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Purpose: Previous studies have demonstrated impaired cerebellar function in patients with obstructive sleep apnea (OSA), which is associated with impaired cognition. However, the effects of OSA on resting-state functional connectivity (FC) in the cerebellum has not been determined. The purpose of this study was to investigate resting-state FC of the cerebellar subregions and its relevance to clinical symptoms in patients with OSA. Methods: Sixty-eight patients with OSA and seventy-two healthy controls (HCs) were included in the study. Eight subregions of the cerebellum were selected as regions of interest, and the FC values were calculated for each subregion with other voxels. A correlation analysis was performed to examine the relationship between clinical and cognitive data. Results: Patients with OSA showed higher FC in specific regions, including the right lobule VI with the right posterior middle temporal gyrus and right angular gyrus, the right Crus I with the bilateral precuneus/left superior parietal lobule, and the right Crus II with the precuneus/right posterior cingulate cortex. Furthermore, the oxygen depletion index was negatively correlated with aberrant FC between the right Crus II and the bilateral precuneus / right posterior cingulate cortex in OSA patients (p = 0.004). Conclusion: The cerebellum is functionally lateralized and closely linked to the posterior default mode network. Higher FC is related to cognition, emotion, language, and sleep in OSA. Abnormal FC may offer new neuroimaging evidence and insights for a deeper comprehension of OSA-related alterations. This study reveals altered resting-state functional connectivity in the cerebellum (8 cerebellar subregions) of obstructive sleep apnea (OSA) patients. These changes correlate with cognitive, emotional, linguistic, and sleep deficits, suggesting functional impairments and compensation in the cerebellum of OSA patients. [ABSTRACT FROM AUTHOR]

Objectives: To summarize the clinicopathological and genetic features of malignant paragangliomas in head and neck cancer and to explore the appropriate treatment options for this rare lesion. Methods: Six patients harboring head and neck malignant paraganglioma from Beijing Tongren Hospital were retrospectively reviewed. The clinicopathological characteristics, gene mutations, and prognosis of these patients were analyzed. Results: Of these 6 patients, 3 were male and 3 were female; 4 patients harbored malignant carotid body tumors, and two had malignant vagal paragangliomas. Three patients had cervical lymph node metastasis, two presented with lung and bone metastasis, and 1 had lung and liver metastasis. Of the 6 patients, four underwent surgical resection, and the other two patients denied surgery and instead received chemotherapy with paclitaxel, ifosfamide, and dacarbazine. These 2 patients with vagal paraganglioma received postoperative radiotherapy. All 6 patients are still alive at the present time, with a median follow-up time of 66 months. Positive Ki-67 expression in tumor tissue ranged from 1% to 40%. Genetic mutations in SDHD, SDHB, ATR, and MAP3K13 were identified in 4 patients. Conclusions: After comprehensive treatment, head and neck malignant paraganglioma can attain a favorable prognosis. Genetic mutations are commonly detected in patients with malignant paragangliomas. This study also identified mutations in ATR and MAP3K13 in these patients. [ABSTRACT FROM AUTHOR]

Background: Lung adenocarcinoma, a leading cause of cancer-related mortality, demands precise prognostic indicators for effective management. The presence of spread through air space (STAS) indicates adverse tumor behavior. However, comparative differences between 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography(PET)/computed tomography(CT) and CT in predicting STAS in lung adenocarcinoma remain inadequately explored. This retrospective study analyzes preoperative CT and 18F-FDG PET/CT features to predict STAS, aiming to identify key predictive factors and enhance clinical decision-making. Methods: Between February 2022 and April 2023, 100 patients (108 lesions) who underwent surgery for clinical lung adenocarcinoma were enrolled. All these patients underwent 18F-FDG PET/CT, thin-section chest CT scan, and pathological biopsy. Univariate and multivariate logistic regression was used to analyze CT and 18F-FDG PET/CT image characteristics. Receiver operating characteristic curve analysis was performed to identify a cut-off value. Results: Sixty lesions were positive for STAS, and 48 lesions were negative for STAS. The STAS-positive was frequently observed in acinar predominant. However, STAS-negative was frequently observed in minimally invasive adenocarcinoma. Univariable analysis results revealed that CT features (including nodule type, maximum tumor diameter, maximum solid component diameter, consolidation tumor ratio, pleural indentation, lobulation, spiculation) and all 18F-FDG PET/CT characteristics were statistically significant difference in STAS-positive and STAS-negative lesions. And multivariate logistic regression results showed that the maximum tumor diameter and SUVmax were the independent influencing factors of CT and 18F-FDG PET/CT in STAS, respectively. The area under the curve of maximum tumor diameter and SUVmax was 0.68 vs. 0.82. The cut-off value for maximum tumor diameter and SUVmax was 2.35 vs. 5.05 with a sensitivity of 50.0% vs. 68.3% and specificity of 81.2% vs. 87.5%, which showed that SUVmax was superior to the maximum tumor diameter. Conclusion: The radiological features of SUVmax is the best model for predicting STAS in lung adenocarcinoma. These radiological features could predict STAS with excellent specificity but inferior sensitivity.Highlights: • Evaluated PET/CT and CT features for predicting STAS in lung adenocarcinoma. • SUVmax and maximum tumor diameter were independent influential factors for STAS(+) in lung adenocarcinoma. • SUVmax showed higher predictive efficacy than maximum tumor diameter. • Radiological characteristics may serve as noninvasive biomarkers for STAS prediction in lung adenocarcinoma. [ABSTRACT FROM AUTHOR]

This paper addresses the optimal control problems with an interval-valued objective function. We consider a type of total order relationships ≤ adm between two intervals. For each total order relationship, Kuhn–Tucker sufficient conditions for the optimal control problems with an interval-valued objective function are obtained. A numerical example is considered and solved. Kuhn–Tucker sufficient conditions provided under the total order relationship ≤ adm are sufficient conditions under the partial order relationship ⪯ LU for interval-valued optimal control problems. The results of this paper could help construct evolutionary algorithms to solve interval-valued optimal control problems. [ABSTRACT FROM AUTHOR]

Recent studies confirmed that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) can regulate the proliferation and migration of tumour cells.[[1], [3]] Lung adenocarcinoma (LUAD) is the subtype with the largest proportion of lung cancer.[[5]] Huang et al. confirmed that GABA content in LUAD tissues was obviously higher than normal tissues by collecting clinical tissues.[7] By analysing GABA expression in different LUAD patients, we established a GABA-driven LUAD classification and developed a GABA-driven prognostic signature. (F) Nomogram for LUAD patients. gl In conclusion, based on the differential expression of GABA in LUAD patients, we classified LUAD patients and comprehensively considered the clinical significance of the classification. After difference analysis of these genes in tumour and normal tissue by "limma" package, 108 GABA core difference genes were obtained according to the absolute value of logFC > .5 (Table S1). Based on 108 GABA core differential genes, consensus clustering was performed in The Cancer Genome Atlas (TCGA)-LUAD queue ( I n i = 555) by using the "ConsensusClusterPlus" package. [Extracted from the article]

In this study, ultrahigh-performance concrete (UHPC) was utilized in precast segmental beams to reduce the self-weight, shorten the construction time, and improve the performance and durability of bridges. Owing to the discontinuity in the joints, shear behavior plays a critical role in the overall structural performance of precast UHPC segmental beams (PUSBs). Therefore, four dry-jointed segmental specimens along with one monolithic specimen were designed and tested under a two-point concentrated load with various joint types, shear span-to-depth ratios (λ), and numbers of shear keys. Two types of shear failure modes were observed in the tests: shear compression failure of the web (λ = 1.44 and 2.56) and local shear failure of the flanges at the joint (λ = 3.67). The shear capacity, stiffness, and cracking load of the dry-jointed segmental specimens were lower than those of the monolithic specimen, and the single-keyed specimen exhibited better shear behavior than the three-keyed specimen. Increasing λ decreased the shear strength and stiffness of the segmental beams and considerably affected their failure modes and crack distributions. Additionally, four UHPC design codes were evaluated for their accuracy in estimating the shear strength of the specimens, and a simplified strut-and-tie model was developed to predict the shear strength of externally pre-stressed PUSBs. Finally, several design recommendations were proposed. This study is expected to facilitate the research and application of PUSBs. [ABSTRACT FROM AUTHOR]

