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Inactivation of phosphatase and tensin homolog (PTEN) is prevalent in human prostate cancer and causes high-grade adenocarcinoma with a long latency. Cancer-associated fibroblasts (CAFs) play a pivotal role in tumor progression, but it remains elusive whether and how PTEN-deficient prostate cancers reprogram CAFs to overcome the barriers for tumor progression. Here, we report that PTEN deficiency induced Kruppel-like factor 5 (KLF5) acetylation and that interruption of KLF5 acetylation orchestrated intricate interactions between cancer cells and CAFs that enhance FGF receptor 1 (FGFR1) signaling and promote tumor growth. Deacetylated KLF5 promoted tumor cells to secrete TNF-[alpha], which stimulated inflammatory CAFs to release FGF9. CX3CR1 inhibition blocked FGFR1 activation triggered by FGF9 and sensitized PTEN- deficient prostate cancer to the AKT inhibitor capivasertib. This study reveals the role of KLF5 acetylation in reprogramming CAFs and provides a rationale for combined therapies using inhibitors of AKT and CX3CR1., Introduction Prostate cancer is the most common cancer and the second leading cause of cancer-related death in men in the United States (1). Most prostate cancers are localized and androgen [...]

Optical chromatography is a powerful optofluidic technique enabling label-free fractionation of microscopic bioparticles from heterogenous mixtures. However, sophisticated instrumentation requirements for precise alignment of optical scattering and fluidic drag forces is a fundamental shortcoming of this technique. Here, we introduce a subwavelength thick (

The scarcity of freshwater poses a significant threat to sustainable development and human well-being. Exploring and developing state-of-the-art semipermeable materials for seawater desalination could be a potential solution to address this issue. In this study, we unveil the desalination potential of a newly synthesized multilayer covalent organic framework (COF), named ABBPM, showcasing remarkable water permeance reaching 52 L cm−2 day−1 MPa−1 alongside a NaCl rejection rate of 97%. This outstanding performance can be attributed to the advantageous combination of its large pore size (∼3 nm), wide organic skeleton (∼0.94 nm), and the ordered ABC stacking pattern, which creates tortuous yet express water pathways, significantly enhancing filtration efficiency. Free energy analysis reveals that compared to the energy barriers (∼4 kJ mol−1) faced by water molecules, ions encounter higher energy barriers (∼9 kJ mol−1 to ∼11 kJ mol−1) when traversing the 3L ABBPM membrane, which can be primarily attributed to the broad organic skeleton. Moreover, the translocation velocity of water across the multilayer ABBPM membranes surpasses that observed in nanopores on a single-layer graphene or MoS2. Therefore, this study not only presents the multilayer ABBPM COF as a promising candidate for efficient desalination but also proposes a strategic design approach for layered porous structures, with pore sizes exceeding the diameters of hydrated ions, for desalination technology advancement. [ABSTRACT FROM AUTHOR]

Two-dimensional van der Waals materials, with atomic-level thickness and unique electronic structures, have tremendous potential in electronic device applications, making them highly desirable for research in high-performance non-volatile memory. Here, we report a method for the van der Waals epitaxial growth of air-stable and uniformly distributed thin films of a 1T-CrS2 single crystal, based on a simple chemical vapor deposition technique using a binary metal precursor co-reaction growth mechanism controlled by the evaporation rate of the precursor. The corresponding 1T-CrS2 electronic devices can maintain their electrical performance without degradation for up to one month in air. Based on this, we have constructed a floating-gate memory device with a full van der Waals heterostructure, exhibiting a large storage window ratio (approximately 79%), a high on/off ratio (107), and stability for over 1000 cycles. The device demonstrates excellent multi-level data storage stability and can be optically programmed with stable operation using 532 nm laser pulses, showcasing outstanding optoelectronic storage performance. The excellent electrical stability of these two-dimensional materials, the non-volatile nature of the devices, and the stable multi-level storage characteristics present enormous potential for the integration of high-performance non-volatile memory. [ABSTRACT FROM AUTHOR]

Continuous rotating detonation engines have been extensively studied due to their high thermal efficiency. The utilization of solid particles as fuel can effectively reduce costs and enhance detonation performance. We have constructed a compressible gas–solid multimedium flow combustion numerical method, employing the double flux model coupled with fifth-order weighted essentially non-oscillatory and third-order total variation diminishing Runge–Kutta schemes to solve the unsteady multi-component chemical reaction Eulerian–Eulerian equations. Finite-rate methods and surface reaction models are used to simulate the combustion of gaseous mixtures and carbon particles. The effects of the inlet total pressure spatial fluctuations and particle diameter on the flow field characteristics of the continuous rotating detonation engine are investigated. The results indicate that changing the fluctuation period significantly affects the number, propagation direction, and intensity of gas–solid two-phase continuous rotating detonation waves (CRDW). The variation of fluctuation amplitude noticeably alters the combustion characteristics of the two-phase continuous rotating detonation wave, and excessively high amplitudes cannot form continuous rotating detonation waves. Introducing solid particles into fuel significantly mitigates the impact of inlet total pressure spatial fluctuation and promotes propagation stability on the detonation waves. Moreover, when solid particle diameters reach or exceed the micrometer scale, they contribute more favorably to generating a stable detonation flow field. However, excessive particle sizes result in a low surface reaction rate and inadequate contribution of heat released from particle combustion to the propagation of detonation waves. [ABSTRACT FROM AUTHOR]

In this study, we successfully synthesized high-quality 2D layered BiOI crystals using a novel space-confined molten salt method. These crystals exhibit a bandgap of 1.9 eV, closely aligning with theoretical expectations. The photodetectors fabricated from these BiOI nanosheets demonstrate exceptional ultraviolet (UV) detection capabilities. Key performance metrics include an ultrahigh photoresponsivity of 1048 mA W−1, an impressive external quantum efficiency of 420%, and a significant detectivity of 4.7 × 1012 Jones, coupled with a fast response time of 420/690 μs at 310 nm. This study not only highlights the potential of BiOI in UV photodetectors but also marks a substantial advancement in the development of high-performance bismuth-based semiconductor optoelectronic devices. [ABSTRACT FROM AUTHOR]

In the context of human active response to exponentially increasing data volumes, memristors have emerged as a focal point in systematic problem‐solving approaches. Particularly, organic memristors, characterized by excellent scalability, flexibility, and 3D stacking capabilities, have shown its tremendous potential in innovative electronic applications. However, the modulation of molecular assembly and interface interaction at the electrode surface poses a challenging task, despite their crucial role in determining the memristive performance. Herein, a collaborative method involving hydrophobic molecular design and interface engineering is proposed to generate high‐quality nanofilms with optimal photoelectric and electrochemical properties. By subjecting the bottom electrode to O2 plasma treatment and chemical modification using a hydrophobic ionic liquid poly(diallyldimethylammonium) bis(trifluoromethanesulfonyl)imide (PTFSI), the hydrophobic compound DN demonstrates exceptional affinity and stronger intermolecular interactions with the electrode surface. Consequently, the two‐terminal device array comprising Al/DN@PTFSI/ITO exhibits robust non‐volatile write‐once‐read‐many times (WORM) memory behavior, resulting in a tripling production yield from 30% to 92% along with a lower threshold voltage of 1.5 V, higher ON/OFF current ratio of 103 and excellent stability. This study presents a versatile approach to optimize the film assembly and material/electrode interface, thereby accelerating the development of organic memristors toward future applications. [ABSTRACT FROM AUTHOR]