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8. Pioglitazone reduces cardiovascular events and dementia but increases bone fracture in elderly patients with type 2 diabetes mellitus: a national cohort study

Author

Yen, Chieh-Li, primary, Wu, Chao-Yi, additional, Tsai, Chung-Ying, additional, Lee, Cheng-Chia, additional, Li, Yi-Jung, additional, Peng, Wei-Sheng, additional, Liu, Jia-Rou, additional, Liu, Yuan-Chang, additional, Jenq, Chang-Chyi, additional, Yang, Huang-Yu, additional, and See, Lai-Chu, additional

Published
2023
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14. Pioglitazone Reduces Mortality and Adverse Events in Patients With Type 2 Diabetes and With Advanced Chronic Kidney Disease: National Cohort Study

Author

Yen, Chieh-Li, primary, Wu, Chao-Yi, additional, See, Lai-Chu, additional, Li, Yi-Jung, additional, Tseng, Min-Hua, additional, Peng, Wei-Sheng, additional, Liu, Jia-Rou, additional, Chen, Yung-Chang, additional, Yen, Tzung-Hai, additional, Tian, Ya-Chung, additional, Yang, Chih-Wei, additional, Anderson, Gerard F., additional, and Yang, Huang-Yu, additional

Published
2020
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19. Comparison of the clinical features and outcomes of infective endocarditis between hemodialysis and non-hemodialysis patients

Author

Hsiao,Ching-Chung, Weng,Cheng-Hao, Li,Yi-Jung, Wu,Hsin-Hsu, Chen,Yung-Chang, Chen,Yu-Ming, Hsu,Hsiang-Hao, Tian,Ya-Chung, Hsiao,Ching-Chung, Weng,Cheng-Hao, Li,Yi-Jung, Wu,Hsin-Hsu, Chen,Yung-Chang, Chen,Yu-Ming, Hsu,Hsiang-Hao, and Tian,Ya-Chung

Abstract

Ching-Chung Hsiao,1,* Cheng-Hao Weng,1,2,* Yi-Jung Li,1 Hsin-Hsu Wu,1,2 Yung-Chang Chen,1 Yu-Ming Chen,1 Hsiang-Hao Hsu,1 Ya-Chung Tian1 1Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, 2Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan *These authors contributed equally to this work Abstract: Hemodialysis (HD) patients are more susceptible to infective endocarditis (IE) due to the increased risk of bacterial invasion through intravascular access. However, it remains unclear whether the causative organisms and outcomes of IE in HD patients differ from those in non-HD patients. This study clarified the differences in clinical presentation and outcomes between HD and non-HD patients. At our hospital, we performed a retrospective study of 39 HD and 51 non-HD patients with echocardiography-confirmed IE between June 2000 and February 2007. No differences in sex, intravenous drug use, previous diagnosis of congestive heart failure, and previous valvular surgery were observed between these two groups. The number of patients with diabetic mellitus in these two groups was significantly different (28.2% HD vs 5.9% non-HD patients). The C-reactive protein levels in the two groups were not significantly different. By contrast, the erythrocyte sedimentation rate was significantly higher in the HD patients (HD vs non-HD: 87.2±33.32 vs 52.96±28.19). The incidence of IE involving the mitral valve (MV; 45.1%) or the aortic valve (AV; 43.1%) was similar among the non-HD patients, whereas a preference of IE involving the MV (79.5%) over the AV (15.4%) was noted among the HD patients. The HD patients had a significantly higher Staphylococcus aureus infection rate (HD: 46.2%; non-HD: 27.5%). The proportion of methicillin-resistant S. aureus (MRSA; 83.8%) infection accounting for S. aureus IE in the HD group was higher than that (28.6%) in the non-HD group. The in-hospital mortality rat

Published
2017

20. The value of time-averaged serum high-sensitivity C-reactive protein in prediction of mortality and dropout in peritoneal dialysis patients