Introduction: Extirpation of multiple head and neck paragangliomas carries challenge due to close anatomic relationships with critical neurovascular bundles. Objectives: This study aims to assess whether the application of 3-D models can assist with surgical planning and treatment of these paragangliomas, decrease surgically related morbidity and mortality. Methods: Fourteen patients undergoing surgical resection of multiple head and neck paragangliomas were enrolled in this study. A preoperative 3-D model was created based on radiologic data, and relevant critical anatomic relationships were preoperatively assessed and intraoperatively validated. Results: All 14 patients presented with multiple head and neck paragangliomas, including bilateral carotid body tumors (CBT, n = 9), concurrent CBT with glomus jugulare tumors (GJT, n = 4), and multiple vagal paragangliomas (n = 1). Ten patients underwent genomic analysis and all harbored succinate dehydrogenase complex subunit D (SDHD) mutations. Under guidance of the 3-D model, the internal carotid artery (ICA) was circumferentially encased by tumor on 5 of the operated sides, in 4 (80%) of which the tumor was successfully dissected out from the ICA, whereas ICA reconstruction was required on one side (20%). Following removal of CBT, anterior rerouting of the facial nerve was avoided in 3 (75%) of 4 patients during the extirpation of GJT with assistance of a 3-D model. Two patients developed permanent postoperative vocal cord paralysis. There was no vessel rupture or mortality in this study cohort. Conclusion: The 3-D model is beneficial for establishment of a preoperative strategy, as well as planning and guiding the intraoperative procedure for resection of multiple head and neck paragangliomas. [ABSTRACT FROM AUTHOR]

Due to their featured mechanical and structural merits, such as the light self-weight, excellent prestressing efficiency, appealing appearance, and optimal shear force and bending moment distributions in corrugated steel webs (CSWs) and concrete flanges, the prestressed concrete composite box girders with CSWs (CCBGCSWs) are popularly applied in highway bridges nowadays. To further enhance the cracking resistance of the concrete flanges of conventional prestressed CCBGCSWs, by replacing the regular concrete flanges with that made by ultra-high-performance concrete (UHPC) (i.e., with the much superior mechanical properties), this paper proposed a novel non-prismatic prestressed CSW–UHPC composite box girder to achieve the lighter dead weight, superior spanning capacity, and more rapid and cost-efficient construction for highway bridges. Owing to the differences in both the geometric dimensions and material properties, shear lag behavior of the proposed novel non-prismatic prestressed CSW–UHPC composite box girder could significantly differ from that of conventional prestressed CCBGCSWs. The shear lag effect refers to the non-uniform distributions of the longitudinal bending normal stress within the flanges caused by shear interaction between the webs and flanges, and the improper consideration of the shear lag behavior would impair the safety of thin-walled CCBGCSWs, especially the proposed novel non-prismatic prestressed CSW–UHPC composite box girder. Therefore, to investigate the shear lag behavior of the proposed novel non-prismatic prestressed CSW–UHPC composite box girder during different construction stages, a representative test specimen (5.55 m in length) with different boundary conditions (e.g., simply supported and cantilever) was designed and investigated under five different loading cases using the experimental tests and finite element (FE) analyses. In addition, a modified bar simulation method was proposed for the theoretical analysis of the shear lag behavior of the girder, and its feasibility and effectiveness were demonstrated through the comparisons to the experimental and numerical results. Finally, the results indicated that (i) the shear lag effect of UHPC flanges in the stress concentration region of the proposed novel non-prismatic CSW–UHPC composite box girder was more pronounced than that in the non-stress concentration region under different loading conditions; (ii) the shear lag coefficient (λ) of UHPC flanges in the non-stress and stress concentrated regions of the girder could be conservatively recommended not less than 1.1 and 1.25, respectively; and (iii) the boundary conditions and loading forms had significant influences on the shear lag behavior of the girder. The results of this study could serve as the experimental, numerical, and theoretical references for the shear lag behavior of the novel non-prismatic prestressed CSW–UHPC composite box girders. [ABSTRACT FROM AUTHOR]

Background: Mental stress-induced neurotransmitters can affect the immune system in various ways. Therefore, a better understanding of the role of neurotransmitters in the tumour immune microenvironment is expected to promote the development of novel anti-tumour therapies. Methods: In this study, we analysed the plasma levels of neurotransmitters in anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb)-resistance patients and sensitive patients, to identify significantly different neurotransmitters. Subsequently, animal experiments and experiments in vitro were used to reveal the specific mechanism of norepinephrine's (NE) effect on immunotherapy. Results: The plasma NE levels were higher in anti-PD-1 mAb-resistance patients, which may be the main cause of anti-PD-1 mAb resistance. Then, from the perspective of the immunosuppressive microenvironment to explore the specific mechanism of NE-induced anti-PD-1 mAb resistance, we found that NE can affect the secretion of C-X-C Motif Chemokine Ligand 9 (CXCL9) and adenosine (ADO) in tumour cells, thereby inhibiting chemotaxis and function of CD8+ T cells. Notably, the WNT7A/β-catenin signalling pathway plays a crucial role in this progression. Conclusion: NE can affect the secretion of CXCL9 and ADO in tumour cells, thereby inhibiting chemotaxis and the function of CD8+ T cells and inducing anti-PD-1 mAb resistance in lung adenocarcinoma (LUAD). [ABSTRACT FROM AUTHOR]

Introduction: Resection of carotid body tumor (CBT) in patients of advanced ages has not been appreciated. Objectives: This study aims to assess the clinical characteristics and perioperative comorbidities for CBT resection in patients of advanced age and to validate the application of an "isolated island" technique for extirpation of CBT. Methods: Eight patients of advanced age (≥60 years) who underwent CBT resection were enrolled as the study group (SG). Another 29 patients of younger age (<45 years old) underwent CBT extirpation were assigned as the control group (CG). The perioperative issues were compared between these 2 groups. Results: The "isolated island" technique was successfully applied for resection of CBT in all 37 patients. The prevalence of Shamblin classification I, II, and III tumors in the SG was 12.5%, 62.5%, and 25%; whereas in the CG was 10.3%, 55.2%, and 34.5%, respectively. Bilateral CBT was observed in 7 patients of the CG and none in the SG. Vascular reconstruction was required for 1 (12.5%) patient in the SG, while it was required for 8 (27.6%) patients in the CG. Postoperative vocal cord palsy occurred in 37.5% of patients in SG, whereas the vocal cord palsy (34.5%) and dysphagia (6.9%) were commonly encountered in CG. In addition to postoperative length of stay (P =.004), no significant difference for operative time, intraoperative blood loss, or mortality were observed between these 2 groups (P >.05). Conclusion: Extirpation of CBT in patients of advanced age is rationale in appropriately selected patients. The "isolated island" technique is safe for CBT resection with seemingly low complication rates. [ABSTRACT FROM AUTHOR]

Background: Mycoplasma pneumoniae can be divided into different subtypes on the basis of the sequence differences of adhesive protein P1, but the relationship between different subtypes, macrolide resistance and clinical manifestations are still unclear. In the present study, we established a molecular beacon based real-time polymerase chain reaction (real-time PCR) p1 gene genotyping method, analyzed the macrolide resistance gene mutations and the relationship of clinical characteristics with the genotypes.Methods: A molecular beacon based real-time PCR p1 gene genotyping method was established, the mutation sites of macrolide resistance genes were analyzed by PCR and sequenced, and the relationship of clinical characteristics with the genotypes was analyzed.Results: The detection limit was 1-100 copies/reaction. No cross-reactivity was observed in the two subtypes. In total, samples from 100 patients with positive M. pneumoniae detection results in 2019 and 2021 were genotyped using the beacon based real-time PCR method and P1-1 M. pneumoniae accounted for 69.0%. All the patients had the A2063G mutation in the macrolide resistance related 23S rRNA gene. Novel mutations were also found, which were C2622T, C2150A, C2202G and C2443A mutations. The relationship between p1 gene genotyping and the clinical characteristics were not statistically related.Conclusion: A rapid and easy clinical application molecular beacon based real-time PCR genotyping method targeting the p1 gene was established. A shift from type 1 to type 2 was found and 100.0% macrolide resistance was detected. Our study provided an efficient method for genotyping M. pneumoniae, valuable epidemiological monitoring information and clinical treatment guidance to control high macrolide resistance. [ABSTRACT FROM AUTHOR]

