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27 results on '"Li, Cuiliu"'

17. Serum Pigment Epithelium-Derived Factor Levels are Associated with Estradiol and Decrease After Adjusting for Alanine Aminotransferase in Chinese Women Based on Multiple Linear Regression Analysis

Author

Li,Cuiliu, Zhang,Yunna, Gao,Fang, Li,Cuiliu, Zhang,Yunna, and Gao,Fang

Abstract

Cuiliu Li, Yunna Zhang, Fang Gao The Second Department of Endocrinology, Cangzhou Central Hospital, Cangzhou, 061001, People’s Republic of ChinaCorrespondence: Cuiliu Li, Tel +8603172075935, Email licuiliu1989@163.comPurpose: To assess changes in pigment epithelium-derived factor (PEDF) levels in patients with metabolic syndrome (MetS) and to investigate sexual dimorphism in serum PEDF levels and their relationships with estradiol.Methods: A total of 318 individuals (145 men, 173 women) who underwent health examinations in our department were selected. Serum PEDF, estradiol and other metabolic parameters were determined. Homeostasis model assessment of insulin resistance (HOMA- IR) and homeostasis model assessment of β-cell function (HOMA-β) were calculated to evaluate insulin resistance and β-cell function, respectively. Multiple linear regression analysis was used to analyse the factors influencing serum PEDF.Results: Serum PEDF levels were significantly higher in subjects with MetS in both men and women (12.09± 2.75 vs 8.97± 3.19 μg/mL in men and 11.31± 2.79 vs 8.40± 2.32 μg/mL in women, MetS vs non-MetS, P< 0.001). Correlation analysis showed that serum PEDF levels were significantly correlated with body mass index (BMI), waist circumference, waist-to-hip ratio, diastolic blood pressure (DBP), fasting and 2-h postprandial glucose, fasting and 2-h postprandial insulin, HOMA-β, HOMA-IR, hemoglobin A1c (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid (UA), triacylglycerol (TG) and high-density lipoprotein cholesterol (HDL-C). Elevated ALT, HOMA-IR and TG were significant predictors of increased PEDF concentrations. In women, estradiol was inversely correlated with PEDF levels (r=− 0.25, P=0.011), and the association was no longer significant after adjustment for ALT.Conclusion: PEDF could be used as a biomarker of MetS in both men and women. This study reported for the first time that circulating PEDF displays se

Published
2022

21. Eu3+-Postdoped UIO-66-Type Metal–Organic Framework as a Luminescent Sensor for Hg2+ Detection in Aqueous Media

Author

Li Cuiliu, Zhu Chengyu, Qin Xiaohong, Zhang Wenjun, and Zhang Xiaoxiong

Subjects
Lanthanide, Detection limit, Aqueous solution, 010405 organic chemistry, Chemistry, Inorganic chemistry, Photothermal therapy, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Inorganic Chemistry, Metal, Isophthalic acid, chemistry.chemical_compound, visual_art, visual_art.visual_art_medium, Physical and Theoretical Chemistry, Luminescence, Biosensor
Abstract

Because of its extreme toxicity, the determination of Hg2+ in aqueous solution is an important subject for human health and environmental monitoring. In this study, a novel UIO-66-type metal-organic framework (MOF) doped with Eu3+ (isophthalic acid and 2,6-pyridinedicarboxylic acid and zirconium chloride served as the organic connectors and metal precursor, respectively) was prepared by a hydrothermal method and postsynthetic modification. The obtained lanthanide MOFs exhibited good photothermal and fluorescence stability in aqueous solution. As a luminescent probe, dispersions of the material can specifically recognize Hg2+ in many ions and have a detection limit of 8.26 nM. This novel lanthanide MOF shows great potential applications for biosensing, imaging, environmental analysis, and so on.

Published
2019

24. Eu

Author

Zhang, Xiaoxiong, Zhang, Wenjun, Li, Cuiliu, Qin, Xiaohong, and Zhu, Chengyu

Abstract

Because of its extreme toxicity, the determination of Hg

Published
2019

27. The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.

Author

Su N, Zhao N, Wang G, Wang L, Zhang Y, Li R, Liu Y, Yang X, Li C, and Hou M

Subjects
Female, Humans, Male, Middle Aged, Adiponectin blood, Blood Glucose metabolism, Diabetes Mellitus, Type 2 blood, Diabetic Angiopathies blood, Lipid Metabolism, Receptors, Adiponectin blood
Abstract

Background/aims: The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters., Methods: A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM + MVC group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected as control group (NC group). Clinical data and biological parameters were detected and recorded. T test was performed to compare the differences between two groups, and the results were corrected using Bonferroni method. Meanwhile, the correlation analysis and multiple stepwise regression analysis were used to analyze the association of APN and AdipoR1 with clinical factors., Results: The levels of APN and AdipoR1 were significantly decreased in T2DM group and T2DM + MVC group compared with NC group, with the lowest value in T2DM + MVC group (all P<0.01). Serum APN levels were positively correlated with FINS and TG (r = 0.412, 0.316, respectively; both P<0.05), and negatively correlated with SBP, DBP and LDL-C (r = -0.292, -0.383, -0.334, respectively; all P<0.05). Serum levels of AdipoR1 were positively correlated with APN (r = 0.726, P<0.01), and negatively correlated with BMI, SBP, DBP, FBG, TC and LDL-C (r = -0.440, -0.446, -0.374, -0.444, -0.344, -0.709, respectively; all P<0.01)., Conclusion: Serum levels of APN and AdipoR1 are significantly lower in T2DM group and T2DM + MVC group, showing lowest value in T2DM + MVC group. APN and AdipoR1 levels may influence glucose and lipid metabolism in T2DM patients., Competing Interests: The authors declare to have no competing interests., (© Copyright by the Author(s). Published by Cell Physiol Biochem Press.)

Published
2019
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