1. Anti-migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice
- Author
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Mulder, I.A., Li, M. (Minghui), de Vries, T., Qin, T., Yanagisawa, T., Sugimoto, K., van den Bogaerdt, A., Danser, A.H.J. (Jan), Wermer, M.J.H. (Marieke), Maagdenberg, A.M.J.M. (Arn), Maassen van den Brink, A. (Antoinette), Ferrari, M.D. (Michel), Ayata, C., Mulder, I.A., Li, M. (Minghui), de Vries, T., Qin, T., Yanagisawa, T., Sugimoto, K., van den Bogaerdt, A., Danser, A.H.J. (Jan), Wermer, M.J.H. (Marieke), Maagdenberg, A.M.J.M. (Arn), Maassen van den Brink, A. (Antoinette), Ferrari, M.D. (Michel), and Ayata, C.
- Abstract
Objective: Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRPmediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. Methods: Middle cerebral artery was occluded for 12 to 60 minutes in mice. We compared infarct risk and volumes, collateral flow, and neurological deficits after pretreat
- Published
- 2020
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