Background  Invasion depth influences the choice for extirpation of nasopharyngeal malignancies. This study aims to validate the feasibility of endoscopic endonasal resection of lesions with a posterolateral invasion. As a secondary goal, the study intends to propose a classification system of endoscopic endonasal nasopharyngectomy determined by the depth of posterolateral invasion. Methods  Eight cadaveric specimens (16 sides) underwent progressive nasopharyngectomy using an endoscopic endonasal approach. Resection of the torus tubarius, Eustachian tube (ET), medial pterygoid plate and muscle, lateral nasal wall, and lateral pterygoid plate and muscle were sequentially performed to expose the fossa of Rosenmüller, petroclival region, parapharyngeal space (PPS), and jugular foramen, respectively. Results  Technical feasibility of endonasal nasopharyngectomy toward a posterolateral direction was validated in all 16 sides. Nasopharyngectomy was classified into four types as follows: (1) type 1: resection restricted to the posterior or superior nasopharynx; (2) type 2: resection includes the torus tubarius which is suitable for lesions extended into the petroclival region; (3) type 3: resection includes the distal cartilaginous ET, medial pterygoid plate, and muscle, often required for lesions extending laterally into the PPS; And (4) type 4: resection includes the lateral nasal wall, pterygoid plates and muscles, and all the cartilaginous ET. This extensive resection is required for lesions involving the carotid artery or extending to the jugular foramen region. Conclusion  Selected lesions with posterolateral invasion into the PPS or jugular foramen is amenable to a resection via expanded endonasal approach. Classification of nasopharyngectomy based on tumor depth of posterolateral invasion helps to plan a surgical approach. [ABSTRACT FROM AUTHOR]

Objectives  The vidian nerve provides parasympathetic innervation to the nasal cavity and the lacrimal gland. Previous anatomic studies have primarily focused on preservation or severance of the vidian nerve proximal to the pterygopalatine ganglion (PPG). This study aimed to assess its neural fibers within the pterygopalatine fossa after synapsing at the PPG, and to explore potential clinical implications for endoscopic endonasal skull base surgery. Methods  An endonasal transpterygoid approach was performed on eight cadaveric specimens (16 sides). The PPG and maxillary nerve within the pterygopalatine fossa were divided. The vidian nerve was traced retrograde into the foramen lacerum, and postganglionic fibers distal to the PPG were dissected following the zygomatic nerve into the orbit. Potential communicating branches between the ophthalmic nerve (V1) and the PPG were also explored. Results  All sides showed a plexus of neural communications between the PPG and the maxillary nerve. The zygomatic nerve exits the maxillary nerve close to the foramen rotundum, piercing the orbitalis muscle to enter the orbit in all sides. The zygomatic nerve was identified running beneath the inferior rectus muscle toward a lateral direction. In 7/16 sides (43.75%), a connecting branch between V 1 and the pterygopalatine ganglion was observed. Conclusion  Neural communications between the PPG and the maxillary nerve were present in all specimens. A neural branch from V 1 to the PPG potentially contributes additional postganglionic parasympathetic function to the lacrimal gland. [ABSTRACT FROM AUTHOR]

In recent years, the research work of artificial intelligence technology has progressed rapidly, and various classic Few-Shot learning models have achieved unprecedented success in many artificial intelligence application fields. These include face recognition, object classification detection and tracking, speech recognition, and natural language processing, which greatly facilitate our lives. This paper aims to identify dance fitness movements based on contour image spatial frequency domain features and Few-Shot learning technology. This paper proposes a Few-Shot learning method based on contrastive average loss for Few-Shot learning. This method makes the learned model more representative by improving the loss function and performing a normalization process, and it proposes a feature extraction algorithm that combines improved LBP and HOG for action recognition technology. The experimental results show that the recognition accuracy of the algorithm in this paper is 93.10%, 90.30%, and 92.70% for walking, opening hands, and running, respectively. This illustrates the effectiveness of the fusion feature algorithm. [ABSTRACT FROM AUTHOR]

Objective  Structural anomalies of the jugular foramen (JF) and adjacent structures may contribute to development of pulsatile tinnitus (PT). The goal of this study was to assess anatomical variants in the ipsilateral JF region in patients with PT and to explore possible predisposing factors for PT. Methods  One hundred ninety-five patients with PT who underwent CT angiography and venography of the temporal bone were retrospectively analyzed. Anatomic variants including dominance of the ipsilateral JF, bony deficiency of the sigmoid sinus and internal carotid artery canal, high riding or dehiscent jugular bulb, dehiscence of the superior semicircular canal, tumors in the JF region, or cerebellopontine angle were assessed. Results  Of 195 patients with PT, the prevalence of a dominant JF on the ipsilateral side of patients with PT was 67.2%. Furthermore, the dominant JF demonstrated a significant correlation with the presence of ipsilateral PT (p  < 0.001). No anatomical variants were present in 22 patients (11.3%), whereas in patients with structural variants, bony deficiency of the sigmoid sinus was most common (65.6%), followed by high riding (54.9%) or dehiscent jugular bulb (14.4%). Dehiscent internal carotid artery canal (3.1%) and superior semicircular canal (4.1%) were occasionally identified, while arteriovenous fistula, arterial aneurysm and tumors arising from the JF region or cerebellopontine angle were rarely encountered. Conclusion  Structural abnormalities of the JF and adjacent structures may predispose to the development of PT. Knowledge of these anatomical variants in the JF region may help establish a clinical strategy for addressing PT. [ABSTRACT FROM AUTHOR]

This paper proposes an alternative time-dependent seismic fragility assessment framework considering the variable correlation of structural random parameters for aging highway bridges subject to non-uniform chloride-induced corrosion attacks. The proposed systematic framework is implemented to perform a probabilistic time-dependent seismic fragility assessment for a typical multi-span reinforced concrete continuous girder (MSRCCG) bridge. Effects of non-uniform chloride-induced deterioration on the time-evolving seismic capacity, seismic demand of reinforced concrete (RC) columns, and the time-dependent seismic fragility of the case-study bridge are investigated using nonlinear sectional moment-curvature and nonlinear time history analysis. Furthermore, this paper performs comparative studies to investigate the influence of variable correlation of structural random parameters on the time-variant seismic capacity, seismic demand of RC columns, and time-dependent seismic fragility of the case-study bridge. The results indicate the following conclusions: (1) Non-uniform chloride-induced corrosion may change the vulnerable position and the damage mechanisms of RC columns; (2) Due to non-uniform chloride-induced deterioration, the flexural capacity and curvature ductility of RC columns may exhibit a nonlinear reduction, while there is a nonlinear accelerated growth of time-dependent seismic fragility for aging highway bridges along their service lives; (3) The time-variant seismic capacity (i.e., the flexural capacity and curvature ductility) and seismic demand of RC columns tends to have a certain reduction and increase by ignoring the variable correlation of structural random parameters, respectively; and (4) The time-dependent seismic vulnerabilities of aging highway bridges may be overestimated by ignoring the variable correlation of structural random parameters. [ABSTRACT FROM AUTHOR]

High-flux solar simulators are research-grade sources of artificial radiation mimicking optical characteristics of concentrating solar systems. They allow for experimental evaluation of high-temperature solar thermal devices and materials under controlled and reproducible conditions. In this study, we demonstrate the application of close-range photogrammetry in tandem with radiometry to optically align radiation modules of a multi-source high-flux solar simulator and to characterize its radiative output. The photogrammetric setup consists of photogrammetry targets, a digital camera and photogrammetry software. The radiometric measurements are conducted using mobile Lambertian targets, a heat flux gauge, and a complementary metal-oxide semi-conductor camera equipped with neutral density filters. An iterative procedure for adjusting lamp positions allows obtaining optical configurations of radiative modules meeting experimental requirements of high and ultra-high temperature solar thermal and thermochemical research. Close-range photogrammetry is demonstrated to be a convenient and effective method to obtain the as-built geometric configuration of the solar simulator setup. We report characteristics of an example radiative module configuration for a subset of six radiation modules. The peak and mean radiative fluxes over a 60-mm diameter flat target located in the focal plane are 3080 kW m−2 and 1135 kW m−2, respectively. The mean aiming error, defined as the average distance between theoretical and actual aiming points in the focal plane, is reduced from 37.20 mm to 4.50 mm for the pre- and post-alignment configurations, respectively. • Optical alignment and radiative flux characterization of a high-flux solar simulator are presented. • A combined methodology of close-range photogrammetry and radiometry is applied. • Close-range photogrammetry allows capturing the geometric configuration of the entire HFSS setup. • The mean aiming error is reduced from 37.20 mm to 4.50 mm after photogrammetry alignment. • A mean radiative flux of 1135 kW m-2 is obtained over a 60-mm dia. flat target using six lamps. [ABSTRACT FROM AUTHOR]