Author

Liu,Shou-Hsuan, Chen,Chao-Yu, Li,Yi-Jung, Wu,Hsin-Hsu, Lin,Chan-Yu, Chen,Yung-Chang, Chang,Ming-Yang, Hsu,Hsiang-Hao, Ku,Cheng-Lung, Tian,Ya-Chung, Liu,Shou-Hsuan, Chen,Chao-Yu, Li,Yi-Jung, Wu,Hsin-Hsu, Lin,Chan-Yu, Chen,Yung-Chang, Chang,Ming-Yang, Hsu,Hsiang-Hao, Ku,Cheng-Lung, and Tian,Ya-Chung

Abstract

Shou-Hsuan Liu,1–3,* Chao-Yu Chen,1,* Yi-Jung Li,1,2 Hsin-Hsu Wu,1,2 Chan-Yu Lin,1 Yung-Chang Chen,1 Ming-Yang Chang,1 Hsiang-Hao Hsu,1 Cheng-Lung Ku,2,3 Ya-Chung Tian1 1Kidney Research Center, Department of Nephrology, Lin-Kou Chang Gung Memorial Hospital and Department of Medicine, 2Graduate Institute of Clinical Medical Sciences, 3Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan *These authors contributed equally to this work Purpose: C-reactive protein (CRP) is a useful biomarker for prediction of long-term outcomes in patients undergoing chronic dialysis. This observational cohort study evaluated whether the time-averaged serum high-sensitivity CRP (HS-CRP) level was a better predictor of clinical outcomes than a single HS-CRP level in patients undergoing peritoneal dialysis (PD). Patients and methods: We classified 335 patients into three tertiles according to the time-averaged serum HS-CRP level and followed up regularly from January 2010 to December 2014. Clinical outcomes such as cardiovascular events, infection episodes, newly developed malignancy, encapsulating peritoneal sclerosis (EPS), dropout (death plus conversion to hemodialysis), and mortality were assessed. Results: During a 5-year follow-up, 164 patients (49.0%) ceased PD; this included 52 patient deaths (15.5%), 100 patients (29.9%) who converted to hemodialysis, and 12 patients (3.6%) who received a kidney transplantation. The Kaplan–Meier survival analysis and log-rank test revealed a significantly worse survival accumulation in patients with high time-average HS-CRP levels. A multivariate Cox regression analysis revealed that a higher time-averaged serum HS-CRP level, older age, and the occurrence of cardiovascular events were independent mortality predictors. A higher time-averaged serum HS-CRP level, the occurrence of cardiovascular events, infection episodes

Published
2017

23. MP558TIME-AVERAGED HIGH-SENSITIVITY C-REACTIVE PROTEIN PREDICTS MORTALITY AND DROPOUT IN PERITONEAL DIALYSIS PATIENTS

Author

Tian, Ya-Chung, primary, Liu, Shou-Hsuan, additional, Li, Yi-Jung, additional, Wu, Hsin-Hsu, additional, Lee, Cheng-Chia, additional, Tu, Kun-Hua, additional, Lin, Chan-Yu, additional, Chen, Yung-Chang, additional, Chang, Ming-Yang, additional, Chen, Yu-Ming, additional, Hsu, Hsiang-Hao, additional, and Yang, Chih-Wei, additional

Published
2017
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24. Conversion to mTOR-inhibitors with calcineurin inhibitor elimination or minimization reduces urinary polyomavirus BK load in kidney transplant recipients

Author

Yen, Chieh-Li, primary, Tian, Ya-Chung, additional, Wu, Hsin-Hsu, additional, Weng, Cheng-Hao, additional, Chen, Yung-Chang, additional, Tu, Kun-Hua, additional, Liu, Shou-Hsuan, additional, Lee, Cheng-Chia, additional, Lai, Ping-Chin, additional, Fang, Ji-Tseng, additional, Hung, Cheng-Chieh, additional, Yang, Chih-Wei, additional, and Li, Yi-Jung, additional

Published
2016
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26. Stimulation of transforming growth factor-beta-1 and contact with type I collagen cooperatively facilitate irreversible transdifferentiation in proximal tubular cells

