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Ulcerative colitis (UC) is associated with the shedding of the gut mucus. Decellularized porcine small intestinal submucosa (SIS‐ECM) contains numerous active forms of extracellular matrix as well as growth factors. Herein, a mucus‐mimetic hydrogel (MAG) is designed as a barrier therapy by integrating SIS‐ECM with hyaluronic acid and epigallocatechin‐3‐gallate. MAG not only presented the viscoelastic behaviors with G' of 4000 Pa but also good thixotropy. Moreover, MAG as a physical shielding is effective to hinder E. coli invasion. Besides, the good repairing effect on the injured Caco‐2 cells is presented by MAG. When MAG as a biomimetic mucus is rectally administrated to colitis mouse, it alleviated effectively the colitis symptoms and improved the colonic shorting. Moreover, expression of IL‐1β, IL‐6, and TNF‐α at the laminae propria is substantially inhibited by MAG. Besides, the colonic epitheliums are well rearranged, and the tight junction proteins (ZO‐1, Occludin‐1, Claudin‐5) between them are greatly upregulated after MAG treatment. Meanwhile, the mucus secretion of goblets cells is effectively repaired by MAG treatment. The repairing mechanism of intestinal mucosa barriers is associated with promoting the proliferation and differentiation of intestinal stem cells. Collectively, MAG might be a promising strategy of barrier therapy for UC. [ABSTRACT FROM AUTHOR]

The human retina perceives and preprocesses the spectral information of incident light, enabling fast image recognition and efficient chromatic adaptation. In comparison, it is reluctant to implement parallel spectral preprocessing and temporal information fusion in current complementary metal‐oxide‐semiconductor (CMOS) image sensors, requiring intricate circuitry, frequent data transmission, and color filters. Herein, an active‐matrix synaptic phototransistor array (AMSPA) is developed based on organic/inorganic semiconductor heterostructures. The AMSPA provides wavelength‐dependent, bidirectional photoresponses, enabling dynamic imaging and in‐sensor spectral preprocessing functions. Specifically, near‐infrared light induces inhibitory photoresponse while UV light results in exhibitory photoresponse. With rational structural design of the organic/inorganic hybrid heterostructures, the current dynamic range of phototransistor is improved to over 90 dB. Finally, a 32 × 64 AMSPA (128 pixels per inch) is demonstrated with one‐switch‐transistor and one‐synaptic phototransistor (1‐T‐1‐PT) structure, achieving spatial chromatic enhancement and temporal trajectory imaging. These results reveal the feasibility of AMSPA for constructing artificial vision systems. [ABSTRACT FROM AUTHOR]

Wearable sensors designed for continuous, non‐invasive monitoring of physicochemical signals are important for portable healthcare. Oxide field‐effect transistor (FET)‐type biosensors provide high sensitivity and scalability. However, they face challenges in mechanical flexibility, multiplexed sensing of different modules, and the absence of integrated on‐site signal processing and wireless transmission functionalities for wearable sensing. In this work, a fully integrated wearable oxide FET‐based biosensor array is developed to facilitate the multiplexed and simultaneous measurement of ion concentrations (H+, Na+, K+) and temperature. The FET‐sensor array is achieved by utilizing a solution‐processed ultrathin (≈6 nm thick) In2O3 active channel layer, exhibiting high compatibility with standard semiconductor technology, good mechanical flexibility, high uniformity, and low operational voltage of 0.005 V. This work provides an effective method to enable oxide FET‐based biosensors for the fusion of multiplexed physicochemical information and wearable health monitoring applications. [ABSTRACT FROM AUTHOR]

To grasp the overall safety state of coal mine in real time, this paper introduces the concept of safety situation awareness into the field of coal mine safety, and constructs a coal mine safety situation awareness system which integrates intelligent perception, safety situation assessment and risk intelligent early warning. The system collects and processes data comprehensively and effectively through the Internet of Things monitoring, analyzes the national coal mine accident records and extracts the impact factors of coal mine risk, extracts the chain of accident causes through Bayesian network analysis, and establishes the index system of safety situation multilevel prediction, constructs the multilevel prediction model of coal mine risk change trend by the combined application of Bayesian Network, Rough Set Theory and Support Vector Machine; finally, the system presents the results of overall safety situation assessment of coal mine to users through visual charts. The system provides intuitive and effective prediction results for the overall safety situation of coal mines, and provides ideas for the perception study of coal mine safety situation.

Bio‐inspired neuromorphic vision sensors, integrating optical sensing, and processing functions have attracted significant attention for developing future low‐power and high‐efficiency imaging systems. However, the compulsory electrical signal modulation to achieve inhibitory behaviors in most reported neuromorphic vision sensors results in additional hardware and computational latency. Herein, bidirectional photoresponsive optoelectronic synapses based on In2O3/Al2O3/Y6 phototransistors are achieved, realizing all‐optical‐configured synaptic weight updates enabled by dual photogates. The inhibitory and excitatory photoresponses originate from the photogating effects provided by trapped photogenerated electrons in Al2O3 under near‐infrared light and the ionized oxygen vacancies in In2O3 under ultra‐violet light, respectively. The bidirectional phototransistor illustrates outstanding optoelectronic synaptic characteristics with low nonlinearity and asymmetry, demonstrating high efficiencies in both preprocessing and postprocessing tasks, such as noise reduction, contrast enhancement, and pattern recognition. The proposed dual‐photogate optoelectronic synapses provide effective strategies to construct high‐efficiency neuromorphic vision sensors and in‐sensor computing systems. [ABSTRACT FROM AUTHOR]