Streptococcus pneumoniae can cause several diseases including otitis media, sinusitis, pneumonia, sepsis and meningitis. The introduction of pneumococcal vaccines has changed the molecular epidemiological and antibiotic resistance profiles of related diseases. Analysis of molecular patterns and genome sequences of clinical strains may facilitate the identification of novel drug resistance mechanism. Three multidrug resistance 19A isolates were verified, serotyped and the complete genomes were sequenced combining the Pacific Biosciences and the Illumina Miseq platform. Genomic annotation revealed that similar central networks were found in the clinical isolates, and Mauve alignments indicated high similarity between different strains. The pan-genome analysis showed the shared and unique cluster in the strains. Mobile elements were predicted in the isolates including prophages and CRISPER systems, which may participate in the virulence and antibiotic resistance of the strains. The presence of 31 virulence factor genes was predicted from other pathogens for PRSP 19339 and 19343, while 30 for PRSP 19087. Meanwhile, 33 genes antibiotic resistance genes were predicted including antibiotic resistance genes, antibiotic-target genes and antibiotic biosynthesis genes. Further analysis of the antibiotic resistance genes revealed new mutations in the isolates. By comparative genomic analysis, we contributed to the understanding of resistance mechanism of the clinical isolates with other serotype strains, which could facilitate the concrete drug resistance mechanism study. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study was to evaluate the effects of nasal surgery on airflow characteristics in patients with obstructive sleep apnea (OSA) by comparing the alterations of airflow characteristics within the nasal and palatopharyngeal cavities. Methods: Thirty patients with OSA and nasal obstruction who underwent nasal surgery were enrolled. A pre- and postoperative 3-dimensional model was constructed, and alterations of airflow characteristics were assessed using the method of computational fluid dynamics. The other subjective and objective clinical indices were also assessed. Results: By comparison with the preoperative value, all postoperative subjective symptoms statistically improved (p < 0.05), while the Apnea-Hypopnea Index (AHI) changed little (p = 0.492); the postoperative airflow velocity and pressure in both nasal and palatopharyngeal cavities, nasal and palatopharyngeal pressure differences, and total upper airway resistance statistically decreased (all p < 0.01). A significant difference was derived for correlation between the alteration of simulation metrics with subjective improvements (p < 0.05), except with the AHI (p > 0.05). Conclusion: Nasal surgery can decrease the total resistance of the upper airway and increase the nasal airflow volume and subjective sleep quality in patients with OSA and nasal obstruction. The altered airflow characteristics might contribute to the postoperative reduction of pharyngeal collapse in a subset of OSA patients. [ABSTRACT FROM AUTHOR]

[Display omitted] • Key factors for lignin dissociation are investigated by DFT and machine learning. • Oxidating C α -OH to C α = O in lignin benefits the cleavage of β-O-4 and β-1 bonds. • Hydroxyl and methoxy benefit the cleavage of C β -1 and C α -C β bonds in β-1 dimer. • Chlorine atoms substituting in the benzene ring favor the cleavage of β-O-4 bond. • n-Hexane favors the cleavage of C α -C β bond while water has the opposite effect. The bond dissociation energy (BDE) of lignin is a key factor for lignin depolymerization, assisting in revealing the depolymerization mechanism. However, the impact of substituent as well as solvent, which usually stay together, on BDE of lignin remains unclear. Here, density functional theory (DFT) calculation is employed to compute the BDE of C–O and C–C bonds in lignin oligomers with six substituents in four solvents. The relationship models between multiple factors and BDE are established using random forest algorithm, achieving a predictive accuracy of 0.97. The results show that oxidating hydroxyl to ketone benefits the cleavage of β-O-4 and β-1 bonds. Hydroxyl and methoxy effectively contribute to breaking the C β -1 and C α –C β bonds in the β-1 dimer. Polar solvents combined with hydroxyl promote C–O bond dissociation, while alkyl-containing solvents favor C–C bond dissociation. These findings provide valuable insights into lignin depolymerization, pre-depolymerization structural modifications, and the prediction of depolymerization pathways. [ABSTRACT FROM AUTHOR]

Precast Ultra-High-Performance Concrete (UHPC) segmental bridges (PUSBs) are among the most promising structural systems owing to their potential for application in advanced philosophies, such as green and intelligent construction technology, industrialization, prefabrication, and automation. The joints, where precast segments are connected, play a significant role in the construction and structural performance of PUSBs. This study reviews the state-of-the-art knowledge on the shear behavior of UHPC joints, which includes the following aspects: (1) the introduction of joints in PUSBs, including their role, types, experimental methods, and typical shear responses; (2) the development of the experimental database of the push-off tests conducted on UHPC joints; (3) a discussion of the influence of critical factors (e.g., UHPC strength, joint type, confining stress, fiber characteristics, and shear key design) on the shear behavior of UHPC joints; (4) a summary and evaluation of the current analytical models and formulae for predicting the shear resistance of UHPC joints; and (5) the identification of current challenges and recommendations of future research directions for UHPC joints. This review is expected to comprehensively understand the shear performance of UHPC joints and facilitate the research and application of UHPC structures. [Display omitted] • A state-of-the-art review is conducted on the shear performance of joints in precast UHPC members. • The critical factors affecting the shear behavior of UHPC joints are discussed. • Analytical models for predicting the shear strength of UHPC joints are summarized and compared. • Existing formulae for the shear strength of UHPC joints are evaluated based on the experimental database. [ABSTRACT FROM AUTHOR]

In this study, we consider monotone comparative statics under interval uncertainty. We introduce interval-valued supermodular functions and interval-valued quasisupermodular functions with respect to a partial order relation on intervals. In addition, we obtain some sufficient conditions for monotone comparative statics under interval uncertainty. We also apply our results to discuss the monotone comparative statics of interval game with strategic complements. [ABSTRACT FROM AUTHOR]

• A new one-dimensional beam-type refined finite element accounting for non-uniform distortional warping and shear deformation effect is formulated; • The extra distortional angle is introduced to incorporate the secondary distortional moment deformation effect; • The distortional angle and primary distortional curvature are selected as the degrees of freedom for the establishment of the beam finite elements; • The proposed beam finite elements are desirable to the predictions of distortional behavior of thin-walled single- or multi-cell box girders with constant or variable depth; • The significance of the inclusion of secondary distortional deformation effect on the distortional performance is verified. In this paper, a novel one-dimensional refined beam finite element model (FEM) accounting for non-uniform distortional warping and secondary distortional moment deformation effect (SDMDE) is formulated for the distortional analysis of thin-walled multi-cell box girders with cantilevered flanges. The extra distortional angle is introduced to incorporate SDMDE, and the validity of which is proved through rigorous theoretical derivation. The in-plane and out-plane deformations at any point around the edge of transverse section built upon the distortional center are unified in the same form and described in detail. The governing differential equations in terms of two generalized displacements, distortional angle χ and primary distortional angle curvature Θ , are derived based on the principle of minimum potential energy (MPE) and solved exactly so as to provide non-polynomial shape functions for the establishment of element stiffness matrix and nodal load vector. A series of multi-cell rectangular hollow section (RHS) girders are analyzed and particular extensions are given to single-cell and multi-cell bridge girders with cantilevered flanges. Comparisons to the results generated from corresponding ones provided by pioneering work or shell FEM analyses not only validate the correctness and reliability of the present beam element formulations but also highlight the significance of the inclusion of SDMDE when the cantilevered flanges are arranged. [ABSTRACT FROM AUTHOR]

Objective  Access to the infratemporal fossa (ITF) is complicated by its complex neurovascular relationships. In addition, copious bleeding from the pterygoid plexus adds to surgical challenge. This study aims to detail the anatomical relationships among the internal maxillary artery (IMA), pterygoid plexus, V 3, and pterygoid muscles in ITF. Furthermore, it introduces a novel approach that displaces the lateral pterygoid plate (LPP) to access the foramen ovale. Design and Main Outcome Measures  Six cadaveric specimens (12 sides) were dissected using an endonasal approach to the ITF modified by releasing and displacing the LPP and lateral pterygoid muscle (LPTM) as a unit. Subperiosteal elevation of the superior head of LPTM revealed the foramen ovale. The anatomic relationships among the V 3 , pterygoid muscles, pterygoid plexus, and IMA were surveyed. Results  In 9/12 sides (75%), the proximal IMA ran between the temporalis and the LPTM, whereas in 3/12 sides (25%), the IMA pierced the LPTM. The deep temporal nerve was a consistent landmark to separate the superior and inferior heads of LPTM. An endonasal approach displacing the LPP in combination with a subperiosteal elevation of the superior head of LPTM provided access to the posterior trunk of V 3 and foramen ovale while sparing injury of the LPTM and exposing the pterygoid plexus. The anterior trunk of V 3 traveled anterolaterally along the greater wing of sphenoid in all specimens. Conclusion  Displacement of the LPP and LPTM provided direct exposure of foramen ovale and V 3 avoiding dissection of the muscle and pterygoid plexus; thus, this maneuver may prevent intraoperative bleeding and postoperative trismus. [ABSTRACT FROM AUTHOR]

