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2,935 results on '"Li, Xiao-Feng"'

13. Scattering-assisted and logic-controllable WGM laser in liquid crystal micropillar

Author

Zhang, Jin Chuan, Zhu, Hong Yang, Zhu, Xiao Mei, Zhang, Yan Li, Wang, Zhao, Chen, Fei Liang, Li, Ke, Li, Xiao Feng, and Zhang, Wei Li

Subjects
Physics - Optics
Abstract

Whispering gallery mode (WGM) microcavities can efficiently store and manipulate light with strong light confinement and long photon lifetime, while coupling light into and from WGMs is intrinsically hindered by their unique feature of rotational symmetry. Here, a scattering-assisted liquid crystal (LC) micropillar WGM laser is proposed. WGM lasing at the surface of the micropillar is obviously enhanced by fluorescence scattering in the core of the micropillar. Besides, weak scattering of LC molecules also builds efficient coupling channels between the laser modes and the axial transmission modes of the micropillar-based waveguide, providing an all-in-one liquid WGM laser with functions of self-seeding and self-guiding. Furthermore, based on the hysteresis characteristics of the electrically anchored LC molecules under the interaction of thermal force, an erasable read-write liquid memory device is proposed, paving the way for the application of logic-controllable WGM lasers in optical storage and optical control.

Published
2022
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25. TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation

Author

Zu, Shulong, Li, Chunfeng, Li, Lili, Deng, Yong-Qiang, Chen, Xiang, Luo, Dan, Ye, Qing, Huang, Yi-Jiao, Li, Xiao-Feng, Zhang, Rong-Rong, Sun, Nina, Zhang, Xianqi, Aliyari, Saba R, Nielsen-Saines, Karin, Jung, Jae U, Yang, Heng, Qin, Cheng-Feng, and Cheng, Genhong

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Vaccine Related, Rare Diseases, Emerging Infectious Diseases, Vector-Borne Diseases, Biodefense, Infectious Diseases, Prevention, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, TRIM22, Zika virus, Nonstructural protein, Ubiquitination
Abstract

BackgroundRecognition of viral invasion by innate antiviral immune system triggers activation of the type I interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression of a group of genes known as IFN-I-stimulated genes (ISGs) to block viral infection. The tripartite motif containing 22 (TRIM22) is an ISG with strong antiviral functions.ResultsHere we have shown that the TRIM22 has been strongly upregulated both transcriptionally and translationally upon Zika virus (ZIKV) infection. ZIKV infection is associated with a wide range of clinical manifestations in human from mild to severe symptoms including abnormal fetal brain development. We found that the antiviral function of TRIM22 plays a crucial role in counterattacking ZIKV infection. Overexpression of TRIM22 protein inhibited ZIKV growth whereas deletion of TRIM22 in host cells increased ZIKV infectivity. Mechanistically, TRIM22, as a functional E3 ubiquitin ligase, promoted the ubiquitination and degradation of ZIKV nonstructural protein 1 (NS1) and nonstructural protein 3 (NS3). Further studies showed that the SPRY domain and Ring domain of TRIM22 played important roles in protein interaction and degradation, respectively. In addition, we found that TRIM22 also inhibited other flaviviruses infection including dengue virus (DENV) and yellow fever virus (YFV).ConclusionThus, TRIM22 is an ISG with important role in host defense against flaviviruses through binding and degradation of the NS1 and NS3 proteins.

Published
2022

43. 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

Author

Zu, Shulong, Deng, Yong-Qiang, Zhou, Chao, Li, Jie, Li, Lili, Chen, Qi, Li, Xiao-Feng, Zhao, Hui, Gold, Sarah, He, Jun, Li, Xiang, Zhang, Changqing, Yang, Heng, Cheng, Genhong, and Qin, Cheng-Feng

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aged, Angiotensin-Converting Enzyme 2, Animals, Betacoronavirus, COVID-19, Chlorocebus aethiops, Coronavirus Infections, Disease Models, Animal, Fatal Outcome, Female, Humans, Hydroxycholesterols, Mice, Mice, Inbred BALB C, Mice, Transgenic, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Vero Cells, Virus Replication, Clinical Sciences, Developmental Biology, Biochemistry and cell biology
Published
2020

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