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39 results on '"Li, Nantao"'

1. Enhanced Plasmonic Photocatalysis through Cooperative Plasmonic--Photonic Hybridization

Author

Huang, Qinglan, Canady, Taylor D., Gupta, Rohit, Li, Nantao, Singamaneni, Srikanth, and Cunningham, Brian T.

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Plasmonic nanoparticles (NPs) hold tremendous promise for catalyzing light-driven chemical reactions. The conventionally assumed detrimental absorption loss from plasmon damping can now be harvested to drive chemical transformations of the NP adsorbent, through the excitation and transfer of energetic "hot" carriers. The rate and selectivity of plasmonic photocatalysis are dependent on the characteristics of the incident light. By engineering the strength and wavelength of the light harvesting of a NP, it is possible to achieve more efficient and predictive photocatalysts. We report a plasmonic--photonic resonance hybridization strategy to substantially enhance hot electron generation at tunable, narrow-band wavelengths. By coupling the plasmon resonance of silver NPs to the guided mode resonance in a photonic crystal (PC) slab, the reaction rate of a hot-electron-driven reduction conversion is greatly accelerated. The mechanism is broadly compatible with NPs with manifold materials and shapes optimized for the targeted chemistry. The novel enhancement platform sheds light on rational design of high-performance plasmonic photocatalysts., Comment: 18 pages, 4 figures

Published
2019

8. Plasmonic nano-arrays for ultrasensitive bio-sensing

Author

Jiang Jing, Wang Xinhao, Li Shuang, Ding Fei, Li Nantao, Meng Shaoyu, Li Ruifan, Qi Jia, Liu Qingjun, and Liu Gang Logan

Subjects
lspr, nano-array, plasmonics, sensing, spr, Physics, QC1-999
Abstract

Surface plasmon resonance (SPR) and localized SPR (LSPR) effects have been shown as the principles of some highlysensitive sensors in recent decades. Due to the advances in nano-fabrication technology, the plasmon nano-array sensors based on SPR and LSPR phenomena have been widely used in chemical and bioloical analysis. Sensing with surface-enhanced field and sensing for refractive index changes are able to identify the analytes quantitatively and qualitatively. With the newly developed ultrasensitive plasmonic biosensors, platforms with excellent performance have been built for various biomedical applications, including point-of-care diagnosis and personalized medicine. In addition, flexible integration of plasmonics nano-arrays and combining them with electrochemical sensing have significantly enlarged the application scenarios of the plasmonic nano-array sensors, as well as improved the sensing accuracy.

Published
2018
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10. A Target Recycling Amplification Process for the Digital Detection of Exosomal MicroRNAs through Photonic Resonator Absorption Microscopy

Author

Wang, Xiaojing, primary, Shepherd, Skye, additional, Li, Nantao, additional, Che, Congnyu, additional, Song, Tingjie, additional, Xiong, Yanyu, additional, Palm, Isabella Rose, additional, Zhao, Bin, additional, Kohli, Manish, additional, Demirci, Utkan, additional, Lu, Yi, additional, and Cunningham, Brian T., additional

Published
2023
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12. Target Recycling Amplification Process for Digital Detection of Exosomal MicroRNAs Through Photonic Resonator Absorption Microscopy

Author

Wang, Xiaojing, primary, Shepherd, Skye, additional, Li, Nantao, additional, Che, Congnyu, additional, Song, Tingjie, additional, Xiong, Yanyu, additional, Palm, Isabella Rose, additional, Zhao, Bin, additional, Kohli, Manish, additional, Demirci, Utkan, additional, Lu, Yi, additional, and Cunningham, Brian T., additional

Published
2022
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14. Photonic resonator interferometric scattering microscopy

Author

Li, Nantao, primary, Wang, Xiaojing, additional, Tibbs, Joseph, additional, Canady, Taylor D., additional, Huang, Qinglan, additional, Fried, Glenn A., additional, Wang, Xing, additional, Cooper, Laura, additional, Rong, Lijun, additional, Lu, Yi, additional, and Cunningham, Brian T., additional

Published
2022
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15. Microscopies Enabled by Photonic Metamaterials

Author

Xiong, Yanyu, primary, Li, Nantao, additional, Che, Congnyu, additional, Wang, Weijing, additional, Barya, Priyash, additional, Liu, Weinan, additional, Liu, Leyang, additional, Wang, Xiaojing, additional, Wu, Shaoxiong, additional, Hu, Huan, additional, and Cunningham, Brian T., additional

Published
2022
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29. Label-Free Digital Detection of Intact Virions by Enhanced Scattering Microscopy

Author

Li, Nantao, Wang, Xiaojing, Tibbs, Joseph, Che, Congnyu, Peinetti, Ana Sol, Zhao, Bin, Liu, Leyang, Barya, Priyash, Cooper, Laura, Rong, Lijun, Wang, Xing, Lu, Yi, and Cunningham, Brian T.