Objectives  The clinical and radiological characteristics of the basal cell adenoma (BCA) and its association with the internal carotid artery (ICA) in the parapharyngeal space (PPS), have not been sufficiently explored. This study aims to analyze the characteristics of patients with BCA arising in the PPS and to evaluate the feasibility of a total resection via an endoscopic transoral corridor. Design and Main Outcome Measures  The clinical, radiological, and histopathological characteristics of four patients with BCA arising in the PPS were retrospectively analyzed. The endoscopic transoral approach was performed for resection of BCA. Its technical nuances, perioperative comorbidities, and outcomes are introduced. Results  The clinical presentation, symptoms, and signs of patients with BCA are variable. The tumor was lateral to the ICA in two patients and anterior to the ICA in the remaining two. All four BCA were successfully removed en bloc (n  = 3) or by piecemeal (n  = 1) via an endoscopic transoral approach. The ICA was not injured, and no additional nerve damage, venous bleeding, postoperative infection, or salivary gland fistula were encountered in any of the four patients. Cystic degeneration is the predominant appearance of BCA on MRI; however, they are difficult to differentiate from other lesions arising in the PPS. No recurrence was detected at the time of the study analysis. Conclusion  BCA of the PPS could have variable relationships with the ICA. An endoscopic transoral approach can provide an adequate corridor for total resection of BCA in PPS with seemingly low morbidity. [ABSTRACT FROM AUTHOR]

This study conducts an impact assessment of flammable gas dispersion and fire hazards from LNG tank leak. The release source model is used to estimate LNG release rate. A CFD (computational fluid dynamics) based 3D model is established to simulate dispersion behavior of flammable gas from the phase transformation of LNG. Subsequently, a FDS (fire dynamics) based model is built to simulate the pool fire due to LNG tank leak. The impact of gas dispersion and fire on personnel and assets is assessed based on simulation results, which can provide a theoretical basis and method support for major accident assessment of tank leakage in large LNG receiving station. The results show that the dispersion of flammable gas from LNG tank leak has an obvious stage characteristic. The flammable gas reached a steady state around 300 s, and the corresponding coverage area is about 16250 m2. The pool fire simulations indicate that the steady flame is formed at 20 s. The flames flow along the wind, and the maximum temperature of the fire reaches 670°C, and the maximum thermal radiation reaches 624 kW/m2. According to the fire damage criteria, the pool fire from LNG tank leak may pose a serious threat on the safety of adjacent assets and personnel. [ABSTRACT FROM AUTHOR]

Nasal septal deviations (NSD) have been categorized into 7 types. The effect of these different deviations on airflow pattern and warming function has not been fully investigated. The purpose of this study was to utilize a computational fluid dynamics approach to assess the impact of NSD of varying types on nasal airflow and warming function. Patients with each type of NSD were enrolled in the study, and a normal participant as the control. Using a computational fluid dynamics approach, modeling of nasal function was performed. Indices of nasal function including airflow redistribution, total nasal resistance, airflow velocity, and airflow temperature were determined. Among all types of NSD, the maximal velocity and total nasal resistance were markedly higher in type 4 and 7 deviations. The flow partition and velocity distribution were also altered in type 4 and 7 as well as type 2 and 6 deviations. Airflow in all categories of NSD was fully warmed to a similar degree. From a computational aerodynamics perspective, the type of septal deviation may contribute to altered airflow characteristics. However, warming function was similar between septal deviation types. Future studies will help to ascertain the functional importance of septal deviation types and the applicability of these computational studies. [ABSTRACT FROM AUTHOR]

• An updated database consisting of 532 UHPC beams that failed by shear is established. • Ten ML models with different algorithms are developed to predict the shear strength of UHPC beams. • The performance of the ML models is evaluated and compared to empirical models. • The ML models are interpreted using the SHAP methods. • The impact of critical features on the shear strength of UHPC beams is identified. To provide more accurate and reliable predictions of the shear strength of ultrahigh-performance concrete (UHPC) beams, in this study, the machine learning (ML) approaches were employed to develop the data-driven models, and the ML models were interpreted using the Shapley additive explanations (SHAP) method. It was found that the ensemble models, particularly CatBoost, outperform individual ML models and traditional empirical models. The geometric dimensions and shear span-to-depth ratio were the most influential features for predicting the shear strength of UHPC beams, followed by the parameters of reinforcement and material properties of the UHPC. [ABSTRACT FROM AUTHOR]

Background: The surgical significance of the lingual process of the sphenoid bone (LPSB) has not been sufficiently addressed. The purpose of this study was to describe the anatomical details of the LPSB in relation to the quadrangular space. Moreover, the incidence of the LPSB and its correlation with the pneumatization of the sphenoid sinus and the development of the lateral recess of the sphenoid sinus (LRSS) were also evaluated. Methods: A dissection and exposure of the LPSB and the quadrangular space was performed on 10 cadaveric specimens (20 sides). The incidence, length, and height of the LPSB were also assessed on computed tomography (CT) images (60 patients, 120 sides). The association between the presence of the LPSB with the pneumatization type of the sphenoid sinus and the presence of a LRSS was evaluated. Results: In a cadaveric model, the LPSB, in association with the petrolingual ligament extending from the LPSB to the petrous apex, was identified on 7 sides (35%). The LPSB was continuous with the mandibular strut. The overall incidence of a LPSB was 48.33% on CT images, and the average length and height of the LPSB was (mean ± standard deviation) 5.30 ± 1.44 mm and 6.51 ± 1.32 mm, respectively. A significant correlation was identified between presence of the LPSB with the pneumatization type of the sphenoid sinus (p = 0.004) but no correlation was identified with the presence of the LRSS (p = 0.071). Conclusion: The LPSB and the petrolingual ligament are useful landmarks for procedures in the quadrangular space and Meckel's cave. However, the LPSB is not consistently present. [ABSTRACT FROM AUTHOR]

In this study, the impacts of the tropical Pacific-Indian Ocean associated mode (PIOAM) on Madden-Julian Oscillation (MJO) activity were investigated using reanalysis data. In the positive (negative) phase of the PIOAM, the amplitudes of MJO zonal wind and outgoing longwave radiation are significantly weakened (enhanced) over the Indian Ocean, while they are enhanced (weakened) over the central and eastern Pacific. The eastward propagation of the MJO can extend to the central Pacific in the positive phase of the PIOAM, whereas it is mainly confined to west of 160°E in the negative phase. The PIOAM impacts MJO activity by modifying the atmospheric circulation and moisture budget. Anomalous ascending (descending) motion and positive (negative) moisture anomalies occur over the western Indian Ocean and central-eastern Pacific (Maritime Continent and western Pacific) during the positive phase of the PIOAM. The anomalous circulation is almost the opposite in the negative phases of the PIOAM. This anomalous circulation and moisture can modulate the activity of the MJO. The stronger moistening over the Indian Ocean induced by zonal and vertical moisture advection leads to the stronger MJO activity over the Indian Ocean in the negative phase of the PIOAM. During the positive phase of the PIOAM, the MJO propagates farther east over the central Pacific owing to the stronger moistening there, which is mainly attributable to the meridional and vertical moisture advection, especially low-frequency background state moisture advection by the MJO's meridional and vertical velocities. [ABSTRACT FROM AUTHOR]

This paper proposes an alternative time-dependent seismic fragility assessment framework for aging highway bridges considering the non-uniform chloride-induced corrosion and various modeling uncertainty parameters. Firstly, sensitivity analysis with the tornado diagram technique is performed to determine the sensitivity of some typical bridge engineering demand parameters (EDPs) to 22 modeling related uncertain parameters, and then 10 critical parameters are identified. Subsequently, based on a series of nonlinear time history analyses (NLTHAs) on the sample models generated by using the Latin hypercube sampling (LHS) method, comparative studies for the time-invariant and time-evolving seismic response, as well as the time-dependent seismic fragility estimates incorporating different levels of uncertainty are performed, respectively. It is concluded that (1) the uncertainty of the modeling related uncertain parameters may lead to the difference in the trajectory of seismic hysteretic response for a given bridge member, whereas the variation of the peak value of seismic response may result from the couple contributions of the uncertainty of ground motions and modeling related parameters; (2) the inclusion of only ground motion uncertainty is inadequate and inappropriate, and the proper way is to incorporate the uncertainty of the identified critical modeling parameters and ground motions into the time-evolving seismic response and the time-dependent seismic fragility assessment of the deteriorating highway bridges. [ABSTRACT FROM AUTHOR]

