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12. Clinical features of neonatal testicular torsion: A retrospective analysis of 24 cases.

Author

Huang, Shaogang, Zeng, Yefeng, Xu, Rui, Fan, Yibin, Gu, Xianbin, Miao, Qiuling, Wang, Yue, Chen, Pengyu, and Li, Shoulin

Abstract

To analyze the clinical characteristics, surgical management decisions, and outcomes of Neonatal testicular torsion (NTT) in order to offer guidance for future clinical practice. Retrospectively analyzed the clinical data of patients with NTT who were admitted and underwent surgery from January 2008 to October 2023. A total of 24 neonates were enrolled in this study, all of whom were unilateral cases. Age of onset was 0 d (IQR: 0–1.8), while the median duration of symptoms was 73 h (IQR: 26–199). Clinical manifestation included enlarged scrotum (75 %), changes in scrotal color (79 %), and crying upon palpation (17 %). All patients underwent urgent bilateral exploration and performed by orchiectomy and contralateral orchiopexy. NTT primarily occurs prenatally with insidious manifestations, often leading to omission or misdiagnosis. The testicular salvage rate is extremely low. Physicians need to attach importance to neonatal testicular examination, improve the vigilance of NTT. Early bilateral exploration does not necessarily save the affected testes, but it is more important to prevent damage to the contralateral one. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Association of Renal Function (Estimate Glomerular Filtration Rate) with the Number of Febrile Urinary Tract Infections in Children with Neurogenic Bladder.

Author

Zhou, Guanglun, Jiang, Man, Zhu, Wenbin, Liu, Xiaodong, Sun, Junjie, and Li, Shoulin

Subjects
URINARY tract infections, NEUROGENIC bladder, GLOMERULAR filtration rate, KIDNEY physiology, CYSTATIN C, CHRONIC kidney failure
Abstract

Introduction Our objective was to evaluate whether renal function, assessed as the estimated glomerular filtration rate (eGFR), is associated with the number of febrile urinary tract infections (FUTIs) in children diagnosed with neurogenic bladder (NB). Materials and Methods Clinical information of patients diagnosed with NB was prospectively collected between January 2013 and January 2022. Episodes of FUTI were recorded during the follow-up period, and the eGFR was calculated based on the serum cystatin C level. Grading (G1–G5) of chronic kidney disease (CKD) was conducted as described by the eGFR. Results In total, 463 children were included in the final analysis (265 males and 198 females; mean age: 23 months). The median follow-up time was 51 months. A total of 302 children had four or more FUTIs and 161 children had none to three FUTIs. The incidence of developing CKD G3 to G5 gradually increased from the first to third (1.3–2.4%) episodes of FUTI and drastically increased after four episodes (≥ 22.5%), with the incidence recorded to be 100% after eight FUTIs. The odds of CKD G3 to G5 in children with four FUTIs were 17.3 and 43.7 times greater after four and six FUTIs, respectively, than in children with one FUTI. Conclusion This study showed that recurrent FUTIs are common in children with NB and that the risk of rapid progression to CKD G3 to G5 increases substantially after four or more FUTIs episodes. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Comparison of single-stage and two-stage transverse preputial island flap urethroplasty for severe hypospadias with long urethral defect length: A prospective multicenter study

Author

Liu, Pei, primary, Yang, Zhenzhen, additional, Li, Jiayi, additional, Fang, Yiwei, additional, Wang, Xinyu, additional, Fan, Songqiao, additional, Li, Zonghan, additional, Song, Hongcheng, additional, Zhang, Weiping, additional, Sun, Ning, additional, Tang, YunMan, additional, Huang, LuGang, additional, Yang, Yi, additional, Chao, Min, additional, Ma, Hong, additional, Zhang, Jingti, additional, Zhang, Xuhui, additional, Li, Shoulin, additional, Li, Ning, additional, Chen, Chao, additional, He, Dawei, additional, Wu, Wenbo, additional, and Xie, Hua, additional

Published
2022
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32. Risk factors associated with recurrent febrile urinary tract infection in children with neurogenic bladder who perform clean intermittent catheterization.

Author

Zhou, Guanglun, Jiang, Man, Liu, Xiaodong, Li, Shoulin, and Chen, Jinjun

Subjects
URINARY tract infections, INTERMITTENT urinary catheterization, NEUROGENIC bladder, VESICO-ureteral reflux, MULTIVARIATE analysis, UNIVARIATE analysis, ODDS ratio
Abstract