Abstract

Several applications in health diagnostics, food, safety, and environmental monitoring require rapid, simple, selective, and quantitatively accurate viral load monitoring. Here, we introduce the first label-free biosensing method that rapidly detects and quantifies intact virus in human saliva with single-virion resolution. Using pseudotype SARS-CoV-2 as a representative target, we immobilize aptamers with the ability to differentiate active from inactive virions on a photonic crystal, where the virions are captured through affinity with the spike protein displayed on the outer surface. Once captured, the intrinsic scattering of the virions is amplified and detected through interferometric imaging. Our approach analyzes the motion trajectory of each captured virion, enabling highly selective recognition against nontarget virions, while providing a limit of detection of 1 × 103copies/mL at room temperature. The approach offers an alternative to enzymatic amplification assays for point-of-collection diagnostics.

Published
2022
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30. Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing

Author

Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología, Aguirre Pastor, Miguel Ángel, Long, Kenneth D., Li, Nantao, Manoto, Sello Lebohang, Cunningham, Brian T., Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología, Aguirre Pastor, Miguel Ángel, Long, Kenneth D., Li, Nantao, Manoto, Sello Lebohang, and Cunningham, Brian T.

Abstract

The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.

Published
2018

36. A Target Recycling Amplification Process for the Digital Detection of Exosomal MicroRNAs through Photonic Resonator Absorption Microscopy.

Author

Wang X, Shepherd S, Li N, Che C, Song T, Xiong Y, Palm IR, Zhao B, Kohli M, Demirci U, Lu Y, and Cunningham BT

Subjects
Microscopy, Nucleic Acid Amplification Techniques, Photons, Prognosis, MicroRNAs analysis, Biosensing Techniques, Exosomes chemistry
Abstract

Exosomal microRNAs (miRNAs) have considerable potential as pivotal biomarkers to monitor cancer development, dis-ease progression, treatment effects and prognosis. Here, we report an efficient target recycling amplification process (TRAP) for the digital detection of miRNAs using photonic resonator absorption microscopy. We achieve multiplex digital detection with sub-attomolar sensitivity in 20 minutes, robust selectivity for single nucleotide variants, and a broad dynamic range from 1 aM to 1 pM. Compared with traditional qRT-PCR, TRAP showed similar accuracy in profiling exosomal miRNAs derived from cancer cells, but also exhibited at least 31-fold and 61-fold enhancement in the limits of miRNA-375 and miRNA-21 detection, respectively. The TRAP approach is ideal for exosomal or circulating miRNA biomarker quantification, where the miRNAs are present in low concentrations or sample volume, with potentials for frequent, low-cost, and minimally invasive point-of-care testing., (© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

Published
2023
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37. A Photonic Resonator Interferometric Scattering Microscope for Label-free Detection of Nanometer-Scale Objects with Digital Precision in Point-of-Use Environments.

Author

Liu L, Tibbs J, Li N, Bacon A, Shepherd S, Lee H, Chauhan N, Demirci U, Wang X, and Cunningham BT

Abstract

Label-free detection and digital counting of nanometer-scaled objects such as nanoparticles, viruses, extracellular vesicles, and protein molecules enable a wide range of applications in cancer diagnostics, pathogen detection, and life science research. The contrast of interferometric scattering microscopy is amplified through a photonic crystal surface, upon which scattered light from an object combines with illumination from a monochromatic plane wave source. The use of a photonic crystal substrate for interference scattering microscopy results in reduced requirements for high-intensity lasers or oil-immersion objectives, thus opening a pathway toward instruments that are more suitable for environments outside the optics laboratory. Here, we report the design, implementation, and characterization of a compact Photonic Resonator Interferometric Scattering Microscope (PRISM) designed for point-of-use environments and applications. The instrument incorporates two innovative elements that facilitate operation on a desktop in ordinary laboratory environments by users that do not have optics expertise. First, because scattering microscopes are extremely sensitive to vibration, we incorporated an inexpensive but effective solution of suspending the instrument's main components from a rigid metal framework using elastic bands, resulting in an average of 28.7 dBV reduction in vibration amplitude compared to an office desk. Second, an automated focusing module based on the principle of total internal reflection maintains the stability of image contrast over time and spatial position, facilitating automated data collection. In this work, we characterize the system's performance by measuring the contrast from gold nanoparticles with diameters in the 10-40 nm range and by observing various biological analytes, including HIV virus, SARS-CoV-2 virus, exosomes, and ferritin protein.

Published
2022
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39. Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing.

Author

Aguirre MÁ, Long KD, Li N, Manoto SL, and Cunningham BT

Abstract

The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics., Competing Interests: Conflicts of Interest: The authors declare no conflict of interest.

Published
2018
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