• Solar central receiver systems with a polar field and an optional CPC are studied. • Effects of geometrical parameters on energetic and economic performance are explored. • Optimal performance for selected receiver temperatures (600–1800 K) are obtained. • Overall minimum levelized cost of exergy is obtained by a no-CPC system at 900 K. • A CPC benefits energetic and economic performance for receiver temperatures >900 and 1200 K, respectively. Energetic and economic characteristics are studied for solar central receiver systems consisting of a polar heliostat field, a tower, a single-aperture cavity receiver, and an optional compound parabolic concentrator (CPC). System characterization and optimization are performed with a numerical model combining an in-house developed Monte-Carlo ray-tracing optical model, a simplified receiver heat transfer model, and a cost model based on the System Advisor Model (SAM). Based on the model, the effects of receiver temperature on the optical configuration of cost-optimal systems are elucidated, along with the benefits of using a CPC for improved energetic and economic performance. Under the assumptions made in this study, it is found that the overall minimum levelized cost of exergy is obtained by a non-CPC system with a receiver operated at approximately 900 K. A CPC benefits both the energetic and economic performance of systems only at elevated temperatures. The working temperature thresholds at which the energetic and economic performance benefit from the addition of a CPC are identified as 900 K and 1200 K, respectively. The general formulation of the model and broad range of values of the investigated parameters provide a universal predictive capability for studying techno-economic performance of concentrating solar thermal systems. [ABSTRACT FROM AUTHOR]

Prediction and control of ground vibrations become essential as with the development of neighborhoods in the proximity of active mining operations or the need for new infrastructure in urban centers, both requiring the use of blasting. Novel ground vibration prediction models attempt to reproduce a whole vibration waveform from a blast and are based, in most cases, on the collection of vibrational information from a single blasthole. A single blasthole should have the same characteristics (geometry and weights of explosives) as the blastholes used in production shots. In some cases, the collection of the fundamental information (the signature) is straightforward. In more complex cases, the fundamental information from ground vibration data is collected from previous production shots. This study presents a novel methodology to assess the fundamental ground vibration information (the signature) using known information such as one event waveform (a production shot waveform) and the timing sequence used (the comb function) for the shot. The methodology is based on the analysis of group delay, a concept widely used in signal processing, and is modified here for the analysis of ground vibration waveforms. The methodology is developed using real data collected in coal and quarry mining operations, and at the end of this document, one case study with step-by-step calculations is presented to show the benefits of the methodology. [ABSTRACT FROM AUTHOR]

This paper proposes an improved uniform design (UD)-response surface model (RSM) method to reduce the impacts of sample correlation among small sample data caused by UD method and variable substitution process in the traditional UD-RSM method. The proposed B-spline-PLS-UD-RSM method, which is a systematic approach that combines nonlinear B-spline functions, the conventional UD-RSM method and the partial least-squares (PLS) regression technique, assesses the reliability of structures with high nonlinearity and multi-dimensionality. First, two reliability examples from the literature are investigated to demonstrate the efficiency and accuracy of the proposed RSM method. Subsequently, to investigate the applicability of the proposed method in seismic fragility analyses considering various parameter uncertainties and variable correlation, an alternative seismic fragility assessment framework is developed for highway bridges. Furthermore, this paper uses a typical multi-span reinforced concrete continuous girder (MSRCCG) bridge as a case study and performs a comparative analysis of the corresponding seismic fragility evaluations at both bridge component and system levels by using traditional and improved RSM methods. The results indicate the following conclusions: (1) The proposed B-spline-PLS-UD-RSM method can properly reduce the effect of sample correlation and achieve satisfactory reliability results for structures with highly nonlinear and multi-dimensional features through a much smaller sample size; (2) The proposed seismic fragility assessment framework is a good candidate for evaluating the seismic vulnerability of highway bridges incorporating variable correlation of structural parameters; (3) Seismic fragilities of bridge structures tend to be overestimated by using traditional UD-RSM methods and by ignoring the variable correlation of structural random parameters. [ABSTRACT FROM AUTHOR]

Traumatic brain injury (TBI) is one of the leading causes of mortality and permanent disabilities worldwide. Brain edema following TBI remains to be the predominant cause of mortality and disability in patients worldwide. Previous studies have reported that brain edema is closely associated with aquaporin-4 (AQP4) expression. AQP4 is a water channel protein and mediates water homeostasis in a variety of brain disorders. In the current study, a rat TBI model was established, and the features of brain edema following TBI were assessed using multimodal MRI. The results of the multimodal MRI were useful, reliable and were used to evaluate the extent and the type of brain edema following TBI. Brain edema was also successfully alleviated using an intracerebral injection of AQP4 small interfering (si)RNA. The expression of AQP4 and its role in brain edema were also examined in the present study. The AQP4 siRNA was demonstrated to downregulate AQP4 expression following TBI and reduced brain edema at the early stages of TBI (6 and 12 h). The current study revealed the MRI features of brain edema and the changes in AQP4 expression exhibited following TBI, and the results provide important information that can be used to improve the early diagnosis and treatment of brain edema. [ABSTRACT FROM AUTHOR]

Red clay is a special soil layer with complex engineering properties distributed in tropical and subtropical regions. An anchor cable support is a common form of red clay slope support. The effectiveness of the anchor cable support is mainly determined by the anchoring force provided by the red clay stratum. Increase of the water content will lead to the rapid deterioration of the mechanical properties of red clay, which will lead to the reduction of the anchoring force of the slope anchor cable and lead to the failure of the support. Based on the classical Phillips and uniform anchorage shear stress distribution theory, this paper puts forward a uniform-exponential distribution pattern of anchorage shear stress according to the specific characteristics of red clay by using the characteristics of the peak shear strength and residual shear strength of the rock and soil mass. With increasing anchorage force, the dynamic evolution (single exponential distribution ⟶ double single exponential distribution ⟶ uniform index exponential complex distribution ⟶ uniform distribution) of the anchorage shear stress is analysed. Based on the peak and residual test of the cohesive force and internal friction angle, the relationship between the anchoring force and buried depth and water content is established by analysing the factors influencing the anchoring force. It can be found from the field test that, according to the relationship established, the limit anchorage force of the anchor cable in the red clay stratum can be calculated and the water sensitivity of the anchor cable's limit anchorage force can be quantitatively analysed. [ABSTRACT FROM AUTHOR]

Background: Various pathologies, including cerebrospinal fluid leaks and meningoencephaloceles, may arise in the lateral recess of the sphenoid sinus (LRSS), which may be accessed via an endonasal transpterygoid approach. The objective of this study was to evaluate the feasibility of accessing the LRSS via an endoscopic prelacrimal approach. Furthermore, we hypothesized that this approach may protect the pterygopalatine ganglion and vidian nerve. Methods: Five cadaveric heads (9 sides) with a well‐pneumatized LRSS were identified and an endonasal prelacrimal approach was performed. The infraorbital nerve, at the orbital floor, served as a critical landmark. After identification of the foramen rotundum at the pterygoid base, the vascular compartment of the pterygopalatine fossa and the pterygopalatine ganglion were displaced inferomedially and superomedially, respectively. Drilling of the bone inferomedial to the foramen rotundum allowed entry into the LRSS. Results: The average distances from the prelacrimal window to the pterygoid base and the posterior wall of the LRSS were 6.22 ± 0.39 cm and 7.16 ± 0.50 cm, respectively. The average areas of the bony prelacrimal window and pterygoid base window were 4.33 ± 0.32 cm2 and 0.73 ± 0.10 cm2, respectively. The LRSS could be accessed using a 0‐degree endoscope, and pterygopalatine neurovascular structures, including the pterygopalatine ganglion and vidian nerve, could be preserved on all 9 sides. Conclusion: Our findings suggest that an endonasal prelacrimal approach provides a reasonable alternative to access the LRSS while preserving the vidian nerve and pterygopalatine ganglion. [ABSTRACT FROM AUTHOR]

