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Indoor 3D reconstruction is particularly challenging due to complex scene structures involving object occlusion and overlap. This paper presents a hybrid indoor reconstruction method that segments the room point cloud into internal and external components, and then reconstructs the room shape and the indoor objects in different ways. We segment the room point cloud into internal and external points based on the assumption that the room shapes are composed of some large external planar structures. For the external, we seek for an appropriate combination of intersecting faces to obtain a lightweight polygonal surface model. For the internal, we define a set of features extracted from the internal points and train a classification model based on random forests to recognize and separate indoor objects. Then, the corresponding computer aided design (CAD) models are placed in the target positions of the indoor objects, converting the reconstruction into a model fitting problem. Finally, the indoor objects and room shapes are combined to generate a complete 3D indoor model. The effectiveness of this method is evaluated on point clouds from different indoor scenes with an average fitting error of about 0.11 m, and the performance is validated by extensive comparisons with state-of-the-art methods. [ABSTRACT FROM AUTHOR]

Studying the structure–property correlation of small-molecule acceptors (SMAs) is beneficial in optimizing their optoelectronic properties and enhancing photovoltaic performance. Here, we designed and synthesized six N,S-heteroarene (axa-indacenodithiophene, NIT)-based SMAs through molecular engineering (side chain, backbone extension and end group), which are defined as the pentacyclic central core series (NIT68, NIT810, and NIT810-F) and the backbone extension series (T-NIT68, NIT810-T, and NIT810-T-F), respectively. The results reveal that end group engineering (fluorination vs. non-fluorination) has a greater effect on the absorption properties and molecular energy levels as compared with side chain (2-hexyldecyl vs. 2-octyldodecyl) and backbone extension engineering. Theoretical calculation suggests that molecular engineering has a tiny impact on the backbone planarity of these NIT-based SMAs, but has a certain effect on the geometric configuration and electronic structure of molecules. Organic solar cells (OSCs) based on these SMAs were fabricated and device performance was optimized. OSCs based on the backbone extension series showed a higher open-circuit voltage (Voc) than those of the pentacyclic central core series, because of upshifted LUMOs. PBDB-T:NIT810-based OSCs exhibited the best power conversion efficiency (PCE) of 7.25% among these six SMAs. However, when PBDB-T was replaced by fluorinated PM6, the fluorinated NIT810-F and NIT810-T-F-based OSCs exhibited an improved PCE of up to 7.78% and 9.51%, respectively, due to the obviously increased fill factor (FF) and short-circuit current density (Jsc). The improved FF and Jsc should be primarily attributed to the increased exciton dissociation and charge transport properties, suppressed bimolecular recombination, and optimized phase separation. Our work focusing on the effect of molecular engineering on molecular structure, optoelectronic and photovoltaic properties will certainly provide some significant guidance for the molecular design of high-performance SMAs. [ABSTRACT FROM AUTHOR]

Noroviruses (NoVs) are the main cause of acute gastroenteritis in all ages worldwide. The aim of this study was to produce the recombinant P protein of norovirus and to demonstrate its blocking effect. In this study, the engineered strains were induced to express the P protein of NoVs GII.4, which was identified using SDS-PAGE and ELISA as having the capacity to bind to histo-blood group antigens (HBGAs). Rabbits were immunized to obtain neutralizing antibodies. ELISA and ISC-RT-qPCR were used to determine the blocking efficacy of the neutralizing antibody to human norovirus (HuNoV) and murine norovirus (MNV). The recombinant P protein (35 KD) was obtained, and the neutralizing antibody was successfully prepared. The neutralizing antibody could block the binding of the P protein and HuNoV to HBGAs. Neutralizing antibodies can also block MNV invasion into host cells RAW264.7. The recombinant P protein expressed in E. coli can induce antibodies to block HuNoV and MNV. The recombinant P protein of NoVs GII.4 has the value of vaccine development. [ABSTRACT FROM AUTHOR]