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13 results on '"Li, Qinpei"'

1. Assessment and Solution for the Future Trend of the Medical Interpretation Market in China

Author

NGONG,HIN TING OSCAR, Yan, Xinyue, Fan, Yiwen, Cai, Zhe Hao Jacko, Li, Qinpei, Appolloni, Andrea, Series Editor, Caracciolo, Francesco, Series Editor, Ding, Zhuoqi, Series Editor, Gogas, Periklis, Series Editor, Huang, Gordon, Series Editor, Nartea, Gilbert, Series Editor, Ngo, Thanh, Series Editor, Striełkowski, Wadim, Series Editor, Jiang, Yushi, editor, Shvets, Yuriy, editor, and Mallick, Hrushikesh, editor

Published
2022
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6. The SALT OVERLY SENSITIVE 2–CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.

Author

Li, Qinpei, Fu, Haiqi, Yu, Xiang, Wen, Xing, Guo, Hongwei, Guo, Yan, and Li, Jingrui

Subjects
*SALT tolerance in plants, *ARABIDOPSIS, *SALT, *CELLULAR signal transduction
Abstract

High salinity stress promotes plant ethylene biosynthesis and triggers the ethylene signalling response. However, the precise mechanism underlying how plants transduce ethylene signalling in response to salt stress remains largely unknown. In this study, we discovered that SALT OVERLY SENSITIVE 2 (SOS2) inhibits the kinase activity of CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) by phosphorylating the 87th serine (S87). This phosphorylation event activates the ethylene signalling response, leading to enhanced plant salt resistance. Furthermore, through genetic analysis, we determined that the loss of CTR1 or the gain of SOS2-mediated CTR1 phosphorylation both contribute to improved plant salt tolerance. Additionally, in the sos2 mutant, we observed compromised proteolytic processing of ETHYLENE INSENSITIVE 2 (EIN2) and reduced nuclear localization of EIN2 C-terminal fragments (EIN2-C), which correlate with decreased accumulation of ETHYLENE INSENSITIVE 3 (EIN3). Collectively, our findings unveil the role of the SOS2–CTR1 regulatory module in promoting the activation of the ethylene signalling pathway and enhancing plant salt tolerance. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Tactile Recognition in PetH Robot for Wellbeing of the Elderly

Author

Yan, Rui, Li, Qinpei, Tan, Yeow Kee, Wong, Anthony, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Biswas, Jit, editor, Kobayashi, Hisato, editor, Wong, Lawrence, editor, Abdulrazak, Bessam, editor, and Mokhtari, Mounir, editor

Published
2013
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10. New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy

Author

Huijuan Wang, Jun Wang, Li Qinpei, Ailing Ji, Qun Wang, Wen Liu, Mingliang Chen, Yanzhang Li, Tieshan Teng, and Lei Zhang

Subjects
0301 basic medicine, Thyroid Gland, Pharmaceutical Science, Apoptosis, AMP-Activated Protein Kinases, Protein Structure, Secondary, Analytical Chemistry, Drug Discovery, Nuclear Receptor Subfamily 4, Group A, Member 1, thyroid cancer, Molecular Targeted Therapy, Phosphorylation, RNA, Small Interfering, Thyroid cancer, Kinase, Chemistry, TOR Serine-Threonine Kinases, Medullary thyroid cancer, Ribosomal Protein S6 Kinases, 70-kDa, orphan nuclear receptor 4A1 (NR4A1), 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA), Gene Expression Regulation, Neoplastic, Molecular Docking Simulation, Chemistry (miscellaneous), Ribosomal protein s6, Molecular Medicine, Signal transduction, Protein Binding, Antineoplastic Agents, Article, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Cell Line, Tumor, medicine, Humans, Benzopyrans, Protein Interaction Domains and Motifs, Physical and Theoretical Chemistry, Protein kinase A, PI3K/AKT/mTOR pathway, Cell Proliferation, Binding Sites, Organic Chemistry, medicine.disease, 030104 developmental biology, Nuclear receptor, Cancer research, Tumor Suppressor Protein p53
Abstract

Medullary thyroid cancer (MTC) is a relatively rare thyroid cancer responsible for a substantial fraction of thyroid cancer mortality. More effective therapeutic drugs with low toxicity for MTC are urgently needed. Orphan nuclear receptor 4A1 (NR4A1) plays a pivotal role in regulating the proliferation and apoptosis of a variety of tumor cells. Based on the NR4A1 protein structure, 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) was identified from the Specs compounds database using the protein structure-guided virtual screening approach. Computationally-based molecular modeling studies suggested that IMCA has a high affinity for the ligand binding pocket of NR4A1. MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide] and apoptosis assays demonstrated that IMCA resulted in significant thyroid cancer cell death. Immunofluorescence assays showed that IMCA induced NR4A1 translocation from the nucleus to the cytoplasm in thyroid cancer cell lines, which may be involved in the cell apoptotic process. In this study, the quantitative polymerase chain reaction results showed that the IMCA-induced upregulation of sestrin1 and sestrin2 was dose-dependent in thyroid cancer cell lines. Western blot showed that IMCA increased phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) and decreased phosphorylation of ribosomal protein S6 kinase (p70S6K), which is the key enzyme in the mammalian target of rapamycin (mTOR) pathway. The experimental results suggest that IMCA is a drug candidate for MTC therapy and may work by increasing the nuclear export of NR4A1 to the cytoplasm and the tumor protein 53 (p53)-sestrins-AMPK-mTOR signaling pathway.

Published
2018
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