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Objective To systematically assess the applicability of the clinical practice guidelines (CPGs) integrating Chinese and western medicine, thereby providing reference for enhancing their future usability. Methods PubMed, Web of Science, Embase, SinoMed, WanFang Data, and CNKI databases were searched for guidelines for the integration of Chinese and western medicine. Supplementary searches of Chinese Medical Association, Chinese Medicine Administration, MedSci websites, Website of China Association of Chinese Medicine, Medlive, Website of Dangdang, Chinese Association of Integrative Medicine and World Federation of Traditional Chinese Medicine Societies were conducted. The search time frame was from inception of the databases to December 31, 2022. Four reviewers independently evaluated the implementability of clinical practice guidelines by using 'Clinical Practice Guideline (CPG) implementation evaluation tool'. Results A total of 61 integrative Chinese and western medicine guidelines were included. Of the guidelines assessed, 9 guidelines(14.75%) exhibited strong implementability, 40(65.57%) demonstrated average implementability, and 12 (19.67%) demonstrated poor implementability. Among the 5 domains, the dimensions of 'accessibility' and 'implementability' were found to be of high quality, while those of 'communication', 'ease of identification' and 'applicability' were relatively poor. Notably, compared to guidelines published between 2006—2016, those published between 2017—2022 showed improvements in the areas of 'identification' and 'application'. Conclusions The implementabilityof the existing clinical practice guidelines of the integrative Chinese and western medicine is average and needs to be improved. In the future, emphasis should be placed on the integration of medical education and research, publicity of the guidelines, continuous medical education and training, a more concise form of recommendations, application of the guidelines by clinicians, and the implementability of the integrative Chinese and western medicine guideline.

This paper addresses an integrated biomass pricing and logistics network design problem. A bilevel design and pricing model is proposed to capture the dynamic decision process between a biofuel producer as a Stackelberg leader and farmers as Stackelberg followers. The bilevel optimization model is transformed into a tractable single-level formulation by using optimality constraints. Other unique characteristics of our problem at hand include the incorporation of the harvesting time and frequency decisions in the biomass supply chain network design problem for the first time and consideration of the uncertainty in switchgrass yield in a robust optimization setting to take into account the risk-averse behavior of the farmers (suppliers). To efficiently solve the model, we propose a Benders decomposition algorithm enhanced by surrogate constraints, strengthened Benders cuts, and in-out cut loop stabilization. The numerical experiments show that the proposed algorithm is significantly superior to the branch-and-cut approach of CPLEX in terms of run times and gaps. We conduct a case study with data from Texas to validate the capabilities of our mathematical model and solution approach. Based on extensive experiments, the benefits of modeling are analyzed, and significant insights are explored. Funding: This research was partially supported by the National Natural Science Foundation of China [Grants 71771135, 72171129]; and the scholarship from China Scholarship Council (CSC) [Grant CSC 201906210092]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2021.0357. [ABSTRACT FROM AUTHOR]