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The Al-Ti-C alloy was extruded in multiple passes in a continuous manner by continuous equal channel angular pressing process. Through observation of the microstructure evolution, the mechanism of grain refinement and changes in mechanical properties were discussed.The results show that continuous equal channel angular pressing process can effectively refine the microstructure of Al-Ti-C alloy, and the grain size is reduced to about 1 μm.The deformation induction is the most important grain refinement mechanism in the deformation process.The accumulation of high density dislocations causes cracks at the interface between the Al matrix and TiAl3 and voids inside the TiAl3. The cracks further propagate through the entire TiAl3 particles, ultimately leading to the refinement of the second phase TiAl3 structure.At the same time, the pinning mechanism and shearing mechanism of the fine second phase TiAl3 structure promote the refinement of the Al matrix.After one pass of continuous equal channel angular pressing, the hardness of the alloy increases most obviously, which is 59.2% higher than that of the original state.With the increase of the number of extrusion passes, the increasing trend of hardness slows down, the plasticity of the alloy decreases, and toughness increases.

The preparation of high-performance rare earth magnesium (Mg–RE) alloy still heavily relies on expensive master alloy as a critical raw material. In order to address this issue, a series of Mg–3Y–xLa2O3 (x = 0, 0.5, 1, 1.5, 2, and 2.5 wt%) alloys were fabricated utilizing cost-effective rare earth oxides (REmOn). The effect of La2O3 on the microstructure and mechanical properties of the alloys was thoroughly investigated. Upon the addition of La2O3 to the Mg–3Y alloy, in-situ reduction with Y results in the formation of numerous micron-sized Mg17La2 phases, which consequently alters the morphology and quantity of Mg24Y5 phase, as well as the grain size and (0001) basal texture intensity in Mg–3Y alloy. The Mg–3Y–1.5La2O3 alloy exhibits the highest mechanical strength [yield strength (YS) and ultimate tensile strength (UTS) increase by approximately 48.4 MPa and 36.1 MPa, respectively, compared to the Mg–3Y alloy] among all the samples tested. The primary strengthening mechanisms identified are grain boundary, texture, and second-phase strengthening. Moreover, the addition of La2O3 is observed to significantly increase the elongation (EL) of the alloy (Mg–3Y–0.5La2O3). However, the EL gradually decreases as La2O3 continues to increase. [ABSTRACT FROM AUTHOR]

Objective To analyze the differences of the morbidity, clinicopathologic features and prognosis of Uygur lung cancer patients in Xinjiang. Methods We collected the clinical data of 558 Uygur lung cancer patients treated in the Affiliated Cancer Hospital of Xinjiang Medical University from January 1st, 2005 to December 31st, 2014. Comparative analysis and follow-up visit were conducted on TNM stage, pathological type, driver gene, etc.. Results The male/female ratio was 1.37:1. Lung adenocarcinoma was dominating among the female and urban patients, while squamous carcinoma and small cell lung cancer mostly occurred in the male and rural patients and those with smoking history. Small cell lung cancer patients had the lowest 3-year survival rate, and lung adenocarcinoma patients had the highest 3-year survival rate; 21.8%(65/298) of these patients had EGFR gene mutation and mainly were nonsmoking, adenocarcinoma and female patients; 6.9% (11/159) had EML4-AL gene fusion, and mostly expressed in the adenocarcinoma patients, nonsmoking patients or the patients with smoking history but without EGFR gene mutation. The difference in overall survival (OS) between the patients with EGFR gene mutation in stage Ⅳ and the EGFR wild-type patients was not significant statistically (P=0.597). The difference in overall survival (OS) between the patients with EML4-ALK gene fusion in stage Ⅳ and the patients without EML4-ALK gene fusion was not significant statistically (P=0.941). Conclusion Uygur lung cancer patients have relevant characteristics in clinical features, pathological type, epidemiological distribution and driver gene. Pathological type and TNM stage are independent factors influencing the prognosis of Uygur NSCLC patients.