Objective: To identify the clinical and urodynamic risk factors associated with the development of recurrent febrile urinary tract infections (FUTIs) in children with neurogenic bladder (NB) who perform clean intermittent catheterization (CIC). Methods: Children with NB receiving CIC were prospectively enrolled from January to December 2019 and followed up prospectively for 2 years. All data were compared between occasional (0–1 FUTI) and recurrent FUTIs (≥2 FUTI) groups. In addition, the risk factors for recurrent FUTIs in children were evaluated. Results: Complete data from 321 children were analyzed. Occasional FUTIs occurred in 223 patients, and 98 patients experienced recurrent FUTIs. Univariate and multivariate analyses, showed late‐initiation and low‐frequency CIC, vesicoureteral reflux (VUR), small bladder capacity and low compliance, and detrusor overactivity were associated with an increased risk of recurrent FUTIs. Children with high‐grade VUR (grades IV‒V) had a higher risk of recurrent FUTIs than those with low‐grade VUR (grades I‒III) (odds ratio [OR]: 26.95 vs. OR: 4.78, p < 0.001). Conclusions: Our study suggests that late‐initiation and low‐frequency CIC, VUR, small bladder capacity and low compliance, and detrusor overactivity were associated with recurrent FUTIs in patients with NB. In addition, high‐grade VUR is a crucial risk factor for recurrent FUTIs. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Case Report: Long-term follow-up of desert hedgehog variant caused 46, XY gonadal dysgenesis with multiple complications in a Chinese child

Author

Pan, Lili, Li, Zhuoguang, Su, Zhe, Su, Wei, Zheng, Rongfei, Chen, Weiyan, He, Xuezhi, Song, Jianming, Li, Shoulin, and Wen, Pengqiang

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

Background: Desert hedgehog (DHH), as a member of the Hedgehog (HH) family, is mainly involved in testicular development and peripheral nerve sheath formation. A DHH variant has been identified in patients with 46, XY gonadal dysgenesis (46, XY GD) with or without neuropathy, but few reports mention the involvement of other complications.Case presentation: Here, we report a Chinese female patient who was hospitalized at 14.3 years old due to slow breast development for more than 1 year. She had a female genitalia phenotype and breast development started at 13 years old but progressed slowly. She was not yet menarche on admission, and she had intermittent muscle cramps in her hands and feet. Her karyotype analysis was 46, XY and the SRY gene was positive. Surgical exploration revealed no uterus or ovaries, and the pathology of bilateral gonads was dysplastic testis tissue, which was consistent with partial gonadal dysgenesis (PGD). Genetic analysis identified a homozygous pathogenic variant in DHH exon 3 (c.1027T>C, p. Cys343Arg). During the 6-year follow-up, she received estrogen replacement therapy, resulting in breast development progression without gender dysphoria. However, her peripheral neuropathy became more obvious, and a nerve conduction study (NCS) indicated decreased nerve conduction velocity and action potential. In addition, she also suffered complications such as obesity, insulin resistance, fatty liver, and gastric ulcers.Conclusion: In the present study, we reported a case of 46, XY GD with minifascicular neuropathy caused by a DHH homozygous variant, and we summarized the reported cases worldwide. For the first time in such patients, we showed a comparison of NCS changes with age as well as the presence of multiple complications not previously reported.

Published
2022
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34. Anatomical Laparoscopic Orchiopexy and Hybrid Transscrotal Orchiopexy for High Inguinal Undescended Testis: A Novel and Interfascial Technique

Author

Zhao, Weiguang, primary, Sun, Peng, additional, Xie, Jinjin, additional, Sun, Junjie, additional, Zhou, Wei, additional, Yang, Zhilin, additional, Fan, Yibin, additional, Yin, Jianchun, additional, Xu, Qitao, additional, Zhang, Yingtian, additional, Zhou, Guanglun, additional, Jiang, Junhai, additional, and Li, Shoulin, additional

Published
2022
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42. A multicenter study on surgical procedure selection and risk factor analysis of postoperative complications after TIP and Duckett hypospadias repair

Author

Fang, YiWei, primary, Sun, Ning, additional, Song, HongCheng, additional, Zhang, WeiPing, additional, Tang, YunMan, additional, Huang, LuGang, additional, Yang, Yi, additional, Chao, Min, additional, Ma, Hong, additional, Zhang, JingTi, additional, Zhang, XuHui, additional, Li, ShouLin, additional, Li, Ning, additional, Chen, Chao, additional, He, DaWei, additional, Wu, WenBo, additional, Xie, Hua, additional, and Guan, Yong, additional

Published
2022
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48. Development and Validation of a Nomogram for Predicting Urethral Plate Transection in Hypospadias Surgery: A Nationwide Multicenter Study

Author

Li, Jiayi, primary, Wang, Xinyu, additional, Zhang, Weiping, additional, Fang, Yiwei, additional, Yang, Zhenzhen, additional, Liu, Pei, additional, Fan, Songqiao, additional, Li, Zonghan, additional, Song, Hongcheng, additional, Tang, Yunman, additional, Huang, LuGang, additional, Yang, Yi, additional, Chao, Min, additional, Ma, Hong, additional, Zhang, Jingti, additional, Zhang, Xuhui, additional, Li, Shoulin, additional, Li, Ning, additional, Chen, Chao, additional, He, Dawei, additional, Wu, Wenbo, additional, Xie, Hua, additional, Guan, Yong, additional, Yang, Yanfang, additional, and Yang, Bin, additional

Published
2022
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