Author

Yen, Chieh-Li, primary, Li, Yi-Jung, additional, Wu, Hsin-Hsu, additional, Weng, Cheng-Hao, additional, Lee, Cheng-Chia, additional, Chen, Yung-Chang, additional, Chang, Ming-Yang, additional, Yen, Tzung-Hai, additional, Hsu, Hsiang-Hao, additional, Hung, Cheng-Chieh, additional, Yang, Chih-Wei, additional, and Tian, Ya-Chung, additional

Published
2016
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27. Low-level environmental exposure to lead and progressive chronic kidney diseases

Author

Lin, Ja-Liang, Lin-Tan, Dan-Tzu, Li, Yi-Jung, Chen, Kuan-Hsing, and Huang, Yen-Lin

Subjects
Chronic kidney failure -- Environmental aspects, Chronic kidney failure -- Research, Chronic kidney failure -- Risk factors, Lead in the body -- Health aspects, Health, Health care industry
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2006.01.005 Byline: Ja-Liang Lin, Dan-Tzu Lin-Tan, Yi-Jung Li, Kuan-Hsing Chen, Yen-Lin Huang Keywords: Progressive renal insufficiency; Repeated lead chelation therapy; Low-level environmental lead exposure; Nondiabetic chronic kidney diseases Abstract: To determine whether low-normal body lead burden (BLB) accelerates progressive renal insufficiency in nondiabetic patients with chronic kidney diseases (CKD). Author Affiliation: Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, School of Medicine, Chang Gung University, Taipei, Taiwan, ROC. Article Note: (footnote) Supported by Dr. Chun-Chen Yu and the National Science Council Foundation of Republic of China under the Contract No. NSC: 92-2314-B-182A.

Published
2006

29. The value of time-averaged serum high-sensitivity C-reactive protein in prediction of mortality and dropout in peritoneal dialysis patients.

Author

Shou-Hsuan Liu, Chao-Yu Chen, Yi-Jung Li, Hsin-Hsu Wu, Chan-Yu Lin, Yung-Chang Chen, Ming-Yang Chang, Hsiang-Hao Hsu, Cheng-Lung Ku, Ya-Chung Tian, Liu, Shou-Hsuan, Chen, Chao-Yu, Li, Yi-Jung, Wu, Hsin-Hsu, Lin, Chan-Yu, Chen, Yung-Chang, Chang, Ming-Yang, Hsu, Hsiang-Hao, Ku, Cheng-Lung, and Tian, Ya-Chung

Subjects
C-reactive protein, COHORT analysis, PERITONEAL dialysis, REGRESSION analysis, KAPLAN-Meier estimator
Abstract

Purpose: C-reactive protein (CRP) is a useful biomarker for prediction of long-term outcomes in patients undergoing chronic dialysis. This observational cohort study evaluated whether the time-averaged serum high-sensitivity CRP (HS-CRP) level was a better predictor of clinical outcomes than a single HS-CRP level in patients undergoing peritoneal dialysis (PD).Patients and Methods: We classified 335 patients into three tertiles according to the time-averaged serum HS-CRP level and followed up regularly from January 2010 to December 2014. Clinical outcomes such as cardiovascular events, infection episodes, newly developed malignancy, encapsulating peritoneal sclerosis (EPS), dropout (death plus conversion to hemodialysis), and mortality were assessed.Results: During a 5-year follow-up, 164 patients (49.0%) ceased PD; this included 52 patient deaths (15.5%), 100 patients (29.9%) who converted to hemodialysis, and 12 patients (3.6%) who received a kidney transplantation. The Kaplan-Meier survival analysis and log-rank test revealed a significantly worse survival accumulation in patients with high time-average HS-CRP levels. A multivariate Cox regression analysis revealed that a higher time-averaged serum HS-CRP level, older age, and the occurrence of cardiovascular events were independent mortality predictors. A higher time-averaged serum HS-CRP level, the occurrence of cardiovascular events, infection episodes, and EPS were important predictors of dropout. The receiver operating characteristic analysis verified that the value of the time-average HS-CRP level in predicting the 5-year mortality and dropout was superior to a single serum baseline HS-CRP level.Conclusion: This study shows that the time-averaged serum HS-CRP level is a better marker than a single baseline measurement in predicting the 5-year mortality and dropout in PD patients. [ABSTRACT FROM AUTHOR]

