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Antigen presentation by HLA class II molecules to CD4+ T cells is an essential step for generating antibodies to hepatitis B antigens. In this study, we investigated the association between the HLA‐DRB1 gene and the status of antibodies to hepatitis B surface and e antigens. Our results revealed a significant association between the status of anti‐HBsAg and HLA‐DRB1*04:03 (OR = 4.11, 95% CI = 1.50–10.84, p = 0.005, Padj. = 0.05) as well as HLA‐DRB1*15:01 (OR = 1.74, 95% CI = 1.20–2.50, p = 0.002, Padj. = 0.045). MHC II binding predictions and in silico docking demonstrated strong binding affinity of HBsAg peptides to these two HLA‐DRB1 molecules. Conversely, the status of anti‐HBeAg was inversely associated with HLA‐DRB1*14:54 (OR = 0.34, 95% CI = 0.18–0.64, p = 0.001, Padj. = 0.011), and in silico analysis revealed weak binding affinity of HBeAg peptides to HLA‐DRB1*14:54. In conclusion, these findings support the involvement of HLA‐DRB1 in humoral immunity against HBV infection. [ABSTRACT FROM AUTHOR]

Aiming at the problem of left-behind children, empty-nest elderly, and people with reduced mobility, an autonomous family companion robot was designed. Based on the architecture of robot operating system(ROS), firstly, an autonomous mobile family companion robot was built with Jetson TX1 as the core, then the software was designed, which makes it not only able to communicate with people in natural language, but also use eye expressions and humanoid upper limbs for physical communication, and realize human-machine interaction through User Interface(UI). The rationality of the robot design is verified by the physical test, and the robot can meet the company work of daily family and continue to be developed to do more work.

Melioidosis is a serious infectious disease caused by the environmental Gram-negative bacillus Burkholderia pseudomallei. It has been shown that the host immune system, mainly comprising various types of immune cells, fights against the disease. The present study was to specify correlation between septicemic melioidosis and the levels of multiple immune cells. First, the genes with differential expression patterns between patients with septicemic melioidosis (B. pseudomallei) and health donors (control/healthy) were identified. These genes being related to cytokine binding, cell adhesion molecule binding, and MHC relevant proteins may influence immune response. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed 23 enriched immune response pathways. We further leveraged the microarray data to investigate the relationship between immune response and septicemic melioidosis, using the CIBERSORT analysis. Comparison of the percentages of 22 immune cell types in B. pseudomallei vs. control/healthy revealed that those of CD4 memory resting cells, CD8+ T cells, B memory cells, and CD4 memory activated cells were low, whereas those of M0 macrophages, neutrophils, and gamma delta T cells were high. The multivariate logistic regression analysis further revealed that CD8+ T cells, M0 macrophages, neutrophils, and naive CD4+ cells were strongly associated with the onset of septicemic melioidosis, and M2 macrophages and neutrophils were associated with the survival in septicemic melioidosis. Taken together, these data point to a complex role of immune cells on the development and progression of melioidosis. [ABSTRACT FROM AUTHOR]

According to the characteristics of small batch, multi-variety and fast delivery orders of clothing, the method of integration, standardization and modularization of clothing technology was adopted, and the intelligent sewing unit was used to complete the modular production and assembly of clothing. Through 5G technology, internet of things, cloud platform and other technologies, the intelligent sewing unit network was formed into an intelligent garment production line, which made the garment production management visible and transparent. The advanced planning and scheduling system was used to realize the production planning and scheduling, and the manu facturing execution system was used to dispatch the automatic guided transport vehicle or hanging production line to distribute materials, and the intelligent sewing unit was used to sew the clothing, so as to realize the dynamic modular flexible manufacturing of the clothing products. The garment flexible production line based on intelligent sewing unit can improve the production efficiency of garment workshop and meet the demand of high-quality and personalized garment orders. [ABSTRACT FROM AUTHOR]