Search

Your search keyword '"Li, Si-yi"' showing total 155 results
Start Over Author "Li, Si-yi"
155 results on '"Li, Si-yi"'

7. C‐Reactive Protein Is Not the Driver Factor in Ulcerative Colitis.

Author

Ge, Zhong-Bo, Zhang, Xin-Yun, Zhang, Chun-Miao, Xu, Tao-Tao, Li, Si-Yi, Wei, Meng-Xiao, Ding, Xin-Yuan, Bai, Cai-Juan, Wang, Han, Zhou, Hai-Hong, Wang, Ming-Yu, and Mandal, Palash

Subjects
INTESTINAL mucosa, RESEARCH funding, BODY weight, ULCERATIVE colitis, DESCRIPTIVE statistics, MICE, COLON (Anatomy), SPLEEN, DEXTRAN, DRUG efficacy, ANIMAL experimentation, DATA analysis software, C-reactive protein, BIOMARKERS, PHENOTYPES
Abstract

Purpose: C‐reactive protein (CRP) functions as a nonspecific marker in various inflammatory disorders, particularly in evaluating the efficacy of pharmacological treatments in patients with ulcerative colitis. The existing body of evidence does not offer adequate support for the direct implication of CRP in modulating the advancement of ulcerative colitis. Methods: Our study employed a rigorous mouse model. An ulcerative colitis mouse model was established by subjecting CRP‐deficient mice to dextran sulfate sodium (DSS) treatment. The phenotype of the mice, which encompassed parameters such as body weight, colon length, and spleen weight, was meticulously evaluated. Additionally, various physiological and biochemical indicators were assessed, including colon histopathology, expression levels of inflammatory factors, and staining of the intestinal mucus layer. Results: The absence of CRP did not significantly affect the phenotype, physiological characteristics, and biochemical indices in a mouse model of ulcerative colitis compared to mice with wild‐type CRP. Additionally, eliminating intestinal bacteria flora interference through antibiotic treatment revealed that mice lacking CRP did not demonstrate any notable variations in the ulcerative colitis model. Meanwhile, the survival rate of mice lacking CRP did not exhibit a statistically significant difference compared to wild‐type mice. Conclusion: The results of our study suggest that CRP may not directly mediate ulcerative colitis. Instead, it is more likely to be a bystander that is present alongside with elevated inflammatory factors. Further investigation is warranted to determine the precise role of CRP in humans, given the significant limitations associated with the use of mouse models. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Factors Influencing Transformational Leadership among Lecturers in Public Universities of Xi’an, China: A Pilot Test

Author

Li Si Yi, Chin Nyuk Sang, Li Si Yi, and Chin Nyuk Sang

Abstract

This study examines the factors influencing transformational leadership among lecturers in public universities in Xi’an, China, focusing on the reliability and validity of a pilot test measuring job satisfaction, organizational structure alignment, organizational justice, social responsibility, mindfulness, and spiritual intelligence. Using Cronbach's Alpha, Composite Reliability (rho_a and rho_c), and the Heterotrait-Monotrait ratio (HTMT), the study confirmed the reliability and validity of the measurement instruments. All constructs showed high internal consistency (Cronbach's Alpha: 0.872-0.943) and robust Composite Reliability. Convergent validity, assessed through the Average Variance Extracted (AVE), exceeded the 0.5 threshold for all constructs. Discriminant validity, evaluated using the HTMT ratio and the Fornell & Larcker criterion, revealed some high HTMT values, indicating potential overlap, while interaction terms demonstrated better discriminant validity, highlighting nuanced construct relationships. The study underscores the importance of rigorous psychometric evaluation in organizational research. Validated constructs provide reliable tools for both researchers and practitioners, enabling accurate assessments of organizational dynamics and informing strategies for improvement. Additionally, the study identifies areas for further refinement and calls for future research to validate these constructs across different contexts and cultures, ensuring broader applicability and robustness of the measurement instruments.