Background: The functional significance of the posterior segment of the septum is not fully understood. Aims/Objectives: The purpose of this study was to evaluate the impact of posterior septum resection with varying extents on nasal airflow pattern and warming function, and to determine the appropriate resection extent on posterior septum without disturbing airflow pattern. Material and Methods: Three dimensional models were established from the nasal CT scan of a healthy female volunteer without nasal disease. The models included the normal, as well as 1 cm, 2 cm, and 3 cm extent of posterior septum resection by virtual surgery. Using computational fluid dynamics, the airflow characteristics such as average and peak airflow velocity, average wall shear stress, average temperature and turbulence kinetic energy were recorded and compared among the four models. Results: By comparison with the normal model, the virtual surgeries with varying extents of posterior septum resection (1 cm, 2 cm, and 3 cm), demonstrated little alteration on indices of the average and peak airflow velocity, average wall shear stress, airflow temperature and turbulence kinetic energy. However, a statistical difference of the abovementioned indices existed when compared between varying planes of the nasal cavity (p <.001), although this did not appear to be significantly influenced by the degree of posterior septectomy. Conclusions and significance: From an aerodynamics perspective, little disturbance on airflow pattern and warming function of nasal cavity could be detected with increasing resection of posterior septum (up to 3 cm). These results may imply that resection of the posterior septum (up to 3 cm) has little impact on nasal function. [ABSTRACT FROM AUTHOR]

Background: To investigate whether the serum free thyroxine (FT4) level is a prognostic factor for the first-attack neuromyelitis optica spectrum disorders (NMOSD).Methods: This retrospective study enrolled 109 patients with first-attack NMOSD. The Expanded Disability Status Scale (EDSS) and the relapse rate were used to evaluate the outcomes. The logistic regression model was used to analyze the independent effects of FT4 on relapse and final EDSS. Kaplan-Meier analysis, scatter plot smoothing method, and two-phase piecewise linear regression model were used to investigate the relationship between the FT4 level and the relapse rate.Results: Multivariate analysis revealed that serum FT4 level might be a risk factor for both final EDSS (β = 0.17; 95% confidence interval: 0.03-0.32) and the relapse rate (HR = 1.18; 95% confidence interval: 1.05-1.32). Furthermore, 1400 days after the onset, nearly 100% of patients in the high-FT4 group relapsed, while only 40% of the patients in the low-FT4 group relapsed. Finally, we found that the relationship between the FT4 level and the NMOSD relapse rate was nonlinear. The risk of NMOSD relapse increased with the FT4 level up to the inflection point of 12.01 pmol/L (HR = 1.45; 95% confidence interval: 1.06-1.98). When the FT4 level was > 12.01 pmol/L, there was no correlation between the FT4 level and the risk of NMOSD relapse (HR = 1.05; 95% confidence interval: 0.78-1.41).Conclusion: Serum FT4 level may be a prognostic indicator for the first-attack in patients with NMOSD. High FT4 levels are associated with poor neurofunctions and a high relapse rate in patients with the first-attack in patients with NMOSD. [ABSTRACT FROM AUTHOR]

• Flat and curved reflectors are investigated for redirecting convergent radiative beams. • Monte Carlo ray-tracing optical simulations are employed. • Optical characteristics of output beams are discussed. • Benefits and disadvantages of the investigated reflectors are explored. We investigate optical characteristics of flat, ellipsoidal, hyperboloidal, and paraboloidal reflectors for redirecting convergent radiative beams common in concentrating solar applications. Optical simulations are performed with selected types of radiative sources including a generic uniformly-emitting spherical cap and a specific realization of a multi-source high-flux solar simulator. Two-dimensional ray-tracing simulations are conducted for an ideal optical system without optical imperfections consisting of a spherical cap source, a beam-redirecting reflector, and a target tailored to capture all radiation. System optical performance is evaluated in terms of output beam optical characteristics of rim angle, ray distribution and relative position to the input beam. Three-dimensional Monte-Carlo ray-tracing simulations are performed for a practical optical system with a realistic solar simulator as radiation source and the four beam-redirecting reflectors. We predict optical characteristics of resulting radiative power, spatial and directional flux distribution, optical efficiencies on specified flat and hemispherical targets, and clearance between simulator, reflector and target. From the model system with a solar simulator and exemplary parameters, it is concluded that the investigated four types of reflectors enable redirection of the horizontal-axis beam from the solar simulator to non-horizontal axis targets. The flat reflector enables the highest system optical efficiency of 97% at the expense of the smallest clearance between the source, the reflector and the reflected image. Curved reflectors render a larger degree of freedom to design the characteristics of the output beam. Thus, curved reflectors are suitable for applications that require large clearance between system components and/or high radiative flux output on cavity surface, but at the expense of lower system optical efficiency. [ABSTRACT FROM AUTHOR]

Background: Endonasal access to the inferomedial and inferolateral intraconal space via the orbital floor has not been reported. The primary purpose of this study was to assess the feasibility of accessing the inferior intraconal space through the orbital floor via a transnasal prelacrimal approach. Secondarily, it aims to highlight anatomical relationships of neurovascular structures in this space, as a requirement to prevent complications. Methods: Six cadaveric heads (12 sides) were dissected using a transnasal prelacrimal approach. The orbital floor, medial to the infraorbital canal, was removed and the periorbita opened to expose the inferior rectus muscle. The inferomedial and inferolateral intraconal space was accessed alongside the medial and lateral border of inferior rectus muscle, respectively. Various anatomical relationships of adjacent neurovascular structures were recorded, and the distances among the recti muscles and optic nerve were also measured. Results: The infraorbital nerve is located at the inferolateral aspect of inferior rectus muscle. In the inferomedial intraconal space, we identified the inferomedial muscular trunk of the ophthalmic artery, optic nerve, and branches of the oculomotor nerve; whereas the inferolateral intraconal space contained the inferolateral muscular trunk of ophthalmic artery, branches of the oculomotor and nasociliary nerve, and abducens nerve. Distances from the medial, inferior, and lateral recti muscles to the optic nerve were (mean ± standard deviation) 4.70 ± 1.18 mm, 5.60 ± 0.93 mm, and 7.98 ± 1.99 mm, respectively. Distances from the inferior rectus muscle to the inferior borders of medial and lateral recti muscles were 4.45 ± 1.23 mm and 8.77 ± 1.80 mm. Conclusion: It is feasible to access the inferior intraconal space through the orbital floor via a transnasal prelacrimal approach. The access may be subdivided into inferomedial and inferolateral corridors according to the entry point at the medial or lateral border of the inferior rectus muscle. Neurovascular structures in the inferior intraconal space are visualized directly, which should enhance their preservation. [ABSTRACT FROM AUTHOR]

Objectives: Ultrasound-guided superior laryngeal nerve (SLN) block is a practical and painless approach to avoid the hemodynamic stress response during endotracheal intubation and relieve sore throat after laryngeal surgery. The main purpose of this study was to establish an optimal dosage of local anesthetic when performing SLN block to help anesthetists balance analgesia and side effects. Methods: Twenty fresh larynx specimens were obtained immediately after resection and then injected with 2-, 3-, 4-, or 5- mL of a lidocaine-blue dye mixture at bilateral SLN puncture sites. Superficial areas of deposited blue dye were measured. Dye leakage and surrounding dyed tissue were recorded. Another 40 patients were included in the ultrasound investigation. Distances between the internal branch of the SLN (iSLN) and adjacent structures were calculated. Results: The dye spread area was greater with the administration of larger doses, especially to the visceral space. A 2- or 3-mL injection of local anesthetic was sufficient to infiltrate the SLN gap. A higher incidence of dye leaking out of the thyrohyoid membrane and anterior epiglottis space was observed; furthermore, there was substantially more dyed hyoid/thyroid cartilage with 4 and 5 mL of injected dye mixture than 2 mL. There was no significant difference between the specimen and ultrasound measurements of for length of iSLN-adjacent structures. Conclusions: In the Chinese population, 2- or 3- mL of local anesthetic is a safe dose during SLN block. A larger volume could overflow from the cavity to cause complications. The thyrohyoid membrane combined with the superior laryngeal artery is a reliable target for positioning the iSLN during ultrasound-guided regional anesthesia. [ABSTRACT FROM AUTHOR]

