Feng

Subjects
Adult, Male, China, Coinfection, viruses, virus diseases, COVID-19, Bacterial Infections, Middle Aged, Virus Diseases, Humans, Female, Letter to the Editor, Aged
Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2; previously provisionally named 2019 novel coronavirus or 2019‐nCoV) disease (COVID‐19) in China at the end of 2019 has caused a global pandemic and remains as a major public health issue This article is protected by copyright. All rights reserved.

Published
2020

14. Erratum to: Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China

Author

Lin, Yong Ping, primary, Yang, Zi Feng, additional, Liang, Ying, additional, Li, Zheng Tu, additional, Bond, Helen S., additional, Chua, Huiying, additional, Luo, Ya Sha, additional, Chen, Yuan, additional, Chen, Ting Ting, additional, Guan, Wen Da, additional, Lai, Jimmy Chun Cheong, additional, Siu, Yu Lam, additional, Pan, Si Hua, additional, Malik Peiris, J. S., additional, Cowling, Benjamin J., additional, and Mok, Chris Ka Pun, additional

Published
2017
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15. Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China

Author

Lin, Yong Ping, primary, Yang, Zi Feng, additional, Liang, Ying, additional, Li, Zheng Tu, additional, Bond, Helen S., additional, Chua, Huiying, additional, Luo, Ya Sha, additional, Chen, Yuan, additional, Chen, Ting Ting, additional, Guan, Wen Da, additional, Lai, Jimmy Chun Cheong, additional, Siu, Yu Lam, additional, Pan, Si Hua, additional, Peiris, J. S. Malik, additional, Cowling, Benjamin J., additional, and PunMok, Chris Ka, additional

Published
2016
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16. Characteristics of Traveler with Middle East Respiratory Syndrome, China, 2015

Author

Da Guan, Wen, primary, Mok, Chris Ka Pun, additional, Chen, Zi Lin, additional, Feng, Li Qiang, additional, Li, Zheng Tu, additional, Huang, Ji Cheng, additional, Ke, Chang Wen, additional, Deng, Xilong, additional, Ling, Yun, additional, Wu, Shi Guan, additional, Niu, Xue Feng, additional, Perera, Ranawaka A, additional, Da Xu, Yuan, additional, Zhao, Jincun, additional, Zhang, Lin Qi, additional, Li, Yi Min, additional, Chen, Rong Chang, additional, Peiris, Malik, additional, Chen, Ling, additional, and Zhong, Nan Shan, additional

Published
2015
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18. Clinical and pathogen features of COVID-19-associated infections during an Omicron strain outbreak in Guangzhou, China.

Author

Cheng L-l, Li Z-t, Wu H-k, Li F, Qiu Y, Wang T, Peng H, Liu Z-h, Huang P-r, Zhou L, Gao L-f, Huang H-j, Zhang B, Deng X-l, Chen X, Ye F, Liu X-q, Guan W-j, Li Y-p, Li Y-m, Li S-y, and Zhong N-s

Abstract

Although the Omicron variant has been associated with greater transmissibility and tropism of the upper respiratory tract, the clinical and pathogenic features of patients infected with the Omicron variant during an outbreak in China have been unclear. Adults with COVID-19 were retrospectively enrolled from seven medical centers in Guangzhou, China, and clinical information and specimens ( BALF, sputum, and throat swabs) from participants were collected. Conventional detection methods, metagenomics next-generation sequencing (mNGS), and other methods were used to detect pathogens in lower respiratory tract samples. From December 2022 to January 2023, we enrolled 836 patients with COVID-19, among which 56.7% patients had severe/critical illness. About 91.4% of patients were infected with the Omicron strain (BA.5.2). The detection rate of possible co-infection pathogens was 53.4% by mNGS, including Klebsiella pneumoniae (16.3%), Aspergillus fumigatus (12.2%), and Pseudomonas aeruginosa (11.8%). The co-infection rate was 19.5%, with common pathogens being Streptococcus pneumoniae (11.5%), Haemophilus influenzae (9.2%), and Adenovirus (6.9%). The superinfection rate was 75.4%, with common pathogens such as Klebsiella pneumoniae (26.1%) and Pseudomonas aeruginosa (19.4%). Klebsiella pneumoniae (27.1%% vs 6.1%, P < 0.001), Aspergillus fumigatus (19.6% vs 5.3%, P = 0.001), Acinetobacter baumannii (18.7% vs 4.4%, P = 0.001), Pseudomonas aeruginosa (16.8% vs 7.0%, P = 0.024), Staphylococcus aureus (14.0% vs 5.3%, P = 0.027), and Streptococcus pneumoniae (0.9% vs 10.5%, P = 0.002) were more common in severe cases. Co-infection and superinfection of bacteria and fungi are common in patients with severe pneumonia associated with Omicron variant infection. Sequencing methods may aid in the diagnosis and differential diagnosis of pathogens., Importance: Our study has analyzed the clinical characteristics and pathogen spectrum of the lower respiratory tract associated with co-infection or superinfection in Guangzhou during the outbreak of the Omicron strain, particularly after the relaxation of the epidemic prevention and control strategy in China. This study will likely prompt further research into the specific issue, which will benefit clinical practice.

Published
2024
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