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Reconstructing 3D coronary arteries is important for coronary artery disease diagnosis, treatment planning and operation navigation. Traditional reconstruction techniques often require many projections, while reconstruction from sparse-view X-ray projections is a potential way of reducing radiation dose. However, the extreme sparsity of coronary arteries in a 3D volume and ultra-limited number of projections pose significant challenges for efficient and accurate 3D reconstruction. To this end, we propose 3DGR-CAR, a 3D Gaussian Representation for Coronary Artery Reconstruction from ultra-sparse X-ray projections. We leverage 3D Gaussian representation to avoid the inefficiency caused by the extreme sparsity of coronary artery data and propose a Gaussian center predictor to overcome the noisy Gaussian initialization from ultra-sparse view projections. The proposed scheme enables fast and accurate 3D coronary artery reconstruction with only 2 views. Experimental results on two datasets indicate that the proposed approach significantly outperforms other methods in terms of voxel accuracy and visual quality of coronary arteries. The code will be available in https://github.com/windrise/3DGR-CAR., Comment: 10 pages, 5 figures, Accepted at MICCAI 2024

Generative self-supervised learning demonstrates outstanding representation learning capabilities in both Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs). However, there are currently no generative pre-training methods related to selective state space models (Mamba) that can handle long-range dependencies effectively. To address this challenge, we introduce a generative self-supervised learning method for Mamba (MambaMIM) based on Selective Structure State Space Sequence Token-interpolation (S6T), a general-purpose pre-training method for arbitrary Mamba architectures. Our method, MambaMIM, incorporates a bottom-up 3D hybrid masking strategy in the encoder to maintain masking consistency across different architectures. Additionally, S6T is employed to learn causal relationships between the masked sequence in the state space. MambaMIM can be used on any single or hybrid Mamba architectures to enhance the Mamba long-range representation capability. Extensive downstream experiments reveal the feasibility and advancement of using Mamba for pre-training medical image tasks. The code is available at: https://github.com/FengheTan9/MambaMIM, Comment: 10 pages, 7 figures

Sparse-view CT is a promising strategy for reducing the radiation dose of traditional CT scans, but reconstructing high-quality images from incomplete and noisy data is challenging. Recently, 3D Gaussian has been applied to model complex natural scenes, demonstrating fast convergence and better rendering of novel views compared to implicit neural representations (INRs). Taking inspiration from the successful application of 3D Gaussians in natural scene modeling and novel view synthesis, we investigate their potential for sparse-view CT reconstruction. We leverage prior information from the filtered-backprojection reconstructed image to initialize the Gaussians; and update their parameters via comparing difference in the projection space. Performance is further enhanced by adaptive density control. Compared to INRs, 3D Gaussians benefit more from prior information to explicitly bypass learning in void spaces and allocate the capacity efficiently, accelerating convergence. 3D Gaussians also efficiently learn high-frequency details. Trained in a self-supervised manner, 3D Gaussians avoid the need for large-scale paired data. Our experiments on the AAPM-Mayo dataset demonstrate that 3D Gaussians can provide superior performance compared to INR-based methods. This work is in progress, and the code will be publicly available.