Published
2024

10. Transforming Higher Education: A Systematic Review of Transformational Leadership among University Lecturers in Xi'an, China

Author

Li Si Yi, Chin Nyuk Sang, Li Si Yi, and Chin Nyuk Sang

Abstract

This systematic review explores the dynamics of transformational leadership among university lecturers in public universities in Xi'an, China. Drawing on a range of validated research instruments and employing a rigorous methodology, this study investigates the interplay between spiritual intelligence, mindfulness, organizational justice, structure alignment, social responsibility, job satisfaction, and their impact on transformational leadership. Through a comprehensive analysis of self-administered questionnaires, this review sheds light on the critical factors influencing leadership behaviors in higher education settings, offering valuable insights for academics, policymakers, and institutional leaders aiming to foster transformative educational environments.

Published
2024

20. Electroacupuncture Alleviates Diabetic Neuropathic Pain and Downregulates p-PKC and TRPV1 in Dorsal Root Ganglions and Spinal Cord Dorsal Horn

Author

Ma, Yi-qi, primary, Hu, Qun-qi, additional, Kang, Yu rong, additional, Ma, Li-qian, additional, Qu, Si-ying, additional, Wang, Han-zhi, additional, Zheng, Yin-mu, additional, Li, Si-yi, additional, Shao, Xiao-mei, additional, Li, Xiao-yu, additional, Hu, Han-tong, additional, Jiang, Yong-liang, additional, Fang, Jian-qiao, additional, and He, Xiao-fen, additional

Published
2023
Full Text
View/download PDF

23. Mild haemoglobin drop and clinical outcomes in acute coronary syndrome patients: finding from the BleeMACS registry

Author

ZHANG, Ze-Kun, YAN, Yan, LI, Si-Yi, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Henriques, José P., D’Ascenzo, Fabrizio, Saucedo, Jorge, GONG, Wei, and NIE, Shao-Ping

Subjects
Research Article
Abstract

BACKGROUND: Haemoglobin drop is common in acute coronary syndrome (ACS) patients and correlates with poor prognosis. However, the association between mild haemoglobin drop and adverse clinical outcome remains insufficiently investigated. This study aimed to examine the association between in-hospital haemoglobin drop and risk for adverse clinical outcomes in ACS patients, especially those with mild drop. METHODS: Included patients from the BleeMACS (Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome) registry were categorized into three groups by the presence and amount of in-hospital haemoglobin drop (non-drop, mild drop and severe drop). The cut-off point between mild drop and severe drop is ≥ 3 g/dL. Multivariate Cox regression was used to assess the association between haemoglobin drop and major adverse cardiac endpoints (MACE). Patients taking potent P2Y(12) inhibitors were selected for the additional analysis. Propensity score matching was used to avoid selective bias in the additional analysis. RESULTS: Of 6911 patients, 4949 patients (71.6%) experienced in-hospital haemoglobin drop. Compare with non-drop group, patients with haemoglobin drop had higher risk of MACE [adjusted hazard ratio (HR) = 1.36, 95% CI: 1.03–1.80 for mild drop group; adjusted HR = 1.70, 95% CI: 1.07–2.68 for severe drop group]. Patients in mild drop group were less likely to receive potent P2Y(12) inhibitors at discharge (mild drop group vs. severe drop group vs. non-drop group: 10.9% vs. 10.7% vs. 23.8%). After propensity score matching adjustment among patients with potent P2Y(12) inhibitors, patients in mild drop group were not associated with an increased risk of MACE than those in non-drop group (adjusted HR = 1.52, 95% CI: 0.49–4.72). CONCLUSIONS: In-hospital haemoglobin drop was common in ACS patients and associated with a higher risk for adverse events. Reduced prescription for potent P2Y(12) inhibitors may be responsible for poor prognoses among patients with mild haemoglobin drop.

