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11. Super-resolution multicolor fluorescence microscopy enabled by an apochromatic super-oscillatory lens with extended depth-of-focus

Author

Li, Wenli, He, Pei, Fan, Yulong, Du, Yangtao, Gao, Bo, Chu, Zhiqin, An, Chengxu, Lei, Dangyuan, Yuan, Weizheng, and Yu, Yiting

Subjects
Physics - Optics
Abstract

Multicolor super-resolution imaging remains an intractable challenge for both far-field and near-field based super-resolution techniques. Planar super-oscillatory lens (SOL), a far-field subwavelength-focusing diffractive lens device, holds great potential for achieving sub-diffraction-limit imaging at multiple wavelengths. However, conventional SOL devices suffer from a numerical aperture (NA) related intrinsic tradeoff among the depth of focus (DoF), chromatic dispersion and focus spot size, being an essential characteristics of common diffractive optical elements. Typically, the limited DoF and significant chromatism associated with high NA can lead to unfavorable degradation of image quality although increasing NA imporves the resolution. Here, we apply a multi-objective genetic algorithm (GA) optimization approach to design an apochromatic binary-phase SOL that generates axially jointed multifoci concurrently having prolonged DoF, customized working distance (WD) and suppressed side-lobes yet minimized main-lobe size, optimizing the aforementioned NA-dependent tradeoff. Experimental implementation of this GA-optimized SOL demonstrates simultaneous focusing of blue, green and red light beams into an optical needle half of the incident wavelength in diameter at 428 um WD, resulting in an ultimate resolution better than one third of the incident wavelength in the lateral dimension. By integrating this apochromatic SOL device with a commercial fluorescence microscope, we employ the optical needle to perform, for the first time, three-dimensional super-resolution multicolor fluorescence imaging of the unseen fine structure of neurons at one go. The present study provides not only a practical route to far-field multicolor super-resolution imaging but also a viable approach for constructing imaging systems avoiding complex sample positioning and unfavorable photobleaching.

Published
2022

18. Preparation and Fluorescent Wavelength Control of Multi-Color Nitrogen-Doped Carbon Nano-Dots

Author

Li, Wenli, Tang, Ju, Li, Yuzhao, Bai, Han, Zhang, Weizuo, Zhang, Jin, Xiao, Yiming, and Xu, Wen

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

It is known that, by taking advantage of heteroatom doping, the electronic states and transition channels in carbon nano-dots (CNDs) can be effectively modulated. Thus, the photoluminescence (PL) properties of CNDs can be changed. For potential applications of CNDs as advanced materials for optoelectronic devices, it is important and significant to develop the practical techniques for doping heteroatoms into CNDs. In this work, we synthesize the multi-color fluorescent by using a fast and effective microwave method where the CNDs are nitrogen-doped. We examine the influence of different ratios of the raw materials on the structure and optical properties of N-CNDs. The results show that the prepared N-CNDs can generate blue (445 nm), green (546 nm), and orange (617 nm) fluorescence or PL with the mass ratio of the raw materials at 1:1, 1:2 and 1:3, respectively. We find that the N content in N-CNDs leads to different surface/edge states in $n-\pi^*$ domain. Thus, the wavelength of the PL emission from N-CNDs can be tuned via controlling the N concentration doped into the CNDs. Moreover, it is shown that the intensity of the PL from N-CNDs is mainly positively related to the content of C-O groups attached on the surface/edges of the N-CNDs. This study provides an effective experimental method and technical way to improve the fluorescent emission, and to modulate the color of the PL emission from CNDs.

Published
2021
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30. Genome-Wide Copy Number Variation and Structural Variation: A Novel Tool for Improved Livestock Genomic Selection

Author

Li, Wenli, Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Mukhopadhyay, Chandra Sekhar, editor, Choudhary, Ratan Kumar, editor, and Panwar, Harsh, editor

Published
2023
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31. Health State Assessment of Large Complex Equipment Based on Modified ER Algorithm

Author

Li, HaiYan, Li, WenLi, Liu, SongBin, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Yadav, Sanjay, editor, Kumar, Harish, editor, Wan, Meher, editor, Arora, Pawan Kumar, editor, and Yusof, Yusri, editor

Published
2023
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32. Medication rule and mechanism of traditional Chinese medicine in treating metabolism-associated fatty liver disease based on bioinformatics technology