• The shear behavior of externally prestressed UHPC beams without stirrups is experimentally investigated. • Effects of the a / d ratio, stirrups, and longitudinal reinforcement ratio are discussed. • An equation for predicting the shear-cracking strength of prestressed UHPC beams is proposed. • Effects of key parameters on the shear strength of prestressed UHPC beams without stirrups are analyzed. • Prediction equations of shear strength of prestressed UHPC beams without stirrups are proposed. Externally prestressed ultra-high-performance concrete (UHPC) beams without stirrups (EPUBs-WS) that simplify the reinforcement design and construction procedure are becoming a competitive option in bridge engineering. To investigate the shear behavior of EPUBs-WS, five specimens were designed and tested considering several critical parameters, such as the shear span-to-depth ratio (λ), shear stirrups, and longitudinal reinforcement ratio. The EPUBs-WS exhibits diagonal tension failure as the fibers pull out and the specimen shears off into two parts along the critical diagonal crack. However, the beam with λ = 3.67 exhibited flexural failure due to the large λ. The stiffness, shear-cracking strength, and shear strength of EPUBs-WS decrease as λ increases. Stirrups enhance the shear resistance of EPUBs but result in a more brittle shear failure mode. A higher reinforcement ratio augments the dowel action in EPUBs-WS, which contributes to a ductile shear failure mechanism. The web-shear cracking force accounts for 46% to 87% of the shear capacity, implying that the shear-cracking strength is a significant factor in the design of EPUBs-WS. An equation for predicting the shear-cracking strength of prestressed UHPC beams is proposed and validated using a database of experimental results reported in the literature. A parametric analysis is performed using 40 available specimens to investigate the effects of compressive strength, λ , reinforcement ratio, fiber reinforcing index, and prestressing level on the shear strength of prestressed UHPC beams without stirrups. By considering the key parameters, equations for estimating the shear strength are proposed and exhibit good accuracy. [ABSTRACT FROM AUTHOR]

The two-step calcium oxide based calcination–carbonation cycle is studied for carbon dioxide capture and solar thermochemical energy storage applications. An indirectly-irradiated packed-bed solar thermochemical reactor is experimentally evaluated using simulated high-flux solar irradiation provided by a multi-source solar simulator. Experimental runs include a single calcination reaction step as well as single and multiple (up to four) consecutive calcination–carbonation cycles. The samples are characterised using scanning electron microscopy (SEM) and X-ray diffraction (XRD). The reactor temperature peaked at 1,035°C. The average solar-to-chemical conversion efficiency, defined as the ratio of heat consumed by the reaction to radiant heat supplied to the reactor, was found to be between approximately 1.3% and 8.6% for the five performed experimental runs. The necessary advancements to the presented reactor design identified during the experimental campaign include improvements in thermomechanical characteristics of ceramic and metallic parts of the reactor to prevent fast mechanical and chemical degradation, application of more robust high-temperature reaction chamber seals, and optimisation of reactor geometry and gas flow patterns towards spatially more uniform thermal conditions and chemical reaction rates. • A packed-bed solar thermochemical reactor is experimentally evaluated. • The reactor is indirectly heated using simulated high-flux solar irradiation. • Cyclic calcination–carbonation of calcium carbonate is demonstrated. • A maximum solar-to-chemical conversion efficiency of 8.6% is achieved. • Improvements in the reactor design are suggested for better performance. [ABSTRACT FROM AUTHOR]

Klebsiella pneumoniae is an opportunistic pathogen belonging to the Enterobacteriaceae family, which is the leading cause of nosocomial infections. The emergence of hypervirulent and multi-drug resistant K. pneumoniae is a serious health threat. In the process of infection, K. pneumoniae needs to adapt to different environmental conditions, and the two-component regulatory system (TCS) composed of a sensor histidine kinase and response regulator is an important bacterial regulatory system in response to external stimuli. Understanding how K. pneumoniae perceives and responds to complex environmental stimuli provides insights into TCS regulation mechanisms and new targets for drug design. In this review, we analyzed the TCS composition and summarized the regulation mechanisms of TCSs, focusing on the regulation of genes involved in virulence, antibiotic resistance, and stress response. Collectively, these studies demonstrated that several TCSs play important roles in the regulation of virulence, antibiotic resistance and stress responses of K. pneumoniae. A single two-component regulatory system can participate in the regulation of several stress responses, and one stress response process may include several TCSs, forming a complex regulatory network. However, the function and regulation mechanism of some TCSs require further study. Hence, future research endeavors are required to enhance the understanding of TCS regulatory mechanisms and networks in K. pneumoniae , which is essential for the design of novel drugs targeting TCSs. • Klebsiella pneumoniae is an opportunistic pathogen and main cause of nosocomial infections. • Understanding how K. pneumoniae senses and responds to environmental stimuli is important. • Progress in roles of two-component regulatory systems (TCSs) were reviewed. • The regulation focused on the regulation of virulence, antibiotic resistance and stress response. • Insights into the regulatory mechanisms provide clues for the design of novel drugs targeting the TCSs. [ABSTRACT FROM AUTHOR]

• A three-dimensional compound parabolic concentrator (CPC) is designed for a high-temperature solar chemical reactor. • The optical design is guided by Monte Carlo ray-tracing simulations. • A cooling system is designed using engineering heat transfer correlations. • The CPC increases the concentration ratio, reduces spillage loss and reduces flux non-uniformity. A three-dimensional compound parabolic concentrator (CPC) is designed for high-temperature solar thermochemical applications driven by radiation from a multi-source high-flux solar simulator. The basic geometrical parameters of the CPC including the acceptance angle and the entry aperture radius are determined using optical simulations. A cooling system for overheating protection is designed using engineering heat transfer correlations. A prototype CPC is manufactured using additive manufacturing and single point diamond turning techniques. The optical simulations show that the CPC increases the concentration ratio by a factor of 4.1 at an optical efficiency of 85.4%, reduces spillage loss from 78.9% to 32.1%, and reduces the flux non-uniformity on the target surface. [ABSTRACT FROM AUTHOR]

Derivation of effective-medium permittivities (in the traditional sense) of one-dimensional gratings is revisited. In the present derivation, carried out in Fourier-space and for conical mounting, systematic treatment and mathematical rigour are emphasized. An error of a previous paper published in this journal concerning the 2nd-order effective permittivity in TM polarization is corrected. The derived formulas of the 4th-order effective permittivity and the 2nd-order effective permittivity, when restricted to TE and TM polarizations respectively, agree well with the previous results. The symmetry of the effective permittivities with respect to the sign of the Floquet exponential factor and the sign of grating period is noted and proven. [ABSTRACT FROM AUTHOR]

Abstract In this study, a theoretical model called the improved softened membrane model for torsion (ISMMT) is proposed for evaluating prestressed composite box girders with corrugated steel webs (PCBGCSWs) under pure torsion. First, considering the mechanical properties of PCBGCSWs, a series of equations are derived from equilibrium and compatibility conditions and constitutive relationships of the materials. In the equations, the criteria of shear flow equivalence and shear strain equivalence are adopted to determine the relationships between the concrete flanges and the corrugated steel webs (CSWs) before and after the yielding of the CSWs, respectively. Then, the solution algorithms, including a general algorithm for the entire torsional process and a simplified algorithm for the stage when both steel bars, the prestressing steel and the CSWs are in the elastic state, of the ISMMT are presented to solve all the equations. To validate the feasibility of the proposed theoretical model, the experimental results of a prismatic PCBGCSW under pure torsion available in the literature are selected for comparison. Additionally, a three-dimensional (3D) finite element (FE) model of the specimen is established using ABAQUS software. The results from the theoretical model, including the overall torque-twist curve, shear strain in the CSWs and strains in the prestressing steels and steel bars, are compared with those from the FE model and the experiment. The theoretical, numerical and experimental results are in good agreement, demonstrating that the proposed analytical model accurately predicts the torsional behaviour of the PCBGCSWs under pure torsion, including the torsional behaviour during the pre- and post-cracking stages. Highlights • A theoretical model (ISMMT) is proposed for evaluating PCBGCSWs under pure torsion • The general and simplified solution algorithms of the ISMMT are proposed • The feasibility of the ISMMT is validated by the numerical and experimental results • The criteria for determining the relationships between the concrete flanges and the CSWs are proved to be reasonable [ABSTRACT FROM AUTHOR]

Knowledge reduction is one of the key issues in formal concept analysis, and there have been many studies on this topic. Granule knowledge reduction and attribute reduction are two of the most important knowledge reduction in formal concept analysis. Firstly, theorem to character granule knowledge reduction is given, and granule knowledge reduction method in concept lattices based on 0-1 linear integer programming is proposed in this paper. Then, characterization theorems of three types attributes are obtained in attribute reduction, and attribute reduction method in concept lattices based on 0-1 linear integer programming is proposed. [ABSTRACT FROM AUTHOR]