Published
2022

30. Identifying the Antitumor Effects of Curcumin on Lung Adenocarcinoma Using Comprehensive Bioinformatics Analysis

Author

Yang,Fei-Ran, Li,Si-Yi, Hu,Xi-Wen, Li,Xiu-Rong, Li,Hui-Jie, Yang,Fei-Ran, Li,Si-Yi, Hu,Xi-Wen, Li,Xiu-Rong, and Li,Hui-Jie

Abstract

Fei-Ran Yang,1,* Si-Yi Li,1,* Xi-Wen Hu,1 Xiu-Rong Li,2 Hui-Jie Li2 1College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2Department of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui-Jie Li; Xiu-Rong Li, Department of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jingshi Road, Jinan, Shandong, 250014, People’s Republic of China, Email 2008lihuijie@163.com; szylxr2012@126.comBackground: As the main component of turmeric (Curcuma longa L.), curcumin is widely used in the treatment of various diseases. Previous studies have demonstrated that curcumin has great potential as a therapeutic agent, but the lack of understanding of the functional mechanism of the drug has hindered the widespread use of the natural product. In the present study, we used comprehensive bioinformatics analysis and in vitro experiments to explore the anti-tumor mechanism of curcumin.Materials and Methods: LUAD mRNA expression data were obtained from TCGA database and differentially expressed genes (DEGs) were identified using R software. Functional enrichment analysis was conducted to further clarify its biological properties and hub genes were identified by a protein–protein interaction (PPI) network analysis. Survival analysis and molecular docking were used to analyze the effectiveness of the hub genes. By an in vitro study, we evaluated whether curcumin could influence the proliferation, migration, and invasion activities of LUAD cells.Results: In this study, 1783 DEGs from LUAD tissue samples compared to normal samples were evaluated. Functional enrichment analysis and the PPI network revealed the characteristics of the DEGs. We performed a topological analysis and identified 10 hub gen

Published
2022

33. 패션 공유 플랫폼의 품질 특성이 신뢰에 미치는 영향에 관한 연구-중국 여성 소비자를 중심으로

Author

Min-Jung Park and Li Si Yi

Subjects
General Medicine
Abstract

본 연구는 중국 여성 소비자를 대상으로 패션 공유 플랫폼의 영향력을 살펴보고자 하였다. 패션 공유 플랫폼의 품질 특성, 제품 품질이 신뢰와 재이용 의도에 미치는 영향을 알아보고, 소비자의 혁신성향에 따라 패션 공유 플랫폼의 품질 특성, 제품 품질, 소비자의 신뢰, 재이용 의도 간의 영향 관계에 차이가 있는가를 알아보고자 한다. 본 연구는 중국 여성 소비자를 대상으로 설문조사를 실시하였다. 연구대상의 인구통계학적 특성에 관한 문항을 제외한 문항들은 모두 7점 리 커트 척도로 측정하였으며, 수집된 자료의 통계처리는 SPSS 24.0과 AMOS 24.0을 사용하여 분석하였다. 본 연구 결과, 패션 공유 플랫폼의 품질 특성(정보 품질 및 서비스 품질)이 모두 소비자 신뢰에 정(+)의 영향을 미치는 것으로 나타났다. 또한, 패션 공유 플랫폼의 제품 품질이 좋다고 지각할수록 소비자의 신뢰에 긍정적인 영향을 미치는 것으로 나타났다. 그리고 소비자의 신뢰가 재이용 의도에 긍정적인 영향을 미치는 것으로 나타났다. 마지막으로 소비자의 혁신성 정도에 따라 패션 공유 플랫폼의 품질 특성과 제품 품질이 소비자의 신뢰에 미치는 영향에 차이가 있는 것으로 나타났다. 이러한 연구 결과는 패션 공유 플랫폼에 대한 연구가 많이 부족한 상황에서 패션 공유 플랫폼의 품질 특성과 제품 품질이 소비자 신뢰에 미치는 영향을 실증적으로 밝혔다는 점에 학문적 의의가 있으며, 패션 공유 플랫폼의 마케팅 전략을 수립하는데 유용한 정보를 제공하였다는 점에 실용적 의의가 있다.

