Search

Your search keyword '"Li, Jingxia"' showing total 792 results
Start Over Author "Li, Jingxia"
792 results on '"Li, Jingxia"'

2. FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway

Author

Heng Yanyan, Wei Wei, Cheng Linzhong, Wu Feifei, Dong Haoyu, Li Jingxia, Fu Jianing, Yang Bingjie, Liang Xinyue, Liu Chunyan, Li Haiju, Liu Haihua, and Zhang Pengfei

Subjects
vascular smooth muscle cell, senescence, NLRP3 inflammasome, PPARγ, catalase, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Diabetes accelerates vascular senescence, which is the basis for atherosclerosis and stiffness. The activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and oxidative stress are closely associated with progressive senescence in vascular smooth muscle cells (VSMCs). The vascular protective effect of FGF21 has gradually gained increasing attention, but its role in diabetes-induced vascular senescence needs further investigation. In this study, diabetic mice and primary VSMCs are transfected with an FGF21 activation plasmid and treated with a peroxisome proliferator-activated receptor γ (PPARγ) agonist (rosiglitazone), an NLRP3 inhibitor (MCC950), and a spleen tyrosine kinase (SYK)-specific inhibitor, R406, to detect senescence-associated markers. We find that FGF21 overexpression significantly restores the level of catalase (CAT), vascular relaxation, inhibits the intensity of ROSgreen fluorescence and p21 immunofluorescence, and reduces the area of SA-β-gal staining and collagen deposition in the aortas of diabetic mice. FGF21 overexpression restores CAT, inhibits the expression of p21, and limits the area of SA-β-gal staining in VSMCs under high glucose conditions. Mechanistically, FGF21 inhibits SYK phosphorylation, the production of the NLRP3 dimer, the expression of NLRP3, and the colocalization of NLRP3 with PYCARD (ASC), as well as NLRP3 with caspase-1, to reverse the cleavage of PPARγ, preserve CAT levels, suppress ROSgreen density, and reduce the expression of p21 in VSMCs under high glucose conditions. Our results suggest that FGF21 alleviates vascular senescence by regulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway in diabetic mice.

Published
2024
Full Text
View/download PDF

6. A Robust Economy Optimization Method of Virtual Power Plant Participating in Day-Ahead Invitation Demand Response

Author

Zhong, Yongjie, Ji, Ling, Li, Jingxia, Wang, Yong, Wang, Zidong, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Yang, Qingxin, editor, Dong, Xuzhu, editor, and Ma, Weiming, editor

Published
2023
Full Text
View/download PDF

7. Example of Integrated Energy Demonstration Project Based on Clean Coal Power

Author

Zhong, Yongjie, Ji, Ling, Li, Jingxia, Wang, Zidong, Wang, Yong, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Yang, Qingxin, editor, Dong, Xuzhu, editor, and Ma, Weiming, editor

Published
2023
Full Text
View/download PDF

14. Energy Management System for Flexible Load Aggregator Based on Redis

Author

WU Shiwei, JI Ling, JIANG Yanjun, LIU Wenbiao, LI Jingxia, and LIU Yongxiao

Subjects
flexible load aggregator, redis, adjustable potential, control, simulation, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

For ease of study and modeled training of control strategy for flexible load aggregator， an energy management and simulation system is established， which， in the light of information exchange technology featuring Reid′s subscription/publication， uses a load adjustable potential calculation method of physical model and a fast control method to support the flexible load aggregation and regulation process of power grid， realizing the automatic response and fast distribution of flexible load. The system simulates the scenario of flexible load participating in new energy consumption and power grid peak shaving and valley filling， and can be used for control strategy research and simulation to underpin flexible load aggregators to participate in power grid regulation. The system has been applied and verified in the pilot project.

Published
2022
Full Text
View/download PDF

24. Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

Author

Xu, Yan, Xiang, Zheng, Alnaggar, Mohammed, Kouakanou, Léonce, Li, Jiawei, He, Junyi, Yang, Jiashuang, Hu, Yi, Chen, Yan, Lin, Li, Hao, Jianlei, Li, Jingxia, Chen, Jibing, Li, Man, Wu, Qingling, Peters, Christian, Zhou, Qinghua, Li, Jianshuang, Liang, Yingqing, Wang, Xiaohua, Han, Baohui, Ma, Meili, Kabelitz, Dieter, Xu, Kecheng, Tu, Wenwei, Wu, Yangzhe, and Yin, Zhinan

Published
2021
Full Text
View/download PDF

25. The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer.

Author

Cui, Zhili, Zhou, Liyuan, An, Xin, Liu, Wenli, Li, Jingxia, Zhang, Yueping, and Zhang, Wei

Subjects
ENDOMETRIAL cancer, MACROPHAGE migration inhibitory factor, RECEIVER operating characteristic curves, CIRCULAR RNA
Abstract

Background: Circular RNAs (circRNAs) exhibit unique patterns of expression and high levels of stability in patient plasma samples such that they represent ideal non-invasive biomarkers that can be leveraged to detect a wide array of diseases including endometrial cancer (EC). This study was designed to identify circRNAs with potential diagnostic utility in serum samples from EC patients while also evaluating the utility of macrophage migration inhibitory factor (MIF) as a biomarker when screening for this form of cancer in the clinic. Methods: Levels of circEPSTI1 and MIF were assessed in the plasma of EC patients and healthy subjects (n=186 each) through qPCR and ELISAs. The diagnostic utility of these biomarkers was assessed with receiver operating characteristic curve (ROC) analyses. Results: Relative to healthy subjects, EC patient serum contained significantly elevated circEPSTI1 and MIF. An association was noted between circEPSTI1 expression in stages, histologic grade, and residual tumor. ROC curves confirmed that serum circEPSTI1 levels distinguished between controls and patients with EC with an Area of 0.835 and serum MIF levels distinguished between controls and patients with EC with an Area of 0.6646. When instead diagnosing patients based on the combination of MIF and circEPSTI1, the Area further rose to 0.8604. Conclusion: Assessing the combination of circEPSTI1 and MIF may be a viable approach to reliably diagnosing EC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

48. Supplemental Figure 1 from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
Full Text
View/download PDF

49. Supplemental Figure 2 from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
Full Text
View/download PDF

50. Data from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results