Published
2017
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31. High-Sensitivity C-Reactive Protein Predicts Mortality and Technique Failure in Peritoneal Dialysis Patients

Author

Liu, Shou-Hsuan, primary, Li, Yi-Jung, additional, Wu, Hsin-Hsu, additional, Lee, Cheng-Chia, additional, Lin, Chan-Yu, additional, Weng, Cheng-Hao, additional, Chen, Yung-Chang, additional, Chang, Ming-Yang, additional, Hsu, Hsiang-Hao, additional, Fang, Ji-Tseng, additional, Hung, Cheng-Chieh, additional, Yang, Chih-Wei, additional, and Tian, Ya-Chung, additional

Published
2014
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35. Leptospira santorosaiSerovar Shermani Detergent Extract Induces an Increase in Fibronectin Production through a Toll-Like Receptor 2-Mediated Pathway

Author

Tian, Ya-Chung, Hung, Cheng-Chieh, Li, Yi-Jung, Chen, Yung-Chang, Chang, Ming-Yang, Yen, Tzung-Hai, Hsu, Hsiang-Hao, Wu, Mai-Szu, Phillips, Aled, and Yang, Chih-Wei

Abstract

ABSTRACTLeptospirosis can activate inflammatory responses through Toll-like receptors (TLRs) and may cause renal tubulointerstitial fibrosis characterized by the accumulation of extracellular matrix (ECM). We have previously demonstrated that Leptospira santorosaiserovar Shermani detergent extract stimulates ECM accumulation in vitro. The aim of this study was to examine the mechanistic basis of these previous observations and, in particular, to examine the potential involvement of TLRs. The addition of serovar Shermani detergent extract led to an increase in fibronectin gene expression and production. Inhibition of TLR2 but not TLR4 expression abrogated serovar Shermani detergent extract-mediated increases in fibronectin production. This response was also blocked by the knockdown of the gene expression of the TLR2 downstream transducers myeloid differentiation factor 88 (MyD88) and tumor necrosis factor receptor-associated factor 6 (TRAF6). Serovar Shermani detergent extract also activated nuclear factor-κB, and its inhibition by curcumin-attenuated serovar Shermani detergent extract induced increases in fibronectin production. These effects were also mimicked by the specific TLR2 agonist, Pam(3)CsK(4), a response that was also abrogated by the knockdown of MyD88 and TRAF6. Similarly, the administration of live leptospires to cells also induced fibronectin production that was blocked by inhibition of TLR2 and MyD88 expression. In conclusion, serovar Shermani detergent extract can induce fibronectin production through the TLR2-associated cascade, providing evidence of an association between TLRs and leptospirosis-mediated ECM deposition.

Published
2011
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36. Leptospira santorosai Serovar Shermani Detergent Extract Induces an Increase in Fibronectin Production through a Toll-Like Receptor 2-Mediated Pathway

Author

Tian, Ya-Chung, Hung, Cheng-Chieh, Li, Yi-Jung, Chen, Yung-Chang, Chang, Ming-Yang, Yen, Tzung-Hai, Hsu, Hsiang-Hao, Wu, Mai-Szu, Phillips, Aled, and Yang, Chih-Wei

