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The mitochondrial proteins translocation and degradation coordinate to maintain the proteostasis network of mitochondria. Their dysfunction is one of the pathogenesis mechanims of metabolic diseases. The dysfunction of transportation and degradation prevents the nuclear-encoded mitochondrial protein from importing and cells from clearing abnormal proteins in time, which ultimately leads to mitochondrial damage. In the diabetic cardiomyocyte, decreased activity of electron transport chain (ETC), increased production of reactive oxygen species (ROS) and decreased energy productivity caused by disorders of mitochondrial transportation and degradation are main reasons for the development of diabetic cardiomyopathy (DCM).

This review reported lipid mediators associated with inflammatory responses in adipose tissue, pro-inflammatory mediators: eicosane compounds derived from cyclooxy-genase (e.g. prostaglandins); Pro-resolving mediators: lipoxins produced by omega-6 polyunsaturated fatty acids, and resolvins produced by omega-3 polyunsaturated fatty acids. The treatment of inflammatory responses should not be limited to the use of acute cascade antagonists or inhibitors, but should be expanded to take into account the great therapeutic potential of inducers or agonists in the inflammatory resolution phase.

Abstract: To set up a device of cell perfusion, and use the method of cell perfusion -NMR to monitor the 31P spectrum in cells. The result has shown the temperature and pressure and flow rate of the device were invariable relatively and could be controlled. The method of cell perfusion -NMR can monitor the 31P spectrum online, and can Speculate changes of energy metabolism in cells under drug stimulation. [Copyright &y& Elsevier]

Auriculariales accommodates species with diverse basidiomes and hymenophores. From morphological and phylogenetic perspectives, we perform a taxonomic study on Heteroradulum , a recently validated genus within the Auriculariales . The genus Grammatus is merged into Heteroradulum , and thus its generic type G.labyrinthinus is combined with Heteroradulum and G.semis is reaccepted as a member of Heteroradulum . Heteroradulumaustraliense is newly described on the basis of three Australian specimens. Heteroradulumyunnanense is excluded from this genus and its taxonomic position at the generic level is considered uncertain. Accordingly, the circumscription of Heteroradulum is re-delimited and the concept of this genus is adjusted by including irpicoid to poroid hymenophores and a hyphal system with clamp connections or simple septa. A key to all nine accepted species of Heteroradulum is presented., (Qian-Zhu Li, Shi-Liang Liu, Xue-Wei Wang, Tom W. May, Li-Wei Zhou.)

In the title compound, C(26)H(25)ClN(4)O(3)S, the acyclic imine group exhibits an E configuration. The triazole ring is oriented at dihedral angles of 53.84 (2), 70.77 (1) and 32.59 (3)° with respect to the benzene rings of the 2-chloro-benzyl-idene, 4-methyl-benzyl-sulfanyl and 3,4,5-trimethoxy-phenyl groups, respectively. The crystal packing is stabilized by weak inter-molecular C-H⋯N, C-H⋯S and C-H⋯π inter-actions.

In the title mononuclear complex, [Ni(C(8)H(7)O(3))(2)(C(3)H(4)N(2))(2)], the Ni(II) atom, lying on a twofold rotation axis, is coordinated by four carboxyl-ate O atoms from two bidentate 3-hydroxy-phenylacetato ligands and two N atoms from two imidazole mol-ecules in a distorted octa-hedral geometry. A three-dimensional network is formed via inter-molecular O-H⋯O and N-H⋯O hydrogen bonds and π-π stacking inter-actions between the imidazole and benzene rings of neighboring mol-ecules [centroid-centroid distance = 3.856 (2) Å].

The title compound, C(22)H(24)N(4)O(4)S, adopts a trans configuration with respect to the C=N double bond. A weak intra-molecular C-H⋯N hydrogen bond is observed between the N atom of the C=N double bond and its neighboring phenyl H atom. The crystal structure is stabilized by inter-molecular C-H⋯N hydrogen bonds and C-H⋯π inter-actions.

In the mol-ecular structure of the title compound, C(13)H(12)N(2)O(4)S(2), there is a dihedral angle of 0.41 (13)° between the benzene and thia-zole rings. In the crystal, inversion dimers linked by two C-H⋯O inter-actions together with π-π stacking between the parallel benzene rings of adjacent mol-ecules [centroid-centroid distance = 3.673 (2) Å].