1. Predictive value of albumin-globulin ratio for the risk of Kawasaki disease in febrile children
- Author
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LI Haifeng, ZHANG Pingping, LI Yunyan, CHEN Zhuanggui, ZHONG Guifang
- Subjects
kawasaki disease ,albumin ,globulin ,fever ,children ,albumin-globulin ratio(a/g) ,Medicine - Abstract
Objective To evaluate the predictive value for serum albumin-globulin ratio (A/G) for the risk of Kawasaki disease (KD) in febrile children. Methods In this single-center retrospective cohort study, the big-data platform of a certain third-tier A-level hospital was employed. Clinical and laboratory data of 432 febrile children aged 0-16 were collected. The children were divided into 4 groups based on the quartiles and median of their serum A/G ratios. The correlation between the A/G and the risk of KD was analyzed. Results The total incidence rate of KD in 432 children with fever was 14.4% (62/432).A significant negative correlation was observed between the A/G and the risk of KD. For each increase of 0.1 in the A/G, the risk of KD was decreased by 18% (OR=0.82, 95% CI 0.76-0.88, P < 0.001). Subgroup analysis showed a consistent negative correlation between the A/G and KD risk across different ages, genders, and biochemical markers. Conclusions A/G may be a useful biomarker for assessing the risk of KD in febrile children. As the A/G increases, the risk of KD is gradually decreased. This finding has potential clinical application value for early diagnosis and risk assessment of KD.
- Published
- 2024
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