Published
2019
Full Text
View/download PDF

35. Phytochemical library screening reveals betulinic acid as a novel Skp2‐SCF E3 ligase inhibitor in non–small cell lung cancer

Author

He, Dan‐Hua, primary, Chen, Yu‐Fei, additional, Zhou, Yi‐Le, additional, Zhang, Shi‐Bing, additional, Hong, Ming, additional, Yu, Xianjun, additional, Wei, Su‐Fen, additional, Fan, Xiang‐Zhen, additional, Li, Si‐Yi, additional, Wang, Qi, additional, Lu, Yongzhi, additional, and Liu, Yong‐Qiang, additional

Published
2021
Full Text
View/download PDF

38. 17.9 A High-Conversion-Ratio and 97.4% Peak-Efficiency 3-Switch Boost Converter with Duty-Dependent Charge Topology for 1.2A High Driving Current and 20% Reduction of Inductor DC Current in MiniLED Applications

Author

Lin, Yen-An, primary, Li, Si-Yi, additional, Huang, Zheng-Lun, additional, Huang, Chong-Sin, additional, Liang, Chin-Hsiang, additional, Chang, Kai-Syun, additional, Chung, Kai-Cheng, additional, Chen, Ke-Horng, additional, Lin, Ying-Hsi, additional, Lin, Shian-Ru, additional, and Tsai, Tsung-Yen, additional

Published
2021
Full Text
View/download PDF

40. Admission hyperglycemia as an independent predictor of long‐term prognosis in acute myocardial infarction patients without diabetes: A retrospective study

Author

Cui, Cai‐yan, primary, Zhou, Ming‐gang, additional, Cheng, Lian‐chao, additional, Ye, Tao, additional, Zhang, Yu‐mei, additional, Zhu, Feng, additional, Li, Si‐yi, additional, Jiang, Xing‐lin, additional, Chen, Qiang, additional, Qi, Ling‐yao, additional, Chen, Xu, additional, Yang, Si‐qi, additional, and Cai, Lin, additional

Published
2020
Full Text
View/download PDF

48. Admission hyperglycemia as an independent predictor of long‐term prognosis in acute myocardial infarction patients without diabetes: A retrospective study.

Author

Cui, Cai‐yan, Zhou, Ming‐gang, Cheng, Lian‐chao, Ye, Tao, Zhang, Yu‐mei, Zhu, Feng, Li, Si‐yi, Jiang, Xing‐lin, Chen, Qiang, Qi, Ling‐yao, Chen, Xu, Yang, Si‐qi, and Cai, Lin

Subjects
HYPERGLYCEMIA, MYOCARDIAL infarction, PEOPLE with diabetes, PROGNOSIS, FORECASTING, BLOOD sugar, MORTALITY
Abstract

Aims/Introduction: The predictive value of admission hyperglycemia in the long‐term prognosis of acute myocardial infarction patients is still controversial. We aimed to investigate this value based on the diabetes status. Materials and Methods: We carried out a multicenter, retrospective study of 1,288 acute myocardial infarction patients enrolled in 11 hospitals between March 2014 and June 2019 in Chengdu, China. The patients were classified into those with diabetes and those without diabetes, each was further divided into: hyperglycemia and non‐hyperglycemia subgroups, according to the optimal cut‐off value of the blood glucose to predict all‐cause mortality during follow up. The end‐points were all‐cause death and major adverse cardiovascular and cerebrovascular events, including all‐cause death, non‐fatal myocardial infarction, vessel revascularization and non‐fatal stroke. Results: In the follow‐up period of 15 months, we observed 210 (16.3%), 6 (0.5%), 57 (4.4%) and 34 (2.6%) cases of death, non‐fatal myocardial infarction, revascularization and non‐fatal stroke, respectively. The optimal cut‐off values of admission blood glucose for patients with diabetes and patients without diabetes to predict all‐cause mortality during follow up were 14.80 and 6.77 mmol/L, respectively. We divided patients with diabetes (n = 331) into hyperglycemia (n = 92) and non‐hyperglycemia (n = 239), and patients without diabetes (n = 897) into hyperglycemia (n = 425) and non‐hyperglycemia (n = 472). The cumulative rates of all‐cause death and major adverse cardiovascular and cerebrovascular events among the patients in each hyperglycemia group was higher than that in the corresponding non‐hyperglycemia group (P < 0.001). In patients without diabetes, admission hyperglycemia was an independent predictor of all‐cause mortality and major adverse cardiovascular and cerebrovascular events. Conclusion: Admission hyperglycemia was an independent predictor for long‐term prognosis in acute myocardial infarction patients without diabetes. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results