Abstract

Leptospirosis can activate inflammatory responses through Toll-like receptors (TLRs) and may cause renal tubulointerstitial fibrosis characterized by the accumulation of extracellular matrix (ECM). We have previously demonstrated that Leptospira santorosai serovar Shermani detergent extract stimulates ECM accumulation in vitro. The aim of this study was to examine the mechanistic basis of these previous observations and, in particular, to examine the potential involvement of TLRs. The addition of serovar Shermani detergent extract led to an increase in fibronectin gene expression and production. Inhibition of TLR2 but not TLR4 expression abrogated serovar Shermani detergent extract-mediated increases in fibronectin production. This response was also blocked by the knockdown of the gene expression of the TLR2 downstream transducers myeloid differentiation factor 88 (MyD88) and tumor necrosis factor receptor-associated factor 6 (TRAF6). Serovar Shermani detergent extract also activated nuclear factor-B, and its inhibition by curcumin-attenuated serovar Shermani detergent extract induced increases in fibronectin production. These effects were also mimicked by the specific TLR2 agonist, Pam(3)CsK(4), a response that was also abrogated by the knockdown of MyD88 and TRAF6. Similarly, the administration of live leptospires to cells also induced fibronectin production that was blocked by inhibition of TLR2 and MyD88 expression. In conclusion, serovar Shermani detergent extract can induce fibronectin production through the TLR2-associated cascade, providing evidence of an association between TLRs and leptospirosis-mediated ECM deposition.

Published
2010

37. Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury.

Author

Lee, Cheng-Chia, Chang, Chih-Hsiang, Cheng, Ya-Lien, Kuo, George, Chen, Shao-Wei, Li, Yi-Jung, Chen, Yi-Ting, and Tian, Ya-Chung

Subjects
ACUTE kidney failure, CYCLOPHILINS, SURGICAL intensive care, INTENSIVE care units, CARDIAC surgery, CHORIONIC villus sampling
Abstract

Acute kidney injury (AKI) is associated with increased morbidity and mortality and is frequently encountered in cardiovascular surgical intensive care units (CVS-ICU). In this study, we aimed at investigating the utility of cyclophilin A (CypA) for the early detection of postoperative AKI in patients undergoing cardiac surgery. This was a prospective observational study conducted in a CVS-ICU of a tertiary care university hospital. All prospective clinical and laboratory data were evaluated as predictors of AKI. Serum and urine CypA, as well as urine neutrophil gelatinase-associated lipocalin (uNGAL), were examined within 6 h after cardiac surgery. The discriminative power for the prediction of AKI was evaluated using the area under the receiver operator characteristic curve (AUROC). We found that both serum CypA and urine CypA were significantly higher in the AKI group than in the non-AKI group. For discriminating AKI and dialysis-requiring AKI, serum CypA demonstrated acceptable AUROC values (0.689 and 0.738, respectively). The discrimination ability of urine CypA for predicting AKI was modest, but it was acceptable for predicting dialysis-requiring AKI (AUROC = 0.762). uNGAL best predicted the development of AKI, but its sensitivity was not good. A combination of serum CypA and uNGAL enhanced the overall performance for predicting the future development of AKI and dialysis-requiring AKI. Our results suggest that CypA is suitable as a biomarker for the early detection of postoperative AKI in CVS–ICU. However, it has better discriminating ability when combined with uNGAL for predicting AKI in CVS-ICU patients. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Concurrent Cytomegalovirus Colitis and Bacteroides fragilis Peritonitis in a Peritoneal Dialysis Patient.

Author

Hsieh CY, Chang MY, Chen KH, Jenq CC, Li YJ, Chen TC, Yang CW, and Chen YM

Subjects
Anti-Bacterial Agents therapeutic use, Antiviral Agents therapeutic use, Bacteroides Infections diagnosis, Bacteroides Infections drug therapy, Colitis diagnosis, Colitis drug therapy, Colonoscopy, Cytomegalovirus Infections diagnosis, Cytomegalovirus Infections drug therapy, Female, Ganciclovir therapeutic use, Humans, Kidney Failure, Chronic therapy, Middle Aged, Peritonitis diagnosis, Peritonitis drug therapy, Sigmoidoscopy, Viremia diagnosis, Viremia drug therapy, Viremia virology, Bacteroides Infections microbiology, Bacteroides fragilis isolation & purification, Colitis virology, Cytomegalovirus isolation & purification, Cytomegalovirus Infections virology, Peritoneal Dialysis, Peritonitis microbiology
Published
2015
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