Author

Zhang Yunkun, Yao Rong, Li Lin, Li Wenli, Li Changqing, Pan Yu, and Li Shunxiang

Subjects
Metabolism-associated fatty liver disease (MAFLD), Bioinformatics technology, Medication rule, Core formula, Mechanism, Medicine, Other systems of medicine, RZ201-999
Abstract

[Abstract]: [Objective]: To analyze the main syndrome types, medication rules, and core prescription characteristics of traditional Chinese medicine (TCM) in the treatment of metabolism-associated fatty liver disease (MAFLD), and to predict the anti-MAFLD mechanism of core formula, so as to provide references for the clinical application of TCM and the development of new drugs. [Methods]: Literature research on TCM in treating MAFLD was retrieved from China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Wanfang Database since the establishment of the database to July 2022. Excel 2019 and Chinese Medicine Inheritance Computing Platform (V3.0) were used for frequency analysis, association rule analysis, and cluster analysis of effective prescriptions. The key components, targets, and action pathways of anti-MAFLD core formulas were predicted by network pharmacology. Finally, the interactions between the obtained core components and their core targets were verified reversely by molecular docking technology. [Results]: A total of 218 articles were screened and selected, including 352 prescriptions, involving 270 traditional Chinese herbs. The drugs were used a total of 3 901 times, and a total of 10 915 cases were collected, among which the prevalence rate was higher in males. The main types of TCM syndrome included intermingled phlegm and blood stasis syndrome, liver depression and spleen deficiency syndrome, and damp-heat in liver and gallbladder syndrome, among which Shanzha (Crataegi Fructus), Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Fuling (Poria), Zexie (Alismatis Rhizoma), Chaihu (Bupleuri Radix), and Baizhu (Atractylodis Macrocephalae Rhizoma) were the most frequently used. The properties of Chinese medicine primarily encompassed thermal characteristics, with a predominant emphasis on cold and warm; the flavors of herbs were predominantly characterized by bitterness and sweetness, while the majority exhibited tropism towards the spleen and liver meridians. The drugs were primarily classified based on their efficacy in tonifying deficiencies, promoting diuresis and moistening, enhancing blood circulation and removing blood stasis, heat-clearing, etc. The association rules were employed to derive a set of 20 core drug pairs, while cluster analysis was utilized to identify three distinct groups of core drug combinations. Network pharmacological showed that the main components of the core formula “Shanzha (Crataegi Fructus) - Danshen (Salviae Miltiorrhizae Radix et Rhizoma) - Zexie (Alismatis Rhizoma) - Chaihu (Bupleuri Radix) - Fuling (Poria)” in the treatment of MAFLD were quercetin, apigenin, puerarin, luteolin, ursolic acid, kaempferol, tanshinone IIA, emodin, paeonol, etc., which involved RAC-alpha serine/threonine-protein kinase 1 (AKT1), cellular tumor antigen p53 (TP53), interleukin (IL)-6, IL-1β, signal transducer and activator of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), peroxisome proliferative activated receptor gamma (PPARG), and other key targets. The molecular docking results showed that the core components had good binding to lipid and atherosclerosis, and phosphatidylinositol 3 kinase (PI3K)/AKT signaling pathway-associated proteins. [Conclusion]: The main principles of TCM for the treatment of MAFLD involve soothing the liver and strengthening the spleen, eliminating phlegm and dampness, clearing heat and dampness, as well as promoting blood circulation and removing blood stasis. The core formula may exert anti-MAFLD effects mediated through multiple components, targets, and signaling pathways. This study establishes a theoretical foundation for the clinical application of TCM in the treatment of MAFLD, and serves as a reference for further exploration of new drugs against MAFLD.

Published
2023
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50. Siting thousands of radio transmitter towers on terrains with billions of points

Author

Franklin, W. Randolph, de Magalhães, Salles Viana Gomes, and Li, Wenli

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

This paper presents a system that sites (finds optimal locations for) thousands of radio transmitter towers on terrains of up to two billion elevation posts. Applications include cellphone towers, camera systems, or even mitigating environmental visual nuisances. The transmitters and receivers may be situated above the terrain. The system has been parallelized with OpenMP to run on a multicore CPU., Comment: 16 pages, 7 figures, submitted

Published
2020

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