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This study proposed the numerical simulation method of full-length prestressed anchor grouting support based on the post-grouting technology, and the modification of the embedded PILE structural unit in FLAC3D software. Specifically, we conducted the numerical simulation and made comparison in terms of the control effect of roadway surrounding rock under six types of factors: ground stress, strength grade of original rock, length of supporting members, layout spacing, grouting strengthening index and prestress, with the aim to reveal how these factors affect the deformation of surrounding rock and the evolution of plastic zone. Then, we proposed the sensitivity evaluation index of control effect under full-length prestressed anchor grouting support. The influencing factors are divided into 3 levels: strength of surrounding rock, ground stress and design of bolt-grouting support members. Suggestions for engineering are also given according to the sensitivity level of each factor. Finally, the combined high-strength grouting bolt and high-strength hollow grouting cable are developed based on a typical roadway in weak broken strata. It can effectively enhance the self-carrying capacity of weak broken surrounding rock, give full play to the supporting potential of anchoring members, and limit the deformation and failure of roadway surrounding rock. Through the field application, the full-length prestressed bolt-grouting support is verified.

Objective To investigate the status of HIV-1 transmitted drug resistance and the first T lymphocyte count in Kunming city, and to provide reference for antiviral treatment. Methods Newly discovered HIV/AIDS patients living in Kunming were selected, plasma was collected, gene sequence in pol region was amplified, genotype determination, drug resistance mutation and CD4+ T lymphocyte analysis were performed. Results A total of 647 HIV-1 pol gene sequences were obtained. The most of them are URFs subtype (29.37%), and then CRF08 &lowbar; BC subtype (26.28%) and CRF07&lowbar;BC subtype (16.54%) respectively. Most of them were male (77.43%), 50 years old and above accounted for the largest proportion (32.15%), and the main transmission route was heterosexual transmission (56.88%). Gender, education level, transmission route and gene subtype were the influencing factors of drug resistance ( P < 0. 05). The transmited drug resistance rate of HIV/AIDS patients was 11.75%, and the resistance rates of nucleoside reverse transcriptase inhibitors (NRTIs ), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors ( Pis) and integrase inhibitors (INSTIs) were 0.77%, 7.73%, 3.40% and 0.31%, respectively. The mutation rates of NRTIs, NNRTIs, Pis and INSTIs resistance sites were 2.16%, 19.47%, 3.86%and 1.39%, respectively. The first CD4 + T lymphocyte count was mainly 200-350 cell/µL, accounting for 29.37%, followed by <200 cell /µL, accounting for 27.82%, and the late detection rate was 30.91%. Conclusion The transmitted drug resistance of HIV-1 in Kunming is at the moderate level, and NNRTIs related drug resistance is the main factor. The INSTIs drugs that not widely used in Kunming are also resistant, while Kunming city has a high proportion of late detection. We should strengthen AIDS publicity work, expand the detection scope, and detect cases as early as possible, in order to improve patients quality of life and reduce transmission. [ABSTRACT FROM AUTHOR]

BackgroundOwing to its excellent mechanical properties and corrosion resistance, 304L stainless steel is widely used as the core structure material in advanced nuclear power systems.PurposeThis study aims to investigate the damage characteristics of selective laser melted (SLM) 304L stainless steel under Xe ion irradiation and compare them with that of traditionally manufactured (TM) 304 stainless steel under the same experimental conditions.MethodsSLM 304L and TM 304L alloy samples were irradiated with 5 MeV Xe ions at 550 ℃. The irradiation dose was 3.53×1015 ions·cm-2. The microstructure and nano-hardness changes of the both alloy samples before and after irradiation were characterized by transmission electron microscopy (TEM) and nanoindentation, respectively. TEM samples were prepared by focused ion beam.ResultsThe TEM images show that dislocation loops and bubbles appeared in the irradiated alloy samples. The average sizes and number densities of dislocation loops in the SLM 304L and TM 304L alloy samples are (2.13±0.53) nm and (1.94±0.46) nm, 1.48×1022 m-3 and 6.94×1022 m-3, respectively. The average sizes and number densities of Xe bubbles in the SLM 304L and TM 304L alloy samples are (3.71±1.40) nm and (1.37±0.46) nm, 3.50×1022 m-3 and 1.73×1023 m-3, respectively. The both alloy samples show the irradiation hardening after Xe ion irradiation. The irradiation hardening degrees of the SLM 304L and TM 304L alloy samples are 14% and 32%, respectively.ConclusionsThe calculation results based on the dispersed barrier hardening model (DBH) reveal that the dislocation loops and Xe bubbles caused by irradiation play an important role in irradiation hardening of the two kinds of alloys.

Barley (Hordeum vulgare L.) is the fourth-largest cereal crop widely grown for livestock feed, brewing malts and human food. The TIFY family is a plant-specific protein family with diverse functions in plant growth, development and stress responses. However, a genome-wide comprehensive analysis of the TIFY gene family has not yet been characterized in Hordeum vulgare. In the present study, 21 and 22 TIFY family members were identified in the genomes of Hv_Morex and Hv_Barke, respectively. The HvTIFY proteins could be divided into the TIFY, ZIM/ZML and JAZ groups, and the JAZ group could be further clustered into six subgroups. HvTIFY genes were conserved in the two genotypes, and all of the duplicated gene pairs in the barley TIFY family were dominated by intense purifying selection. Tandem duplication was the main driving force for the expansion of the HvTIFY gene family. In silico gene expression profiling revealed most members of the Hv_Morex JAZ group were predominantly expressed in reproductive organs and root tissues and were also more involved in the responses to cold treatment and spot blotch infection than other groups. Quite a few JAZ genes (Hv_MoJAZ1, Hv_MoJAZ4, Hv_MoJAZ6, Hv_MoJAZ9, Hv_MoJAZ11, Hv_MoJAZ12 and Hv_MoJAZ14) were found to be tightly associated with the growth of barley and the responses to cold and spot blotch infection stresses. The genome-wide comprehensive analysis of the structure and function of the HvTIFY genes will contribute further to our understanding of the functions of these genes in response to abiotic and biotic stresses in Hordeum vulgare. [ABSTRACT FROM AUTHOR]