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621 results on '"Li, Yuanfeng"'

13. NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

Author

Wang, Yahui, Liu, Xinyi, Zuo, Xianbo, Wang, Cuiling, Zhang, Zheng, Zhang, Haitao, Zeng, Tao, Chen, Shunqi, Liu, Mengyu, Chen, Hongxia, Song, Qingfeng, Li, Qi, Yang, Chenning, Le, Yi, Xing, Jinliang, Zhang, Hongxin, An, Jiaze, Jia, Weihua, Kang, Longli, Zhang, Hongxing, Xie, Hui, Ye, Jiazhou, Wu, Tianzhun, He, Fuchu, Zhang, Xuejun, Li, Yuanfeng, and Zhou, Gangqiao

Published
2024
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15. Energy Management Strategy of Hybrid Energy Storage System Based on Multi-objective Model Predictive Control

Author

Shen, Yongpeng, Sun, Songnan, Li, Yuanfeng, Xie, Junchao, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Sun, Fengchun, editor, Yang, Qingxin, editor, Dahlquist, Erik, editor, and Xiong, Rui, editor

Published
2023
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44. Microenvironment‐Adaptive Metallo‐Polymeric Nanodecoys via Subcomponent Coordination for Bacterial Biofilm Eradication and Immunomodulation.

Author

Li, Yuanfeng, Hua, Lei, He, Wei, Chen, Lei, Piao, Yinzi, Peng, Mengna, Li, Dongdong, Shi, Linqi, and Liu, Yong

Subjects
*BLOCK copolymers, *REACTIVE oxygen species, *BIOFILMS, *HEALING, *METALLOENZYMES
Abstract

Biofilm‐associated infections pose complex challenges that require addressing the multifaceted requirements of biofilm disruption, bacterial killing, and immunomodulation. In this study, microenvironment‐adaptive metallo‐polymeric nanodecoys (MPNs) are synthesized through one‐pot subcomponent coordination in aqueous solution, effectively eradicating bacterial biofilms and modulating immune response. Within the acidic microenvironment of biofilms, the positively charged MPNs demonstrated the ability to interact with and eliminate bacteria while facilitating a Fenton‐like reaction for efficient eradication of bacterial biofilms. As the local microenvironment shifted from a neutral to a basic state during subsequent tissue healing processes, the MPNs adaptively harness the multiple properties to bind pathogen‐associated molecular patterns, scavenge reactive oxygen species, thereby modulating the immune response, alleviating inflammation, and promoting tissue healing. This study presents an efficient strategy for preparing enzyme‐mimicking materials that closely resemble natural metalloenzymes, and the MPNs offer an efficient alternative to current antibiotic treatments for biofilm‐associated infections. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A‐Mediated Endolysosomal Trafficking and Degradation of EGFR.

Author

Cao, Pengbo, Chen, Hongxia, Zhang, Ying, Zhang, Qi, Shi, Mengting, Han, Huihui, Wang, Xiaowen, Jin, Liang, Guo, Bingqian, Hao, Rongjiao, Zhao, Xi, Li, Yuanfeng, Gao, Chengming, Liu, Xinyi, Wang, Yahui, Yang, Aiqing, Yang, Chenning, Si, Anfeng, Li, Hua, and Song, Qingfeng

Subjects
EPIDERMAL growth factor receptors, HEPATOCELLULAR carcinoma, GUANOSINE triphosphatase, PHENOTYPES, GENETIC overexpression
Abstract

Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown. By performing a genome‐wide survey on prognosis‐associated focal CNAs in 814 HCC patients by an integrative computational framework based on transcriptomic data, genomic amplification is identified at 8q24.13 as a promising candidate. Further evidence is provided that the 8q24.13 amplification‐driven overexpression of Rab GTPase activating protein TBC1D31 exacerbates HCC growth and metastasis both in vitro and in vivo through activating Epidermal growth factor receptor (EGFR) signaling. Mechanistically, TBC1D31 acts as a Rab GTPase activating protein to catalyze GTP hydrolysis for Rab22A and then reduces the Rab22A‐mediated endolysosomal trafficking and degradation of EGFR. Notably, overexpression of TBC1D31 markedly increases the resistance of HCC cells to lenvatinib, whereas inhibition of the TBC1D31‐EGFR axis can reverse this resistance phenotype. This study highlights that TBC1D31 at 8q24.13 is a new critical oncogene, uncovers a novel mechanism of EGFR activation in HCC, and proposes the potential strategies for treating HCC patients with TBC1D31 amplification or overexpression. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Proteomic analysis of toxic effects of short-term cadmium exposure on goat livers.

Author

Liu, Guangyang, Shen, Xiaoyun, and Li, Yuanfeng

Subjects
POISONS, DRUG metabolism, HEAVY metals, POLLUTION, FOOD chains
Abstract

Food safety is closely related to environmental pollution. It is worth noting that the long-term accumulation of Cd, a toxic heavy metal, in animals may pose a threat to human health through food chain. Previous studies have found that Cd exposure may cause liver metabolic disorders of black goats, but the mechanism of its impact on liver proteome of goats has not been widely studied. Therefore, in this study, ten male goats (Nubian black goat × native black goat) were exposed to Cd via drinking water containing CdCl2 (20 mg Cd·kg − 1·BW) for 30 days (five male goats per group). Blood physiology and liver antioxidant indices in black goats were determined and differentially expressed proteins (DEPs) in the livers of Cd-exposed goats were profiled by using TMT-labelled proteomics. It was found that plasma Hb and RBC levels as well as PCV values were decreased, liver SOD, GSH-Px, T-AOC and CAT levels were decreased, and MDA level was increased in Cd-treated goats, and 630 DEPs (up 326, down 304) in the livers of Cd-treated goats. Proteomics analysis revealed that Cd exposure affected glutathione metabolism and drug metabolism-cytochrome P450. We identified GP×2, GSTM3, and TBXAS1 as potential protein markers of early Cd toxicity in goats. This study provided theoretical basis for early diagnosis of Cd poisoning in goats. [ABSTRACT FROM AUTHOR]

Published
2024
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