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Background and purpose: Radiotherapy is an important means to treat pelvic tumors. It is important to improve the accuracy of radiotherapy and enhance the effectiveness. This study aimed to compare and analyze the influence of positioning errors during the radiotherapy of patients using surface guided radiotherapy (SGRT) automatic positioning versus traditional surface marking positioning. Methods: We performed a retrospective analysis of 50 patients with pelvic tumors who received radiotherapy and had simple positioning fixation methods at the Fudan University Shanghai Cancer Center from April 2023 to April 2024. A total of 25 patients were treated using SGRT (observation group), and 25 patients were treated using traditional surface marking (control group). After positioning according to the two positioning techniques, cone beam computed tomography (CBCT) images were collected. These data were compared with the initial reference computed tomography (CT) images within 6 dimensions. The correction error values of the six dimensions were recorded. We calculated the averages, standard deviations, and the number of cases and probabilities in different interval distributions. SPSS 27.0 was used to perform statistical analysis of the data from the two groups of patients. We also analyzed the correlation of patients in the observation group within the 6 dimensions. Results: The non-parametric test showed significant differences in only the LNG and PITCH directions (P

For investigating the corrosion behavior of aluminum alloy materials in saturated NaCl solution environment and selecting suitable materials for this harsh environment, based on the actual working conditions of industrial waste salt refining and recycling equipment, five common types of aluminum alloy materials of 2024, 3003, 5052, 6061 and 7075 were selected to carry out short-term and long-term corrosion experiments in saturated NaCl solution at 70 ℃, 80 ℃, 90 ℃, 100 ℃ and 110 ℃, respectively. The corrosion morphology and corrosion products were analyzed by X-ray diffraction(XRD), scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and other methods. Results indicated that 6061 possessed excellent corrosion resistance in both short-term and long-term corrosion, the corrosion products of aluminum alloy materials were mainly Al2O3 and Al(OH)3, and the corrosion types included local pitting and denudation. Moreover, the simulation predictions revealed that GM(1,1) model could reflect the change law of the aluminum alloy corrosion process well, and the corrosion degree at different times could be calculated to achieve the effect of risk prediction.

In order to investigate the corrosion mechanism of waste salt thermochemical treatment and screen suitable metal materials for use in the reactor, several common alloy materials, including 316L, Inconel625, Incoloy825, C276 and TA2, were selected and subjected to a 20 h short-term corrosion tests at 800, 850 and 900 ℃ in 80% NaCl-20% Na2SO4 mixed salt. Results showed that Inconel625 could be used in the waste salt thermochemical treatment device. The Inconel625 alloy was subjected to a 10 d corrosion test. The corrosion products were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy spectrum analysis (EDS). The main corrosion products were found to be NiO and Cr2O3. It was determined that the corrosion behavior followed the corrosion mechanism “oxidation activation theory” and the “acid-base melting model”.

Simple Summary: This study explores the impact of inflammation on sperm motility of goats, and investigates the potential protective role of quercetin, a natural compound, in preserving sperm functionality. Sperm motility is essential for successful fertilization, yet it is susceptible to impairment by inflammation. Neutrophils, key cellular mediator in the inflammatory responses, which compromise sperm through releasing NETs, phagocytosis and induction of oxidative stress. Quercetin, derived from the plant Cuscuta Chinensis, is known for its antioxidant properties and ability to protect sperm from oxidative damage. In this study, it was found that neutrophils, when activated by sperm, significantly decreased sperm motility and integrity. However, quercetin treatment effectively inhibited the formation of NETs and reduced oxidative stress, helping to preserve sperm motility and the integrity of sperm's plasma membrane and acrosome. The results showed that quercetin had no harmful effects on sperm or neutrophils and improved sperm survival and motility. These findings suggest that quercetin could be developed as a potential sperm protector, offering a new approach to improving fertility rates in livestock by mitigating the detrimental effects of inflammation and oxidative stress on sperm quality. Enhancing or protecting sperm motility has always been a pivotal approach to improving the ewe pregnancy rate. Sperm motility is highly susceptible to the immune status of the reproductive tract. Neutrophil extracellular traps (NETs) have been demonstrated to capture sperm and impair its motility in human, swine, and goat species. Quercetin is a flavonoid derived from Cuscuta Chinensis Lam., which can protect sperm from oxidative damage. In this study, we investigated whether inflammation decreases sperm motility and tried to clarify the potential protective mechanism of quercetin on goat sperm motility. Sperm-triggered NETs were analyzed by immunofluorescence analysis. Sperm acrosome integrity was detected by using giemsa staining. Quercetin exhibited no cytotoxicity towards sperm and PMNs within the concentration range of 20–80 μM. PMNs impaired both the survival rate and rapid linear motility of sperm, while quercetin significantly enhanced these parameters. PMNs captured sperm through NETs composed of DNA, citrullinated histone 3 (citH3), and neutrophil elastase (NE); however, quercetin effectively inhibited the release of sperm-stimulated NETs. The stimulation of PMNs with sperm resulted in a significant increase in levels of ROS and MDA, which decreased by quercetin. Moreover, PMNs caused integrity violation to both the plasma membrane and acrosome in sperm; this effect was significantly alleviated by quercetin. In conclusion, quercetin effectively ameliorated PMN-reduced sperm motility through the inhibition of NETs and oxidative stress, and preserving sperm plasma membrane and acrosome integrity, thereby providing preliminary insights into the underlying mechanisms and theoretical support for the development of potential sperm protectors. [ABSTRACT FROM AUTHOR]

Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. A common strategy for POP reconstruction is to use scaffold materials to reconstruct the prolapsed pelvic organ. However, the existing materials for pelvic reconstruction do not meet the clinical requirements for biocompatibility, mechanics and immunological rejection. To address these concerns, urinary bladder decellularized materials (UBDM) was selected due to their good strain-stress resistance. To enhance its biocompatibility, laminin/nidogen was used to modify the UBDM with a mussel-inspired polydopamine coating. We found that the biocompatibility and mechanical properties of laminin/nidogen-Dopamine-UBDM were significantly enhanced and that the degradation rate of laminin/nidogen-Dopamine-UBDM was markedly reduced. Moreover, the expression of CD31 in the laminin/nidogen-Dopamine-UBDM group was higher than that in the normal UBDM group. The laminin/nidogen-Dopamine-UBDM treatment mainly guided M2 type macrophages and led to an inflammatory response. These results indicate that laminin/nidogen adsorbed urinary bladder decellularized materials are promising for use in pelvic reconstruction., Competing Interests: None.